Exogenous prenatal corticosterone exposure mimics the effects of prenatal stress on adult brain stress response systems and fear extinction behavior

• Published in: Psychoneuroendocrinology Vol. 38; no. 11; pp. 2746 - 2757
• Main Authors: Bingham, Brian C., Sheela Rani, C.S., Frazer, Alan, Strong, Randy, Morilak, David A.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.11.2013; Elsevier
• Subjects: Adult and adolescent clinical studies; Animals; Anxiety disorders. Neuroses; Behavioral psychophysiology; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Brain-Derived Neurotrophic Factor - biosynthesis; Corticosterone; Corticosterone - blood; Corticosterone - pharmacology; Corticotropin-Releasing Hormone - biosynthesis; Disorder; Endocrinology & Metabolism; Extinction, Psychological - drug effects; Fear - drug effects; Fear - psychology; Fear conditioning; Fear extinction; Female; Fundamental and applied biological sciences. Psychology; Gene Expression - drug effects; Glucocorticoids; Hormones and behavior; Male; Medical sciences; Mental Recall - drug effects; Post-traumatic stress; Post-traumatic stress disorder; Pregnancy; Prenatal Exposure Delayed Effects - metabolism; Prenatal Exposure Delayed Effects - psychology; Prenatal stress; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Rats; Receptors, Glucocorticoid - metabolism; Stress vulnerability; Stress, Psychological - metabolism; Stress, Psychological - psychology; Tyrosine 3-Monooxygenase - biosynthesis; Tyrosine hydroxylase; Glucocorticoids; Corticosterone; Fear extinction; Tyrosine hydroxylase; Disorder; Post-traumatic stress; Fear conditioning; Prenatal stress; Stress vulnerability; Affect affectivity; Central nervous system; Anxiety disorder; Posttraumatic stress disorder; Tyrosine 3-monooxygenase; Glucocorticoid; Encephalon; Prenatal; Adult; Behavior; Conditioning; Human; Enzyme; Steroid hormone; Extinction; Mimic; Emotion emotionality; Exposure; Vulnerability; Stress; Fear; Adrenal hormone; Oxidoreductases

Exposure to early-life stress is a risk factor for the development of cognitive and emotional disorders later in life. We previously demonstrated that prenatal stress (PNS) in rats results in long-term, stable changes in central stress-response systems and impairs the ability to extinguish condition...