The Efficacy of Crotalidae Polyvalent Immune Fab (Ovine) Antivenom Versus Placebo Plus Optional Rescue Therapy on Recovery From Copperhead Snake Envenomation: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial

• Published in: Annals of emergency medicine Vol. 70; no. 2; pp. 233 - 244.e3
• Main Authors: Gerardo, Charles J., Quackenbush, Eugenia, Lewis, Brandon, Rose, S. Rutherfoord, Greene, Spencer, Toschlog, Eric A., Charlton, Nathan P., Mullins, Michael E., Schwartz, Richard, Denning, David, Sharma, Kapil, Kleinschmidt, Kurt, Bush, Sean P., Ryan, Samantha, Gasior, Maria, Anderson, Victoria E., Lavonas, Eric J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2017
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Agkistrodon; Animals; Antivenins - therapeutic use; Child; Crotalid Venoms - poisoning; Double-Blind Method; Emergency; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments - therapeutic use; Lower Extremity - injuries; Lower Extremity - physiopathology; Male; Middle Aged; Patient Outcome Assessment; Recovery of Function; Snake Bites - drug therapy; Snake Bites - physiopathology; Snake Bites - rehabilitation; United States; Upper Extremity - injuries; Upper Extremity - physiopathology; Young Adult

Copperhead snake (Agkistrodon contortrix) envenomation causes limb injury resulting in pain and disability. It is not known whether antivenom administration improves limb function. We determine whether administration of antivenom improves recovery from limb injury in patients envenomated by copperhe...