Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats

The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfu...

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Published inScientific reports Vol. 14; no. 1; pp. 8247 - 17
Main Authors Darwish, Asmaa Badawy, Mohsen, Amira Mohamed, ElShebiney, Shaimaa, Elgohary, Rania, Younis, Mostafa Mohamed
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.04.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/154/152
631/154/433
631/154/53
BDNF
Biological activity
Chitosan
Chitosan lipid nanoparticles
Cognitive ability
Diabetes
Diabetes mellitus
Diabetic cognitive deficit model
Drug delivery
Humanities and Social Sciences
Inflammation
Metformin
multidisciplinary
Nanoparticles
Oxidative stress
Piperine
Science
Science (multidisciplinary)
Spatial memory
Stearic acid
Tripolyphosphate
Y-maze
Zeta potential
Piperine
Chitosan lipid nanoparticles
Diabetic cognitive deficit model
BDNF
Y-maze
Spatial memory
Online AccessGet full text

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Abstract The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfully loaded on CLNPs prepared using chitosan, stearic acid, Tween 80 and Tripolyphosphate (TPP) at different concentrations. The developed CLNPs exhibited high entrapment efficiency that ranged from 85.12 to 97.41%, a particle size in the range of 59.56–414 nm and a negatively charged zeta potential values (− 20.1 to − 43.9 mV). In vitro release study revealed enhanced PP release from CLNPs compared to that from free PP suspensions for up to 24 h. In vivo studies revealed that treatment with the optimized PP-CLNPs formulation (F2) exerted a cognitive enhancing effect and ameliorated the oxidative stress associated with diabetes. PP-CLNPs acted as an effective bio-enhancer which increased the potency of metformin in protecting brain tissue from diabetes-induced neuroinflammation and memory deterioration. These results suggested that CLNPs could be a promising drug delivery system for encapsulating PP and thus can be used as an adjuvant therapy in the management of high-risk diabetic cognitive impairment conditions.
AbstractList The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfully loaded on CLNPs prepared using chitosan, stearic acid, Tween 80 and Tripolyphosphate (TPP) at different concentrations. The developed CLNPs exhibited high entrapment efficiency that ranged from 85.12 to 97.41%, a particle size in the range of 59.56-414 nm and a negatively charged zeta potential values (- 20.1 to - 43.9 mV). In vitro release study revealed enhanced PP release from CLNPs compared to that from free PP suspensions for up to 24 h. In vivo studies revealed that treatment with the optimized PP-CLNPs formulation (F2) exerted a cognitive enhancing effect and ameliorated the oxidative stress associated with diabetes. PP-CLNPs acted as an effective bio-enhancer which increased the potency of metformin in protecting brain tissue from diabetes-induced neuroinflammation and memory deterioration. These results suggested that CLNPs could be a promising drug delivery system for encapsulating PP and thus can be used as an adjuvant therapy in the management of high-risk diabetic cognitive impairment conditions.
The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfully loaded on CLNPs prepared using chitosan, stearic acid, Tween 80 and Tripolyphosphate (TPP) at different concentrations. The developed CLNPs exhibited high entrapment efficiency that ranged from 85.12 to 97.41%, a particle size in the range of 59.56–414 nm and a negatively charged zeta potential values (− 20.1 to − 43.9 mV). In vitro release study revealed enhanced PP release from CLNPs compared to that from free PP suspensions for up to 24 h. In vivo studies revealed that treatment with the optimized PP-CLNPs formulation (F2) exerted a cognitive enhancing effect and ameliorated the oxidative stress associated with diabetes. PP-CLNPs acted as an effective bio-enhancer which increased the potency of metformin in protecting brain tissue from diabetes-induced neuroinflammation and memory deterioration. These results suggested that CLNPs could be a promising drug delivery system for encapsulating PP and thus can be used as an adjuvant therapy in the management of high-risk diabetic cognitive impairment conditions.
The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfully loaded on CLNPs prepared using chitosan, stearic acid, Tween 80 and Tripolyphosphate (TPP) at different concentrations. The developed CLNPs exhibited high entrapment efficiency that ranged from 85.12 to 97.41%, a particle size in the range of 59.56–414 nm and a negatively charged zeta potential values (− 20.1 to − 43.9 mV). In vitro release study revealed enhanced PP release from CLNPs compared to that from free PP suspensions for up to 24 h. In vivo studies revealed that treatment with the optimized PP-CLNPs formulation (F2) exerted a cognitive enhancing effect and ameliorated the oxidative stress associated with diabetes. PP-CLNPs acted as an effective bio-enhancer which increased the potency of metformin in protecting brain tissue from diabetes-induced neuroinflammation and memory deterioration. These results suggested that CLNPs could be a promising drug delivery system for encapsulating PP and thus can be used as an adjuvant therapy in the management of high-risk diabetic cognitive impairment conditions.
Abstract The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfully loaded on CLNPs prepared using chitosan, stearic acid, Tween 80 and Tripolyphosphate (TPP) at different concentrations. The developed CLNPs exhibited high entrapment efficiency that ranged from 85.12 to 97.41%, a particle size in the range of 59.56–414 nm and a negatively charged zeta potential values (− 20.1 to − 43.9 mV). In vitro release study revealed enhanced PP release from CLNPs compared to that from free PP suspensions for up to 24 h. In vivo studies revealed that treatment with the optimized PP-CLNPs formulation (F2) exerted a cognitive enhancing effect and ameliorated the oxidative stress associated with diabetes. PP-CLNPs acted as an effective bio-enhancer which increased the potency of metformin in protecting brain tissue from diabetes-induced neuroinflammation and memory deterioration. These results suggested that CLNPs could be a promising drug delivery system for encapsulating PP and thus can be used as an adjuvant therapy in the management of high-risk diabetic cognitive impairment conditions.
The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfully loaded on CLNPs prepared using chitosan, stearic acid, Tween 80 and Tripolyphosphate (TPP) at different concentrations. The developed CLNPs exhibited high entrapment efficiency that ranged from 85.12 to 97.41%, a particle size in the range of 59.56-414 nm and a negatively charged zeta potential values (- 20.1 to - 43.9 mV). In vitro release study revealed enhanced PP release from CLNPs compared to that from free PP suspensions for up to 24 h. In vivo studies revealed that treatment with the optimized PP-CLNPs formulation (F2) exerted a cognitive enhancing effect and ameliorated the oxidative stress associated with diabetes. PP-CLNPs acted as an effective bio-enhancer which increased the potency of metformin in protecting brain tissue from diabetes-induced neuroinflammation and memory deterioration. These results suggested that CLNPs could be a promising drug delivery system for encapsulating PP and thus can be used as an adjuvant therapy in the management of high-risk diabetic cognitive impairment conditions.The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone or in combination with the antidiabetic drug Metformin (MET) in the management of cognitive deficit in diabetic rats. Piperine was successfully loaded on CLNPs prepared using chitosan, stearic acid, Tween 80 and Tripolyphosphate (TPP) at different concentrations. The developed CLNPs exhibited high entrapment efficiency that ranged from 85.12 to 97.41%, a particle size in the range of 59.56-414 nm and a negatively charged zeta potential values (- 20.1 to - 43.9 mV). In vitro release study revealed enhanced PP release from CLNPs compared to that from free PP suspensions for up to 24 h. In vivo studies revealed that treatment with the optimized PP-CLNPs formulation (F2) exerted a cognitive enhancing effect and ameliorated the oxidative stress associated with diabetes. PP-CLNPs acted as an effective bio-enhancer which increased the potency of metformin in protecting brain tissue from diabetes-induced neuroinflammation and memory deterioration. These results suggested that CLNPs could be a promising drug delivery system for encapsulating PP and thus can be used as an adjuvant therapy in the management of high-risk diabetic cognitive impairment conditions.
