An autocatalytic multicomponent DNAzyme nanomachine for tumor-specific photothermal therapy sensitization in pancreatic cancer

• Published in: Nature communications Vol. 14; no. 1; pp. 6905 - 21
• Main Authors: Yan, Jiaqi, Ma, Xiaodong, Liang, Danna, Ran, Meixin, Zheng, Dongdong, Chen, Xiaodong, Zhou, Shichong, Sun, Weijian, Shen, Xian, Zhang, Hongbo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 14; 14/19; 14/32; 147/135; 147/143; 59; 631/61/350/354; 631/61/54/152; 631/67/1059/602; Biocompatibility; Calcium (intracellular); Calcium (mitochondrial); Calcium efflux; Calcium homeostasis; Calcium ions; Calcium phosphates; Cancer; Cancer therapies; Cell Line, Tumor; Curcumin; Curcumin - pharmacology; Deoxyribozymes; DNA, Catalytic; Efflux; Ethanolamine; Gene regulation; Gene therapy; Heat shock proteins; Homeostasis; Hsp70 protein; Humanities and Social Sciences; Humans; Hydrophobicity; Irradiation; Laser radiation; Micelles; MicroRNAs - genetics; Mineralization; miRNA; mRNA; multidisciplinary; Nanoparticles - chemistry; Neoplasms; Oligopeptides; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - therapy; Phototherapy - methods; Photothermal Therapy; Polyethylene glycol; Polyethylene Glycols - chemistry; PTEN protein; Science; Science (multidisciplinary); Toxicity; Tumor suppressor genes; Tumors

Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but their ability to recognize disease tissue and further achieve synergistic gene regulation has rarely been studied. Herein, Arginylglycylaspartic acid (RGD)-modified Distearyl acylphosphatidyl ethanolamine (DSPE)-polye...