Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy

The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the activation...

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Published inCell death & disease Vol. 15; no. 5; pp. 307 - 16
Main Authors Mai, Zizhao, Lin, Yunfan, Lin, Pei, Zhao, Xinyuan, Cui, Li
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.05.2024
Springer Nature B.V
Nature Publishing Group
Subjects
631/67
692/699/67/1059/2325
Animals
Antibodies
Biochemistry
Biomaterials
Biomedical and Life Sciences
Cancer
Cancer immunotherapy
Cancer vaccines
Cell Biology
Cell Culture
Cell therapy
Extracellular matrix
Extracellular Matrix - metabolism
Humans
Immune checkpoint inhibitors
Immunology
Immunotherapy
Immunotherapy - methods
Life Sciences
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
Oncolysis
Review
Review Article
Tumor microenvironment
Tumor Microenvironment - immunology
Tumors
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Abstract The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the activation of cancer-associated fibroblasts and the accumulation and crosslinking of ECM proteins. Furthermore, it provides a detailed exploration of how ECM stiffness influences the behaviors of both tumor and immune cells. Significantly, the impact of ECM stiffness on the response to various immunotherapy strategies, such as immune checkpoint blockade, adoptive cell therapy, oncolytic virus therapy, and therapeutic cancer vaccines, is thoroughly examined. The review also addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies. The insights offered aim to guide future research, with the potential to enhance the effectiveness of cancer immunotherapy modalities.
AbstractList The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the activation of cancer-associated fibroblasts and the accumulation and crosslinking of ECM proteins. Furthermore, it provides a detailed exploration of how ECM stiffness influences the behaviors of both tumor and immune cells. Significantly, the impact of ECM stiffness on the response to various immunotherapy strategies, such as immune checkpoint blockade, adoptive cell therapy, oncolytic virus therapy, and therapeutic cancer vaccines, is thoroughly examined. The review also addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies. The insights offered aim to guide future research, with the potential to enhance the effectiveness of cancer immunotherapy modalities.
Abstract The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the activation of cancer-associated fibroblasts and the accumulation and crosslinking of ECM proteins. Furthermore, it provides a detailed exploration of how ECM stiffness influences the behaviors of both tumor and immune cells. Significantly, the impact of ECM stiffness on the response to various immunotherapy strategies, such as immune checkpoint blockade, adoptive cell therapy, oncolytic virus therapy, and therapeutic cancer vaccines, is thoroughly examined. The review also addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies. The insights offered aim to guide future research, with the potential to enhance the effectiveness of cancer immunotherapy modalities.
The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the activation of cancer-associated fibroblasts and the accumulation and crosslinking of ECM proteins. Furthermore, it provides a detailed exploration of how ECM stiffness influences the behaviors of both tumor and immune cells. Significantly, the impact of ECM stiffness on the response to various immunotherapy strategies, such as immune checkpoint blockade, adoptive cell therapy, oncolytic virus therapy, and therapeutic cancer vaccines, is thoroughly examined. The review also addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies. The insights offered aim to guide future research, with the potential to enhance the effectiveness of cancer immunotherapy modalities.The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the activation of cancer-associated fibroblasts and the accumulation and crosslinking of ECM proteins. Furthermore, it provides a detailed exploration of how ECM stiffness influences the behaviors of both tumor and immune cells. Significantly, the impact of ECM stiffness on the response to various immunotherapy strategies, such as immune checkpoint blockade, adoptive cell therapy, oncolytic virus therapy, and therapeutic cancer vaccines, is thoroughly examined. The review also addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies. The insights offered aim to guide future research, with the potential to enhance the effectiveness of cancer immunotherapy modalities.
ArticleNumber 307
Author Zhao, Xinyuan
Mai, Zizhao
Lin, Yunfan
Cui, Li
Lin, Pei
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/38693104$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/s41419-018-0458-4
10.7554/eLife.79957
10.1038/onc.2009.299
10.4049/jimmunol.0901352
10.1016/j.coche.2016.01.011
10.1016/j.ceb.2015.06.006
10.3389/fimmu.2021.791453
10.1016/j.jconrel.2022.01.024
10.3390/cancers14153810
10.1158/1078-0432.CCR-18-0205
10.1016/j.biomaterials.2020.120114
10.1002/adhm.201300597
10.1016/j.jmbbm.2014.09.020
10.1007/s11523-021-00809-2
10.1172/JCI26532
10.1126/science.aaw5473
10.1172/JCI161400
10.3389/fimmu.2020.01689
10.1136/gutjnl-2022-327913
10.1038/s41388-023-02715-5
10.1002/adhm.202100794
10.1038/nrd4663
10.1073/pnas.0800835105
10.3892/ijo.2017.3978
10.3389/fonc.2020.01563
10.1056/NEJMoa1817323
10.1016/j.bbagen.2014.03.017
10.1038/nri.2017.74
10.1038/s41388-019-0885-4
10.1016/j.isci.2022.103758
10.1042/BSR20180243
10.1186/s40425-019-0556-6
10.1016/j.jtho.2020.03.003
10.1158/1078-0432.CCR-22-0308
10.5501/wjv.v10.i5.229
10.3389/fimmu.2019.02320
10.1136/jitc-2020-000564
10.1038/s41591-022-01726-1
10.1039/D2SC02708A
10.4049/jimmunol.1102757
10.1002/hep.24108
10.1136/jitc-2020-000664
10.1126/scitranslmed.abp9229
10.1016/j.canlet.2011.12.020
10.1126/science.aaa4967
10.1038/s41408-021-00459-7
10.1007/s13346-023-01337-4
10.1371/journal.pone.0083786
10.1021/acsami.0c16478
10.1152/ajpcell.00018.2009
10.1126/science.aal3118
10.1038/s41598-019-43759-6
10.3892/or.2015.4103
10.3389/fimmu.2015.00500
10.1007/s00262-019-02404-x
10.1016/j.bbrc.2017.12.115
10.1136/jitc-2021-004479
10.1111/j.1349-7006.2011.01861.x
10.3389/fphar.2021.698275
10.1016/S1470-2045(20)30533-7
10.1016/j.tranon.2021.101335
10.1038/nri3191
10.1073/pnas.1817147116
10.1186/s12916-022-02605-9
10.1093/jnci/djj397
10.3389/fimmu.2021.729820
10.1167/iovs.17-22400
10.3390/cancers12092687
10.2147/OV.S145262
10.15252/embj.2018100532
10.1080/2162402X.2018.1440167
10.1016/j.jconrel.2022.09.029
10.3389/fimmu.2022.868809
10.1038/cr.2008.328
10.3390/cancers12020490
10.1016/j.ejca.2008.06.031
10.1136/jitc-2020-001395
10.3390/vaccines9020085
10.1073/pnas.2105367118
10.1126/science.1237572
10.1016/j.bbamcr.2019.118526
10.1136/jitc-2019-000432
10.1186/s40425-018-0474-z
10.1016/j.xcrp.2021.100515
10.1053/j.gastro.2022.07.076
10.1016/j.ijbiomac.2021.05.158
10.1038/s41586-020-2612-2
10.1021/bc200158j
10.1088/1758-5090/aaafbc
10.1158/1078-0432.CCR-19-3806
10.1158/2326-6066.CIR-13-0007
10.3389/fmolb.2019.00160
10.1186/s12964-019-0443-2
10.1021/acsami.0c16638
10.1016/j.modpat.2023.100155
10.15252/emmm.201910923
10.1126/scitranslmed.3010467
10.1038/s41392-021-00544-0
10.1016/j.omto.2022.03.009
10.1111/j.1742-4658.2010.07919.x
10.1038/nri3499
10.3390/cancers13143565
10.1158/1078-0432.CCR-20-2400
10.1007/s12672-023-00613-6
10.1021/acsami.2c14781
10.1172/JCI200320530
10.1038/nrm3904
10.1002/pros.21233
10.1038/s41467-020-18794-x
10.1038/s41568-019-0238-1
10.1161/CIRCRESAHA.120.316533
10.1136/jitc-2020-001800
10.1038/gt.2009.142
10.1021/acsnano.3c00764
10.1074/jbc.RA117.000758
10.1002/pro.4508
10.1038/s41392-023-01407-6
10.1172/JCI74725
10.1016/j.ijrobp.2020.11.053
10.1186/s13073-020-00780-z
10.1136/jitc-2022-005267
10.1158/1078-0432.CCR-17-1788
10.1186/s13045-021-01102-5
10.1038/s41571-018-0007-1
10.7554/eLife.55185
10.1038/s41419-023-05553-1
10.1042/CS20180435
10.1158/2326-6066.CIR-13-0027
10.1038/oncsis.2017.54
10.1002/ange.202217339
10.1126/scitranslmed.aaf5219
10.1038/s41598-017-17787-z
