Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock

Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virology Vol. 86; no. 18; pp. 9888 - 9898
Main Authors RUDD, Penny A, WILSON, Jane, AKIRA, Shizuo, KHROMYKH, Alexander A, SUHRBIER, Andreas, GARDNER, Joy, LARCHER, Thibaut, BABARIT, Candice, LE, Thuy T, ANRAKU, Itaru, KUMAGAI, Yutaro, LOO, Yueh-Ming, GALE, Michael
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.2012
Subjects
Adaptor Proteins, Vesicular Transport - deficiency
Adaptor Proteins, Vesicular Transport - genetics
Adaptor Proteins, Vesicular Transport - physiology
Alphavirus Infections - immunology
Alphavirus Infections - pathology
Alphavirus Infections - prevention & control
Animals
Biological and medical sciences
Chikungunya Fever
Chikungunya virus - immunology
Chikungunya virus - pathogenicity
Chikungunya virus - physiology
Fundamental and applied biological sciences. Psychology
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humans
Interferon Regulatory Factor-3 - deficiency
Interferon Regulatory Factor-3 - genetics
Interferon Regulatory Factor-3 - physiology
Interferon Regulatory Factor-7 - deficiency
Interferon Regulatory Factor-7 - genetics
Interferon Regulatory Factor-7 - physiology
Interferon-alpha - biosynthesis
Interferon-alpha - pharmacology
Interferon-beta - biosynthesis
Life Sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbiology
Miscellaneous
Myeloid Differentiation Factor 88 - deficiency
Myeloid Differentiation Factor 88 - genetics
Myeloid Differentiation Factor 88 - physiology
Pathogenesis and Immunity
Receptor, Interferon alpha-beta - deficiency
Receptor, Interferon alpha-beta - genetics
Receptor, Interferon alpha-beta - physiology
Santé publique et épidémiologie
Shock, Hemorrhagic - immunology
Shock, Hemorrhagic - prevention & control
Virology
Virus Replication - drug effects
Infection
Virus
Hemorrhagic fever
Viral disease
Arbovirus disease
Chikungunya virus
Togaviridae
Alphavirus
Interferon
Online AccessGet full text

Cover

Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we show that CHIKV infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon (IFN-alpha/beta) in serum, similar to 50- and similar to 10-fold increases in levels of IFN-gamma and tumor necrosis factor (TNF), respectively, increased virus replication, edema, vasculitis, hemorrhage, fever followed by hypothermia, oliguria, thrombocytopenia, and raised hematocrits. These features are consistent with hemorrhagic shock and were also evident in infected IFN-alpha/beta receptor-deficient mice. In situ hybridization suggested CHIKV infection of endothelium, fibroblasts, skeletal muscle, mononuclear cells, chondrocytes, and keratinocytes in IRF3/7(-/-) mice; all but the latter two stained positive in wild-type mice. Vaccination protected IRF3/7(-/-) mice, suggesting that defective antibody responses were not responsible for mortality. IPS-1- and TRIF-dependent pathways were primarily responsible for IFN-alpha/beta induction, with IRF7 being upregulated > 100-fold in infected wild-type mice. These studies suggest that inadequate IFN-alpha/beta responses following virus infection can be sufficient to induce hemorrhagic fever and shock, a finding with implications for understanding severe CHIKV disease and dengue hemorrhagic fever/dengue shock syndrome.
Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we show that CHIKV infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7 −/− ) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon (IFN-α/β) in serum, ∼50- and ∼10-fold increases in levels of IFN-γ and tumor necrosis factor (TNF), respectively, increased virus replication, edema, vasculitis, hemorrhage, fever followed by hypothermia, oliguria, thrombocytopenia, and raised hematocrits. These features are consistent with hemorrhagic shock and were also evident in infected IFN-α/β receptor-deficient mice. In situ hybridization suggested CHIKV infection of endothelium, fibroblasts, skeletal muscle, mononuclear cells, chondrocytes, and keratinocytes in IRF3/7 −/− mice; all but the latter two stained positive in wild-type mice. Vaccination protected IRF3/7 −/− mice, suggesting that defective antibody responses were not responsible for mortality. IPS-1- and TRIF-dependent pathways were primarily responsible for IFN-α/β induction, with IRF7 being upregulated >100-fold in infected wild-type mice. These studies suggest that inadequate IFN-α/β responses following virus infection can be sufficient to induce hemorrhagic fever and shock, a finding with implications for understanding severe CHIKV disease and dengue hemorrhagic fever/dengue shock syndrome.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we show that CHIKV infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon (IFN-α/β) in serum, ∼50- and ∼10-fold increases in levels of IFN-γ and tumor necrosis factor (TNF), respectively, increased virus replication, edema, vasculitis, hemorrhage, fever followed by hypothermia, oliguria, thrombocytopenia, and raised hematocrits. These features are consistent with hemorrhagic shock and were also evident in infected IFN-α/β receptor-deficient mice. In situ hybridization suggested CHIKV infection of endothelium, fibroblasts, skeletal muscle, mononuclear cells, chondrocytes, and keratinocytes in IRF3/7(-/-) mice; all but the latter two stained positive in wild-type mice. Vaccination protected IRF3/7(-/-) mice, suggesting that defective antibody responses were not responsible for mortality. IPS-1- and TRIF-dependent pathways were primarily responsible for IFN-α/β induction, with IRF7 being upregulated >100-fold in infected wild-type mice. These studies suggest that inadequate IFN-α/β responses following virus infection can be sufficient to induce hemorrhagic fever and shock, a finding with implications for understanding severe CHIKV disease and dengue hemorrhagic fever/dengue shock syndrome.
