Genetic sequencing of a 1944 Rocky Mountain spotted fever vaccine

Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii . Its discovery and characterization by Howard Ricketts has been hailed as a remarkable historical example of detection and control of an emerging infectious disease, and s...

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Published inScientific reports Vol. 13; no. 1; pp. 4687 - 11
Main Authors Xiao, Yongli, Beare, Paul A., Best, Sonja M., Morens, David M., Bloom, Marshall E., Taubenberger, Jeffery K.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 22.03.2023
Nature Publishing Group
Nature Portfolio
Subjects
631/326
631/337
Animals
Coxiella burnetii
Deoxyribonucleic acid
DNA
Genomes
Humanities and Social Sciences
Infectious diseases
multidisciplinary
Next-generation sequencing
Pathogens
Phenols
Q fever
Rickettsia rickettsii
Rickettsia rickettsii - genetics
Rocky Mountain spotted fever
Rocky Mountain Spotted Fever - microbiology
Rocky Mountain Spotted Fever - prevention & control
Science
Science (multidisciplinary)
Tick-borne diseases
Ticks - microbiology
Vaccines
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Abstract Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii . Its discovery and characterization by Howard Ricketts has been hailed as a remarkable historical example of detection and control of an emerging infectious disease, and subsequently led to the establishment of the Rocky Mountain Laboratories (RML). Here, we examined an unopened bottle of a vaccine, labeled as containing RMSF inactivated by phenol-formalin of infected ticks, developed prior to 1944 at RML by DNA analysis using Illumina high throughput sequencing technology. We found that it contains DNA from the Rocky Mountain wood tick ( Dermacentor andersoni ), the vector of RMSF, the complete genome of Rickettsia rickettsii , the pathogen of RMSF, as well as the complete genome of Coxiella burnetii , the pathogen of Q-fever. In addition to genomic reads of Rickettsia rickettsii and Coxiella burnetii , smaller percentages of the reads are from Rickettsia rhipicephali and Arsenophonus nasoniae , suggesting that the infected ticks used to prepare the vaccine carried more than one pathogen. Together, these findings suggest that this early vaccine was likely a bivalent vaccine for RMSF and Q-fever. This study is the among the first molecular level examinations of an historically important vaccine.
AbstractList Abstract Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii. Its discovery and characterization by Howard Ricketts has been hailed as a remarkable historical example of detection and control of an emerging infectious disease, and subsequently led to the establishment of the Rocky Mountain Laboratories (RML). Here, we examined an unopened bottle of a vaccine, labeled as containing RMSF inactivated by phenol-formalin of infected ticks, developed prior to 1944 at RML by DNA analysis using Illumina high throughput sequencing technology. We found that it contains DNA from the Rocky Mountain wood tick (Dermacentor andersoni), the vector of RMSF, the complete genome of Rickettsia rickettsii, the pathogen of RMSF, as well as the complete genome of Coxiella burnetii, the pathogen of Q-fever. In addition to genomic reads of Rickettsia rickettsii and Coxiella burnetii, smaller percentages of the reads are from Rickettsia rhipicephali and Arsenophonus nasoniae, suggesting that the infected ticks used to prepare the vaccine carried more than one pathogen. Together, these findings suggest that this early vaccine was likely a bivalent vaccine for RMSF and Q-fever. This study is the among the first molecular level examinations of an historically important vaccine.
Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii. Its discovery and characterization by Howard Ricketts has been hailed as a remarkable historical example of detection and control of an emerging infectious disease, and subsequently led to the establishment of the Rocky Mountain Laboratories (RML). Here, we examined an unopened bottle of a vaccine, labeled as containing RMSF inactivated by phenol-formalin of infected ticks, developed prior to 1944 at RML by DNA analysis using Illumina high throughput sequencing technology. We found that it contains DNA from the Rocky Mountain wood tick (Dermacentor andersoni), the vector of RMSF, the complete genome of Rickettsia rickettsii, the pathogen of RMSF, as well as the complete genome of Coxiella burnetii, the pathogen of Q-fever. In addition to genomic reads of Rickettsia rickettsii and Coxiella burnetii, smaller percentages of the reads are from Rickettsia rhipicephali and Arsenophonus nasoniae, suggesting that the infected ticks used to prepare the vaccine carried more than one pathogen. Together, these findings suggest that this early vaccine was likely a bivalent vaccine for RMSF and Q-fever. This study is the among the first molecular level examinations of an historically important vaccine.
Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii . Its discovery and characterization by Howard Ricketts has been hailed as a remarkable historical example of detection and control of an emerging infectious disease, and subsequently led to the establishment of the Rocky Mountain Laboratories (RML). Here, we examined an unopened bottle of a vaccine, labeled as containing RMSF inactivated by phenol-formalin of infected ticks, developed prior to 1944 at RML by DNA analysis using Illumina high throughput sequencing technology. We found that it contains DNA from the Rocky Mountain wood tick ( Dermacentor andersoni ), the vector of RMSF, the complete genome of Rickettsia rickettsii , the pathogen of RMSF, as well as the complete genome of Coxiella burnetii , the pathogen of Q-fever. In addition to genomic reads of Rickettsia rickettsii and Coxiella burnetii , smaller percentages of the reads are from Rickettsia rhipicephali and Arsenophonus nasoniae , suggesting that the infected ticks used to prepare the vaccine carried more than one pathogen. Together, these findings suggest that this early vaccine was likely a bivalent vaccine for RMSF and Q-fever. This study is the among the first molecular level examinations of an historically important vaccine.
Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii. Its discovery and characterization by Howard Ricketts has been hailed as a remarkable historical example of detection and control of an emerging infectious disease, and subsequently led to the establishment of the Rocky Mountain Laboratories (RML). Here, we examined an unopened bottle of a vaccine, labeled as containing RMSF inactivated by phenol-formalin of infected ticks, developed prior to 1944 at RML by DNA analysis using Illumina high throughput sequencing technology. We found that it contains DNA from the Rocky Mountain wood tick (Dermacentor andersoni), the vector of RMSF, the complete genome of Rickettsia rickettsii, the pathogen of RMSF, as well as the complete genome of Coxiella burnetii, the pathogen of Q-fever. In addition to genomic reads of Rickettsia rickettsii and Coxiella burnetii, smaller percentages of the reads are from Rickettsia rhipicephali and Arsenophonus nasoniae, suggesting that the infected ticks used to prepare the vaccine carried more than one pathogen. Together, these findings suggest that this early vaccine was likely a bivalent vaccine for RMSF and Q-fever. This study is the among the first molecular level examinations of an historically important vaccine.Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii. Its discovery and characterization by Howard Ricketts has been hailed as a remarkable historical example of detection and control of an emerging infectious disease, and subsequently led to the establishment of the Rocky Mountain Laboratories (RML). Here, we examined an unopened bottle of a vaccine, labeled as containing RMSF inactivated by phenol-formalin of infected ticks, developed prior to 1944 at RML by DNA analysis using Illumina high throughput sequencing technology. We found that it contains DNA from the Rocky Mountain wood tick (Dermacentor andersoni), the vector of RMSF, the complete genome of Rickettsia rickettsii, the pathogen of RMSF, as well as the complete genome of Coxiella burnetii, the pathogen of Q-fever. In addition to genomic reads of Rickettsia rickettsii and Coxiella burnetii, smaller percentages of the reads are from Rickettsia rhipicephali and Arsenophonus nasoniae, suggesting that the infected ticks used to prepare the vaccine carried more than one pathogen. Together, these findings suggest that this early vaccine was likely a bivalent vaccine for RMSF and Q-fever. This study is the among the first molecular level examinations of an historically important vaccine.
ArticleNumber 4687
Author Beare, Paul A.
Bloom, Marshall E.
Xiao, Yongli
Best, Sonja M.
Morens, David M.
Taubenberger, Jeffery K.
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  givenname: Sonja M.
  surname: Best
  fullname: Best, Sonja M.
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  givenname: David M.
  surname: Morens
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  givenname: Jeffery K.
  surname: Taubenberger
  fullname: Taubenberger, Jeffery K.
  organization: Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
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AM James (31894_CR31) 2006; 43
RR Parker (31894_CR35) 1935; 57
CD Paddock (31894_CR68) 2005; 1063
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C Yunker (31894_CR28) 1986; 88
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JJ Martinez (31894_CR16) 2005; 123
S Dergousoff (31894_CR76) 2010; 52
GT Harrell (31894_CR11) 1949; 83
VA Harden (31894_CR1) 1990
MG Madariaga (31894_CR53) 2003; 3
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H Li (31894_CR14) 1998; 24
R Ormsbee (31894_CR51) 1978; 19
P Wang (31894_CR42) 2017; 35
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P Parola (31894_CR65) 2013; 26
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I Pascucci (31894_CR66) 2021
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RD Hillman Jr (31894_CR15) 2013; 15
F Dantas-Torres (31894_CR3) 2007; 7
JW Sumner (31894_CR40) 1995; 13
DE Wood (31894_CR60) 2019; 20
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A Alhassan (31894_CR44) 2019
HT Ricketts (31894_CR6) 1906; XLVII
FC Knoop (31894_CR7) 2014
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AM Bolger (31894_CR79) 2014; 30
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RR Spencer (31894_CR32) 1925; 1896–1970
HR Cox (31894_CR54) 1940; 20
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RE Trowbridge (31894_CR63) 2006; 91
ME Wikswo (31894_CR67) 2008; 45
W Burgdorfer (31894_CR64) 1975; 12
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HL DuPont (31894_CR36) 1973; 128
A Brinkmann (31894_CR78) 2020; 21
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RR Parker (31894_CR25) 1924; 39
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DH Paris (31894_CR59) 2008; 102
MT Balas (31894_CR73) 2005; 10
31894_CR23
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DC Koboldt (31894_CR81) 2012; 22
GE Davis (31894_CR27) 1938; 53
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31894_CR18
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A Osterloh (31894_CR39) 2020; 14
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31894_CR5
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V Blanda (31894_CR22) 2020; 25
RH Kenyon (31894_CR37) 1972; 125
31894_CR2
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SSID ssj0000529419
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Snippet Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii . Its discovery and...
Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii. Its discovery and...
Abstract Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii. Its discovery and...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 4687
SubjectTerms 631/326
631/337
Animals
Coxiella burnetii
Deoxyribonucleic acid
DNA
Genomes
Humanities and Social Sciences
Infectious diseases
multidisciplinary
Next-generation sequencing
Pathogens
Phenols
Q fever
Rickettsia rickettsii
Rickettsia rickettsii - genetics
Rocky Mountain spotted fever
Rocky Mountain Spotted Fever - microbiology
Rocky Mountain Spotted Fever - prevention & control
Science
Science (multidisciplinary)
Tick-borne diseases
Ticks - microbiology
Vaccines
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Title Genetic sequencing of a 1944 Rocky Mountain spotted fever vaccine
URI https://link.springer.com/article/10.1038/s41598-023-31894-0
https://www.ncbi.nlm.nih.gov/pubmed/36949107
https://www.proquest.com/docview/2789597702
https://www.proquest.com/docview/2790051897
https://pubmed.ncbi.nlm.nih.gov/PMC10031714
https://doaj.org/article/7e4c405387b44c7f8416fe26a2682682
Volume 13
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