Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock

• Published in: Journal of Virology Vol. 86; no. 18; pp. 9888 - 9898
• Main Authors: RUDD, Penny A, WILSON, Jane, AKIRA, Shizuo, KHROMYKH, Alexander A, SUHRBIER, Andreas, GARDNER, Joy, LARCHER, Thibaut, BABARIT, Candice, LE, Thuy T, ANRAKU, Itaru, KUMAGAI, Yutaro, LOO, Yueh-Ming, GALE, Michael
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.09.2012
• Subjects: Adaptor Proteins, Vesicular Transport - deficiency; Adaptor Proteins, Vesicular Transport - genetics; Adaptor Proteins, Vesicular Transport - physiology; Alphavirus Infections - immunology; Alphavirus Infections - pathology; Alphavirus Infections - prevention & control; Animals; Biological and medical sciences; Chikungunya Fever; Chikungunya virus - immunology; Chikungunya virus - pathogenicity; Chikungunya virus - physiology; Fundamental and applied biological sciences. Psychology; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Interferon Regulatory Factor-3 - deficiency; Interferon Regulatory Factor-3 - genetics; Interferon Regulatory Factor-3 - physiology; Interferon Regulatory Factor-7 - deficiency; Interferon Regulatory Factor-7 - genetics; Interferon Regulatory Factor-7 - physiology; Interferon-alpha - biosynthesis; Interferon-alpha - pharmacology; Interferon-beta - biosynthesis; Life Sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiology; Miscellaneous; Myeloid Differentiation Factor 88 - deficiency; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - physiology; Pathogenesis and Immunity; Receptor, Interferon alpha-beta - deficiency; Receptor, Interferon alpha-beta - genetics; Receptor, Interferon alpha-beta - physiology; Santé publique et épidémiologie; Shock, Hemorrhagic - immunology; Shock, Hemorrhagic - prevention & control; Virology; Virus Replication - drug effects; Infection; Virus; Hemorrhagic fever; Viral disease; Arbovirus disease; Chikungunya virus; Togaviridae; Alphavirus; Interferon

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