Author Yueh-Ming Loo
Candice Babarit
Joy Gardner
Thuy T. Le
Yutaro Kumagai
Penny A. Rudd
Thibaut Larcher
Michael Gale Jr
Jane Wilson
Shizuo Akira
Alexander A. Khromykh
Itaru Anraku
Andreas Suhrbier
Author_xml – sequence: 1
  givenname: Penny A
  surname: RUDD
  fullname: RUDD, Penny A
  organization: Queensland Institute of Medical Research, Brisbane, Queensland, Australia
– sequence: 2
  givenname: Jane
  surname: WILSON
  fullname: WILSON, Jane
  organization: Queensland Institute of Medical Research, Brisbane, Queensland, Australia
– sequence: 3
  givenname: Shizuo
  surname: AKIRA
  fullname: AKIRA, Shizuo
  organization: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
– sequence: 4
  givenname: Alexander A
  surname: KHROMYKH
  fullname: KHROMYKH, Alexander A
  organization: Australian Infectious Diseases Research Centre, School of Chemistry & Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia
– sequence: 5
  givenname: Andreas
  surname: SUHRBIER
  fullname: SUHRBIER, Andreas
  organization: Queensland Institute of Medical Research, Brisbane, Queensland, Australia
– sequence: 6
  givenname: Joy
  surname: GARDNER
  fullname: GARDNER, Joy
  organization: Queensland Institute of Medical Research, Brisbane, Queensland, Australia
– sequence: 7
  givenname: Thibaut
  surname: LARCHER
  fullname: LARCHER, Thibaut
  organization: Institut National de Recherche Agronomique, Unité Mixte de Recherche 703, Ecole Nationale Vétérinaire, Nantes, France
– sequence: 8
  givenname: Candice
  surname: BABARIT
  fullname: BABARIT, Candice
  organization: Institut National de Recherche Agronomique, Unité Mixte de Recherche 703, Ecole Nationale Vétérinaire, Nantes, France
– sequence: 9
  givenname: Thuy T
  surname: LE
  fullname: LE, Thuy T
  organization: Queensland Institute of Medical Research, Brisbane, Queensland, Australia
– sequence: 10
  givenname: Itaru
  surname: ANRAKU
  fullname: ANRAKU, Itaru
  organization: Queensland Institute of Medical Research, Brisbane, Queensland, Australia
– sequence: 11
  givenname: Yutaro
  surname: KUMAGAI
  fullname: KUMAGAI, Yutaro
  organization: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
– sequence: 12
  givenname: Yueh-Ming
  surname: LOO
  fullname: LOO, Yueh-Ming
  organization: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States
– sequence: 13
  givenname: Michael
  surname: GALE
  fullname: GALE, Michael
  organization: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26325427$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22761364$$D View this record in MEDLINE/PubMed
https://hal.science/hal-01191139$$DView record in HAL
BookMark eNpdkUtrGzEUhUVJaZy0u66LKHRR6KS6kkaj2RSCqWsXQ0sfoTuh0WhmlNiSkcYO-feRYzd9rARX3zk6V-cMnfjgLUIvgVwAUPn-89XigpC6FAXQJ2gCpJZFWQI_QRNCKC1KJn-dorOUrgkBzgV_hk4prQQwwSdIL_xoY2dj8PibTZvgk8UzbcYQE2ZY-xZX-GsMozUj1r12Po14Oribre-3_k7jKxe3Cc_tOsQ46N4ZPLM7Gx-U34dgbp6jp51eJfvieJ6jn7OPP6bzYvnl02J6uSxMyWEsNGOsAWbatpJCVNJyIwSIRgrbNCIPKTRtJfKeUpBad0baWrYlE5TWvDWEnaMPB9_Ntlnb1lg_Rr1Sm-jWOt6poJ3698a7QfVhp1j-lFJW2eDtwWD4Tza_XKr9jADUAKzeQWbfHVgTQ0rRdo8CIGpfi8q1qIdaFNCMv_o72yP8u4cMvDkCOhm96qL2xqU_nGC05HSf8fUxo-uHWxet0mmtrndOyfyQVLWUkt0DpKqiYg
