Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats

• Published in: Scientific reports Vol. 14; no. 1; pp. 8247 - 17
• Main Authors: Darwish, Asmaa Badawy, Mohsen, Amira Mohamed, ElShebiney, Shaimaa, Elgohary, Rania, Younis, Mostafa Mohamed
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/152; 631/154/433; 631/154/53; BDNF; Biological activity; Chitosan; Chitosan lipid nanoparticles; Cognitive ability; Diabetes; Diabetes mellitus; Diabetic cognitive deficit model; Drug delivery; Humanities and Social Sciences; Inflammation; Metformin; multidisciplinary; Nanoparticles; Oxidative stress; Piperine; Science; Science (multidisciplinary); Spatial memory; Stearic acid; Tripolyphosphate; Y-maze; Zeta potential; Piperine; Chitosan lipid nanoparticles; Diabetic cognitive deficit model; BDNF; Y-maze; Spatial memory

The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfu...