Efficient, cell-based simulations of cardiac electrophysiology; The Kirchhoff Network Model (KNM)

• Published in: NPJ systems biology and applications Vol. 9; no. 1; pp. 25 - 7
• Main Authors: Jæger, Karoline Horgmo, Tveito, Aslak
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.06.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/553/2695; 631/553/2700; 631/57; Bioinformatics; Biology; Biomedical and Life Sciences; Brief Communication; Cardiomyocytes; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Electrophysiology; Fibroblasts; Heart; Life Sciences; Mathematical models; Myocytes; Ordinary differential equations; Partial differential equations; Simulation; Systems Biology

Mathematical models based on homogenized representation of cardiac tissue have greatly improved our understanding of cardiac electrophysiology. However, these models are too coarse to investigate the dynamics at the level of the myocytes since the cells are not present in homogenized models. Recentl...