ArticleNumber 8247
Author Darwish, Asmaa Badawy
Elgohary, Rania
ElShebiney, Shaimaa
Younis, Mostafa Mohamed
Mohsen, Amira Mohamed
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  organization: Pharmaceutical Technology Department, National Research Centre (Affiliation ID: 60014618)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38589438$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1100/2012/637953
10.1080/00498254.2017.1405293
10.3109/03639045.2015.1044904
10.1016/j.ijbiomac.2014.08.040
10.3390/ijms24054289
10.1155/2016/3710921
10.2174/18756417MTExfMTQ1z
10.1016/j.bbr.2017.09.031
10.1016/j.ejpb.2006.07.014
10.1248/bpb.33.598
10.1080/03639045.2018.1518455
10.1016/j.ijbiomac.2014.02.002
10.1016/j.ejps.2019.04.019
10.1016/0378-5173(89)90306-2
10.1016/j.lfs.2021.120299
10.1016/j.ijpharm.2015.07.042
10.1002/jps.21944
10.3109/10837450.2013.763261
10.59566/IJBS.2008.4221
10.1016/bs.acc.2021.07.006
10.1080/10408397709527233
10.1016/S2221-1691(13)60060-X
10.1179/135100004225004742
10.2147/IJN.S87336
10.1016/j.fitote.2014.05.005
10.1016/j.colsurfb.2019.110749
10.1002/jps.21793
10.1016/j.jnutbio.2019.05.009
10.7324/JAPS.2018.81217
10.1016/j.ejps.2016.12.035
10.3390/pharmaceutics10040185
10.1080/03639045.2017.1291666
10.1007/s11095-017-2260-x
10.3389/fphar.2020.01325
10.1080/10837450.2019.1584633
10.1016/j.lfs.2006.12.027
10.1080/15376510701781520
10.1016/j.xphs.2021.05.007
10.1002/ptr.2676
10.1016/0306-4522(95)00241-A
10.1055/s-0034-1366278
10.3390/antiox12020462
10.1007/s11892-016-0775-x
10.1080/03639045.2016.1220571
10.1016/j.ijpharm.2006.06.036
10.1039/D0RA07640F
10.1111/1541-4337.12246
10.1016/j.colsurfb.2005.06.001
10.1002/ddr.21632
10.1016/j.yexmp.2008.12.004
10.1016/j.ijpharm.2019.02.027
10.1016/j.ijpharm.2015.08.056
10.3329/jbau.v11i1.18197
10.2147/IJN.S269004
10.1016/j.npep.2015.08.009
10.1016/j.cellimm.2013.07.004
10.1134/S0965545X06020039
10.3390/pharmaceutics11020086
10.1016/j.fbio.2022.101909
10.5114/aoms.2015.56342
10.1021/bi973101r
10.1136/bmjopen-2017-020768
10.1016/j.jare.2017.10.003
10.1016/S0166-4328(02)00272-3
10.1097/FJC.0b013e31818d07c0
10.1039/C5TB00431D
10.4049/jimmunol.1001829
10.1016/j.jep.2015.04.006
10.1007/s10126-005-0097-5
10.3390/molecules26113281
10.1016/j.jnutbio.2012.03.018
10.1016/j.ijpharm.2014.09.013
10.4103/0974-8490.171096
10.1016/S0165-0327(12)70004-6
10.1007/s10571-014-0025-1
10.1016/0003-2697(78)90342-1
10.1016/j.lfs.2020.117671
10.7150/ijbs.23247
10.3109/02652049409040440
10.3109/1061186X.2012.747529
10.1016/j.jep.2003.10.016
10.1016/j.fct.2008.06.014
10.1007/s002130050523
10.1016/j.jconrel.2004.02.002
10.3109/03639045.2012.736515
10.4196/kjpp.2014.18.1.1
10.22159/ijap.2020v12i5.38360
10.1007/s10847-009-9605-y
10.1016/j.diabres.2020.108025
10.1007/s11418-017-1140-3
10.1016/j.lfs.2016.06.002
10.1016/j.jddst.2020.101910
10.1166/jnd.2013.1027
10.1016/j.ijpharm.2015.05.065
10.1007/978-1-4939-8994-2_10
10.2174/1872214811307020009
10.1016/S1043-4526(05)49003-8
10.1016/j.ijpharm.2018.04.021
10.1021/la103576a
10.1016/j.curtheres.2022.100672
10.3390/ijerph17031035
10.1016/j.ijpharm.2020.119470
10.3390/biom9030100
10.22159/ijpps.2016v8i11.14365
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Keywords Piperine
Chitosan lipid nanoparticles
Diabetic cognitive deficit model
BDNF
Y-maze
Spatial memory
Language English
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References Charoenputtakhun, Opanasopit, Rojanarata, Ngawhirunpat (CR60) 2014; 19
Wattanathorn, Chonpathompikunlert, Muchimapura, Priprem, Tankamnerdthai (CR108) 2008; 46
Zhu, Liu, Liu, Chen, Liu, Yin (CR111) 2020; 11
Xue, Hu, Lu, Zhang, Jiang, An, Guo, Zhou, Hou, Jiang (CR29) 2015; 495
Li, Wang, Wang, Li, Matsumoto, Tang (CR37) 2007; 80
D'Hooge, Pei, Raes, Lebrun, van Bogaert, de Deyn (CR38) 1996; 46
Wang, Han, Jiang, Huang, Fu, Wang, Zheng, Li, Li (CR106) 2019; 561
Mao, Huang, Zhong, Xian, Ip (CR11) 2014; 34
Roshanbakhsh, Salmani, Dehghan, Nazari, Javan, Pourabdolhossein (CR103) 2020; 253
Shahidi, Abuzaytoun (CR26) 2005; 49
Sunila, Kuttan (CR12) 2004; 90
Roy, Lloyd (CR110) 2012; 142
Sonvico, Cagnani, Rossi, Motta, Di Bari, Cavatorta, Alonso, Deriu, Colombo (CR43) 2006; 324
Rathore, Mahor, Jain, Haque, Kesharwani (CR45) 2020; 10
Vijayakumar, Surya, Nalini (CR10) 2004; 9
Rajaram, Natham (CR47) 2013; 4
Kalwat, Huang, McGlynn, Cobb (CR96) 2018; 2018
Yusuf, Khan (CR76) 2013; 21
Bădescu, Tătaru, Kobylinska, Georgescu, Zahiu, Zăgrean, Zăgrean (CR112) 2016; 9
Dudhatra, Mody, Awale, Patel, Modi, Kumar, Kamani, Chauhan (CR15) 2012; 2012
Bruinsmann, Pigana, Aguirre, Dadalt Souto, Garrastazu Pereira, Bianchera, TiozzoFasiolo, Colombo, Marques, Raffin Pohlmann, Stanisçuaski Guterres, Sonvico (CR22) 2019; 11
Rahman, Peng, Hu, Chen, Rahman, Uddin, Quinn, Moni (CR3) 2020; 17
El-Hadi, Ahmed, Zaki, Mohsen (CR54) 2020; 12
Abd El-Alim, Salama, Darwish (CR59) 2020; 585
Akanda, Rai, Slipper, Chowdhry, Lamprou, Getti, Douroumis (CR77) 2015; 493
Mathias, Hussain (CR18) 2010; 99
Ding, Cheng, Li, Gref, Chen (CR19) 2016; 2016
Mukhopadhyay, Chakraborty, Bhattacharya, Mishra, Kundu (CR85) 2015; 72
Mostafa, Abd El-Alim, Asfour, Al-Okbi, Mohamed, Hamed, Awad (CR53) 2019; 24
Abou Taleb, Darwish, Abood, Mohamed (CR68) 2020; 81
Gan, Wang, Cochrane, McCarron (CR52) 2005; 44
Mogilevskaya, Akopova, Zelenetskii, Ozerin (CR75) 2006; 48
Lokhande, Mishra, Kulkarni, Naik (CR65) 2013; 7
Wen, Sakamoto, Miller (CR93) 2010; 185
Pattanaik, Hota, Prabhakar, Kharbanda, Pandhi (CR90) 2009; 23
Asfour, Salama, Mohsen (CR42) 2021; 110
Hecq, Siepmann, Siepmann, Amighi, Goole (CR28) 2015; 41
Abo-Zeid, Farghaly (CR88) 2009; 7
Fu, Sun, Zuo (CR98) 2010; 33
Hu, Wang, Chen, Ma, You, Zhang, Liang, Tan, Xiao, Tang, Gao (CR97) 2015; 169
Kerner, Bruckel (CR1) 2014; 122
Bhalekar, Madgulkar, Desale, Marium (CR9) 2017; 43
Huang, Cai, Lapitsky (CR74) 2015; 3
Kraeuter, Guest, Sarnyai (CR39) 2019; 1916
Atal (CR14) 1979; 10
Arantes, Faraco, Ferreira, Oliveira, Martins-Santos, Cassini-Vieira, Barcelos, Ferreira, Goulart (CR71) 2020; 188
Dash (CR2) 2013; 7
Mihara, Uchiyama (CR40) 1978; 86
Chen, Wu, Mi, Lin, Yu, Sung (CR70) 2004; 96
Umar, Golam Sarwar, Umar, Ahmad, Sajad, Ahmad, Katiyar, Khan (CR87) 2013; 284
Saha, Seal, Noor (CR73) 2014; 11
Alquraan, Alzoubi, Hammad, Rababa’h, Mayyas (CR104) 2019; 9
Cassel, Jeltsch (CR109) 1995; 69
Diop, Auberval, Viciglio, Langlois, Bietiger, Mura, Peronet, Bekel, Julien David, Zhao, Pinget, Jeandidier, Vauthier, Marchioni, Frere, Sigrist (CR86) 2015; 491
Khalili-Fomeshi, Azizi, Esmaeili, Gol, Kazemi, Ashrafpour, Moghadamnia, Hosseinzadeh (CR105) 2018; 337
Singh, Bali, Singh, Jaggi (CR5) 2014; 18
Guadarrama-Escobar, Serrano-Castañeda, Anguiano-Almazán, Vázquez-Durán, Peña-Juárez, Vera-Graziano, Morales-Florido, Rodriguez-Perez, Rodriguez-Cruz, Miranda-Calderón, Escobar-Chávez (CR30) 2023; 24
Sankalia, Mashru, Sankalia, Sutariya (CR69) 2007; 65
Abousamra, Mohsen (CR57) 2016; 8
Zilliox, Chadrasekaran, Kwan, Russell (CR6) 2016; 16
Gajdosík, Gajdosíková, Stefek, Navarová, Hozová (CR36) 1999; 18
Kumar, Mittal, Babu, Mittal (CR81) 2021; 17
Govindarajan (CR7) 1977; 9
Butterfield (CR100) 2023; 12
Bulaj, Kortemme, Goldenberg (CR41) 1998; 37
Bsngun, Tandiono, Arianto (CR72) 2018; 8
Salvatore, Pafundi, Morgillo, Di Liello, Galiero, Nevola, Marfella, Monaco, Rinaldi, Adinolfi, Sasso (CR91) 2020; 160
Bayindir, Yuksel (CR55) 2010; 99
Elnaggar, Etman, Abdelmonsif, Abdallah (CR102) 2015; 2015
Arora, Athari, Nainwal (CR84) 2022; 49
