GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas

• Published in: Virchows Archiv : an international journal of pathology Vol. 466; no. 6; pp. 665 - 674
• Main Authors: Hosoda, Waki, Sasaki, Eiichi, Murakami, Yoshiko, Yamao, Kenji, Shimizu, Yasuhiro, Yatabe, Yasushi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2015; Springer Nature B.V
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma, Mucinous - genetics; Adenocarcinoma, Mucinous - mortality; Adenocarcinoma, Mucinous - pathology; Aged; Aged, 80 and over; Biomarkers, Tumor - genetics; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - mortality; Carcinoma, Pancreatic Ductal - pathology; Carcinoma, Papillary - genetics; Carcinoma, Papillary - mortality; Carcinoma, Papillary - pathology; Chromogranins; Cystadenoma - genetics; Cystadenoma - mortality; Cystadenoma - pathology; DNA Mutational Analysis; Female; Genotypes; GTP-Binding Protein alpha Subunits, Gs - genetics; Heterogeneity; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Medicine; Medicine & Public Health; Microdissection; Middle Aged; Mutation; Original Article; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Pathology; Reverse Transcriptase Polymerase Chain Reaction; Tumors; IPMN-associated adenocarcinoma; Mucinous; Pancreas; Tubular

In contrast to pancreatic ductal adenocarcinomas (PDAs), intraductal papillary mucinous neoplasms (IPMNs) frequently harbour GNAS mutations. To characterise GNAS -mutated pancreatic carcinomas, we examined mutations of GNAS and KRAS in 290 pancreatic adenocarcinomas and 77 pancreatic intraepithelial...