Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs - Chen, Xueyi; Arun, Bhavatharini; Nino-Meza, Oscar J.; Sarhan, Mona O.; Singh, Medha; Jeon, Byeonghoon; Mane, Kishor; Shah, Maunank; Tucker, Elizabeth W.; Carroll, Laurence S.; Freundlich, Joel S.; Peloquin, Charles A.; et al. (Nature communications, 2024)
Keywords: 59; 59/78; 631/326/22/1290; 64; 64/60; 692/308/575; 692/420/254; 82/58; 96; 96/21; 96/63; Adult; Animals; Antibiotics; Antitubercular Agents - pharmacokinetics; Antitubercular Agents - therapeutic use; Bactericidal activity; Biodistribution; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain injury; Compartments; Disease Models, Animal; Dosage; Drug resistance; Exposure; Female; Fluorine isotopes; Head injuries; Humanities and Social Sciences; Humans; Lung - diagnostic imaging; Lung - metabolism; Lungs; Male; Mass spectrometry; Mass spectroscopy; Meningitis; Mice; multidisciplinary; Multidrug resistance; Mycobacterium tuberculosis - drug effects; Partitioning; Penetration resistance; Pharmacokinetics; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Rabbits; Science; Science (multidisciplinary); Tissue Distribution; Tissues; Tuberculosis; Tuberculosis, Meningeal - diagnostic imaging; Tuberculosis, Meningeal - drug therapy; Tuberculosis, Multidrug-Resistant - diagnostic imaging; Tuberculosis, Multidrug-Resistant - drug therapy