10.1007/s11033-021-06440-8
10.1007/s10637-023-01335-w
10.3390/cancers11050721
10.1136/jitc-2021-003254
10.1038/s41467-018-03347-0
10.1016/j.matbio.2018.03.016
10.1186/s13045-022-01252-0
10.1016/j.ajpath.2019.12.007
10.1186/s12967-022-03768-y
10.3389/fcell.2022.1064484
10.1038/mt.2013.110
10.1038/nrc745
10.3389/fcell.2021.675562
10.1093/oncolo/oyac254
10.1126/science.1110955
10.1136/jitc-2020-001193
10.1158/0008-5472.CAN-14-3041
10.1007/s11523-021-00810-9
10.1016/j.ymthe.2018.05.003
10.1083/jcb.201704053
10.1096/fj.10-163022
10.1515/mr-2021-0028
10.1038/s41580-023-00583-1
10.1038/s41598-018-25589-0
10.1186/s12967-022-03780-2
10.1186/s12935-022-02634-7
10.1021/acsnano.2c12463
10.1007/s00018-013-1339-8
10.1016/j.canlet.2021.06.009
10.1038/s41419-019-1435-2
10.1016/j.ejca.2015.07.035
10.1158/0008-5472.CAN-17-0657
10.1186/s13045-019-0795-5
10.1038/s41467-023-40398-4
10.1021/acsbiomaterials.8b01276
10.4049/jimmunol.179.2.1381
10.1136/gutjnl-2018-317570
10.3389/fcell.2023.1130823
10.1084/jem.20200053
10.7554/eLife.58688
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References Chen, Terajima, Yang, Sun, Ahn, Pankova (CR31) 2015; 125
Wang-Gillam, Lim, McWilliams, Suresh, Lockhart, Brown (CR171) 2022; 28
Seo, Bhardwaj, Choi, Gonzalez, Andresen Eguiluz, Wang (CR16) 2015; 7
Zhao, Huang, Qin, Qiao, Ren, Shen (CR76) 2021; 518
Zhao, Baldin, Isayev, Werner, Zamyatnin, Bazhin (CR139) 2021; 9
Ishikawa, Rubin, Bächinger, Kalamajski (CR14) 2018; 293
Chin, Norman, Gentleman, Coppens, Day (CR87) 2020; 12
Feng, Feng, Zhang, Li, Yao (CR103) 2021; 12
Loeffler (CR145) 2006; 116
Valkenburg, de Groot, Pienta (CR83) 2018; 15
Martín-Otal, Lasarte-Cia, Serrano, Casares, Conde, Navarro (CR124) 2022; 10
Santos Apolonio, Lima de Souza Gonçalves, Cordeiro Santos, Silva Luz, Silva Souza, Rocha Pinheiro (CR131) 2021; 10
Roth, Hoop, Williams, Hayes, Baum (CR18) 2023; 32
Hu, Lin, Chen, Maruyama, Tian, Chen (CR140) 2020; 252
Enomoto, Matsushima, Shibata, Aoshima, Yagi, Meguro (CR54) 2018; 132
Liu, Kilpatrick, Lukasz, Jarvis, McDonnell, Wallace (CR34) 2018; 59
Kankeu Fonkoua, Sirpilla, Sakemura, Siegler, Kenderian (CR82) 2022; 25
He, Lee, Jiang (CR5) 2022; 2
Datta, Dai, Bianchi, De Castro Silva, Mehra, Garrido (CR113) 2022; 163
Kuermanbayi, Yang, Zhao, Li, Wang, Yang (CR56) 2022; 13
Lim, Rathmell, Rathmell (CR89) 2020; 9
Zhao, Ding, Lu, Huang, Jing, Yang (CR71) 2020; 190
Hupfer, Brichkina, Koeniger, Keber, Denkert, Pfefferle (CR38) 2021; 118
O’Connor, Hao, Shen, Bashour, Akimova, Hancock (CR86) 2012; 189
Yasunaga, Manabe, Tarin, Matsumura (CR141) 2011; 22
Goehrig, Nigri, Samain, Wu, Cappello, Gabiane (CR84) 2019; 68
Jacobs, Deschoolmeester, Zwaenepoel, Flieswasser, Deben, Van den Bossche (CR70) 2018; 7
Piao, You, Guo, Zhang, Li, Geng (CR36) 2017; 50
Li, Pan, Liu, Yin, Miao, Zhao (CR53) 2023; 72
Rosenberg, Restifo (CR118) 2015; 348
Peranzoni, Rivas-Caicedo, Bougherara, Salmon, Donnadieu (CR66) 2013; 70
Enukashvily, Ponomartsev, Ketkar, Suezov, Chubar, Prjibelski (CR12) 2023; 14
Spira, Wertheim, Kim, Tan, Lenz, Nikolinakos (CR164) 2023; 28
Zhang, Pei, Zhou, Xie, Yang, Shen (CR123) 2023; 17
Li, Yang, Hua, Wang, Liu, Jia (CR75) 2012; 318
Kloss, Lee, Zhang, Chen, Melenhorst, Lacey (CR169) 2018; 26
Kiyokawa, Kawamura, Ghouse, Acar, Barçın, Martínez-Quintanilla (CR136) 2021; 27
Peng, Zou, Xia, Gao, Li, Liu (CR9) 2018; 38
Rice, Cortes, Lachowski, Cheung, Karim, Morton (CR45) 2017; 6
Yuan, Teng, Yang, He, Meng, Chen (CR151) 2022; 351
Lin, Tsai, Kandaswami, Lee, Huang, Hwang (CR51) 2011; 102
Kuczek, Larsen, Thorseth, Carretta, Kalvisa, Siersbæk (CR90) 2019; 7
Gulati, Rühl, Kannan, Pircher, Schuberth, Nytko (CR130) 2018; 24
Ahn, Lee, Kang, Kim, Choi, Saw (CR125) 2014; 3
Huijbers, Ringvall, Femel, Kalamajski, Lukinius, Åbrink (CR142) 2010; 24
Rocconi, Grosen, Ghamande, Chan, Barve, Oh (CR166) 2020; 21
Narayan, Barber-Rotenberg, Jung, Lacey, Rech, Davis (CR170) 2022; 28
Sun (CR2) 2021; 2
Egeblad, Werb (CR22) 2002; 2
Scott, Wiseman, Welt, Adjei, Lee, Hopkins (CR147) 2003; 9
Erpenbeck, Gruhn, Kudryasheva, Günay, Meyer, Busse (CR97) 2019; 10
Khokha, Murthy, Weiss (CR23) 2013; 13
Jiang, Zhang, Wang, Liu, Luo, Hua (CR3) 2022; 15
Kniazeva, Putnam (CR102) 2009; 297
Yang, Ge, Song, Zhao, Zhao, Hu (CR152) 2021; 183
Zhong, Lu, Tang, Wiel, Wei, Cao (CR98) 2023; 42
Ye, Kuang, Xie, Liang, Zhang, Zhang (CR116) 2020; 12
Saraswathibhatla, Indana, Chaudhuri (CR63) 2023; 24
Schrader, Gordon-Walker, Aucott, van Deemter, Quaas, Walsh (CR33) 2011; 53
Pankova, Jiang, Chatzifrangkeskou, Vendrell, Buzzelli, Ryan (CR13) 2019; 38
Millet, Bollmann, Ringuette Goulet, Bernard, Chabaud, Huot (CR48) 2022; 14
Rahbari, Kedrin, Incio, Liu, Ho, Nia (CR19) 2016; 8
Bougherara, Mansuet-Lupo, Alifano, Ngô, Damotte, Le frère-Belda (CR78) 2015; 6
Kalluri, Neilson (CR44) 2003; 112
Yeow, Kotamraju, Wang, Chopra, Azme, Wu (CR121) 2019; 11
Wu, Sun, Shen, Li, Tong, Guo (CR25) 2023; 14
Hong, Hwang, McManus, Amsterdam, Tian, Kalmukova (CR42) 2005; 309
Ebelt, Zamloot, Zuniga, Passi, Sobocinski, Young (CR155) 2021; 13
Wang, Chen, Liu (CR96) 2022; 22
Provenzano, Inman, Eliceiri, Keely (CR39) 2009; 28
Wang, Yang, Jia, Wang, Yang, Dong (CR88) 2022; 11
Shin, Kim, Jon (CR146) 2023; 17
Li, Liu, Zhao, Zhai (CR24) 2015; 34
Van Limbergen, Hoeben, Lieverse, Houben, Overhof, Postma (CR143) 2021; 109
Huang, Cheng, Lin, Lin, Su, Juliano (CR81) 2010; 185
Paz-Ares, Kim, Vicente, Felip, Lee, Lee (CR160) 2020; 15
Zhang, Xu, Zeng, Wei, He, Huang (CR112) 2023; 135
Ishikawa, Kokura, Enoki, Sakamoto, Okayama, Ideno (CR122) 2014; 9
CR64
Bachy, Wu, Gamradt, Thierry, Milani, Chlasta (CR95) 2022; 25
Loriot, Necchi, Park, Garcia-Donas, Huddart, Burgess (CR174) 2019; 381
Li, Wu, Hu, Ding, Tang, Xiang (CR111) 2021; 10
Mennens, Bolomini-Vittori, Weiden, Joosten, Cambi, van den Dries (CR99) 2017; 7
Kelly, Milligan, Mastria, Kim, Zelenetz, Dobbins (CR149) 2022; 343
Carmona-Rodríguez, Martínez-Rey, Fernández-Aceñero, González-Martín, Paz-Cabezas, Rodríguez-Rodríguez (CR85) 2020; 8
Giaccone, Bazhenova, Nemunaitis, Tan, Juhász, Ramlau (CR167) 2015; 51
Lachowski, Cortes, Rice, Pinato, Rombouts, Del Rio Hernandez (CR52) 2019; 9
Kaufman, Kohlhapp, Zloza (CR134) 2015; 14
Chin, Xia, Discher, Janmey (CR4) 2016; 11
Hallmann, Zhang, Di Russo, Li, Song, Hannocks (CR65) 2015; 36
Cai, Marchuk, Beemiller, Beppler, Rubashkin, Weaver (CR59) 2017; 356
Jensen, Madsen, Hansen, Schmidt, Svane, Karsdal (CR114) 2018; 6
Xie, Dougan, Jailkhani, Ingram, Fang, Kummer (CR126) 2019; 116
Brauchle, Kasper, Daum, Schierbaum, Falch, Kirschniak (CR154) 2018; 68-69
Mierke (CR27) 2023; 11
Erdogan, Ao, White, Means, Brewer, Yang (CR15) 2017; 216
Kim, Lee, Kim, Huang, Yoon, Yun (CR138) 2006; 98
Alonso-Nocelo, Raimondo, Vining, López-López, de la Fuente, Mooney (CR47) 2018; 10
Tripathi, Potdar, Yamashita, Weidow, Cummings, Kirchhofer (CR30) 2011; 71
Jiang, Hu, Wu, Cafarello, Di Matteo, Shen (CR100) 2021; 9
Kato, Noma, Ohara, Kashima, Katsura, Sato (CR68) 2018; 24
Faubert, Solmonson, DeBerardinis (CR40) 2020; 368
CR79
Chuang, Chang, Li, Cui, Lee, Chen (CR94) 2020; 12
Lo, Wang, Scholler, Monslow, Avery, Newick (CR128) 2015; 75
Yuan, Xie, Song, Li, Li, Hu (CR110) 2022; 13
Tenti, Vannucci (CR32) 2020; 69
Kang, Bang, Kondo, Chung, Muro, Dussault (CR161) 2020; 26
Zhang (CR41) 2009; 19
Natkanski, Lee, Mistry, Casal, Molloy, Tolar (CR60) 2013; 340
Restifo, Dudley, Rosenberg (CR117) 2012; 12
Tolcher, Gordon, Mahoney, Seto, Zavodovskaya, Hsueh (CR165) 2023; 11
McKenzie, Hicks, Svec, Naughton, Edmunds, Howe (CR35) 2018; 8
You, Huh, Kwon, Kim, Chae, Lee (CR11) 2017; 77
Bonnans, Chou, Werb (CR20) 2014; 15
Zhao, Zhou, Khan, Alansary, Friedmann, Yang (CR91) 2021; 12
Lin, Shen, Liang (CR132) 2023; 8
Liu, Luo, Deng, Ju, Song (CR43) 2020; 12
Sahai, Astsaturov, Cukierman, DeNardo, Egeblad, Evans (CR8) 2020; 20
Xie, Martin (CR55) 2020; 126
Strauss, Gatti-Mays, Cho, Hill, Salas, McClay (CR163) 2020; 8
Gialeli, Theocharis, Karamanos (CR21) 2011; 278
Freeman, Mielgo (CR67) 2020; 12
Winkler, Abisoye-Ogunniyan, Metcalf, Werb (CR80) 2020; 11
Huang, Zhang, Wan, Zhou, Zheng, Lin (CR7) 2021; 6
Castiglioni, Yang, Williams, Gogineni, Lane, Wang (CR92) 2023; 14
Chen, Zhang, Zhou, Liu, Zhao, Zhou (CR93) 2020; 5
