Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

• Published in: NPJ Parkinson's Disease Vol. 10; no. 1; pp. 7 - 17
• Main Authors: Patterson, Joseph R., Kochmanski, Joseph, Stoll, Anna C., Kubik, Michael, Kemp, Christopher J., Duffy, Megan F., Thompson, Kajene, Howe, Jacob W., Cole-Strauss, Allyson, Kuhn, Nathan C., Miller, Kathryn M., Nelson, Seth, Onyekpe, Christopher U., Beck, John S., Counts, Scott E., Bernstein, Alison I., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1689/1718; 631/378/548; Biomedical and Life Sciences; Biomedicine; Dopamine; Neurodegeneration; Neurology; Neurosciences

Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease progression and the development of disease modifying therapies. The rat alpha-synuclein (α-syn) preformed fibril (PFF) model induces synchro...