Contextual Fear Conditioning in Humans: Cortical-Hippocampal and Amygdala Contributions

• Published in: The Journal of neuroscience Vol. 28; no. 24; pp. 6211 - 6219
• Main Authors: Alvarez, Ruben P, Biggs, Arter, Chen, Gang, Pine, Daniel S, Grillon, Christian
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 11.06.2008; Society for Neuroscience
• Subjects: Adult; Amygdala - blood supply; Amygdala - physiology; Cerebral Cortex - blood supply; Cerebral Cortex - physiology; Conditioning, Psychological - physiology; Fear; Female; Galvanic Skin Response; Hippocampus - blood supply; Hippocampus - physiology; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Models, Biological; Neural Pathways - blood supply; Neural Pathways - physiology; Oxygen - blood; Psychophysics; Time Factors

Functional imaging studies of cued fear conditioning in humans have mostly confirmed findings in animals, but it is unclear whether the brain mechanisms that underlie contextual fear conditioning in animals are also preserved in humans. We investigated this issue using functional magnetic resonance...