The RNA-binding protein hnRNP F is required for the germinal center B cell response

• Published in: Nature communications Vol. 14; no. 1; p. 1731
• Main Authors: Huang, Hengjun, Li, Yuxing, Zhang, Gaopu, Ruan, Gui-Xin, Zhu, Zhijian, Chen, Wenjing, Zou, Jia, Zhang, Rui, Wang, Jing, Ouyang, Yu, Xu, Shengli, Ou, Xijun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 45/91; 631/250/1619/40; 631/250/2152/2153/1982; 631/250/2502; 631/337/1645/1792; 64/60; Affinity; Alternative splicing; Antibodies; Antibody response; Antigens; B-Lymphocytes; Base Sequence; c-Myc protein; CD40 antigen; Cell proliferation; Cell surface; Clonal deletion; Gene deletion; Gene regulation; Germinal Center - metabolism; Germinal centers; Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism; Heterogeneous-Nuclear Ribonucleoprotein Group F-H - metabolism; Heterogeneous-Nuclear Ribonucleoproteins - genetics; Heterogeneous-Nuclear Ribonucleoproteins - metabolism; Humanities and Social Sciences; Introns; Lymphocytes; Lymphocytes B; Lymphocytes T; multidisciplinary; Myc protein; Post-transcription; Proteins; Regulatory mechanisms (biology); Ribonucleic acid; RNA; RNA Precursors - genetics; RNA Precursors - metabolism; RNA-binding protein; Science; Science (multidisciplinary); Splicing

The T cell-dependent (TD) antibody response involves the generation of high affinity, immunoglobulin heavy chain class-switched antibodies that are generated through germinal center (GC) response. This process is controlled by coordinated transcriptional and post-transcriptional gene regulatory mech...