CitedBy_id crossref_primary_10_1016_j_virol_2014_06_023
crossref_primary_10_1128_jvi_01601_22
crossref_primary_10_2217_fvl_15_107
crossref_primary_10_1016_j_jneuroim_2017_12_018
crossref_primary_10_1099_jgv_0_000002
crossref_primary_10_3389_fmed_2022_654395
crossref_primary_10_1371_journal_pone_0139481
crossref_primary_10_1128_JVI_00872_19
crossref_primary_10_1007_s12250_017_4072_x
crossref_primary_10_1128_JVI_01913_17
crossref_primary_10_1099_vir_0_071845_0
crossref_primary_10_1128_JVI_01143_21
crossref_primary_10_1186_s13071_016_1838_1
crossref_primary_10_1038_s41435_020_00116_2
crossref_primary_10_3390_v10050235
crossref_primary_10_1172_jci_insight_121100
crossref_primary_10_1128_JVI_01538_20
crossref_primary_10_15252_emmm_201404459
crossref_primary_10_1016_j_jaci_2015_01_039
crossref_primary_10_1371_journal_pone_0107141
crossref_primary_10_1128_JVI_01403_13
crossref_primary_10_3389_fimmu_2022_1092370
crossref_primary_10_1016_j_scitotenv_2022_160163
crossref_primary_10_1093_infdis_jiu114
crossref_primary_10_1099_jgv_0_000263
crossref_primary_10_1016_j_clim_2013_10_004
crossref_primary_10_2139_ssrn_4181455
crossref_primary_10_3389_fimmu_2019_03083
crossref_primary_10_1016_j_berh_2020_101502
crossref_primary_10_15212_ZOONOSES_2022_0028
crossref_primary_10_1016_j_cell_2020_06_029
crossref_primary_10_1242_dmm_049804
crossref_primary_10_1371_journal_ppat_1009215
crossref_primary_10_1016_j_vaccine_2015_07_099
crossref_primary_10_1089_vim_2021_0171
crossref_primary_10_3390_v11020175
crossref_primary_10_1016_j_coviro_2017_11_006
crossref_primary_10_1371_journal_ppat_1003118
crossref_primary_10_1371_journal_ppat_1006748
crossref_primary_10_3389_fimmu_2020_00592
crossref_primary_10_3390_v15091869
crossref_primary_10_1002_art_34631
crossref_primary_10_1016_j_ajpath_2014_02_026
crossref_primary_10_1371_journal_pntd_0003354
crossref_primary_10_1089_vbz_2014_1710
crossref_primary_10_3390_ijms241310517
crossref_primary_10_1172_JCI84417
crossref_primary_10_1016_j_antiviral_2013_06_009
crossref_primary_10_1128_JVI_01545_14
crossref_primary_10_3390_cells10061324
crossref_primary_10_1038_s44298_024_00025_5
crossref_primary_10_1099_jgv_0_000992
crossref_primary_10_1146_annurev_immunol_101220_014952
crossref_primary_10_1371_journal_ppat_1003619
crossref_primary_10_3389_fimmu_2020_00695
crossref_primary_10_1002_art_40403
crossref_primary_10_1007_s00335_018_9776_1
crossref_primary_10_1093_infdis_jiw284
crossref_primary_10_1128_JVI_01788_19
crossref_primary_10_3389_fpubh_2020_618624
crossref_primary_10_1016_S1473_3099_16_30385_1
crossref_primary_10_1099_jgv_0_001174
crossref_primary_10_3390_v15010048
crossref_primary_10_4049_jimmunol_1401833
crossref_primary_10_1016_j_antiviral_2015_07_002
crossref_primary_10_4049_jimmunol_1300304
crossref_primary_10_1126_scitranslmed_aax7888
crossref_primary_10_3390_tropicalmed8070365
crossref_primary_10_1128_mSphereDirect_00190_17
crossref_primary_10_1556_avet_2014_023
crossref_primary_10_1016_j_virol_2016_01_009
crossref_primary_10_3389_fimmu_2020_588382
crossref_primary_10_1016_j_actatropica_2022_106705
crossref_primary_10_3389_fimmu_2019_02736
crossref_primary_10_1128_mbio_02687_22
crossref_primary_10_3390_v11060578
crossref_primary_10_1016_j_cmrp_2019_03_006
crossref_primary_10_1016_j_virol_2014_11_013
crossref_primary_10_1038_s42003_020_01285_6
crossref_primary_10_1371_journal_pntd_0002124
crossref_primary_10_3390_v12111252
crossref_primary_10_1371_journal_ppat_1007880
crossref_primary_10_4049_jimmunol_1300799
crossref_primary_10_3390_v11100961
crossref_primary_10_1128_JVI_02609_13
crossref_primary_10_3389_fimmu_2017_00493
crossref_primary_10_1089_vim_2017_0052
crossref_primary_10_1146_annurev_virology_101416_041808
crossref_primary_10_1371_journal_ppat_1006155
crossref_primary_10_1371_journal_ppat_1008292
crossref_primary_10_1016_j_xcrm_2023_101024
crossref_primary_10_1016_j_celrep_2017_10_054
crossref_primary_10_3390_vaccines8020209
crossref_primary_10_3389_fcimb_2020_00407
crossref_primary_10_3390_v10020086
crossref_primary_10_1128_JVI_03364_13
crossref_primary_10_1128_JVI_01032_14
crossref_primary_10_1371_journal_pone_0241592
crossref_primary_10_3389_fimmu_2020_606874
crossref_primary_10_1016_j_vaccine_2013_05_086
crossref_primary_10_1128_mSphere_00209_18
crossref_primary_10_1128_JVI_00816_17
crossref_primary_10_1016_j_micpath_2019_103581
crossref_primary_10_1371_journal_ppat_1006427
crossref_primary_10_3390_pathogens10060771
crossref_primary_10_1155_2013_973516
crossref_primary_10_1371_journal_ppat_1006788
crossref_primary_10_7554_eLife_34273
crossref_primary_10_1038_s41584_019_0276_9
crossref_primary_10_1128_JVI_01122_21
crossref_primary_10_1016_j_virol_2017_08_009
crossref_primary_10_3389_fimmu_2023_1281667
crossref_primary_10_1016_j_cub_2020_08_044
crossref_primary_10_1128_JVI_00841_19
crossref_primary_10_3390_v11030290
crossref_primary_10_1016_j_antiviral_2015_06_009
crossref_primary_10_3390_v13030377
crossref_primary_10_3390_pathogens9100848
crossref_primary_10_3390_vaccines7010022
crossref_primary_10_1186_s12964_023_01392_x
crossref_primary_10_1371_journal_pone_0155243
crossref_primary_10_1016_j_dci_2013_06_002
crossref_primary_10_1128_JVI_00909_15
crossref_primary_10_1128_JVI_03418_13
crossref_primary_10_1093_infdis_jiaa364
crossref_primary_10_1080_21645515_2015_1101197
crossref_primary_10_1128_mbio_03363_21
crossref_primary_10_1016_j_matcom_2016_12_011
crossref_primary_10_1016_j_micinf_2017_07_001
crossref_primary_10_1111_1756_185X_13273
crossref_primary_10_1128_spectrum_05371_22
crossref_primary_10_1128_JVI_01866_14
crossref_primary_10_4049_jimmunol_1601426
Cites_doi 10.1016/S1471-4906(03)00065-6
10.4049/jimmunol.0900255
10.1074/jbc.M411569200
10.1016/S0021-9150(99)00021-0
10.1007/BF01314622
10.1074/jbc.272.12.8050
10.1128/JVI.74.19.9294-9299.2000
10.1016/0166-0934(94)00136-5
10.1126/science.1087262
10.1086/512162
10.1128/JVI.05008-11
10.1099/vir.0.82093-0
10.1097/QCO.0b013e32833c1d16
10.1016/j.immuni.2008.11.012
10.2353/ajpath.2009.090328
10.4049/jimmunol.169.8.4279
10.1111/j.1365-4632.2010.04644.x
10.1128/JVI.00949-10
10.4049/jimmunol.1103185
10.1016/j.meegid.2011.06.009
10.1128/JVI.02133-10
10.1002/eji.200737760
10.1038/sj.icb.7100008
10.1177/0883073808314151
10.1186/ar3221
10.4269/ajtmh.1968.17.107
10.4049/jimmunol.0904181
10.1007/s00011-011-0364-z
10.1128/JVI.00232-11
10.1371/journal.pmed.0050060
10.1016/S0014-5793(98)01514-2