Bazan-Peregrino, Garcia-Carbonero, Laquente, Álvarez, Mato-Berciano, Gimenez-Alejandre (CR135) 2021; 9
Ghosh, Thodeti, Dudley, Mammoto, Klagsbrun, Ingber (CR101) 2008; 105
Lin, Doi, Muro, Hou, Esaki, Hara (CR158) 2021; 16
Yoon, Pan, Wang (CR58) 2022; 10
Zhou, Zhu, Xu, Liu, Shen (CR173) 2023; 41
Huse (CR61) 2017; 17
Choi, Lee, Yoo, Yoon, Kim, Kim (CR137) 2010; 17
Biragyn, Schiavo, Olkhanud, Sumitomo, King, McCain (CR148) 2007; 179
Tan, Khattak, Felip, Kelly, Rich, Wang (CR159) 2021; 16
Hawinkels, Zuidwijk, Verspaget, de Jonge-Muller, van Duijn, Ferreira (CR26) 2008; 44
Hurkmans, Jensen, Koolen, Aerts, Karsdal, Mathijssen (CR115) 2020; 8
Poli, Bianchi, Virotta, Bettini, Moretti, Trachsel (CR144) 2013; 1
Sterner, Sterner (CR120) 2021; 11
Liu, Zhou, Wang, Li, Jiang, Liu (CR168) 2022; 20
Deng, Zhao, Kong, Han, Shen, Zhou (CR1) 2022; 20
Yoo, Oh, Choi, Kudo, Ueno, Kondo (CR162) 2020; 8
Fonović, Turk (CR29) 2014; 1840
Yokoda, Nagalo, Vernon, Oklu, Albadawi, DeLeon (CR133) 2017; 6
Malfanti, Bausart, Vanvarenberg, Ucakar, Préat (CR153) 2023; 13
Redman, Friedman, Robbins, Sievers, Yang, Lassoued (CR156) 2022; 132
Almici, Arshakyan, Carrasco, Martínez, Ramírez, Enguita (CR105) 2023; 36
Melero, Tanos, Bustamante, Sanmamed, Calvo, Moreno (CR172) 2023; 15
Lakins, Ghorani, Munir, Martins, Shields (CR69) 2018; 9
Manfredi, Cianciotti, Potenza, Tassi, Noviello, Biondi (CR119) 2020; 11
Ghasemi, Mousavibahar, Hashemnia, Karimi, Khodadadi, Tavilani (CR17) 2021; 48
Azadi, Aboulkheyr Es, Razavi Bazaz, Thiery, Asadnia, Ebrahimi Warkiani (CR106) 2019; 1866
Cho, Daste, Ravaud, Salas, Isambert, McClay (CR157) 2020; 8
Gao, Qiao, Xing, Huang, Qian, Wang (CR50) 2020; 10
Duan, Liu, Hu, Shi, Liu, Xue (CR28) 2019; 17
Pakravan, Mossahebi-Mohammadi, Ghazimoradi, Cho, Sadeghizadeh, Babashah (CR73) 2022; 20
Cheng, Li, Deng, Tai, Zeng, Zhang (CR72) 2018; 9
Henke, Nandigama, Ergün (CR6) 2020; 6
Dong, Zheng, Wang, Lin, You, Wu (CR46) 2019; 12
Chen, Zhao, Zhang, Shen, Xu, Yi (CR107) 2022; 17
Zhang, Qi, Zhao, Li, Shao, Zhang (CR74) 2019; 10
Jang, Beningo (CR10) 2019; 11
Arnold, Gu, Ambati, Rasaily, Ramirez-Pena, Joseph (CR49) 2020; 39
Liu, Lei, Li, Xin, Zhang, Fu (CR150) 2022; 14
Rømer, Thorseth, Madsen (CR77) 2021; 12
Ding, Wang, Zhang, Xu, Li, Liang (CR109) 2021; 14
Wang, Lo, Scholler, Sun, Majumdar, Kapoor (CR127) 2014; 2
Kakarla, Chow, Mata, Shaffer, Song, Wu (CR129) 2013; 21
Davidson, Song, Lee, Llewellyn, Du, Baker (CR104) 2019; 5
Miyazawa, Ito, Asano, Tanaka, Sato, Kondo (CR108) 2018; 495
Chaudhuri, Cooper-White, Janmey, Mooney, Shenoy (CR62) 2020; 584
Prauzner-Bechcicki, Raczkowska, Madej, Pabijan, Lukes, Sepitka (CR37) 2015; 41
Muñoz, Williams, Dixon, Dupuis, McWatters, Avritscher (CR57) 2021; 9
BR Seo (6697_CR16) 2015; 7
L Paz-Ares (6697_CR160) 2020; 15
JH Hong (6697_CR42) 2005; 309
YK Kang (6697_CR161) 2020; 26
R Khokha (6697_CR23) 2013; 13
J Piao (6697_CR36) 2017; 50
D Pankova (6697_CR13) 2019; 38
M Yasunaga (6697_CR141) 2011; 22
O Chaudhuri (6697_CR62) 2020; 584
AR Lim (6697_CR89) 2020; 9
F Feng (6697_CR103) 2021; 12
JM Arnold (6697_CR49) 2020; 39
BC Cho (6697_CR157) 2020; 8
A Lo (6697_CR128) 2015; 75
B Deng (6697_CR1) 2022; 20
E Kniazeva (6697_CR102) 2009; 297
R Zhang (6697_CR74) 2019; 10
F Manfredi (6697_CR119) 2020; 11
PP Provenzano (6697_CR39) 2009; 28
B Erdogan (6697_CR15) 2017; 216
M Alonso-Nocelo (6697_CR47) 2018; 10
C Zhang (6697_CR112) 2023; 135
CY Lin (6697_CR51) 2011; 102
AM Scott (6697_CR147) 2003; 9
G Giaccone (6697_CR167) 2015; 51
H Bougherara (6697_CR78) 2015; 6
E Henke (6697_CR6) 2020; 6
EJ Van Limbergen (6697_CR143) 2021; 109
X Jiang (6697_CR100) 2021; 9
H Zhong (6697_CR98) 2023; 42
EJM Huijbers (6697_CR142) 2010; 24
Y Loriot (6697_CR174) 2019; 381
T Ishikawa (6697_CR122) 2014; 9
J Schrader (6697_CR33) 2011; 53
CC Kloss (6697_CR169) 2018; 26
X Zhao (6697_CR71) 2020; 190
R Hallmann (6697_CR65) 2015; 36
Y Dong (6697_CR46) 2019; 12
A Hupfer (6697_CR38) 2021; 118
6697_CR79
M Tripathi (6697_CR30) 2011; 71
E You (6697_CR11) 2017; 77
KC Valkenburg (6697_CR83) 2018; 15
A Castiglioni (6697_CR92) 2023; 14
B Faubert (6697_CR40) 2020; 368
CS Yuan (6697_CR151) 2022; 351
YC Chuang (6697_CR94) 2020; 12
H Liu (6697_CR150) 2022; 14
DP Hurkmans (6697_CR115) 2020; 8
C Jensen (6697_CR114) 2018; 6
R Kalluri (6697_CR44) 2003; 112
6697_CR64
ND Ebelt (6697_CR155) 2021; 13
S Azadi (6697_CR106) 2019; 1866
C Yoo (6697_CR162) 2020; 8
J Huang (6697_CR7) 2021; 6
P Gulati (6697_CR130) 2018; 24
M Loeffler (6697_CR145) 2006; 116
H Ghasemi (6697_CR17) 2021; 48
YE Zhang (6697_CR41) 2009; 19
R Yokoda (6697_CR133) 2017; 6
A Miyazawa (6697_CR108) 2018; 495
V Narayan (6697_CR170) 2022; 28
R Zhao (6697_CR91) 2021; 12
M Chen (6697_CR93) 2020; 5
YL Yeow (6697_CR121) 2019; 11
Y Jiang (6697_CR3) 2022; 15
NI Enukashvily (6697_CR12) 2023; 14
M Fonović (6697_CR29) 2014; 1840
J Strauss (6697_CR163) 2020; 8
E Brauchle (6697_CR154) 2018; 68-69
Y Cheng (6697_CR72) 2018; 9
I Jang (6697_CR10) 2019; 11
X Ding (6697_CR109) 2021; 14
CW Yoon (6697_CR58) 2022; 10
AMA Rømer (6697_CR77) 2021; 12
GL Poli (6697_CR144) 2013; 1
JY Huang (6697_CR81) 2010; 185
Y Xie (6697_CR55) 2020; 126
W Li (6697_CR24) 2015; 34
J Jacobs (6697_CR70) 2018; 7
A Wang-Gillam (6697_CR171) 2022; 28
MHW Chin (6697_CR87) 2020; 12
X Gao (6697_CR50) 2020; 10
RC Sterner (6697_CR120) 2021; 11
A Biragyn (6697_CR148) 2007; 179
S Wang (6697_CR96) 2022; 22
S Kuermanbayi (6697_CR56) 2022; 13
Y Zhang (6697_CR123) 2023; 17
J Roth (6697_CR18) 2023; 32
B Tan (6697_CR159) 2021; 16
D Lachowski (6697_CR52) 2019; 9
M Zhou (6697_CR173) 2023; 41
SFB Mennens (6697_CR99) 2017; 7
G Yuan (6697_CR110) 2022; 13
J Kiyokawa (6697_CR136) 2021; 27
B Liu (6697_CR34) 2018; 59
M Huse (6697_CR61) 2017; 17
L Erpenbeck (6697_CR97) 2019; 10
LA Kankeu Fonkoua (6697_CR82) 2022; 25
S Bachy (6697_CR95) 2022; 25
MD Davidson (6697_CR104) 2019; 5
S Ahn (6697_CR125) 2014; 3
A Spira (6697_CR164) 2023; 28
LCS Wang (6697_CR127) 2014; 2
JM Redman (6697_CR156) 2022; 132
M Millet (6697_CR48) 2022; 14
K Pakravan (6697_CR73) 2022; 20
M Egeblad (6697_CR22) 2002; 2
X Li (6697_CR53) 2023; 72
D Goehrig (6697_CR84) 2019; 68
S Kakarla (6697_CR129) 2013; 21
E Sahai (6697_CR8) 2020; 20
D Lin (6697_CR132) 2023; 8
X He (6697_CR5) 2022; 2
P Freeman (6697_CR67) 2020; 12
YJ Li (6697_CR111) 2021; 10
G Kelly (6697_CR149) 2022; 343
T Kato (6697_CR68) 2018; 24
QP Liu (6697_CR43) 2020; 12
Y Enomoto (6697_CR54) 2018; 132
AJ Rice (6697_CR45) 2017; 6
Y Ye (6697_CR116) 2020; 12
YJ Xie (6697_CR126) 2019; 116
D Liu (6697_CR168) 2022; 20
J Santos Apolonio (6697_CR131) 2021; 10
I Melero (6697_CR172) 2023; 15
AJ McKenzie (6697_CR35) 2018; 8
M Bazan-Peregrino (6697_CR135) 2021; 9
NN Rahbari (6697_CR19) 2016; 8
RS O’Connor (6697_CR86) 2012; 189
IK Choi (6697_CR137) 2010; 17
Q Zhao (6697_CR76) 2021; 518
S Prauzner-Bechcicki (6697_CR37) 2015; 41
A Saraswathibhatla (6697_CR63) 2023; 24
B Duan (6697_CR28) 2019; 17
MA Lakins (6697_CR69) 2018; 9
K Ghosh (6697_CR101) 2008; 105
B Sun (6697_CR2) 2021; 2
SA Rosenberg (6697_CR118) 2015; 348
CC Lin (6697_CR158) 2021; 16
Y Ishikawa (6697_CR14) 2018; 293
Y Chen (6697_CR31) 2015; 125
C Wu (6697_CR25) 2023; 14
Y Chen (6697_CR107) 2022; 17
LJ Hawinkels (6697_CR26) 2008; 44
T Li (6697_CR75) 2012; 318
C Gialeli (6697_CR21) 2011; 278
E Peranzoni (6697_CR66) 2013; 70
E Natkanski (6697_CR60) 2013; 340
DE Kuczek (6697_CR90) 2019; 7
L Carmona-Rodríguez (6697_CR85) 2020; 8
Y Zhao (6697_CR139) 2021; 9
CT Mierke (6697_CR27) 2023; 11
E Almici (6697_CR105) 2023; 36
P Tenti (6697_CR32) 2020; 69
Y Wang (6697_CR88) 2022; 11
Y Hu (6697_CR140) 2020; 252
Y Yang (6697_CR152) 2021; 183
A Malfanti (6697_CR153) 2023; 13
J Winkler (6697_CR80) 2020; 11
C Martín-Otal (6697_CR124) 2022; 10
AW Tolcher (6697_CR165) 2023; 11
C Bonnans (6697_CR20) 2014; 15
HL Kaufman (6697_CR134) 2015; 14
H Shin (6697_CR146) 2023; 17
E Cai (6697_CR59) 2017; 356
L Chin (6697_CR4) 2016; 11
JH Kim (6697_CR138) 2006; 98
RP Rocconi (6697_CR166) 2020; 21
NM Muñoz (6697_CR57) 2021; 9
NP Restifo (6697_CR117) 2012; 12
C Peng (6697_CR9) 2018; 38
J Datta (6697_CR113) 2022; 163
References_xml – volume: 9
  year: 2018
  ident: CR72
  article-title: Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-018-0458-4
– volume: 11
  start-page: e79957.
