CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

• Published in: eLife Vol. 6
• Main Authors: Okuno, Hironobu, Renault Mihara, Francois, Ohta, Shigeki, Fukuda, Kimiko, Kurosawa, Kenji, Akamatsu, Wado, Sanosaka, Tsukasa, Kohyama, Jun, Hayashi, Kanehiro, Nakajima, Kazunori, Takahashi, Takao, Wysocka, Joanna, Kosaki, Kenjiro, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 28.11.2017; eLife Sciences Publications, Ltd
• Subjects: Biology; Cell migration; CHARGE syndrome; CHD7; Chromatin; Cloning; Defects; Developmental Biology; disease modeling; Embryogenesis; Experiments; Fibroblasts; Human Biology and Medicine; Hypotheses; induced pluripotent stem cells; Medicine; Mutation; Neural crest; Patients; Pluripotency; Software; Stem cells; Transplantation; human biology; stem cells; developmental biology; neural crest; CHD7; disease modeling; CHARGE syndrome; cell migration; induced pluripotent stem cells; medicine; human

CHARGE syndrome is caused by heterozygous mutations in the chromatin remodeler, and is characterized by a set of malformations that, on clinical grounds, were historically postulated to arise from defects in neural crest formation during embryogenesis. To better delineate neural crest defects in CHA...