Yeo, Olusanya, Chaw, Elkordy (CR67) 2018; 10
Achouri, Alhanout, Piccerelle, Andrieu (CR49) 2013; 39
Balakrishnan, Vellaichamy, Menon, Manoharan (CR89) 2008; 18
Shrivastava, Vaibhav, Tabassum, Khan, Ishrat, Khan, Ahmad, Islam, Safhi, Islam (CR8) 2013; 24
Motiei, Kashanian (CR32) 2017; 99
Karimi, Avci, Ahi, Gazori, Hamblin, Naderi-Manesh (CR50) 2013; 1
Mohammed, Mansell, Shoker, Wasan, Wasan (CR23) 2019; 45
Ameeduzzafar, Ali, Bhatnagar, Kumar, Ali (CR24) 2014; 65
Shi, Lu, Cao, Liu, Zhang, Zhang, Cui, Cao (CR58) 2017; 43
Bathina, Das (CR92) 2015; 11
Ramadhani, Shabir, McConville (CR20) 2014; 475
Kesarwani, Gupta, Mukerjee (CR82) 2013; 3
Wickramasinghe, Kalansuriya, Attanayake (CR80) 2022; 96
Hemati Azandaryani, Kashanian, Derakhshandeh (CR31) 2017; 34
Imam, Alshehri, Altamimi, Hussain, Qamar, Gilani, Zafar, Alruwaili, Alanazi, Almutairy (CR44) 2021; 26
Fang, Aryal, Hu, Zhang (CR21) 2010; 26
Sanati, Aminyavari, Afshari, Sahebkar (CR94) 2022; 291
Motwani, Chopra, Talegaonkar, Kohli, Ahmad, Khar (CR62) 2008; 68
Wang, Cai, Wang, Wei, Kou, Li, Yang, Guo, Le, Li (CR101) 2019; 70
Levy, Schutze, Fuhrer, Benita (CR56) 1994; 11
Shetty, Secnik, Oglesby (CR78) 2005; 11
Xiang, Zhang, Li, Wang, Zeng, Cai, Tian, Jia, Li (CR95) 2015; 54
Li, Dai, Zhang, Wang, Wei (CR61) 2008; 4
Bellia, Lombardo, Meloni, Della-Morte, Bellia, Lauro (CR4) 2022; 108
Riedel, Platt, Micheau (CR107) 2003; 140
Asfour, Kassem, Salama (CR48) 2019; 134
Mohsen, Salama, Kassem (CR34) 2020; 59
Ramanathan, Jaiswal, Bhattacharya (CR115) 1998; 135
Taqvi, Shah, Gilani (CR13) 2008; 52
Ajazuddin, Alexander, Qureshi, Kumari, Vaishnav, Sharma, Saraf, Saraf (CR16) 2014; 97
Bin-Jumah, Gilani, Jahangir, Zafar, Alshehri, Yasir, Kala, Taleuzzaman, Imam (CR27) 2020; 15
Hussain, Rasul, Anwar, Aziz, Razzaq, Wei, Ali, Li, Li (CR116) 2018; 14
Yun, Noda, Takahashi, Takahashi, Inoue (CR114) 2018; 72
Basha, AbouSamra, Awad, Mansy (CR66) 2018; 544
Asfour, Mohsen (CR33) 2018; 9
Kurita (CR25) 2006; 8
Dash, Murthy, Nath, Chowdhury (CR35) 2010; 67
Attia (CR63) 2013; 04
Samra, Said, Elsherbiny, Liou, El-Shishtawy, Eissa (CR99) 2016; 157
Singh, Lillard (CR46) 2009; 86
Atal, Atal, Vyas, Phadnis (CR83) 2016; 8
Peppas, Sahlin (CR64) 1989; 57
Salinero-Fort, Gómez-Campelo, San Andrés-Rebollo, Cárdenas-Valladolid, Abánades-Herranz, Carrillo de Santa Pau, Chico-Moraleja, Beamud-Victoria, de Miguel-Yanes, Jimenez-Garcia, López-de-Andres, Ramallo-Fariña, De Burgos-Lunar (CR79) 2018; 8
Gorgani, Mohammadi, Najafpour, Nikzad (CR17) 2017; 16
Ren, Wang, Li, Yang, Zuo (CR113) 2018; 48
Vyas, Saraf, Saraf (CR51) 2010; 66
EL Mogilevskaya (58601_CR75) 2006; 48
F Shahidi (58601_CR26) 2005; 49
SI Taqvi (58601_CR13) 2008; 52
VP Singh (58601_CR5) 2014; 18
MH Asfour (58601_CR48) 2019; 134
N Ramadhani (58601_CR20) 2014; 475
OR Guadarrama-Escobar (58601_CR30) 2023; 24
K Kurita (58601_CR25) 2006; 8
M Karimi (58601_CR50) 2013; 1
RH Fang (58601_CR21) 2010; 26
C Wang (58601_CR101) 2019; 70
Q Gan (58601_CR52) 2005; 44
M Abo-Zeid (58601_CR88) 2009; 7
S Dash (58601_CR35) 2010; 67
MH Rahman (58601_CR3) 2020; 17
J Hecq (58601_CR28) 2015; 41
R Singh (58601_CR46) 2009; 86
G Bulaj (58601_CR41) 1998; 37
T Ren (58601_CR113) 2018; 48
M Kalwat (58601_CR96) 2018; 2018
W Kerner (58601_CR1) 2014; 122
MY Levy (58601_CR56) 1994; 11
VS Govindarajan (58601_CR7) 1977; 9
M Mihara (58601_CR40) 1978; 86
NA Peppas (58601_CR64) 1989; 57
C Bellia (58601_CR4) 2022; 108
MH Asfour (58601_CR33) 2018; 9
MG Sankalia (58601_CR69) 2007; 65
GB Dudhatra (58601_CR15) 2012; 2012
M Xue (58601_CR29) 2015; 495
X Zhu (58601_CR111) 2020; 11
S Atal (58601_CR83) 2016; 8
M Mohammed (58601_CR23) 2019; 45
R Wang (58601_CR106) 2019; 561
ES Sunila (58601_CR12) 2004; 90
A El-Hadi (58601_CR54) 2020; 12
H Bsngun (58601_CR72) 2018; 8
FA Bruinsmann (58601_CR22) 2019; 11
SH Abd El-Alim (58601_CR59) 2020; 585
S Pattanaik (58601_CR90) 2009; 23
K Kesarwani (58601_CR82) 2013; 3
SK Dash (58601_CR2) 2013; 7
AM Mohsen (58601_CR34) 2020; 59
SS Imam (58601_CR44) 2021; 26
P Rathore (58601_CR45) 2020; 10
M Yusuf (58601_CR76) 2013; 21
P Arora (58601_CR84) 2022; 49
CK Atal (58601_CR14) 1979; 10
P Mukhopadhyay (58601_CR85) 2015; 72
AB Lokhande (58601_CR65) 2013; 7
YS Yun (58601_CR114) 2018; 72
A Gajdosík (58601_CR36) 1999; 18
Q Xiang (58601_CR95) 2015; 54
LK Yeo (58601_CR67) 2018; 10
M Diop (58601_CR86) 2015; 491
SK Motwani (58601_CR62) 2008; 68
G Riedel (58601_CR107) 2003; 140
M Bin-Jumah (58601_CR27) 2020; 15
Ajazuddin (58601_CR16) 2014; 97
M Sanati (58601_CR94) 2022; 291
M Khalili-Fomeshi (58601_CR105) 2018; 337
S Balakrishnan (58601_CR89) 2008; 18
L Gorgani (58601_CR17) 2017; 16
S Li (58601_CR37) 2007; 80
QQ Mao (58601_CR11) 2014; 34
Y Huang (58601_CR74) 2015; 3
M Abousamra (58601_CR57) 2016; 8
A Vyas (58601_CR51) 2010; 66
P Charoenputtakhun (58601_CR60) 2014; 19
J-C Cassel (58601_CR109) 1995; 69
H Roshanbakhsh (58601_CR103) 2020; 253
S Rajaram (58601_CR47) 2013; 4
S Bathina (58601_CR92) 2015; 11
YS Elnaggar (58601_CR102) 2015; 2015
S Shetty (58601_CR78) 2005; 11
M Motiei (58601_CR32) 2017; 99
MR Bhalekar (58601_CR9) 2017; 43
AY Wen (58601_CR93) 2010; 185
A Hemati Azandaryani (58601_CR31) 2017; 34
DM Mostafa (58601_CR53) 2019; 24
G Hussain (58601_CR116) 2018; 14
ZS Bayindir (58601_CR55) 2010; 99
RS Vijayakumar (58601_CR10) 2004; 9
M Attia (58601_CR63) 2013; 04
YA Samra (58601_CR99) 2016; 157
MH Akanda (58601_CR77) 2015; 493
MH Asfour (58601_CR42) 2021; 110
F Sonvico (58601_CR43) 2006; 324
S Kumar (58601_CR81) 2021; 17
D Hu (58601_CR97) 2015; 169
P Shrivastava (58601_CR8) 2013; 24
SC Chen (58601_CR70) 2004; 96
L Alquraan (58601_CR104) 2019; 9
AK Kraeuter (58601_CR39) 2019; 1916
ASD Wickramasinghe (58601_CR80) 2022; 96
D Achouri (58601_CR49) 2013; 39
KC Saha (58601_CR73) 2014; 11
P Li (58601_CR61) 2008; 4
MA Salinero-Fort (58601_CR79) 2018; 8
LL Shi (58601_CR58) 2017; 43
M Ramanathan (58601_CR115) 1998; 135
Ameeduzzafar (58601_CR24) 2014; 65
T Salvatore (58601_CR91) 2020; 160
R D'Hooge (58601_CR38) 1996; 46
DA Butterfield (58601_CR100) 2023; 12
S Umar (58601_CR87) 2013; 284
T Roy (58601_CR110) 2012; 142
M Fu (58601_CR98) 2010; 33
SV Bădescu (58601_CR112) 2016; 9
M Basha (58601_CR66) 2018; 544
J Wattanathorn (58601_CR108) 2008; 46
VT Arantes (58601_CR71) 2020; 188
NR Mathias (58601_CR18) 2010; 99
LA Zilliox (58601_CR6) 2016; 16
J Ding (58601_CR19) 2016; 2016
S Abou Taleb (58601_CR68) 2020; 81
References_xml – volume: 2012
  year: 2012
  ident: CR15
  article-title: A comprehensive review on pharmacotherapeutics of herbal bioenhancers
  publication-title: ScientificWorldJournal
  doi: 10.1100/2012/637953
– volume: 48
  start-page: 1249
  issue: 12
  year: 2018
  end-page: 1257
  ident: CR113
  article-title: Efficient brain uptake of piperine and its pharmacokinetics characterization after oral administration
  publication-title: Xenobiotica
  doi: 10.1080/00498254.2017.1405293
– volume: 41
  start-page: 2037
  issue: 12
  year: 2015
  end-page: 2044
  ident: CR28
  article-title: Development and evaluation of chitosan and chitosan derivative nanoparticles containing insulin for oral administration
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.3109/03639045.2015.1044904
– volume: 11
  start-page: 559
  issue: 7
  year: 2005
  end-page: 564
  ident: CR78
  article-title: Relationship of glycemic control to total diabetes-related costs for managed care health plan members with type 2 diabetes
  publication-title: J. Manag. Care Pharm.