  year: 2022
  ident: CR88
  article-title: Dendritic cell Piezo1 directs the differentiation of T(H)1 and T(reg) cells in cancer
  publication-title: Elife
  doi: 10.7554/eLife.79957
– volume: 28
  start-page: 4326
  year: 2009
  end-page: 43
  ident: CR39
  article-title: Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage
  publication-title: Oncogene
  doi: 10.1038/onc.2009.299
– volume: 185
  start-page: 1450
  year: 2010
  end-page: 9
  ident: CR81
  article-title: Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0901352
– volume: 11
  start-page: 77
  year: 2016
  end-page: 84
  ident: CR4
  article-title: Mechanotransduction in cancer
  publication-title: Curr Opin Chem Eng
  doi: 10.1016/j.coche.2016.01.011
– volume: 36
  start-page: 54
  year: 2015
  end-page: 61
  ident: CR65
  article-title: The regulation of immune cell trafficking by the extracellular matrix
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/j.ceb.2015.06.006
– volume: 12
  year: 2021
  ident: CR77
  article-title: Immune modulatory properties of collagen in cancer
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.791453
– volume: 343
  start-page: 267
  year: 2022
  end-page: 76
  ident: CR149
  article-title: Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2022.01.024
– volume: 14
  start-page: 3810
  year: 2022
  ident: CR48
  article-title: Cancer-associated fibroblasts in a 3D engineered tissue model induce tumor-like matrix stiffening and EMT transition
  publication-title: Cancers
  doi: 10.3390/cancers14153810
– volume: 24
  start-page: 4820
  year: 2018
  end-page: 33
  ident: CR68
  article-title: Cancer-associated fibroblasts affect intratumoral CD8(+) and FoxP3(+) T cells via IL6 in the tumor microenvironment
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-18-0205
– volume: 252
  year: 2020
  ident: CR140
  article-title: Synergistic tumor immunological strategy by combining tumor nanovaccine with gene-mediated extracellular matrix scavenger
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120114
– volume: 3
  start-page: 1194
  year: 2014
  end-page: 9
  ident: CR125
  article-title: Gold nanoparticles displaying tumor-associated self-antigens as a potential vaccine for cancer immunotherapy
  publication-title: Adv Health Mater
  doi: 10.1002/adhm.201300597
– volume: 41
  start-page: 13
  year: 2015
  end-page: 22
  ident: CR37
  article-title: PDMS substrate stiffness affects the morphology and growth profiles of cancerous prostate and melanoma cells
  publication-title: J Mech Behav Biomed Mater
  doi: 10.1016/j.jmbbm.2014.09.020
– volume: 16
  start-page: 435
  year: 2021
  end-page: 46
  ident: CR159
  article-title: Bintrafusp Alfa, a bifunctional fusion protein targeting TGF-beta and PD-L1, in patients with esophageal adenocarcinoma: results from a phase 1 cohort
  publication-title: Target Oncol
  doi: 10.1007/s11523-021-00809-2
– volume: 116
  start-page: 1955
  year: 2006
  end-page: 62
  ident: CR145
  article-title: Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
  publication-title: J Clin Investig
  doi: 10.1172/JCI26532
– volume: 368
  start-page: eaaw5473.
  year: 2020
  ident: CR40
  article-title: Metabolic reprogramming and cancer progression
  publication-title: Science
  doi: 10.1126/science.aaw5473
– volume: 132
  start-page: e172059
  year: 2022
  ident: CR156
  article-title: Enhanced neoepitope-specific immunity following neoadjuvant PD-L1 and TGF-beta blockade in HPV-unrelated head and neck cancer
  publication-title: J Clin Investig
  doi: 10.1172/JCI161400
– volume: 11
  start-page: 1689
  year: 2020
  ident: CR119
  article-title: TCR redirected T cells for cancer treatment: achievements, hurdles, and goals
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.01689
– volume: 72
  start-page: 710
  year: 2023
  end-page: 21
  ident: CR53
  article-title: Novel TCF21(high) pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix
  publication-title: Gut
  doi: 10.1136/gutjnl-2022-327913
– volume: 42
  start-page: 2183
  year: 2023
  end-page: 2194
  ident: CR98
  article-title: SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity
  publication-title: Oncogene
  doi: 10.1038/s41388-023-02715-5
– volume: 10
  year: 2021
  ident: CR111
  article-title: Biomimetic liposome with surface-bound elastase for enhanced tumor penetration and chemo-immumotherapy
  publication-title: Adv Health Mater
  doi: 10.1002/adhm.202100794
– volume: 14
  start-page: 642
  year: 2015
  end-page: 62
  ident: CR134
  article-title: Oncolytic viruses: a new class of immunotherapy drugs
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd4663
– volume: 105
  start-page: 11305
  year: 2008
  end-page: 10
  ident: CR101
  article-title: Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0800835105
– volume: 50
  start-page: 2033
  year: 2017
  end-page: 42
  ident: CR36
  article-title: Substrate stiffness affects epithelial-mesenchymal transition of cervical cancer cells through miR-106b and its target protein DAB2
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2017.3978
– volume: 10
  start-page: 1563
  year: 2020
  ident: CR50
  article-title: Matrix stiffness-upregulated microRNA-17-5p attenuates the intervention effects of metformin on HCC invasion and metastasis by targeting the PTEN/PI3K/Akt pathway
  publication-title: Front Oncol
  doi: 10.3389/fonc.2020.01563
– volume: 5
  start-page: 880
  year: 2020
  end-page: 90
  ident: CR93
  article-title: Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-kappaB signaling pathway
  publication-title: Bioact Mater
– volume: 381
  start-page: 338
  year: 2019
  end-page: 48
  ident: CR174
  article-title: Erdafitinib in locally advanced or metastatic urothelial carcinoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1817323
– volume: 1840
  start-page: 2560
  year: 2014
  end-page: 70
  ident: CR29
  article-title: Cysteine cathepsins and extracellular matrix degradation
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbagen.2014.03.017
– volume: 17
  start-page: 679
  year: 2017
  end-page: 90
  ident: CR61
  article-title: Mechanical forces in the immune system
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2017.74
– volume: 39
  start-page: 3089
  year: 2020
  end-page: 101
  ident: CR49
  article-title: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression
  publication-title: Oncogene
  doi: 10.1038/s41388-019-0885-4
– volume: 25
  year: 2022
  ident: CR95
  article-title: betaig-h3-structured collagen alters macrophage phenotype and function in pancreatic cancer
  publication-title: iScience
  doi: 10.1016/j.isci.2022.103758
– volume: 38
  start-page: BSR20180243
  year: 2018
  ident: CR9
  article-title: Integrin alphavbeta6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts
  publication-title: Biosci Rep
  doi: 10.1042/BSR20180243
– volume: 7
  start-page: 68
  year: 2019
  ident: CR90
  article-title: Collagen density regulates the activity of tumor-infiltrating T cells
  publication-title: J Immunother Cancer
  doi: 10.1186/s40425-019-0556-6
– volume: 15
  start-page: 1210
  year: 2020
  end-page: 22
  ident: CR160
  article-title: Bintrafusp Alfa, a bifunctional fusion protein targeting TGF-beta and PD-L1, in second-line treatment of patients With NSCLC: results from an expansion cohort of a phase 1 trial
  publication-title: J Thorac Oncol
  doi: 10.1016/j.jtho.2020.03.003
– volume: 28
  start-page: 5254
  year: 2022
  end-page: 62
  ident: CR171
  article-title: Defactinib, pembrolizumab, and gemcitabine in patients with advanced treatment refractory pancreatic cancer: a phase I dose escalation and expansion study
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-22-0308
– volume: 10
  start-page: 229
  year: 2021
  end-page: 55
  ident: CR131
  article-title: Oncolytic virus therapy in cancer: a current review
  publication-title: World J Virol
  doi: 10.5501/wjv.v10.i5.229
– volume: 10
  start-page: 2320
  year: 2019
  ident: CR97
  article-title: Effect of adhesion and substrate elasticity on neutrophil extracellular trap formation
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.02320
– volume: 8
  start-page: e000564
  year: 2020
  ident: CR162
  article-title: Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-beta and PD-L1, in patients with pretreated biliary tract cancer
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-000564
– volume: 28
  start-page: 724
  year: 2022
  end-page: 34
  ident: CR170
  article-title: PSMA-targeting TGFbeta-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
  publication-title: Nat Med
  doi: 10.1038/s41591-022-01726-1
– volume: 13
  start-page: 10349
  year: 2022
  end-page: 60
  ident: CR56
  article-title: In situ monitoring of functional activity of extracellular matrix stiffness-dependent multidrug resistance protein 1 using scanning electrochemical microscopy
  publication-title: Chem Sci
  doi: 10.1039/D2SC02708A
– volume: 189
  start-page: 1330
  year: 2012
  end-page: 9
  ident: CR86
  article-title: Substrate rigidity regulates human T cell activation and proliferation
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1102757
– volume: 53
  start-page: 1192
  year: 2011
  end-page: 205
  ident: CR33
  article-title: Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
  publication-title: Hepatology
  doi: 10.1002/hep.24108
– volume: 8
  start-page: e000664
  year: 2020
  ident: CR157
  article-title: Bintrafusp alfa, a bifunctional fusion protein targeting TGF-beta and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-000664
– volume: 15
  year: 2023
  ident: CR172
  article-title: A first-in-human study of the fibroblast activation protein-targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.abp9229
– volume: 318
  start-page: 154
  year: 2012
  end-page: 61
  ident: CR75
  article-title: Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2011.12.020
– volume: 348
  start-page: 62
  year: 2015
  end-page: 8
  ident: CR118
  article-title: Adoptive cell transfer as personalized immunotherapy for human cancer
  publication-title: Science
  doi: 10.1126/science.aaa4967
– volume: 11
  year: 2021
  ident: CR120
  article-title: CAR-T cell therapy: current limitations and potential strategies
  publication-title: Blood Cancer J
  doi: 10.1038/s41408-021-00459-7
– volume: 13
  start-page: 2550
  year: 2023
  end-page: 2567
  ident: CR153
  article-title: Hyaluronic acid-antigens conjugates trigger potent immune response in both prophylactic and therapeutic immunization in a melanoma model
  publication-title: Drug Deliv Transl Res
  doi: 10.1007/s13346-023-01337-4
– volume: 9
  start-page: e83786
  year: 2014
  ident: CR122
  article-title: Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0083786
– volume: 12
  start-page: 47355
  year: 2020
  end-page: 67
  ident: CR87
  article-title: A hydrogel-integrated culture device to interrogate T cell activation with physicochemical cues
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.0c16478
– volume: 297
  start-page: C179
  year: 2009
  end-page: 87
  ident: CR102
  article-title: Endothelial cell traction and ECM density influence both capillary morphogenesis and maintenance in 3-D
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00018.2009
– volume: 356
  start-page: eaal3118.
