Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS

• Published in: Bioactive materials Vol. 20; pp. 404 - 417
• Main Authors: Wang, Jinping, Qu, Chang, Shao, Xinyue, Song, Guoqiang, Sun, Jingyu, Shi, Donghong, Jia, Ran, An, Hailong, Wang, Hongjun
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.02.2023; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Carrier-free nanoprodrug; Mn-ZnO2 nanoparticle; p53-mutated tumor therapy; Reactive oxygen species; Wild-type p53 protein; Reactive oxygen species; p53-mutated tumor therapy; Mn-ZnO2 nanoparticle; Wild-type p53 protein; Carrier-free nanoprodrug

Human cancers typically express a high level of tumor-promoting mutant p53 protein (Mutp53) with a minimal level of tumor-suppressing wild-type p53 protein (WTp53). In this regard, inducing Mutp53 degradation while activating WTp53 is a viable strategy for precise anti-tumor therapy. Herein, a new c...