In-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules
Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the acc...
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| Published in | Nature communications Vol. 15; no. 1; pp. 5132 - 12 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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London
Nature Publishing Group UK
15.06.2024
Nature Publishing Group Nature Portfolio |
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| Abstract | Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the accurate discrimination of the molecules. Here, we show the use of inertial-kinetic translocation induced by spinning an in-tube micro-pyramidal silicon nanopore fabricated using photovoltaic electrochemical etch-stop technique for biomolecular sensing. By adjusting the kinetic properties of a funnel-shaped centrifugal force field while maintaining a counter-balanced state of electrophoretic and electroosmotic effect in the nanopore, we achieved regulated translocation of proteins and obtained stable signals of long and adjustable dwell times and high conformational sensitivity. Moreover, we demonstrated instantaneous sensing and discrimination of molecular conformations and longitudinal monitoring of molecular reactions and conformation changes by wirelessly measuring characteristic features in current blockade readouts using the in-tube nanopore device.
The authors report a strategy to achieve high S/N ratio signal readout in single molecule sensing by incorporating the inertial forces as a new channel for independently controlling the translocation parameters with high precision. |
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| AbstractList | Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the accurate discrimination of the molecules. Here, we show the use of inertial-kinetic translocation induced by spinning an in-tube micro-pyramidal silicon nanopore fabricated using photovoltaic electrochemical etch-stop technique for biomolecular sensing. By adjusting the kinetic properties of a funnel-shaped centrifugal force field while maintaining a counter-balanced state of electrophoretic and electroosmotic effect in the nanopore, we achieved regulated translocation of proteins and obtained stable signals of long and adjustable dwell times and high conformational sensitivity. Moreover, we demonstrated instantaneous sensing and discrimination of molecular conformations and longitudinal monitoring of molecular reactions and conformation changes by wirelessly measuring characteristic features in current blockade readouts using the in-tube nanopore device. Abstract Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the accurate discrimination of the molecules. Here, we show the use of inertial-kinetic translocation induced by spinning an in-tube micro-pyramidal silicon nanopore fabricated using photovoltaic electrochemical etch-stop technique for biomolecular sensing. By adjusting the kinetic properties of a funnel-shaped centrifugal force field while maintaining a counter-balanced state of electrophoretic and electroosmotic effect in the nanopore, we achieved regulated translocation of proteins and obtained stable signals of long and adjustable dwell times and high conformational sensitivity. Moreover, we demonstrated instantaneous sensing and discrimination of molecular conformations and longitudinal monitoring of molecular reactions and conformation changes by wirelessly measuring characteristic features in current blockade readouts using the in-tube nanopore device. Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the accurate discrimination of the molecules. Here, we show the use of inertial-kinetic translocation induced by spinning an in-tube micro-pyramidal silicon nanopore fabricated using photovoltaic electrochemical etch-stop technique for biomolecular sensing. By adjusting the kinetic properties of a funnel-shaped centrifugal force field while maintaining a counter-balanced state of electrophoretic and electroosmotic effect in the nanopore, we achieved regulated translocation of proteins and obtained stable signals of long and adjustable dwell times and high conformational sensitivity. Moreover, we demonstrated instantaneous sensing and discrimination of molecular conformations and longitudinal monitoring of molecular reactions and conformation changes by wirelessly measuring characteristic features in current blockade readouts using the in-tube nanopore device. The authors report a strategy to achieve high S/N ratio signal readout in single molecule sensing by incorporating the inertial forces as a new channel for independently controlling the translocation parameters with high precision. Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the accurate discrimination of the molecules. Here, we show the use of inertial-kinetic translocation induced by spinning an in-tube micro-pyramidal silicon nanopore fabricated using photovoltaic electrochemical etch-stop technique for biomolecular sensing. By adjusting the kinetic properties of a funnel-shaped centrifugal force field while maintaining a counter-balanced state of electrophoretic and electroosmotic effect in the nanopore, we achieved regulated translocation of proteins and obtained stable signals of long and adjustable dwell times and high conformational sensitivity. Moreover, we demonstrated instantaneous sensing and discrimination of molecular conformations and longitudinal monitoring of molecular reactions and conformation changes by wirelessly measuring characteristic features in current blockade readouts using the in-tube nanopore device.Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the accurate discrimination of the molecules. Here, we show the use of inertial-kinetic translocation induced by spinning an in-tube micro-pyramidal silicon nanopore fabricated using photovoltaic electrochemical etch-stop technique for biomolecular sensing. By adjusting the kinetic properties of a funnel-shaped centrifugal force field while maintaining a counter-balanced state of electrophoretic and electroosmotic effect in the nanopore, we achieved regulated translocation of proteins and obtained stable signals of long and adjustable dwell times and high conformational sensitivity. Moreover, we demonstrated instantaneous sensing and discrimination of molecular conformations and longitudinal monitoring of molecular reactions and conformation changes by wirelessly measuring characteristic features in current blockade readouts using the in-tube nanopore device. Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the accurate discrimination of the molecules. Here, we show the use of inertial-kinetic translocation induced by spinning an in-tube micro-pyramidal silicon nanopore fabricated using photovoltaic electrochemical etch-stop technique for biomolecular sensing. By adjusting the kinetic properties of a funnel-shaped centrifugal force field while maintaining a counter-balanced state of electrophoretic and electroosmotic effect in the nanopore, we achieved regulated translocation of proteins and obtained stable signals of long and adjustable dwell times and high conformational sensitivity. Moreover, we demonstrated instantaneous sensing and discrimination of molecular conformations and longitudinal monitoring of molecular reactions and conformation changes by wirelessly measuring characteristic features in current blockade readouts using the in-tube nanopore device.The authors report a strategy to achieve high S/N ratio signal readout in single molecule sensing by incorporating the inertial forces as a new channel for independently controlling the translocation parameters with high precision. |
| ArticleNumber | 5132 |
| Author | Yuan, Wu Ho, Ho-Pui Yang, Jianxin Pan, Tianle Xie, Zhenming |
| Author_xml | – sequence: 1 givenname: Jianxin surname: Yang fullname: Yang, Jianxin organization: Department of Biomedical Engineering, The Chinese University of Hong Kong – sequence: 2 givenname: Tianle surname: Pan fullname: Pan, Tianle organization: Department of Biomedical Engineering, The Chinese University of Hong Kong – sequence: 3 givenname: Zhenming surname: Xie fullname: Xie, Zhenming organization: Department of Biomedical Engineering, The Chinese University of Hong Kong – sequence: 4 givenname: Wu orcidid: 0000-0001-9405-519X surname: Yuan fullname: Yuan, Wu email: wyuan@cuhk.edu.hk organization: Department of Biomedical Engineering, The Chinese University of Hong Kong – sequence: 5 givenname: Ho-Pui surname: Ho fullname: Ho, Ho-Pui email: aaron.ho@cuhk.edu.hk organization: Department of Biomedical Engineering, The Chinese University of Hong Kong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38879544$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_adma_202400018 crossref_primary_10_1002_smtd_202401321 crossref_primary_10_1021_acs_jpcb_4c08692 crossref_primary_10_1016_j_matdes_2025_113764 |
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| Snippet | Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by... Abstract Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is... |
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| SubjectTerms | 631/57 639/925/927/1058 9/10 Centrifugal force Conformation Dwell time Electrochemistry Humanities and Social Sciences Inertial sensing devices multidisciplinary Photovoltaics Plasma etching Pore size Proteins Science Science (multidisciplinary) Sensitivity Signal to noise ratio Silicon Silicon wafers Translocation |
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| Title | In-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules |
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