– volume: 72
  start-page: 640
  year: 2015
  end-page: 648
  ident: CR85
  article-title: pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2014.08.040
– volume: 24
  start-page: 4289
  issue: 5
  year: 2023
  ident: CR30
  article-title: Chitosan nanoparticles as oral drug carriers
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms24054289
– volume: 2016
  year: 2016
  ident: CR19
  article-title: Smart polymeric nanocarriers
  publication-title: J. Nanomater.
  doi: 10.1155/2016/3710921
– volume: 10
  start-page: 483
  year: 1979
  end-page: 484
  ident: CR14
  article-title: A breakthrough in drug bioavailability—A clue from age old wisdom of Ayurveda
  publication-title: I.D.M.A. Bull.
– volume: 17
  start-page: 437
  issue: 4
  year: 2021
  end-page: 456
  ident: CR81
  article-title: Herbal medicines for diabetes management and its secondary complications
  publication-title: Curr. Diabetes Rev.
  doi: 10.2174/18756417MTExfMTQ1z
– volume: 337
  start-page: 131
  year: 2018
  end-page: 138
  ident: CR105
  article-title: Piperine restores streptozotocin-induced cognitive impairments: Insights into oxidative balance in cerebrospinal fluid and hippocampus
  publication-title: Behav. Brain Res.
  doi: 10.1016/j.bbr.2017.09.031
– volume: 65
  start-page: 215
  issue: 2
  year: 2007
  end-page: 232
  ident: CR69
  article-title: Reversed chitosan-alginate polyelectrolyte complex for stability improvement of alpha-amylase: Optimization and physicochemical characterization
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2006.07.014
– volume: 33
  start-page: 598
  issue: 4
  year: 2010
  end-page: 603
  ident: CR98
  article-title: Neuroprotective effect of piperine on primarily cultured hippocampal neurons
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.33.598
– volume: 45
  start-page: 76
  issue: 1
  year: 2019
  end-page: 87
  ident: CR23
  article-title: Development and in vitro characterization of chitosan-coated polymeric nanoparticles for oral delivery and sustained release of the immunosuppressant drug mycophenolate mofetil
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639045.2018.1518455
– volume: 65
  start-page: 479
  year: 2014
  end-page: 491
  ident: CR24
  article-title: Chitosan nanoparticles amplify the ocular hypotensive effect of cateolol in rabbits
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2014.02.002
– volume: 134
  start-page: 219
  year: 2019
  end-page: 232
  ident: CR48
  article-title: Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2019.04.019
– volume: 57
  start-page: 169
  issue: 2
  year: 1989
  end-page: 172
  ident: CR64
  article-title: A simple equation for the description of solute release. III. Coupling of diffusion and relaxation
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(89)90306-2
– volume: 291
  year: 2022
  ident: CR94
  article-title: Mechanistic insight into the role of metformin in Alzheimer's disease
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2021.120299
– volume: 493
  start-page: 161
  issue: 1–2
  year: 2015
  end-page: 171
  ident: CR77
  article-title: Delivery of retinoic acid to LNCap human prostate cancer cells using solid lipid nanoparticles
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2015.07.042
– volume: 99
  start-page: 2049
  issue: 4
  year: 2010
  end-page: 2060
  ident: CR55
  article-title: Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.21944
– volume: 19
  start-page: 164
  issue: 2
  year: 2014
  end-page: 172
  ident: CR60
  article-title: All-trans retinoic acid-loaded lipid nanoparticles as a transdermal drug delivery carrier
  publication-title: Pharm. Dev. Technol.
  doi: 10.3109/10837450.2013.763261
– volume: 4
  start-page: 221
  issue: 3
  year: 2008
  end-page: 228
  ident: CR61
  article-title: Chitosan-alginate nanoparticles as a novel drug delivery system for nifedipine
  publication-title: Int. J. Biomed. Sci.
  doi: 10.59566/IJBS.2008.4221
– volume: 108
  start-page: 37
  year: 2022
  end-page: 71
  ident: CR4
  article-title: Diabetes and cognitive decline
  publication-title: Adv. Clin. Chem.
  doi: 10.1016/bs.acc.2021.07.006
– volume: 68
  start-page: 513
  issue: 3
  year: 2008
  end-page: 525
  ident: CR62
  article-title: Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: Formulation, optimisation and in vitro characterisation
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 9
  start-page: 115
  issue: 2
  year: 1977
  end-page: 225
  ident: CR7
  article-title: Pepper—Chemistry, technology, and quality evaluation
  publication-title: CRC Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408397709527233
– volume: 3
  start-page: 253
  issue: 4
  year: 2013
  end-page: 266
  ident: CR82
  article-title: Bioavailability enhancers of herbal origin: An overview
  publication-title: Asian Pac. J. Trop. Biomed.
  doi: 10.1016/S2221-1691(13)60060-X
– volume: 9
  start-page: 105
  issue: 2
  year: 2004
  end-page: 110
  ident: CR10
  article-title: Antioxidant efficacy of black pepper ( L.) and piperine in rats with high fat diet induced oxidative stress
  publication-title: Redox Rep.
  doi: 10.1179/135100004225004742
– volume: 2015
  start-page: 5459
  year: 2015
  end-page: 5473
  ident: CR102
  article-title: Novel piperine-loaded Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer’s disease: Pharmaceutical, biological, and toxicological studies
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S87336
– volume: 97
  start-page: 1
  year: 2014
  end-page: 14
  ident: CR16
  article-title: Role of herbal bioactives as a potential bioavailability enhancer for active pharmaceutical ingredients
  publication-title: Fitoterapia
  doi: 10.1016/j.fitote.2014.05.005
– volume: 188
  year: 2020
  ident: CR71
  article-title: Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in in vivo study
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2019.110749
– volume: 99
  start-page: 1
  issue: 1
  year: 2010
  end-page: 20
  ident: CR18
  article-title: Non-invasive systemic drug delivery: Developability considerations for alternate routes of administration
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.21793
– volume: 04
  start-page: 273
  year: 2013
  ident: CR63
  article-title: Formulation and evaluation of betamethasone sodium phosphate loaded nanoparticles for ophthalmic delivery
  publication-title: J. Clin. Exp. Ophthalmol.
– volume: 7
  start-page: 72
  year: 2009
  end-page: 78
  ident: CR88
  article-title: The anti-mutagenic activity of piperine against mitomycine C induced sister chromatid exchanges and chromosomal aberrations in mice
  publication-title: Nat. Sci.