  year: 2017
  ident: CR59
  article-title: Visualizing dynamic microvillar search and stabilization during ligand detection by T cells
  publication-title: Science
  doi: 10.1126/science.aal3118
– volume: 9
  year: 2019
  ident: CR52
  article-title: Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-43759-6
– volume: 34
  start-page: 1345
  year: 2015
  end-page: 52
  ident: CR24
  article-title: Binding of MMP-9-degraded fibronectin to beta6 integrin promotes invasion via the FAK-Src-related Erk1/2 and PI3K/Akt/Smad-1/5/8 pathways in breast cancer
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.4103
– volume: 6
  start-page: 500
  year: 2015
  ident: CR78
  article-title: Real-time imaging of resident T cells in human lung and ovarian carcinomas reveals how different tumor microenvironments control T lymphocyte migration
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2015.00500
– volume: 69
  start-page: 223
  year: 2020
  end-page: 35
  ident: CR32
  article-title: Lysyl oxidases: linking structures and immunity in the tumor microenvironment
  publication-title: Cancer Immunol Immunother
  doi: 10.1007/s00262-019-02404-x
– volume: 495
  start-page: 2344
  year: 2018
  end-page: 9
  ident: CR108
  article-title: Regulation of PD-L1 expression by matrix stiffness in lung cancer cells
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2017.12.115
– volume: 10
  start-page: e004479
  year: 2022
  ident: CR124
  article-title: Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2021-004479
– volume: 102
  start-page: 815
  year: 2011
  end-page: 27
  ident: CR51
  article-title: Matrix metalloproteinase-9 cooperates with transcription factor Snail to induce epithelial-mesenchymal transition
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2011.01861.x
– volume: 12
  year: 2021
  ident: CR103
  article-title: Matrix stiffness induces pericyte-fibroblast transition through YAP activation
  publication-title: Front Pharm
  doi: 10.3389/fphar.2021.698275
– volume: 21
  start-page: 1661
  year: 2020
  end-page: 72
  ident: CR166
  article-title: Gemogenovatucel-T (Vigil) immunotherapy as maintenance in frontline stage III/IV ovarian cancer (VITAL): a randomised, double-blind, placebo-controlled, phase 2b trial
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(20)30533-7
– volume: 17
  year: 2022
  ident: CR107
  article-title: SNF5, a core subunit of SWI/SNF complex, regulates melanoma cancer cell growth, metastasis, and immune escape in response to matrix stiffness
  publication-title: Transl Oncol
  doi: 10.1016/j.tranon.2021.101335
– volume: 12
  start-page: 269
  year: 2012
  end-page: 81
  ident: CR117
  article-title: Adoptive immunotherapy for cancer: harnessing the T cell response
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3191
– volume: 116
  start-page: 7624
  year: 2019
  end-page: 31
  ident: CR126
  article-title: Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1817147116
– volume: 9
  start-page: 1639
  year: 2003
  end-page: 47
  ident: CR147
  article-title: A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
  publication-title: Clin Cancer Res
– volume: 20
  year: 2022
  ident: CR168
  article-title: Bifunctional anti-PD-L1/TGF-betaRII agent SHR-1701 in advanced solid tumors: a dose-escalation, dose-expansion, and clinical-expansion phase 1 trial
  publication-title: BMC Med
  doi: 10.1186/s12916-022-02605-9
– volume: 98
  start-page: 1482
  year: 2006
  end-page: 93
  ident: CR138
  article-title: Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/djj397
– volume: 12
  year: 2021
  ident: CR91
  article-title: Targeting the microtubule-network rescues CTL killing efficiency in dense 3D matrices
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.729820
– volume: 59
  start-page: 803
  year: 2018
  end-page: 14
  ident: CR34
  article-title: Increased substrate stiffness elicits a myofibroblastic phenotype in human lamina cribrosa cells
  publication-title: Investig Ophthalmol Vis Sci
  doi: 10.1167/iovs.17-22400
– volume: 12
  start-page: 2687
  year: 2020
  ident: CR67
  article-title: Cancer-associated fibroblast mediated inhibition of CD8+ cytotoxic T cell accumulation in tumours: mechanisms and therapeutic opportunities
  publication-title: Cancers
  doi: 10.3390/cancers12092687
– volume: 6
  start-page: 39
  year: 2017
  end-page: 49
  ident: CR133
  article-title: Oncolytic virus delivery: from nano-pharmacodynamics to enhanced oncolytic effect
  publication-title: Oncolytic Virother
  doi: 10.2147/OV.S145262
– volume: 38
  year: 2019
  ident: CR13
  article-title: RASSF1A controls tissue stiffness and cancer stem-like cells in lung adenocarcinoma
  publication-title: EMBO J
  doi: 10.15252/embj.2018100532
– volume: 7
  start-page: e1440167
  year: 2018
  ident: CR70
  article-title: Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2018.1440167
– volume: 351
  start-page: 255
  year: 2022
  end-page: 71
  ident: CR151
  article-title: Reshaping hypoxia and silencing CD73 via biomimetic gelatin nanotherapeutics to boost immunotherapy
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2022.09.029
– volume: 13
  year: 2022
  ident: CR110
  article-title: Hepatic tumor stiffness measured by shear wave elastography is prognostic for HCC progression following treatment with anti-PD-1 antibodies plus lenvatinib: a retrospective analysis of two independent cohorts
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.868809
– volume: 19
  start-page: 128
  year: 2009
  end-page: 39
  ident: CR41
  article-title: Non-Smad pathways in TGF-beta signaling
  publication-title: Cell Res
  doi: 10.1038/cr.2008.328
– volume: 12
  start-page: 490
  year: 2020
  ident: CR43
  article-title: Stiffer matrix accelerates migration of hepatocellular carcinoma cells through enhanced aerobic glycolysis via the MAPK-YAP signaling
  publication-title: Cancers
  doi: 10.3390/cancers12020490
– volume: 44
  start-page: 1904
  year: 2008
  end-page: 13
  ident: CR26
  article-title: VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2008.06.031
– volume: 8
  start-page: e001395
  year: 2020
  ident: CR163
  article-title: Bintrafusp alfa, a bifunctional fusion protein targeting TGF-beta and PD-L1, in patients with human papillomavirus-associated malignancies
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-001395
– volume: 9
  start-page: 85
  year: 2021
  ident: CR139
  article-title: Cancer vaccines: antigen selection strategy
  publication-title: Vaccines
  doi: 10.3390/vaccines9020085
– volume: 118
  start-page: e2105367118.
  year: 2021
  ident: CR38
  article-title: Matrix stiffness drives stromal autophagy and promotes formation of a protumorigenic niche
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.2105367118
– volume: 340
  start-page: 1587
  year: 2013
  end-page: 90
  ident: CR60
  article-title: B cells use mechanical energy to discriminate antigen affinities
  publication-title: Science
  doi: 10.1126/science.1237572
– volume: 1866
  year: 2019
  ident: CR106
  article-title: Upregulation of PD-L1 expression in breast cancer cells through the formation of 3D multicellular cancer aggregates under different chemical and mechanical conditions
  publication-title: Biochim Biophys Acta Mol Cell Res
  doi: 10.1016/j.bbamcr.2019.118526
– volume: 8
  start-page: e000432
  year: 2020
  ident: CR85
  article-title: SOD3 induces a HIF-2alpha-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2019-000432
– volume: 6
  start-page: 152
  year: 2018
  ident: CR114
  article-title: Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients
  publication-title: J Immunother Cancer
  doi: 10.1186/s40425-018-0474-z
– volume: 2
  start-page: 100515
  year: 2021
  ident: CR2
  article-title: The mechanics of fibrillar collagen extracellular matrix
  publication-title: Cell Rep Phys Sci
  doi: 10.1016/j.xcrp.2021.100515
– volume: 163
  start-page: 1593
  year: 2022
  end-page: 612
  ident: CR113
  article-title: Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome immunotherapy resistance in pancreatic cancer
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2022.07.076
– volume: 183
  start-page: 1891
  year: 2021
  end-page: 902
  ident: CR152
  article-title: A novel self-assembled epitope peptide nanoemulsion vaccine targeting nasal mucosal epithelial cell for reinvigorating CD8(+) T cell immune activity and inhibiting tumor progression
  publication-title: Int J Biol Macromol
  doi: 10.1016/j.ijbiomac.2021.05.158
– volume: 584
  start-page: 535
  year: 2020
  end-page: 46
  ident: CR62
  article-title: Effects of extracellular matrix viscoelasticity on cellular behaviour
  publication-title: Nature
  doi: 10.1038/s41586-020-2612-2
– volume: 22
  start-page: 1776
  year: 2011
  end-page: 83
  ident: CR141
  article-title: Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue
  publication-title: Bioconjug Chem
  doi: 10.1021/bc200158j
– volume: 10
  start-page: 035004
  year: 2018
  ident: CR47
  article-title: Matrix stiffness and tumor-associated macrophages modulate epithelial to mesenchymal transition of human adenocarcinoma cells
  publication-title: Biofabrication
  doi: 10.1088/1758-5090/aaafbc
– volume: 26
  start-page: 3202
  year: 2020
  end-page: 10
  ident: CR161
  article-title: Safety and tolerability of bintrafusp Alfa, a bifunctional fusion protein targeting TGFbeta and PD-L1, in Asian patients with pretreated recurrent or refractory gastric cancer
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-19-3806
– volume: 1
  start-page: 134
  year: 2013
  end-page: 43
  ident: CR144
  article-title: Radretumab radioimmunotherapy in patients with brain metastasis: a 124I-L19SIP dosimetric PET study
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-13-0007
– volume: 6
  start-page: 160
  year: 2020
  ident: CR6
  article-title: Extracellular matrix in the tumor microenvironment and its impact on cancer therapy
  publication-title: Front Mol Biosci
  doi: 10.3389/fmolb.2019.00160
– volume: 17
  year: 2019
  ident: CR28
  article-title: Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression
  publication-title: Cell Commun Signal
  doi: 10.1186/s12964-019-0443-2
– volume: 12
  start-page: 48432
  year: 2020
  end-page: 41
  ident: CR94
  article-title: Reactive oxygen species and inflammatory responses of macrophages to substrates with physiological stiffness
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.0c16638
– volume: 36
  year: 2023
  ident: CR105
  article-title: Quantitative image analysis of fibrillar collagens reveals novel diagnostic and prognostic biomarkers and histotype-dependent aberrant mechanobiology in lung cancer
  publication-title: Mod Pathol
  doi: 10.1016/j.modpat.2023.100155
– volume: 11
  year: 2019
  ident: CR121
  article-title: Immune-mediated ECM depletion improves tumour perfusion and payload delivery
  publication-title: EMBO Mol Med
  doi: 10.15252/emmm.201910923
– volume: 7
  start-page: 301ra130
  year: 2015
  ident: CR16
  article-title: Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3010467
– volume: 6
  start-page: 153
  year: 2021
  ident: CR7
  article-title: Extracellular matrix and its therapeutic potential for cancer treatment
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-021-00544-0
– volume: 25
  start-page: 69
  year: 2022
  end-page: 77
  ident: CR82
  article-title: CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities
  publication-title: Mol Ther Oncolytics
  doi: 10.1016/j.omto.2022.03.009
– volume: 278
  start-page: 16
  year: 2011
  end-page: 27
  ident: CR21
  article-title: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2010.07919.x
– volume: 13
  start-page: 649
  year: 2013
  end-page: 65
  ident: CR23
  article-title: Metalloproteinases and their natural inhibitors in inflammation and immunity
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3499
– volume: 13
  start-page: 3565
  year: 2021
  ident: CR155
  article-title: Collagenase-expressing salmonella targets major collagens in pancreatic cancer leading to reductions in immunosuppressive subsets and tumor growth
  publication-title: Cancers
  doi: 10.3390/cancers13143565
– volume: 27
  start-page: 889
  year: 2021
  end-page: 902
  ident: CR136
  article-title: Modification of extracellular matrix enhances oncolytic adenovirus immunotherapy in glioblastoma
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-20-2400
– volume: 14
  start-page: 5
  year: 2023
  ident: CR25
  article-title: TEM1 up-regulates MMP-2 and promotes ECM remodeling for facilitating invasion and migration of uterine sarcoma
  publication-title: Discov Oncol
  doi: 10.1007/s12672-023-00613-6
– volume: 14
  start-page: 41834
  year: 2022
  end-page: 50
  ident: CR150
  article-title: MMP-2 inhibitor-mediated tumor microenvironment regulation using a sequentially released bio-nanosystem for enhanced cancer photo-immunotherapy
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.2c14781
– volume: 112
  start-page: 1776
  year: 2003
  end-page: 84
  ident: CR44
  article-title: Epithelial-mesenchymal transition and its implications for fibrosis
  publication-title: J Clin Investig
  doi: 10.1172/JCI200320530
– volume: 15
  start-page: 786
  year: 2014
  end-page: 801
  ident: CR20
  article-title: Remodelling the extracellular matrix in development and disease
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3904
– volume: 71
  start-page: 184
  year: 2011
  end-page: 96
  ident: CR30
  article-title: Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells
  publication-title: Prostate
  doi: 10.1002/pros.21233
– volume: 11
  start-page: 5120.
