Pathogenicity and transmissibility of bovine H5N1 influenza virus

• Published in: Nature (London) Vol. 633; no. 8029; pp. 426 - 432
• Main Authors: Eisfeld, Amie J., Biswas, Asim, Guan, Lizheng, Gu, Chunyang, Maemura, Tadashi, Trifkovic, Sanja, Wang, Tong, Babujee, Lavanya, Dahn, Randall, Halfmann, Peter J., Barnhardt, Tera, Neumann, Gabriele, Suzuki, Yasuo, Thompson, Alexis, Swinford, Amy K., Dimitrov, Kiril M., Poulsen, Keith, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.09.2024; Nature Publishing Group
• Subjects: 13/1; 13/106; 631/326/596/1578; 631/326/596/2555; 631/326/596/2563; 64/60; Animal euthanasia; Animal lactation; Animals; Avian flu; Cattle; Cattle Diseases - epidemiology; Cattle Diseases - transmission; Cattle Diseases - virology; Cow's milk; Dairy cattle; Disease transmission; Epidemics; Farms; Female; Females; Ferrets - virology; Health risk assessment; Health risks; Humanities and Social Sciences; Humans; Infections; Influenza; Influenza A Virus, H5N1 Subtype - immunology; Influenza A Virus, H5N1 Subtype - isolation & purification; Influenza A Virus, H5N1 Subtype - pathogenicity; Influenza A Virus, H5N1 Subtype - physiology; Influenza, Human - epidemiology; Influenza, Human - transmission; Influenza, Human - virology; Laryngeal Masks - virology; Mammals; Mammary gland; Mammary glands; Mammary Glands, Animal - virology; Mice; Mice, Inbred BALB C; Milk; Milk - virology; multidisciplinary; Mustela; Orthomyxoviridae Infections - epidemiology; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - veterinary; Orthomyxoviridae Infections - virology; Pathogenicity; Pathogens; Public health; Science; Science (multidisciplinary); Seroconversion; Sialic acids; Sialic Acids - metabolism; Tropism; United States - epidemiology; Viral Tropism; Viral Zoonoses; Virulence; Viruses; United States; New Mexico; United States > US; Spain

Highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses occasionally infect, but typically do not transmit, in mammals. In the spring of 2024, an unprecedented outbreak of HPAI H5N1 in bovine herds occurred in the USA, with virus spread within and between herds, infections in poultry and cats, an...