Hepatitis B Virus and Hepatitis D Virus Entry, Species Specificity, and Tissue Tropism

• Published in: Cold Spring Harbor perspectives in medicine Vol. 5; no. 8; p. a021378
• Main Authors: Watashi, Koichi, Wakita, Takaji
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.08.2015
• Subjects: Female; Hepatitis B - physiopathology; Hepatitis B - virology; Hepatitis B virus - pathogenicity; Hepatitis B virus - physiology; Hepatitis D - physiopathology; Hepatitis D - virology; Hepatitis Delta Virus - pathogenicity; Hepatitis Delta Virus - physiology; Humans; Male; Receptors, Virus - metabolism; Species Specificity; Taurocholic Acid - metabolism; Tropism; Viral Envelope Proteins - metabolism; Virion - metabolism; Virus Internalization

Entry of hepatitis B (HBV) and hepatitis D viruses (HDV) into a host cell represents the initial step of infection. This process requires multiple steps, including the low-affinity attachment of the virus to the cell surface, followed by high-affinity attachment to specific receptor(s), and subseque...