  year: 2020
  ident: CR80
  article-title: Concepts of extracellular matrix remodelling in tumour progression and metastasis
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-18794-x
– volume: 20
  start-page: 174
  year: 2020
  end-page: 86
  ident: CR8
  article-title: A framework for advancing our understanding of cancer-associated fibroblasts
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-019-0238-1
– volume: 126
  start-page: 530
  year: 2020
  end-page: 2
  ident: CR55
  article-title: TCF21: flipping the phenotypic switch in SMC
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.120.316533
– volume: 9
  start-page: e001800
  year: 2021
  ident: CR57
  article-title: Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-001800
– volume: 17
  start-page: 190
  year: 2010
  end-page: 201
  ident: CR137
  article-title: Effect of decorin on overcoming the extracellular matrix barrier for oncolytic virotherapy
  publication-title: Gene Ther
  doi: 10.1038/gt.2009.142
– volume: 17
  start-page: 10337
  year: 2023
  end-page: 10352
  ident: CR146
  article-title: Nanovaccine displaying immunodominant T cell epitopes of fibroblast activation protein is effective against desmoplastic tumors
  publication-title: ACS Nano
  doi: 10.1021/acsnano.3c00764
– volume: 293
  start-page: 13707
  year: 2018
  end-page: 16
  ident: CR14
  article-title: The endoplasmic reticulum-resident collagen chaperone Hsp47 interacts with and promotes the secretion of decorin, fibromodulin, and lumican
  publication-title: J Biol Chem
  doi: 10.1074/jbc.RA117.000758
– volume: 32
  year: 2023
  ident: CR18
  article-title: Probing the effect of glycosaminoglycan depletion on integrin interactions with collagen I fibrils in the native extracellular matrix environment
  publication-title: Protein Sci
  doi: 10.1002/pro.4508
– volume: 8
  start-page: 156
  year: 2023
  ident: CR132
  article-title: Oncolytic virotherapy: basic principles, recent advances and future directions
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-023-01407-6
– volume: 125
  start-page: 1147
  year: 2015
  end-page: 62
  ident: CR31
  article-title: Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
  publication-title: J Clin Investig
  doi: 10.1172/JCI74725
– volume: 109
  start-page: 1421
  year: 2021
  end-page: 30
  ident: CR143
  article-title: Toxicity of L19-interleukin 2 combined with stereotactic body radiation therapy: a phase 1 study
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2020.11.053
– volume: 12
  year: 2020
  ident: CR116
  article-title: Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1
  publication-title: Genome Med
  doi: 10.1186/s13073-020-00780-z
– volume: 11
  start-page: e005267
  year: 2023
  ident: CR165
  article-title: Phase 1 first-in-human study of dalutrafusp alfa, an anti-CD73-TGF-beta-trap bifunctional antibody, in patients with advanced solid tumors
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2022-005267
– volume: 24
  start-page: 3981
  year: 2018
  end-page: 93
  ident: CR130
  article-title: Aberrant Lck signal via CD28 costimulation augments antigen-specific functionality and tumor control by redirected T cells with PD-1 blockade in humanized mice
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-17-1788
– volume: 14
  start-page: 92
  year: 2021
  ident: CR109
  article-title: The relationship between expression of PD-L1 and HIF-1alpha in glioma cells under hypoxia
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-021-01102-5
– volume: 15
  start-page: 366
  year: 2018
  end-page: 81
  ident: CR83
  article-title: Targeting the tumour stroma to improve cancer therapy
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/s41571-018-0007-1
– ident: CR64
– volume: 9
  start-page: e55185.
  year: 2020
  ident: CR89
  article-title: The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy
  publication-title: Elife
  doi: 10.7554/eLife.55185
– volume: 14
  year: 2023
  ident: CR12
  article-title: Pericentromeric satellite lncRNAs are induced in cancer-associated fibroblasts and regulate their functions in lung tumorigenesis
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-023-05553-1
– volume: 132
  start-page: 1565
  year: 2018
  end-page: 80
  ident: CR54
  article-title: LTBP2 is secreted from lung myofibroblasts and is a potential biomarker for idiopathic pulmonary fibrosis
  publication-title: Clin Sci
  doi: 10.1042/CS20180435
– volume: 2
  start-page: 154
  year: 2014
  end-page: 66
  ident: CR127
  article-title: Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-13-0027
– volume: 6
  year: 2017
  ident: CR45
  article-title: Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
  publication-title: Oncogenesis
  doi: 10.1038/oncsis.2017.54
– volume: 135
  year: 2023
  ident: CR112
  article-title: A polymeric extracellular matrix nanoremodeler for activatable cancer photo-immunotherapy
  publication-title: Angew Chem Int Ed Engl
  doi: 10.1002/ange.202217339
– volume: 8
  start-page: 360ra135
  year: 2016
  ident: CR19
  article-title: Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aaf5219
– volume: 7
  year: 2017
  ident: CR99
  article-title: Substrate stiffness influences phenotype and function of human antigen-presenting dendritic cells
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-17787-z
– volume: 48
  start-page: 4253
  year: 2021
  end-page: 62
  ident: CR17
  article-title: Transitional cell carcinoma matrix stiffness regulates the osteopontin and YAP expression in recurrent patients
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-021-06440-8
– volume: 41
  start-page: 162
  year: 2023
  end-page: 7
  ident: CR173
  article-title: A phase Ib/II study of BLU-554, a fibroblast growth factor receptor 4 inhibitor in combination with CS1001, an anti-PD-L1, in patients with locally advanced or metastatic hepatocellular carcinoma
  publication-title: Investig N Drugs
  doi: 10.1007/s10637-023-01335-w
– volume: 11
  start-page: 721
  year: 2019
  ident: CR10
  article-title: Integrins, CAFs and mechanical forces in the progression of cancer
  publication-title: Cancers
  doi: 10.3390/cancers11050721
– volume: 9
  start-page: e003254
  year: 2021
  ident: CR135
  article-title: VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2021-003254
– volume: 9
  year: 2018
  ident: CR69
  article-title: Cancer-associated fibroblasts induce antigen-specific deletion of CD8 (+) T Cells to protect tumour cells
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-03347-0
– volume: 68-69
  start-page: 180
  year: 2018
  end-page: 93
  ident: CR154
  article-title: Biomechanical and biomolecular characterization of extracellular matrix structures in human colon carcinomas
  publication-title: Matrix Biol
  doi: 10.1016/j.matbio.2018.03.016
– volume: 15
  start-page: 34
  year: 2022
  ident: CR3
  article-title: Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-022-01252-0
– volume: 190
  start-page: 886
  year: 2020
  end-page: 99
  ident: CR71
  article-title: Diminished CD68(+) cancer-associated fibroblast subset induces regulatory T-cell (Treg) infiltration and predicts poor prognosis of oral squamous cell carcinoma patients
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2019.12.007
– volume: 20
  year: 2022
  ident: CR1
  article-title: Biological role of matrix stiffness in tumor growth and treatment
  publication-title: J Transl Med
  doi: 10.1186/s12967-022-03768-y
– volume: 10
  year: 2022
  ident: CR58
  article-title: The application of mechanobiotechnology for immuno-engineering and cancer immunotherapy
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2022.1064484
– volume: 21
  start-page: 1611
  year: 2013
  end-page: 20
  ident: CR129
  article-title: Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma
  publication-title: Mol Ther
  doi: 10.1038/mt.2013.110
– volume: 2
  start-page: 161
  year: 2002
  end-page: 74
  ident: CR22
  article-title: New functions for the matrix metalloproteinases in cancer progression
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc745
– volume: 9
  year: 2021
  ident: CR100
  article-title: Protein phosphatase 2A mediates yap activation in endothelial cells upon VEGF stimulation and matrix stiffness
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.675562
– volume: 28
  start-page: e124
  year: 2023
  end-page: e127
  ident: CR164
  article-title: Bintrafusp Alfa: a bifunctional fusion protein targeting PD-L1 and TGF-beta, in patients with pretreated colorectal cancer: results from a phase I trial
  publication-title: Oncologist
  doi: 10.1093/oncolo/oyac254
– volume: 309
  start-page: 1074
  year: 2005
  end-page: 8
  ident: CR42
  article-title: TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
  publication-title: Science
  doi: 10.1126/science.1110955
– ident: CR79
– volume: 8
  start-page: e001193
  year: 2020
  ident: CR115
  article-title: Blood-based extracellular matrix biomarkers are correlated with clinical outcome after PD-1 inhibition in patients with metastatic melanoma
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-001193
– volume: 75
  start-page: 2800
  year: 2015
  end-page: 10
  ident: CR128
  article-title: Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-14-3041
– volume: 16
  start-page: 447
  year: 2021
  end-page: 59
  ident: CR158
  article-title: Bintrafusp Alfa, a bifunctional fusion protein targeting TGF beta and PD-L1, in patients with esophageal squamous cell carcinoma: results from a phase 1 cohort in Asia
  publication-title: Target Oncol
  doi: 10.1007/s11523-021-00810-9
– volume: 26
  start-page: 1855
  year: 2018
  end-page: 66
  ident: CR169
  article-title: Dominant-negative TGF-beta receptor enhances PSMA-targeted human CAR T cell proliferation and augments prostate cancer eradication
  publication-title: Mol Ther
  doi: 10.1016/j.ymthe.2018.05.003
– volume: 216
  start-page: 3799
  year: 2017
  end-page: 816
  ident: CR15
  article-title: Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201704053
– volume: 24
  start-page: 4535
  year: 2010
  end-page: 44
  ident: CR142
  article-title: Vaccination against the extra domain-B of fibronectin as a novel tumor therapy
  publication-title: FASEB J
  doi: 10.1096/fj.10-163022
– volume: 2
  start-page: 125
  year: 2022
  end-page: 39
  ident: CR5
  article-title: Extracellular matrix in cancer progression and therapy
  publication-title: Med Rev
  doi: 10.1515/mr-2021-0028
– volume: 24
  start-page: 495
  year: 2023
  end-page: 516
  ident: CR63
  article-title: Cell-extracellular matrix mechanotransduction in 3D
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-023-00583-1
– volume: 8
  year: 2018
  ident: CR35
  article-title: The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-25589-0
– volume: 20
  year: 2022
  ident: CR73
  article-title: Monocytes educated by cancer-associated fibroblasts secrete exosomal miR-181a to activate AKT signaling in breast cancer cells
  publication-title: J Transl Med
  doi: 10.1186/s12967-022-03780-2
– volume: 22
  year: 2022
  ident: CR96
  article-title: Matrix stiffness-dependent STEAP3 coordinated with PD-L2 identify tumor responding to sorafenib treatment in hepatocellular carcinoma
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-022-02634-7
– volume: 17
  start-page: 7475
  year: 2023
  end-page: 86
  ident: CR123
  article-title: Nattokinase-mediated regulation of tumor physical microenvironment to enhance chemotherapy, radiotherapy, and CAR-T therapy of solid tumor
  publication-title: ACS Nano
  doi: 10.1021/acsnano.2c12463
– volume: 70
  start-page: 4431
  year: 2013
  end-page: 48
  ident: CR66
  article-title: Positive and negative influence of the matrix architecture on antitumor immune surveillance
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-013-1339-8
– volume: 518
  start-page: 35
  year: 2021
  end-page: 48
  ident: CR76
  article-title: Cancer-associated fibroblasts induce monocytic myeloid-derived suppressor cell generation via IL-6/exosomal miR-21-activated STAT3 signaling to promote cisplatin resistance in esophageal squamous cell carcinoma
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2021.06.009
– volume: 10
  year: 2019
  ident: CR74
  article-title: Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1435-2
– volume: 51
  start-page: 2321
  year: 2015
  end-page: 9
  ident: CR167
  article-title: A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2015.07.035
