Active ingredients in Chinese medicines promoting blood circulation as Na＋/K＋-ATPase inhibitors

• Published in: Acta pharmacologica Sinica Vol. 32; no. 2; pp. 141 - 151
• Main Authors: Chen, Ronald JY, Jinn, Tzyy-rong, Chen, Yi-ching, Chung, Tse-yu, Yang, Wei-hung, Tzen, Jason TC
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2011; Nature Publishing Group
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Blood Circulation - drug effects; Cardiac Glycosides - pharmacology; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Immunology; Internal Medicine; Medical Microbiology; Models, Theoretical; Pharmacology/Toxicology; Review; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors; Vaccine; blood circulation; Na; steroid-like compound; cardiac glycoside; magnesium lithospermate B; neuroprotection; ginsenoside; traditional Chinese medicine; ATPase inhibitors; K

The positive inotropic effect of cardiac glycosides lies in their reversible inhibition on the membrane-bound Na＋/K＋-ATPase in human myocardium. Steroid-like compounds containing a core structure similar to cardiac glycosides are found in many Chinese medicines conventionally used for promoting bloo...