– volume: 70
  start-page: 147
  year: 2019
  end-page: 155
  ident: CR101
  article-title: Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2019.05.009
– volume: 8
  start-page: 147
  year: 2018
  end-page: 156
  ident: CR72
  article-title: Preparation and evaluation of chitosan-tripolyphosphate nanoparticles suspension as an antibacterial agent
  publication-title: J. Appl. Pharm. Sci.
  doi: 10.7324/JAPS.2018.81217
– volume: 99
  start-page: 285
  year: 2017
  end-page: 291
  ident: CR32
  article-title: Novel amphiphilic chitosan nanocarriers for sustained oral delivery of hydrophobic drugs
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2016.12.035
– volume: 10
  start-page: 185
  issue: 4
  year: 2018
  ident: CR67
  article-title: Brief effect of a small hydrophobic drug (cinnarizine) on the physicochemical characterisation of niosomes produced by thin-film hydration and microfluidic methods
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics10040185
– volume: 43
  start-page: 1003
  issue: 6
  year: 2017
  end-page: 1010
  ident: CR9
  article-title: Formulation of piperine solid lipid nanoparticles (SLN) for treatment of rheumatoid arthritis
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639045.2017.1291666
– volume: 34
  start-page: 2798
  issue: 12
  year: 2017
  end-page: 2808
  ident: CR31
  article-title: Folate conjugated hybrid nanocarrier for targeted letrozole delivery in breast cancer treatment
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-017-2260-x
– volume: 11
  start-page: 1325
  year: 2020
  ident: CR111
  article-title: The antidepressant-like effects of hesperidin in streptozotocin-induced diabetic rats by activating Nrf2/ARE/glyoxalase 1 pathway
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.01325
– volume: 24
  start-page: 729
  issue: 6
  year: 2019
  end-page: 738
  ident: CR53
  article-title: Transdermal fennel essential oil nanoemulsions with promising hepatic dysfunction healing effect: In vitro and in vivo study
  publication-title: Pharm. Dev. Technol.
  doi: 10.1080/10837450.2019.1584633
– volume: 80
  start-page: 1373
  issue: 15
  year: 2007
  end-page: 1381
  ident: CR37
  article-title: Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2006.12.027
– volume: 18
  start-page: 691
  issue: 9
  year: 2008
  end-page: 696
  ident: CR89
  article-title: Antigenotoxic effects of curcumin and piperine alone or in combination against 7,12-dimethylbenz(a)anthracene induced genotoxicity in bone marrow of golden Syrian hamsters
  publication-title: Toxicol. Mech. Methods
  doi: 10.1080/15376510701781520
– volume: 110
  start-page: 3208
  issue: 9
  year: 2021
  end-page: 3220
  ident: CR42
  article-title: Fabrication of all-trans retinoic acid loaded chitosan/tripolyphosphate lipid hybrid nanoparticles as a novel oral delivery approach for management of diabetic nephropathy in rats
  publication-title: J. Pharm. Sci.
  doi: 10.1016/j.xphs.2021.05.007
– volume: 23
  start-page: 1281
  issue: 9
  year: 2009
  end-page: 1286
  ident: CR90
  article-title: Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.2676
– volume: 69
  start-page: 1
  issue: 1
  year: 1995
  end-page: 41
  ident: CR109
  article-title: Serotonergic modulation of cholinergic function in the central nervous system: Cognitive implications
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(95)00241-A
– volume: 122
  start-page: 384
  issue: 7
  year: 2014
  end-page: 386
  ident: CR1
  article-title: Definition, classification and diagnosis of diabetes mellitus
  publication-title: Exp. Clin. Endocrinol. Diabetes
  doi: 10.1055/s-0034-1366278
– volume: 12
  start-page: 462
  issue: 2
  year: 2023
  ident: CR100
  article-title: Oxidative stress in brain in amnestic mild cognitive impairment
  publication-title: Antioxidants (Basel)
  doi: 10.3390/antiox12020462
– volume: 16
  start-page: 87
  issue: 9
  year: 2016
  ident: CR6
  article-title: Diabetes and cognitive impairment
  publication-title: Curr. Diabetes Rep.
  doi: 10.1007/s11892-016-0775-x
– volume: 43
  start-page: 839
  issue: 5
  year: 2017
  end-page: 846
  ident: CR58
  article-title: Gastrointestinal stability, physicochemical characterization and oral bioavailability of chitosan or its derivative-modified solid lipid nanoparticles loading docetaxel
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639045.2016.1220571
– volume: 324
  start-page: 67
  issue: 1
  year: 2006
  end-page: 73
  ident: CR43
  article-title: Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2006.06.036
– volume: 10
  start-page: 43629
  issue: 71
  year: 2020
  end-page: 43639
  ident: CR45
  article-title: Formulation development, in vitro and in vivo evaluation of chitosan engineered nanoparticles for ocular delivery of insulin
  publication-title: RSC Adv.
  doi: 10.1039/D0RA07640F
– volume: 16
  start-page: 124
  issue: 1
  year: 2017
  end-page: 140
  ident: CR17
  article-title: Piperine—The bioactive compound of black pepper: From isolation to medicinal formulations
  publication-title: Compr. Rev. Food Sci. Food Saf.
  doi: 10.1111/1541-4337.12246
– volume: 44
  start-page: 65
  issue: 2–3
  year: 2005
  end-page: 73
  ident: CR52
  article-title: Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2005.06.001
– volume: 81
  start-page: 374
  issue: 3
  year: 2020
  end-page: 388
  ident: CR68
  article-title: Investigation of a new horizon antifungal activity with enhancing the antimicrobial efficacy of ciprofloxacin and its binary mixture via their encapsulation in nanoassemblies: In vitro and in vivo evaluation
  publication-title: Drug Dev. Res.
  doi: 10.1002/ddr.21632
– volume: 86
  start-page: 215
  issue: 3
  year: 2009
  end-page: 223
  ident: CR46
  article-title: Nanoparticle-based targeted drug delivery
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2008.12.004
– volume: 561
  start-page: 9
  year: 2019
  end-page: 18
  ident: CR106
  article-title: Involvement of metabolism-permeability in enhancing the oral bioavailability of curcumin in excipient-free solid dispersions co-formed with piperine
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2019.02.027
– volume: 495
  start-page: 771
  issue: 2
  year: 2015
  end-page: 782
  ident: CR29
  article-title: Development of chitosan nanoparticles as drug delivery system for a prototype capsid inhibitor
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2015.08.056
– volume: 11
  start-page: 11
  issue: 1
  year: 2014
  end-page: 16
  ident: CR73
  article-title: Isolation and characterization of piperine from the fruits of black pepper ( )
  publication-title: J. Bangladesh Agric. Univ.
  doi: 10.3329/jbau.v11i1.18197
– volume: 15
  start-page: 7861
  year: 2020
  end-page: 7875
  ident: CR27
  article-title: Clarithromycin-loaded ocular chitosan nanoparticle: Formulation, optimization, characterization, ocular irritation, and antimicrobial activity
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S269004
– volume: 54
  start-page: 9
  year: 2015
  end-page: 15
  ident: CR95
  article-title: Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction
  publication-title: Neuropeptides
  doi: 10.1016/j.npep.2015.08.009
– volume: 284
  start-page: 51
  issue: 1–2
  year: 2013
  end-page: 59
  ident: CR87
  article-title: Piperine ameliorates oxidative stress, inflammation and histological outcome in collagen induced arthritis
  publication-title: Cell Immunol.
  doi: 10.1016/j.cellimm.2013.07.004
– volume: 48
  start-page: 116
  issue: 2
  year: 2006
  end-page: 123
  ident: CR75
  article-title: The crystal structure of chitin and chitosan
  publication-title: Polym. Sci. Ser. A
  doi: 10.1134/S0965545X06020039
– volume: 11
  start-page: 86
  issue: 2
  year: 2019
  ident: CR22
  article-title: Chitosan-coated nanoparticles: Effect of chitosan molecular weight on nasal transmucosal delivery
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics11020086
– volume: 49
  year: 2022
  ident: CR84
  article-title: Piperine attenuates production of inflammatory biomarkers, oxidative stress and neutrophils in lungs of cigarette smoke-exposed experimental mice
  publication-title: Food Biosci.
  doi: 10.1016/j.fbio.2022.101909
– volume: 11
  start-page: 1164
  issue: 6
  year: 2015
  end-page: 1178
  ident: CR92
  article-title: Brain-derived neurotrophic factor and its clinical implications
  publication-title: Arch. Med. Sci.
  doi: 10.5114/aoms.2015.56342
– volume: 18
  start-page: 54
  year: 1999
  end-page: 62
  ident: CR36
  article-title: Streptozotocin-induced experimental diabetes in male Wistar rats
  publication-title: Gen. Physiol. Biophys.
– volume: 37
  start-page: 8965
  issue: 25
  year: 1998
  end-page: 8972
  ident: CR41
  article-title: Ionization-reactivity relationships for cysteine thiols in polypeptides
  publication-title: Biochemistry
  doi: 10.1021/bi973101r
– volume: 67
  start-page: 217
  issue: 3
  year: 2010
  end-page: 223
  ident: CR35
  article-title: Kinetic modeling on drug release from controlled drug delivery systems
  publication-title: Acta Pol. Pharm.
– volume: 4
  start-page: 820
  year: 2013
  end-page: 832
  ident: CR47
  article-title: Influence of formulation and process variables on the formation of rifampicin nanoparticles by ionic gelation technique
  publication-title: Res. J. Pharm. Biol. Chem. Sci.
– volume: 8
  issue: 9
  year: 2018
  ident: CR79
  article-title: Prevalence of depression in patients with type 2 diabetes mellitus in Spain (the DIADEMA Study): Results from the MADIABETES cohort
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2017-020768
– volume: 9
  start-page: 17
  year: 2018
  end-page: 26
  ident: CR33
  article-title: Formulation and evaluation of pH-sensitive rutin nanospheres against colon carcinoma using HCT-116 cell line
  publication-title: J. Adv. Res.
  doi: 10.1016/j.jare.2017.10.003
– volume: 8
  start-page: 380
  year: 2016
  ident: CR57
  article-title: Solid lipid nanoparticles and nanostructured lipid carriers of tolnaftate: Design, optimization and in-vitro evaluation
  publication-title: Int. J. Pharm. Pharm. Sci.
