Proteomic analysis of plasma to identify novel biomarkers for intra-amniotic infection and/or inflammation in preterm premature rupture of membranes

• Published in: Scientific reports Vol. 13; no. 1; pp. 5658 - 12
• Main Authors: Back, Ji Hyun, Kim, So Yeon, Gu, Man Bock, Kim, Hyeon Ji, Lee, Kyong-No, Lee, Ji Eun, Park, Kyo Hoon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.04.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4017; 692/53; Amniocentesis; Amniotic Fluid - metabolism; Biomarkers; Biomarkers - metabolism; Case-Control Studies; Chorioamnionitis - diagnosis; Chorioamnionitis - metabolism; Fc receptors; Female; Gestational Age; Haptoglobin; Haptoglobins - metabolism; Humanities and Social Sciences; Humans; Infant, Newborn; Inflammation; Inflammation - metabolism; Liquid chromatography; Mass spectrometry; Mass spectroscopy; multidisciplinary; Plasma; Pregnancy; Proteomes; Proteomics; Retrospective Studies; Rupture; Science; Science (multidisciplinary)

To identify potential plasma biomarkers associated with microbial invasion of the amniotic cavity (MIAC) and/or intraamniotic inflammation (IAI) in women with preterm premature rupture of membranes (PPROM). This retrospective cohort study included 182 singleton pregnant women with PPROM (23–33 weeks...