Acoustofluidic-based therapeutic apheresis system

Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limi...

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Published in	Nature communications Vol. 15; no. 1; pp. 6854 - 10
Main Authors	Wu, Mengxi, Ma, Zhiteng, Xu, Xianchen, Lu, Brandon, Gu, Yuyang, Yoon, Janghoon, Xia, Jianping, Ma, Zhehan, Upreti, Neil, Anwar, Imran J., Knechtle, Stuart J., T. Chambers, Eileen, Kwun, Jean, Lee, Luke P., Huang, Tony Jun
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 10.08.2024 Nature Publishing Group Nature Portfolio
Subjects	49 49/62 631/1647/277 639/166/985 639/166/988 64 64/60 692/700/1720/3187 Acoustics - instrumentation Animal models Animals Antibodies Apheresis Blood Blood Component Removal - instrumentation Blood Component Removal - methods Blood volume Desensitization Female Humanities and Social Sciences Humans Infants Lab-On-A-Chip Devices Mice multidisciplinary Plasmapheresis Plasmapheresis - instrumentation Plasmapheresis - methods Science Science (multidisciplinary)
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Abstract	Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients. Existing apheresis devices cannot accommodate small blood volumes in infants or small animals. Here, the authors have successfully performed highly efficient plasma apheresis in mouse models, each with a blood volume of just 280 μl.
AbstractList	Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients.Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients. Abstract Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients. Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients. Existing apheresis devices cannot accommodate small blood volumes in infants or small animals. Here, the authors have successfully performed highly efficient plasma apheresis in mouse models, each with a blood volume of just 280 μl. Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients. Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current apheresis devices cannot handle small blood volumes in infants or small animals, hindering the testing of animal model advancements. This limitation restricts our ability to provide treatment options for particularly susceptible infants and children with limited therapeutic alternatives. Here, we report our solution to these challenges through an acoustofluidic-based therapeutic apheresis system designed for processing small blood volumes. Our design integrates an acoustofluidic device with a fluidic stabilizer array on a chip, separating blood components from minimal extracorporeal volumes. We carried out plasma apheresis in mouse models, each with a blood volume of just 280 μL. Additionally, we achieved successful plasmapheresis in a sensitized mouse, significantly lowering preformed donor-specific antibodies and enabling desensitization in a transplantation model. Our system offers a new solution for small-sized subjects, filling a critical gap in existing technologies and providing potential benefits for a wide range of patients.Existing apheresis devices cannot accommodate small blood volumes in infants or small animals. Here, the authors have successfully performed highly efficient plasma apheresis in mouse models, each with a blood volume of just 280 μl.
ArticleNumber	6854
Author	Xu, Xianchen Upreti, Neil Lu, Brandon Kwun, Jean Xia, Jianping Huang, Tony Jun T. Chambers, Eileen Wu, Mengxi Knechtle, Stuart J. Ma, Zhiteng Anwar, Imran J. Gu, Yuyang Yoon, Janghoon Lee, Luke P. Ma, Zhehan
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/39127732$$D View this record in MEDLINE/PubMed
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Snippet	Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately, current... Abstract Therapeutic apheresis aims to selectively remove pathogenic substances, such as antibodies that trigger various symptoms and diseases. Unfortunately,...
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SubjectTerms	49 49/62 631/1647/277 639/166/985 639/166/988 64 64/60 692/700/1720/3187 Acoustics - instrumentation Animal models Animals Antibodies Apheresis Blood Blood Component Removal - instrumentation Blood Component Removal - methods Blood volume Desensitization Female Humanities and Social Sciences Humans Infants Lab-On-A-Chip Devices Mice multidisciplinary Plasmapheresis Plasmapheresis - instrumentation Plasmapheresis - methods Science Science (multidisciplinary)
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Title	Acoustofluidic-based therapeutic apheresis system
URI	https://link.springer.com/article/10.1038/s41467-024-50053-1 https://www.ncbi.nlm.nih.gov/pubmed/39127732 https://www.proquest.com/docview/3091214442 https://www.proquest.com/docview/3091288083 https://pubmed.ncbi.nlm.nih.gov/PMC11316742 https://doaj.org/article/94286a8fbbe7487ea7886bf0eb6155d4
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