– volume: 77
  start-page: 4710
  year: 2017
  end-page: 22
  ident: CR11
  article-title: SPIN90 depletion and microtubule acetylation mediate stromal fibroblast activation in breast cancer progression
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-17-0657
– volume: 12
  start-page: 112
  year: 2019
  ident: CR46
  article-title: Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-019-0795-5
– volume: 14
  year: 2023
  ident: CR92
  article-title: Combined PD-L1/TGFbeta blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
  publication-title: Nat Commun
  doi: 10.1038/s41467-023-40398-4
– volume: 5
  start-page: 3899
  year: 2019
  end-page: 908
  ident: CR104
  article-title: Engineered fibrous networks to investigate the influence of fiber mechanics on myofibroblast differentiation
  publication-title: ACS Biomater Sci Eng
  doi: 10.1021/acsbiomaterials.8b01276
– volume: 179
  start-page: 1381
  year: 2007
  end-page: 8
  ident: CR148
  article-title: Tumor-associated embryonic antigen-expressing vaccines that target CCR6 elicit potent CD8+ T cell-mediated protective and therapeutic antitumor immunity
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.2.1381
– volume: 68
  start-page: 693
  year: 2019
  end-page: 707
  ident: CR84
  article-title: Stromal protein betaig-h3 reprogrammes tumour microenvironment in pancreatic cancer
  publication-title: Gut
  doi: 10.1136/gutjnl-2018-317570
– volume: 11
  year: 2023
  ident: CR27
  article-title: The versatile roles of ADAM8 in cancer cell migration, mechanics, and extracellular matrix remodeling
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2023.1130823
– volume: 24
  start-page: 495
  year: 2023
  ident: 6697_CR63
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-023-00583-1
– volume: 11
  start-page: 1689
  year: 2020
  ident: 6697_CR119
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.01689
– volume: 13
  year: 2022
  ident: 6697_CR110
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.868809
– volume: 39
  start-page: 3089
  year: 2020
  ident: 6697_CR49
  publication-title: Oncogene
  doi: 10.1038/s41388-019-0885-4
– volume: 252
  year: 2020
  ident: 6697_CR140
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120114
– volume: 14
  start-page: 92
  year: 2021
  ident: 6697_CR109
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-021-01102-5
– volume: 15
  start-page: 366
  year: 2018
  ident: 6697_CR83
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/s41571-018-0007-1
– volume: 10
  start-page: e004479
  year: 2022
  ident: 6697_CR124
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2021-004479
– volume: 42
  start-page: 2183
  year: 2023
  ident: 6697_CR98
  publication-title: Oncogene
  doi: 10.1038/s41388-023-02715-5
– ident: 6697_CR64
  doi: 10.1084/jem.20200053
– volume: 14
  start-page: 642
  year: 2015
  ident: 6697_CR134
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd4663
– volume: 5
  start-page: 880
  year: 2020
  ident: 6697_CR93
  publication-title: Bioact Mater
– volume: 9
  year: 2021
  ident: 6697_CR100
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.675562
– volume: 77
  start-page: 4710
  year: 2017
  ident: 6697_CR11
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-17-0657
– volume: 6
  start-page: 500
  year: 2015
  ident: 6697_CR78
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2015.00500
– volume: 11
  start-page: e005267
  year: 2023
  ident: 6697_CR165
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2022-005267
– volume: 10
  start-page: 035004
  year: 2018
  ident: 6697_CR47
  publication-title: Biofabrication
  doi: 10.1088/1758-5090/aaafbc
– volume: 8
  start-page: e000564
  year: 2020
  ident: 6697_CR162
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-000564
– volume: 75
  start-page: 2800
  year: 2015
  ident: 6697_CR128
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-14-3041
– volume: 11
  start-page: 721
  year: 2019
  ident: 6697_CR10
  publication-title: Cancers
  doi: 10.3390/cancers11050721
– volume: 16
  start-page: 447
  year: 2021
  ident: 6697_CR158
  publication-title: Target Oncol
  doi: 10.1007/s11523-021-00810-9
– volume: 12
  year: 2021
  ident: 6697_CR91
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.729820
– volume: 278
  start-page: 16
  year: 2011
  ident: 6697_CR21
  publication-title: FEBS J
  doi: 10.1111/j.1742-4658.2010.07919.x
– volume: 53
  start-page: 1192
  year: 2011
  ident: 6697_CR33
  publication-title: Hepatology
  doi: 10.1002/hep.24108
– volume: 22
  year: 2022
  ident: 6697_CR96
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-022-02634-7
– volume: 12
  start-page: 490
  year: 2020
  ident: 6697_CR43
  publication-title: Cancers
  doi: 10.3390/cancers12020490
– volume: 11
  start-page: e79957.
  year: 2022
  ident: 6697_CR88
  publication-title: Elife
  doi: 10.7554/eLife.79957
– volume: 98
  start-page: 1482
  year: 2006
  ident: 6697_CR138
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/djj397
– volume: 9
  start-page: e55185.
  year: 2020
  ident: 6697_CR89
  publication-title: Elife
  doi: 10.7554/eLife.55185
– volume: 12
  start-page: 47355
  year: 2020
  ident: 6697_CR87
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.0c16478
– volume: 41
  start-page: 162
  year: 2023
  ident: 6697_CR173
  publication-title: Investig N Drugs
  doi: 10.1007/s10637-023-01335-w
– volume: 10
  start-page: 1563
  year: 2020
  ident: 6697_CR50
  publication-title: Front Oncol
  doi: 10.3389/fonc.2020.01563
– volume: 6
  start-page: 153
  year: 2021
  ident: 6697_CR7
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-021-00544-0
– volume: 8
  start-page: e000432
  year: 2020
  ident: 6697_CR85
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2019-000432
– volume: 381
  start-page: 338
  year: 2019
  ident: 6697_CR174
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1817323
– volume: 17
  year: 2022
  ident: 6697_CR107
  publication-title: Transl Oncol
  doi: 10.1016/j.tranon.2021.101335
– volume: 7
  start-page: 301ra130
  year: 2015
  ident: 6697_CR16
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3010467
– volume: 12
  year: 2021
  ident: 6697_CR103
  publication-title: Front Pharm
  doi: 10.3389/fphar.2021.698275
– volume: 9
  year: 2019
  ident: 6697_CR52
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-43759-6
– volume: 34
  start-page: 1345
  year: 2015
  ident: 6697_CR24
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.4103
– volume: 105
  start-page: 11305
  year: 2008
  ident: 6697_CR101
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0800835105
– volume: 9
  start-page: e003254
  year: 2021
  ident: 6697_CR135
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2021-003254
– volume: 50
  start-page: 2033
  year: 2017
  ident: 6697_CR36
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2017.3978
– volume: 8
  start-page: e001395
  year: 2020
  ident: 6697_CR163
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-001395
– volume: 11
  year: 2023
  ident: 6697_CR27
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2023.1130823
– volume: 9
  start-page: e001800
  year: 2021
  ident: 6697_CR57
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-001800
– volume: 109
  start-page: 1421
  year: 2021
  ident: 6697_CR143
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2020.11.053
– volume: 2
  start-page: 161
  year: 2002
  ident: 6697_CR22
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc745
– volume: 14
  year: 2023
  ident: 6697_CR92
  publication-title: Nat Commun
  doi: 10.1038/s41467-023-40398-4
– volume: 297
  start-page: C179
  year: 2009
  ident: 6697_CR102
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00018.2009
– volume: 25
  year: 2022
  ident: 6697_CR95
  publication-title: iScience
  doi: 10.1016/j.isci.2022.103758
– volume: 132
  start-page: 1565
  year: 2018
  ident: 6697_CR54
  publication-title: Clin Sci
  doi: 10.1042/CS20180435
– volume: 343
  start-page: 267
  year: 2022
  ident: 6697_CR149
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2022.01.024
– volume: 356
  start-page: eaal3118.
  year: 2017
  ident: 6697_CR59
  publication-title: Science
  doi: 10.1126/science.aal3118
– volume: 12
  start-page: 112
  year: 2019
  ident: 6697_CR46
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-019-0795-5
– volume: 32
  year: 2023
  ident: 6697_CR18
  publication-title: Protein Sci
  doi: 10.1002/pro.4508
– volume: 20
  year: 2022
  ident: 6697_CR73
  publication-title: J Transl Med
  doi: 10.1186/s12967-022-03780-2
– volume: 495
  start-page: 2344
  year: 2018
  ident: 6697_CR108
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2017.12.115
– volume: 6
  start-page: 160
  year: 2020
  ident: 6697_CR6
  publication-title: Front Mol Biosci
  doi: 10.3389/fmolb.2019.00160
– volume: 14
  year: 2023
  ident: 6697_CR12
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-023-05553-1
– volume: 14
  start-page: 41834
  year: 2022
  ident: 6697_CR150
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.2c14781
– volume: 44
  start-page: 1904
  year: 2008
  ident: 6697_CR26
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2008.06.031
– volume: 10
  start-page: 2320
  year: 2019
  ident: 6697_CR97
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.02320
– volume: 7
  year: 2017
  ident: 6697_CR99
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-17787-z
– volume: 11
  year: 2021
  ident: 6697_CR120
  publication-title: Blood Cancer J
  doi: 10.1038/s41408-021-00459-7
– volume: 116
  start-page: 7624
  year: 2019
  ident: 6697_CR126
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1817147116
– volume: 17
  start-page: 10337
  year: 2023
  ident: 6697_CR146
  publication-title: ACS Nano
  doi: 10.1021/acsnano.3c00764
– volume: 9
  start-page: 1639
  year: 2003
  ident: 6697_CR147
  publication-title: Clin Cancer Res
– volume: 584
  start-page: 535
  year: 2020
  ident: 6697_CR62
  publication-title: Nature
  doi: 10.1038/s41586-020-2612-2
– volume: 17
  start-page: 679
  year: 2017
  ident: 6697_CR61
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2017.74
– volume: 163
  start-page: 1593
  year: 2022
  ident: 6697_CR113
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2022.07.076
– volume: 125
  start-page: 1147
  year: 2015
  ident: 6697_CR31
  publication-title: J Clin Investig
  doi: 10.1172/JCI74725
– volume: 11
  start-page: 5120.
  year: 2020
  ident: 6697_CR80
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-18794-x
– volume: 13
  start-page: 10349
  year: 2022
  ident: 6697_CR56
  publication-title: Chem Sci
  doi: 10.1039/D2SC02708A
– volume: 17
  start-page: 7475
  year: 2023
  ident: 6697_CR123
  publication-title: ACS Nano
  doi: 10.1021/acsnano.2c12463
– volume: 216
  start-page: 3799
  year: 2017
  ident: 6697_CR15
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201704053
– volume: 318
  start-page: 154
  year: 2012
  ident: 6697_CR75
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2011.12.020
– volume: 25
  start-page: 69
  year: 2022
  ident: 6697_CR82
  publication-title: Mol Ther Oncolytics
  doi: 10.1016/j.omto.2022.03.009
– volume: 68-69
  start-page: 180
  year: 2018
  ident: 6697_CR154
  publication-title: Matrix Biol
  doi: 10.1016/j.matbio.2018.03.016
– volume: 20
  start-page: 174
  year: 2020
  ident: 6697_CR8
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-019-0238-1
– volume: 14
  start-page: 3810
  year: 2022
  ident: 6697_CR48
  publication-title: Cancers
  doi: 10.3390/cancers14153810
– volume: 20
  year: 2022
  ident: 6697_CR1
  publication-title: J Transl Med
  doi: 10.1186/s12967-022-03768-y
– volume: 15
  start-page: 34
  year: 2022
  ident: 6697_CR3
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-022-01252-0
– volume: 28
  start-page: 4326
  year: 2009
  ident: 6697_CR39
  publication-title: Oncogene
  doi: 10.1038/onc.2009.299
– volume: 340
  start-page: 1587
  year: 2013
  ident: 6697_CR60
  publication-title: Science
  doi: 10.1126/science.1237572
– volume: 36
  start-page: 54
  year: 2015
  ident: 6697_CR65
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/j.ceb.2015.06.006
– volume: 7
  start-page: 68
  year: 2019
  ident: 6697_CR90
  publication-title: J Immunother Cancer
  doi: 10.1186/s40425-019-0556-6
– volume: 24
  start-page: 3981
  year: 2018
  ident: 6697_CR130
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-17-1788
– volume: 368
  start-page: eaaw5473.