– volume: 140
  start-page: 1
  issue: 1–2
  year: 2003
  end-page: 47
  ident: CR107
  article-title: Glutamate receptor function in learning and memory
  publication-title: Behav. Brain Res.
  doi: 10.1016/S0166-4328(02)00272-3
– volume: 52
  start-page: 452
  issue: 5
  year: 2008
  end-page: 458
  ident: CR13
  article-title: Blood pressure lowering and vasomodulator effects of piperine
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/FJC.0b013e31818d07c0
– volume: 3
  start-page: 5957
  issue: 29
  year: 2015
  end-page: 5970
  ident: CR74
  article-title: Factors affecting the stability of chitosan/tripolyphosphate micro- and nanogels: Resolving the opposing findings
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C5TB00431D
– volume: 185
  start-page: 6413
  issue: 11
  year: 2010
  end-page: 6419
  ident: CR93
  article-title: The role of the transcription factor CREB in immune function
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1001829
– volume: 169
  start-page: 109
  year: 2015
  end-page: 123
  ident: CR97
  article-title: The protective effect of piperine on dextran sulfate sodium induced inflammatory bowel disease and its relation with pregnane X receptor activation
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2015.04.006
– volume: 8
  start-page: 203
  issue: 3
  year: 2006
  end-page: 226
  ident: CR25
  article-title: Chitin and chitosan: Functional biopolymers from marine crustaceans
  publication-title: Mar. Biotechnol.
  doi: 10.1007/s10126-005-0097-5
– volume: 26
  start-page: 3281
  issue: 11
  year: 2021
  ident: CR44
  article-title: Formulation of Piperine-chitosan-coated liposomes: Characterization and in vitro cytotoxic evaluation
  publication-title: Molecules (Basel, Switzerland)
  doi: 10.3390/molecules26113281
– volume: 46
  start-page: 557
  issue: 6
  year: 1996
  end-page: 560
  ident: CR38
  article-title: Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists
  publication-title: Arzneimittelforschung
– volume: 24
  start-page: 680
  issue: 4
  year: 2013
  end-page: 687
  ident: CR8
  article-title: Anti-apoptotic and anti-inflammatory effect of piperine on 6-OHDA induced Parkinson's rat model
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2012.03.018
– volume: 7
  start-page: 421
  issue: 5
  year: 2013
  end-page: 426
  ident: CR65
  article-title: Preparation and characterization of repaglinide loaded ethylcellulose nanoparticles by solvent diffusion technique using high pressure homogenizer
  publication-title: J. Pharm. Res.
– volume: 475
  start-page: 514
  issue: 1–2
  year: 2014
  end-page: 522
  ident: CR20
  article-title: Preparation and characterisation of Kolliphor P 188 and P 237 solid dispersion oral tablets containing the poorly water soluble drug disulfiram
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2014.09.013
– volume: 2018
  year: 2018
  ident: CR96
  article-title: BDNF/TrkB signaling in pancreatic islet beta cells
  publication-title: bioRxiv
– volume: 8
  start-page: 56
  issue: 1
  year: 2016
  end-page: 60
  ident: CR83
  article-title: Bio-enhancing effect of piperine with metformin on lowering blood glucose level in alloxan induced diabetic mice
  publication-title: Pharmacogn. Res.
  doi: 10.4103/0974-8490.171096
– volume: 142
  start-page: S8
  issue: Suppl
  year: 2012
  end-page: 21
  ident: CR110
  article-title: Epidemiology of depression and diabetes: A systematic review
  publication-title: J. Affect. Disord.
  doi: 10.1016/S0165-0327(12)70004-6
– volume: 34
  start-page: 403
  issue: 3
  year: 2014
  end-page: 408
  ident: CR11
  article-title: Piperine reverses chronic unpredictable mild stress-induced behavioral and biochemical alterations in rats
  publication-title: Cell. Mol. Neurobiol.
  doi: 10.1007/s10571-014-0025-1
– volume: 86
  start-page: 271
  issue: 1
  year: 1978
  end-page: 278
  ident: CR40
  article-title: Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
  publication-title: Anal. Biochem.
  doi: 10.1016/0003-2697(78)90342-1
– volume: 253
  year: 2020
  ident: CR103
  article-title: Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2020.117671
– volume: 14
  start-page: 341
  issue: 3
  year: 2018
  end-page: 357
  ident: CR116
  article-title: Role of plant derived alkaloids and their mechanism in neurodegenerative disorders
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.23247
– volume: 11
  start-page: 79
  issue: 1
  year: 1994
  end-page: 92
  ident: CR56
  article-title: Characterization of diazepam submicron emulsion interface: Role of oleic acid
  publication-title: J. Microencapsul.
  doi: 10.3109/02652049409040440
– volume: 9
  start-page: 275
  issue: 3
  year: 2016
  end-page: 279
  ident: CR112
  article-title: Effects of caffeine on locomotor activity in streptozotocin-induced diabetic rats
  publication-title: J. Med. Life
– volume: 21
  start-page: 300
  year: 2013
  end-page: 311
  ident: CR76
  article-title: Preparation, characterization, in vivo and biochemical evaluation of brain targeted Piperine solid lipid nanoparticles in an experimentally induced Alzheimer’s disease model
  publication-title: J. Drug Target.
  doi: 10.3109/1061186X.2012.747529
– volume: 90
  start-page: 339
  issue: 2–3
  year: 2004
  end-page: 346
  ident: CR12
  article-title: Immunomodulatory and antitumor activity of Linn. and piperine
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2003.10.016
– volume: 46
  start-page: 3106
  issue: 9
  year: 2008
  end-page: 3110
  ident: CR108
  article-title: Piperine, the potential functional food for mood and cognitive disorders
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2008.06.014
– volume: 135
  start-page: 361
  issue: 4
  year: 1998
  end-page: 367
  ident: CR115
  article-title: Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s002130050523
– volume: 96
  start-page: 285
  issue: 2
  year: 2004
  end-page: 300
  ident: CR70
  article-title: A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2004.02.002
– volume: 39
  start-page: 1599
  issue: 11
  year: 2013
  end-page: 1617
  ident: CR49
  article-title: Recent advances in ocular drug delivery
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.3109/03639045.2012.736515
– volume: 18
  start-page: 1
  issue: 1
  year: 2014
  ident: CR5
  article-title: Advanced glycation end products and diabetic complications
  publication-title: Korean J. Physiol. Pharmacol.
  doi: 10.4196/kjpp.2014.18.1.1
– volume: 12
  start-page: 203
  year: 2020
  end-page: 210
  ident: CR54
  article-title: Enhanced enzymatic activity of L-asparginase via its incorporation in an oil-based nanocarrier
  publication-title: Int. J. Appl. Pharm.
  doi: 10.22159/ijap.2020v12i5.38360
– volume: 66
  start-page: 251
  issue: 3
  year: 2010
  end-page: 259
  ident: CR51
  article-title: Encapsulation of cyclodextrin complexed simvastatin in chitosan nanocarriers: A novel technique for oral delivery
  publication-title: J. Inclus. Phenom. Macrocycl. Chem.
  doi: 10.1007/s10847-009-9605-y
– volume: 160
  year: 2020
  ident: CR91
  article-title: Metformin: An old drug against old age and associated morbidities
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2020.108025
– volume: 72
  start-page: 238
  issue: 1
  year: 2018
  end-page: 245
  ident: CR114
  article-title: Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells
  publication-title: J. Nat. Med.
  doi: 10.1007/s11418-017-1140-3
– volume: 157
  start-page: 187
  year: 2016
  end-page: 199
  ident: CR99
  article-title: Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: Role of NF-κB and NLRP3 inflammasome
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2016.06.002
– volume: 59
  year: 2020
  ident: CR34
  article-title: Development of acetazolamide loaded bilosomes for improved ocular delivery: Preparation, characterization and in vivo evaluation
  publication-title: J. Drug Deliv. Sci. Technol.
  doi: 10.1016/j.jddst.2020.101910
– volume: 1
  start-page: 266
  issue: 3
  year: 2013
  end-page: 278
  ident: CR50
  article-title: Evaluation of chitosan-tripolyphosphate nanoparticles as a p-shRNA delivery vector: Formulation, optimization and cellular uptake study
  publication-title: J. Nanopharm. Drug Deliv.
  doi: 10.1166/jnd.2013.1027
– volume: 491
  start-page: 402
  issue: 1
  year: 2015
  end-page: 408
  ident: CR86
  article-title: Design, characterisation, and bioefficiency of insulin–chitosan nanoparticles after stabilisation by freeze-drying or cross-linking
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2015.05.065
– volume: 1916
  start-page: 105
  year: 2019
  end-page: 111
  ident: CR39
  article-title: The Y-maze for assessment of spatial working and reference memory in mice
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-8994-2_10
– volume: 7
  start-page: 155
  issue: 2
  year: 2013
  end-page: 165
  ident: CR2
  article-title: Cognitive impairment and diabetes
  publication-title: Recent Pat. Endocr. Metab. Immune Drug Discov.
  doi: 10.2174/1872214811307020009
– volume: 49
  start-page: 93
  year: 2005
  end-page: 135
  ident: CR26
  article-title: Chitin, chitosan, and co-products: Chemistry, production, applications, and health effects
  publication-title: Adv. Food Nutr. Res.
  doi: 10.1016/S1043-4526(05)49003-8
– volume: 544
  start-page: 129
  issue: 1
  year: 2018
  end-page: 140
  ident: CR66
  article-title: A potential antibacterial wound dressing of cefadroxil chitosan nanoparticles in situ gel: Fabrication, in vitro optimization and in vivo evaluation
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2018.04.021
– volume: 26
  start-page: 16958
  issue: 22
  year: 2010
  end-page: 16962
  ident: CR21
  article-title: Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method
  publication-title: Langmuir
  doi: 10.1021/la103576a
– volume: 96
  year: 2022
  ident: CR80
  article-title: Nanoformulation of plant-based natural products for type 2 diabetes mellitus: From formulation design to therapeutic applications
  publication-title: Curr. Ther. Res.
