Identification of potential susceptibility genes in patients with primary Sjögren’s syndrome-associated pulmonary arterial hypertension through whole exome sequencing

• Published in: Arthritis research & therapy Vol. 25; no. 1; pp. 1 - 10
• Main Authors: Li, Mucong, Shi, Yue, Zhao, Jiuliang, Wang, Qian, Li, Mengtao, Zhao, Xiuli
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 20.09.2023; BioMed Central; BMC
• Subjects: Analysis; Arthritis; BCR; Care and treatment; Complications and side effects; Development and progression; Diagnosis; Disease susceptibility; DNA sequencing; Family medical history; FLG; Gene mutations; Genes; Genetic aspects; Genetic engineering; Genetic markers; Genomes; Genomics; GIGYF2; Health aspects; Medical colleges; Medical prognosis; Metabolism; Mutation; Nucleotide sequencing; Patients; Primary Sjögren’s syndrome; Pulmonary arterial hypertension; Pulmonary arteries; Pulmonary hypertension; Rheumatic diseases; Risk factors; Sjogren's syndrome; Whole-exome sequencing; Japan; United States > US

Background Pulmonary arterial hypertension (PAH) is a rare complication of primary Sjögren's syndrome (pSS). Several genes have proven to be associated with pSS and PAH. However, there is no study specifically addressing the genetic susceptibility in pSS combined with PAH. Methods Thirty-four u...