  year: 2020
  ident: 6697_CR40
  publication-title: Science
  doi: 10.1126/science.aaw5473
– volume: 10
  year: 2019
  ident: 6697_CR74
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1435-2
– volume: 8
  start-page: 156
  year: 2023
  ident: 6697_CR132
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-023-01407-6
– volume: 3
  start-page: 1194
  year: 2014
  ident: 6697_CR125
  publication-title: Adv Health Mater
  doi: 10.1002/adhm.201300597
– volume: 21
  start-page: 1661
  year: 2020
  ident: 6697_CR166
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(20)30533-7
– volume: 185
  start-page: 1450
  year: 2010
  ident: 6697_CR81
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0901352
– volume: 59
  start-page: 803
  year: 2018
  ident: 6697_CR34
  publication-title: Investig Ophthalmol Vis Sci
  doi: 10.1167/iovs.17-22400
– ident: 6697_CR79
  doi: 10.7554/eLife.58688
– volume: 10
  year: 2021
  ident: 6697_CR111
  publication-title: Adv Health Mater
  doi: 10.1002/adhm.202100794
– volume: 135
  year: 2023
  ident: 6697_CR112
  publication-title: Angew Chem Int Ed Engl
  doi: 10.1002/ange.202217339
– volume: 13
  start-page: 649
  year: 2013
  ident: 6697_CR23
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3499
– volume: 6
  start-page: 152
  year: 2018
  ident: 6697_CR114
  publication-title: J Immunother Cancer
  doi: 10.1186/s40425-018-0474-z
– volume: 17
  year: 2019
  ident: 6697_CR28
  publication-title: Cell Commun Signal
  doi: 10.1186/s12964-019-0443-2
– volume: 112
  start-page: 1776
  year: 2003
  ident: 6697_CR44
  publication-title: J Clin Investig
  doi: 10.1172/JCI200320530
– volume: 189
  start-page: 1330
  year: 2012
  ident: 6697_CR86
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1102757
– volume: 13
  start-page: 3565
  year: 2021
  ident: 6697_CR155
  publication-title: Cancers
  doi: 10.3390/cancers13143565
– volume: 309
  start-page: 1074
  year: 2005
  ident: 6697_CR42
  publication-title: Science
  doi: 10.1126/science.1110955
– volume: 102
  start-page: 815
  year: 2011
  ident: 6697_CR51
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2011.01861.x
– volume: 7
  start-page: e1440167
  year: 2018
  ident: 6697_CR70
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2018.1440167
– volume: 13
  start-page: 2550
  year: 2023
  ident: 6697_CR153
  publication-title: Drug Deliv Transl Res
  doi: 10.1007/s13346-023-01337-4
– volume: 126
  start-page: 530
  year: 2020
  ident: 6697_CR55
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.120.316533
– volume: 12
  start-page: 2687
  year: 2020
  ident: 6697_CR67
  publication-title: Cancers
  doi: 10.3390/cancers12092687
– volume: 5
  start-page: 3899
  year: 2019
  ident: 6697_CR104
  publication-title: ACS Biomater Sci Eng
  doi: 10.1021/acsbiomaterials.8b01276
– volume: 8
  start-page: e001193
  year: 2020
  ident: 6697_CR115
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-001193
– volume: 6
  start-page: 39
  year: 2017
  ident: 6697_CR133
  publication-title: Oncolytic Virother
  doi: 10.2147/OV.S145262
– volume: 24
  start-page: 4535
  year: 2010
  ident: 6697_CR142
  publication-title: FASEB J
  doi: 10.1096/fj.10-163022
– volume: 9
  year: 2018
  ident: 6697_CR72
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-018-0458-4
– volume: 22
  start-page: 1776
  year: 2011
  ident: 6697_CR141
  publication-title: Bioconjug Chem
  doi: 10.1021/bc200158j
– volume: 27
  start-page: 889
  year: 2021
  ident: 6697_CR136
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-20-2400
– volume: 11
  year: 2019
  ident: 6697_CR121
  publication-title: EMBO Mol Med
  doi: 10.15252/emmm.201910923
– volume: 9
  year: 2018
  ident: 6697_CR69
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-03347-0
– volume: 68
  start-page: 693
  year: 2019
  ident: 6697_CR84
  publication-title: Gut
  doi: 10.1136/gutjnl-2018-317570
– volume: 183
  start-page: 1891
  year: 2021
  ident: 6697_CR152
  publication-title: Int J Biol Macromol
  doi: 10.1016/j.ijbiomac.2021.05.158
– volume: 351
  start-page: 255
  year: 2022
  ident: 6697_CR151
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2022.09.029
– volume: 21
  start-page: 1611
  year: 2013
  ident: 6697_CR129
  publication-title: Mol Ther
  doi: 10.1038/mt.2013.110
– volume: 26
  start-page: 1855
  year: 2018
  ident: 6697_CR169
  publication-title: Mol Ther
  doi: 10.1016/j.ymthe.2018.05.003
– volume: 72
  start-page: 710
  year: 2023
  ident: 6697_CR53
  publication-title: Gut
  doi: 10.1136/gutjnl-2022-327913
– volume: 70
  start-page: 4431
  year: 2013
  ident: 6697_CR66
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-013-1339-8
– volume: 24
  start-page: 4820
  year: 2018
  ident: 6697_CR68
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-18-0205
– volume: 28
  start-page: 5254
  year: 2022
  ident: 6697_CR171
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-22-0308
– volume: 6
  year: 2017
  ident: 6697_CR45
  publication-title: Oncogenesis
  doi: 10.1038/oncsis.2017.54
– volume: 10
  start-page: 229
  year: 2021
  ident: 6697_CR131
  publication-title: World J Virol
  doi: 10.5501/wjv.v10.i5.229
– volume: 19
  start-page: 128
  year: 2009
  ident: 6697_CR41
  publication-title: Cell Res
  doi: 10.1038/cr.2008.328
– volume: 38
  year: 2019
  ident: 6697_CR13
  publication-title: EMBO J
  doi: 10.15252/embj.2018100532
– volume: 36
  year: 2023
  ident: 6697_CR105
  publication-title: Mod Pathol
  doi: 10.1016/j.modpat.2023.100155
– volume: 1866
  year: 2019
  ident: 6697_CR106
  publication-title: Biochim Biophys Acta Mol Cell Res
  doi: 10.1016/j.bbamcr.2019.118526
– volume: 15
  start-page: 1210
  year: 2020
  ident: 6697_CR160
  publication-title: J Thorac Oncol
  doi: 10.1016/j.jtho.2020.03.003
– volume: 15
  year: 2023
  ident: 6697_CR172
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.abp9229
– volume: 14
  start-page: 5
  year: 2023
  ident: 6697_CR25
  publication-title: Discov Oncol
  doi: 10.1007/s12672-023-00613-6
– volume: 15
  start-page: 786
  year: 2014
  ident: 6697_CR20
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3904
– volume: 518
  start-page: 35
  year: 2021
  ident: 6697_CR76
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2021.06.009
– volume: 12
  year: 2020
  ident: 6697_CR116
  publication-title: Genome Med
  doi: 10.1186/s13073-020-00780-z
– volume: 11
  start-page: 77
  year: 2016
  ident: 6697_CR4
  publication-title: Curr Opin Chem Eng
  doi: 10.1016/j.coche.2016.01.011
– volume: 348
  start-page: 62
  year: 2015
  ident: 6697_CR118
  publication-title: Science
  doi: 10.1126/science.aaa4967
– volume: 41
  start-page: 13
  year: 2015
  ident: 6697_CR37
  publication-title: J Mech Behav Biomed Mater
  doi: 10.1016/j.jmbbm.2014.09.020
– volume: 51
  start-page: 2321
  year: 2015
  ident: 6697_CR167
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2015.07.035
– volume: 12
  start-page: 48432
  year: 2020
  ident: 6697_CR94
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.0c16638
– volume: 20
  year: 2022
  ident: 6697_CR168
  publication-title: BMC Med
  doi: 10.1186/s12916-022-02605-9
– volume: 8
  start-page: e000664
  year: 2020
  ident: 6697_CR157
  publication-title: J Immunother Cancer
  doi: 10.1136/jitc-2020-000664
– volume: 12
  year: 2021
  ident: 6697_CR77
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.791453
– volume: 118
  start-page: e2105367118.
  year: 2021
  ident: 6697_CR38
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.2105367118
– volume: 17
  start-page: 190
  year: 2010
  ident: 6697_CR137
  publication-title: Gene Ther
  doi: 10.1038/gt.2009.142
– volume: 2
  start-page: 125
  year: 2022
  ident: 6697_CR5
  publication-title: Med Rev
  doi: 10.1515/mr-2021-0028
– volume: 9
  start-page: e83786
  year: 2014
  ident: 6697_CR122
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0083786
– volume: 293
  start-page: 13707
  year: 2018
  ident: 6697_CR14
  publication-title: J Biol Chem
  doi: 10.1074/jbc.RA117.000758
– volume: 2
  start-page: 154
  year: 2014
  ident: 6697_CR127
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-13-0027
– volume: 8
  year: 2018
  ident: 6697_CR35
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-25589-0
– volume: 9
  start-page: 85
  year: 2021
  ident: 6697_CR139
  publication-title: Vaccines
  doi: 10.3390/vaccines9020085
– volume: 2
  start-page: 100515
  year: 2021
  ident: 6697_CR2
  publication-title: Cell Rep Phys Sci
  doi: 10.1016/j.xcrp.2021.100515
– volume: 190
  start-page: 886
  year: 2020
  ident: 6697_CR71
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2019.12.007
– volume: 28
  start-page: e124
  year: 2023
  ident: 6697_CR164
  publication-title: Oncologist
  doi: 10.1093/oncolo/oyac254
– volume: 1840
  start-page: 2560
  year: 2014
  ident: 6697_CR29
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbagen.2014.03.017
– volume: 179
  start-page: 1381
  year: 2007
  ident: 6697_CR148
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.2.1381
– volume: 116
  start-page: 1955
  year: 2006
  ident: 6697_CR145
  publication-title: J Clin Investig
  doi: 10.1172/JCI26532
– volume: 28
  start-page: 724
  year: 2022
  ident: 6697_CR170
  publication-title: Nat Med
  doi: 10.1038/s41591-022-01726-1
– volume: 8
  start-page: 360ra135
  year: 2016
  ident: 6697_CR19
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aaf5219
– volume: 1
  start-page: 134
  year: 2013
  ident: 6697_CR144
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-13-0007
– volume: 10
  year: 2022
  ident: 6697_CR58
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2022.1064484
– volume: 69
  start-page: 223
  year: 2020
  ident: 6697_CR32
  publication-title: Cancer Immunol Immunother
  doi: 10.1007/s00262-019-02404-x
– volume: 16
  start-page: 435
  year: 2021
  ident: 6697_CR159
  publication-title: Target Oncol
  doi: 10.1007/s11523-021-00809-2
– volume: 132
  start-page: e172059
  year: 2022
  ident: 6697_CR156
  publication-title: J Clin Investig
  doi: 10.1172/JCI161400
– volume: 38
  start-page: BSR20180243
  year: 2018
  ident: 6697_CR9
  publication-title: Biosci Rep
  doi: 10.1042/BSR20180243
– volume: 12
  start-page: 269
  year: 2012
  ident: 6697_CR117
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3191
– volume: 26
  start-page: 3202
  year: 2020
  ident: 6697_CR161
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-19-3806
– volume: 48
  start-page: 4253
  year: 2021
  ident: 6697_CR17
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-021-06440-8
– volume: 71
  start-page: 184
  year: 2011
  ident: 6697_CR30
  publication-title: Prostate
  doi: 10.1002/pros.21233
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Snippet The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression...
Abstract The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer...
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SubjectTerms 631/67
692/699/67/1059/2325
Animals
Antibodies
Biochemistry
Biomaterials
Biomedical and Life Sciences
Cancer
Cancer immunotherapy
Cancer vaccines
Cell Biology
Cell Culture
Cell therapy
Extracellular matrix
Extracellular Matrix - metabolism
Humans
Immune checkpoint inhibitors
Immunology
Immunotherapy
Immunotherapy - methods
Life Sciences
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
Oncolysis
Review
Review Article
Tumor microenvironment
Tumor Microenvironment - immunology
Tumors
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Title Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy
URI https://link.springer.com/article/10.1038/s41419-024-06697-4
https://www.ncbi.nlm.nih.gov/pubmed/38693104
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https://doaj.org/article/0d04a7fcae3649499e1b023e1e4e7f15
Volume 15
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