  doi: 10.1016/j.curtheres.2022.100672
– volume: 17
  start-page: 1035
  issue: 3
  year: 2020
  ident: CR3
  article-title: A network-based bioinformatics approach to identify molecular biomarkers for type 2 diabetes that are linked to the progression of neurological diseases
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph17031035
– volume: 585
  year: 2020
  ident: CR59
  article-title: Provesicular elastic carriers of Simvastatin for enhanced wound healing activity: An in-vitro/in-vivo study
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2020.119470
– volume: 9
  start-page: 100
  issue: 3
  year: 2019
  ident: CR104
  article-title: Omega-3 fatty acids prevent post-traumatic stress disorder-induced memory impairment
  publication-title: Biomolecules
  doi: 10.3390/biom9030100
– volume: 66
  start-page: 251
  issue: 3
  year: 2010
  ident: 58601_CR51
  publication-title: J. Inclus. Phenom. Macrocycl. Chem.
  doi: 10.1007/s10847-009-9605-y
– volume: 324
  start-page: 67
  issue: 1
  year: 2006
  ident: 58601_CR43
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2006.06.036
– volume: 26
  start-page: 3281
  issue: 11
  year: 2021
  ident: 58601_CR44
  publication-title: Molecules (Basel, Switzerland)
  doi: 10.3390/molecules26113281
– volume: 134
  start-page: 219
  year: 2019
  ident: 58601_CR48
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2019.04.019
– volume: 9
  start-page: 275
  issue: 3
  year: 2016
  ident: 58601_CR112
  publication-title: J. Med. Life
– volume: 99
  start-page: 1
  issue: 1
  year: 2010
  ident: 58601_CR18
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.21793
– volume: 4
  start-page: 820
  year: 2013
  ident: 58601_CR47
  publication-title: Res. J. Pharm. Biol. Chem. Sci.
– volume: 495
  start-page: 771
  issue: 2
  year: 2015
  ident: 58601_CR29
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2015.08.056
– volume: 49
  start-page: 93
  year: 2005
  ident: 58601_CR26
  publication-title: Adv. Food Nutr. Res.
  doi: 10.1016/S1043-4526(05)49003-8
– volume: 7
  start-page: 421
  issue: 5
  year: 2013
  ident: 58601_CR65
  publication-title: J. Pharm. Res.
– volume: 72
  start-page: 238
  issue: 1
  year: 2018
  ident: 58601_CR114
  publication-title: J. Nat. Med.
  doi: 10.1007/s11418-017-1140-3
– volume: 34
  start-page: 2798
  issue: 12
  year: 2017
  ident: 58601_CR31
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-017-2260-x
– volume: 7
  start-page: 72
  year: 2009
  ident: 58601_CR88
  publication-title: Nat. Sci.
– volume: 96
  year: 2022
  ident: 58601_CR80
  publication-title: Curr. Ther. Res.
  doi: 10.1016/j.curtheres.2022.100672
– volume: 48
  start-page: 116
  issue: 2
  year: 2006
  ident: 58601_CR75
  publication-title: Polym. Sci. Ser. A
  doi: 10.1134/S0965545X06020039
– volume: 7
  start-page: 155
  issue: 2
  year: 2013
  ident: 58601_CR2
  publication-title: Recent Pat. Endocr. Metab. Immune Drug Discov.
  doi: 10.2174/1872214811307020009
– volume: 493
  start-page: 161
  issue: 1–2
  year: 2015
  ident: 58601_CR77
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2015.07.042
– volume: 24
  start-page: 680
  issue: 4
  year: 2013
  ident: 58601_CR8
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2012.03.018
– volume: 4
  start-page: 221
  issue: 3
  year: 2008
  ident: 58601_CR61
  publication-title: Int. J. Biomed. Sci.
  doi: 10.59566/IJBS.2008.4221
– volume: 24
  start-page: 729
  issue: 6
  year: 2019
  ident: 58601_CR53
  publication-title: Pharm. Dev. Technol.
  doi: 10.1080/10837450.2019.1584633
– volume: 17
  start-page: 437
  issue: 4
  year: 2021
  ident: 58601_CR81
  publication-title: Curr. Diabetes Rev.
  doi: 10.2174/18756417MTExfMTQ1z
– volume: 86
  start-page: 271
  issue: 1
  year: 1978
  ident: 58601_CR40
  publication-title: Anal. Biochem.
  doi: 10.1016/0003-2697(78)90342-1
– volume: 99
  start-page: 285
  year: 2017
  ident: 58601_CR32
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2016.12.035
– volume: 68
  start-page: 513
  issue: 3
  year: 2008
  ident: 58601_CR62
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 9
  start-page: 115
  issue: 2
  year: 1977
  ident: 58601_CR7
  publication-title: CRC Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408397709527233
– volume: 52
  start-page: 452
  issue: 5
  year: 2008
  ident: 58601_CR13
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/FJC.0b013e31818d07c0
– volume: 37
  start-page: 8965
  issue: 25
  year: 1998
  ident: 58601_CR41
  publication-title: Biochemistry
  doi: 10.1021/bi973101r
– volume: 65
  start-page: 215
  issue: 2
  year: 2007
  ident: 58601_CR69
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2006.07.014
– volume: 43
  start-page: 1003
  issue: 6
  year: 2017
  ident: 58601_CR9
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639045.2017.1291666
– volume: 2015
  start-page: 5459
  year: 2015
  ident: 58601_CR102
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S87336
– volume: 122
  start-page: 384
  issue: 7
  year: 2014
  ident: 58601_CR1
  publication-title: Exp. Clin. Endocrinol. Diabetes
  doi: 10.1055/s-0034-1366278
– volume: 04
  start-page: 273
  year: 2013
  ident: 58601_CR63
  publication-title: J. Clin. Exp. Ophthalmol.
– volume: 11
  start-page: 79
  issue: 1
  year: 1994
  ident: 58601_CR56
  publication-title: J. Microencapsul.
  doi: 10.3109/02652049409040440
– volume: 18
  start-page: 54
  year: 1999
  ident: 58601_CR36
  publication-title: Gen. Physiol. Biophys.
– volume: 253
  year: 2020
  ident: 58601_CR103
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2020.117671
– volume: 49
  year: 2022
  ident: 58601_CR84
  publication-title: Food Biosci.
  doi: 10.1016/j.fbio.2022.101909
– volume: 99
  start-page: 2049
  issue: 4
  year: 2010
  ident: 58601_CR55
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.21944
– volume: 14
  start-page: 341
  issue: 3
  year: 2018
  ident: 58601_CR116
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.23247
– volume: 10
  start-page: 185
  issue: 4
  year: 2018
  ident: 58601_CR67
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics10040185
– volume: 561
  start-page: 9
  year: 2019
  ident: 58601_CR106
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2019.02.027
– volume: 2016
  year: 2016
  ident: 58601_CR19
  publication-title: J. Nanomater.
  doi: 10.1155/2016/3710921
– volume: 491
  start-page: 402
  issue: 1
  year: 2015
  ident: 58601_CR86
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2015.05.065
– volume: 160
  year: 2020
  ident: 58601_CR91
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2020.108025
– volume: 39
  start-page: 1599
  issue: 11
  year: 2013
  ident: 58601_CR49
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.3109/03639045.2012.736515
– volume: 16
  start-page: 87
  issue: 9
  year: 2016
  ident: 58601_CR6
  publication-title: Curr. Diabetes Rep.
  doi: 10.1007/s11892-016-0775-x
– volume: 41
  start-page: 2037
  issue: 12
  year: 2015
  ident: 58601_CR28
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.3109/03639045.2015.1044904
– volume: 8
  start-page: 147
  year: 2018
  ident: 58601_CR72
  publication-title: J. Appl. Pharm. Sci.
  doi: 10.7324/JAPS.2018.81217
– volume: 46
  start-page: 3106
  issue: 9
  year: 2008
  ident: 58601_CR108
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2008.06.014
– volume: 43
  start-page: 839
  issue: 5
  year: 2017
  ident: 58601_CR58
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639045.2016.1220571
– volume: 48
  start-page: 1249
  issue: 12
  year: 2018
  ident: 58601_CR113
  publication-title: Xenobiotica
  doi: 10.1080/00498254.2017.1405293
– volume: 9
  start-page: 100
  issue: 3
  year: 2019
  ident: 58601_CR104
  publication-title: Biomolecules
  doi: 10.3390/biom9030100
– volume: 1916
  start-page: 105
  year: 2019
  ident: 58601_CR39
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-8994-2_10
– volume: 337
  start-page: 131
  year: 2018
  ident: 58601_CR105
  publication-title: Behav. Brain Res.
  doi: 10.1016/j.bbr.2017.09.031
– volume: 21
  start-page: 300
  year: 2013
  ident: 58601_CR76
  publication-title: J. Drug Target.
  doi: 10.3109/1061186X.2012.747529
– volume: 10
  start-page: 483
  year: 1979
  ident: 58601_CR14
  publication-title: I.D.M.A. Bull.
– volume: 33
  start-page: 598
  issue: 4
  year: 2010
  ident: 58601_CR98
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.33.598
– volume: 110
  start-page: 3208
  issue: 9
  year: 2021
  ident: 58601_CR42
  publication-title: J. Pharm. Sci.
  doi: 10.1016/j.xphs.2021.05.007
– volume: 140
  start-page: 1
  issue: 1–2
  year: 2003
  ident: 58601_CR107
  publication-title: Behav. Brain Res.
  doi: 10.1016/S0166-4328(02)00272-3
– volume: 169
  start-page: 109
  year: 2015
  ident: 58601_CR97
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2015.04.006
– volume: 65
  start-page: 479
  year: 2014
  ident: 58601_CR24
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2014.02.002
– volume: 11
  start-page: 1325
  year: 2020
  ident: 58601_CR111
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.01325
– volume: 284
  start-page: 51
  issue: 1–2
  year: 2013
  ident: 58601_CR87
  publication-title: Cell Immunol.
  doi: 10.1016/j.cellimm.2013.07.004
– volume: 12
  start-page: 203
  year: 2020
  ident: 58601_CR54
  publication-title: Int. J. Appl. Pharm.
  doi: 10.22159/ijap.2020v12i5.38360
– volume: 23
  start-page: 1281
  issue: 9
  year: 2009
  ident: 58601_CR90
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.2676
– volume: 96
  start-page: 285
  issue: 2
  year: 2004
  ident: 58601_CR70
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2004.02.002
– volume: 135
  start-page: 361
  issue: 4
  year: 1998
  ident: 58601_CR115
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s002130050523
– volume: 10
  start-page: 43629
  issue: 71
  year: 2020
  ident: 58601_CR45
  publication-title: RSC Adv.
  doi: 10.1039/D0RA07640F
– volume: 16
  start-page: 124
  issue: 1
  year: 2017
  ident: 58601_CR17
  publication-title: Compr. Rev. Food Sci. Food Saf.
  doi: 10.1111/1541-4337.12246
– volume: 26
  start-page: 16958
  issue: 22
  year: 2010
  ident: 58601_CR21
  publication-title: Langmuir
  doi: 10.1021/la103576a
– volume: 34
  start-page: 403
  issue: 3
  year: 2014
  ident: 58601_CR11
  publication-title: Cell. Mol. Neurobiol.
  doi: 10.1007/s10571-014-0025-1
– volume: 24
  start-page: 4289
  issue: 5
  year: 2023
  ident: 58601_CR30
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms24054289
– volume: 544
  start-page: 129
  issue: 1
  year: 2018
  ident: 58601_CR66
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2018.04.021
– volume: 142
  start-page: S8
  issue: Suppl
  year: 2012
  ident: 58601_CR110
  publication-title: J. Affect. Disord.
  doi: 10.1016/S0165-0327(12)70004-6
– volume: 291
  year: 2022
  ident: 58601_CR94
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2021.120299
– volume: 46
  start-page: 557
  issue: 6
  year: 1996
  ident: 58601_CR38
  publication-title: Arzneimittelforschung
– volume: 67
  start-page: 217
  issue: 3
  year: 2010
  ident: 58601_CR35
  publication-title: Acta Pol. Pharm.
– volume: 8
  start-page: 380
  year: 2016
  ident: 58601_CR57
  publication-title: Int. J. Pharm. Pharm. Sci.
  doi: 10.22159/ijpps.2016v8i11.14365
– volume: 3
  start-page: 5957
  issue: 29
  year: 2015
  ident: 58601_CR74
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C5TB00431D
– volume: 18
  start-page: 691
  issue: 9
  year: 2008
  ident: 58601_CR89
  publication-title: Toxicol. Mech. Methods
  doi: 10.1080/15376510701781520
– volume: 188
  year: 2020
  ident: 58601_CR71
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2019.110749
– volume: 8
  issue: 9
  year: 2018
  ident: 58601_CR79
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2017-020768
– volume: 81
  start-page: 374
  issue: 3
  year: 2020
  ident: 58601_CR68
  publication-title: Drug Dev. Res.
  doi: 10.1002/ddr.21632
– volume: 9
  start-page: 105
  issue: 2
  year: 2004
  ident: 58601_CR10
  publication-title: Redox Rep.
  doi: 10.1179/135100004225004742
– volume: 59
  year: 2020
  ident: 58601_CR34
  publication-title: J. Drug Deliv. Sci. Technol.
  doi: 10.1016/j.jddst.2020.101910
– volume: 185
  start-page: 6413
  issue: 11
  year: 2010
  ident: 58601_CR93
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1001829
– volume: 17
  start-page: 1035
  issue: 3
  year: 2020
  ident: 58601_CR3
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph17031035
– volume: 18
  start-page: 1
  issue: 1
  year: 2014
  ident: 58601_CR5
  publication-title: Korean J. Physiol. Pharmacol.
  doi: 10.4196/kjpp.2014.18.1.1
– volume: 1
  start-page: 266
  issue: 3
  year: 2013
  ident: 58601_CR50
  publication-title: J. Nanopharm. Drug Deliv.
  doi: 10.1166/jnd.2013.1027
– volume: 8
  start-page: 56
  issue: 1
  year: 2016
  ident: 58601_CR83
  publication-title: Pharmacogn. Res.
  doi: 10.4103/0974-8490.171096
– volume: 9
  start-page: 17
  year: 2018
  ident: 58601_CR33
  publication-title: J. Adv. Res.
  doi: 10.1016/j.jare.2017.10.003
– volume: 44
  start-page: 65
  issue: 2–3
  year: 2005
  ident: 58601_CR52
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2005.06.001
– volume: 2012
  year: 2012
  ident: 58601_CR15
  publication-title: ScientificWorldJournal
  doi: 10.1100/2012/637953
– volume: 11
  start-page: 1164
  issue: 6
  year: 2015
  ident: 58601_CR92
  publication-title: Arch. Med. Sci.
  doi: 10.5114/aoms.2015.56342
– volume: 45
  start-page: 76
  issue: 1
  year: 2019
  ident: 58601_CR23
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639045.2018.1518455
– volume: 97
  start-page: 1
  year: 2014
  ident: 58601_CR16
  publication-title: Fitoterapia
  doi: 10.1016/j.fitote.2014.05.005
– volume: 8
  start-page: 203
  issue: 3
  year: 2006
  ident: 58601_CR25
  publication-title: Mar. Biotechnol.
  doi: 10.1007/s10126-005-0097-5
– volume: 108
  start-page: 37
  year: 2022
  ident: 58601_CR4
  publication-title: Adv. Clin. Chem.
  doi: 10.1016/bs.acc.2021.07.006
– volume: 69
  start-page: 1
  issue: 1
  year: 1995
  ident: 58601_CR109
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(95)00241-A
– volume: 12
  start-page: 462
  issue: 2
  year: 2023
  ident: 58601_CR100
  publication-title: Antioxidants (Basel)
  doi: 10.3390/antiox12020462
– volume: 585
  year: 2020
  ident: 58601_CR59
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2020.119470
– volume: 86
  start-page: 215
  issue: 3
  year: 2009
  ident: 58601_CR46
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2008.12.004
– volume: 3
  start-page: 253
  issue: 4
  year: 2013
  ident: 58601_CR82
  publication-title: Asian Pac. J. Trop. Biomed.
  doi: 10.1016/S2221-1691(13)60060-X
– volume: 11
  start-page: 86
  issue: 2
  year: 2019
  ident: 58601_CR22
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics11020086
– volume: 2018
  year: 2018
  ident: 58601_CR96
  publication-title: bioRxiv
– volume: 90
  start-page: 339
  issue: 2–3
  year: 2004
  ident: 58601_CR12
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2003.10.016
– volume: 475
  start-page: 514
  issue: 1–2
  year: 2014
  ident: 58601_CR20
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2014.09.013
– volume: 157
  start-page: 187
  year: 2016
  ident: 58601_CR99
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2016.06.002
– volume: 57
  start-page: 169
  issue: 2
  year: 1989
  ident: 58601_CR64
  publication-title: Int. J. Pharm.
  doi: 10.1016/0378-5173(89)90306-2
– volume: 19
  start-page: 164
  issue: 2
  year: 2014
  ident: 58601_CR60
  publication-title: Pharm. Dev. Technol.
  doi: 10.3109/10837450.2013.763261
– volume: 15
  start-page: 7861
  year: 2020
  ident: 58601_CR27
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S269004
– volume: 11
  start-page: 559
  issue: 7
  year: 2005
  ident: 58601_CR78
  publication-title: J. Manag. Care Pharm.
– volume: 54
  start-page: 9
  year: 2015
  ident: 58601_CR95
  publication-title: Neuropeptides
  doi: 10.1016/j.npep.2015.08.009
– volume: 11
  start-page: 11
  issue: 1
  year: 2014
  ident: 58601_CR73
  publication-title: J. Bangladesh Agric. Univ.
  doi: 10.3329/jbau.v11i1.18197
– volume: 72
  start-page: 640
  year: 2015
  ident: 58601_CR85
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2014.08.040
– volume: 70
  start-page: 147
  year: 2019
  ident: 58601_CR101
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2019.05.009
– volume: 80
  start-page: 1373
  issue: 15
  year: 2007
  ident: 58601_CR37
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2006.12.027
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Snippet The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological activity alone...
Abstract The aim of the present study was to prepare and evaluate Piperine (PP) loaded chitosan lipid nanoparticles (PP-CLNPs) to evaluate its biological...
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SubjectTerms 631/154/152
631/154/433
631/154/53
BDNF
Biological activity
Chitosan
Chitosan lipid nanoparticles
Cognitive ability
Diabetes
Diabetes mellitus
Diabetic cognitive deficit model
Drug delivery
Humanities and Social Sciences
Inflammation
Metformin
multidisciplinary
Nanoparticles
Oxidative stress
Piperine
Science
Science (multidisciplinary)
Spatial memory
Stearic acid
Tripolyphosphate
Y-maze
Zeta potential
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Title Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats
URI https://link.springer.com/article/10.1038/s41598-024-58601-x
https://www.ncbi.nlm.nih.gov/pubmed/38589438
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https://pubmed.ncbi.nlm.nih.gov/PMC11002014
https://doaj.org/article/1a6d32ef087c4bb99b83f34cc83fa6d9
Volume 14
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