10.1371/journal.ppat.1000607
10.1038/nri2075
10.1016/S1473-3099(10)70166-3
10.1084/jem.20090851
10.1161/CIRCRESAHA.111.243246
10.1128/JVI.80.2.737-749.2006
10.1038/nrmicro2368
10.1016/S1074-7613(00)00053-4
10.1038/nature03464
10.1172/JCI40104
10.4269/ajtmh.1969.18.954
10.1086/315164
10.1099/0022-1317-65-2-377
10.4049/jimmunol.0900205
10.1084/jem.20091746
10.1038/nrrheum.2012.64
10.1093/emboj/17.22.6660
10.1046/j.0022-202X.2003.22113.x
10.1038/nature03326
10.1128/JVI.02603-09
10.1002/jlb.66.3.489
10.1128/IAI.01176-10
10.4049/jimmunol.0902947
10.1073/pnas.94.2.634
10.1371/journal.pone.0000527
10.1371/journal.ppat.0030089
10.1084/jem.20060792
10.1097/INF.0b013e3181bc3c5b
10.1128/JVI.00767-10
10.5580/647
10.1086/501355
10.1128/JVI.01224-10
ContentType Journal Article
Copyright 2015 INIST-CNRS
Distributed under a Creative Commons Attribution 4.0 International License
Copyright © 2012, American Society for Microbiology. All Rights Reserved. 2012 American Society for Microbiology
Copyright_xml – notice: 2015 INIST-CNRS
– notice: Distributed under a Creative Commons Attribution 4.0 International License
– notice: Copyright © 2012, American Society for Microbiology. All Rights Reserved. 2012 American Society for Microbiology
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
1XC
VOOES
5PM
DOI 10.1128/JVI.00956-12
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
DatabaseTitleList

CrossRef

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5514
EndPage 9898
ExternalDocumentID oai_HAL_hal_01191139v1
10_1128_JVI_00956_12
22761364
26325427
jvi_86_18_9888
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Canadian Institutes of Health Research
GroupedDBID ---
-~X
.55
.GJ
08R
0R~
18M
29L
2WC
39C
3O-
4.4
41~
53G
5GY
5RE
5VS
6TJ
85S
AAUGY
AAYJJ
ABPPZ
ABPTK
ACGFO
ACNCT
ADBBV
AENEX
AFDAS
AFFNX
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CS3
D0S
DIK
E3Z
EBS
EJD
F20
F5P
FRP
GX1
H13
HYE
HZ~
IH2
IQODW
KQ8
MVM
N9A
O9-
OHT
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TR2
UCJ
UPT
VH1
W2D
W8F
WH7
WOQ
X7M
XFK
Y6R
YQT
ZA5
ZGI
ZXP
~02
~KM
AGVNZ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
1XC
VOOES
5PM
ID FETCH-LOGICAL-c541t-a333b13cdd786678e4c6616b86ebb6d7821bd769568609afc8e98d5362294dc03
IEDL.DBID RPM
ISSN 0022-538X
IngestDate Tue Sep 17 21:08:48 EDT 2024
Tue Oct 15 15:36:20 EDT 2024
Fri Dec 06 02:32:07 EST 2024
Sat Sep 28 07:54:04 EDT 2024
Sun Oct 22 16:04:02 EDT 2023
Wed May 18 15:26:08 EDT 2016
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 18
Keywords Infection
Virus
Hemorrhagic fever
Viral disease
Arbovirus disease
Chikungunya virus
Togaviridae
Alphavirus
Interferon
Language English
License CC BY 4.0
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c541t-a333b13cdd786678e4c6616b86ebb6d7821bd769568609afc8e98d5362294dc03
ORCID 0000-0002-0396-3190
OpenAccessLink https://hal.science/hal-01191139
PMID 22761364
PageCount 11
ParticipantIDs hal_primary_oai_HAL_hal_01191139v1
highwire_asm_jvi_86_18_9888
pubmed_primary_22761364
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3446587
crossref_primary_10_1128_JVI_00956_12
pascalfrancis_primary_26325427
PublicationCentury 2000
PublicationDate 2012-09-01
PublicationDateYYYYMMDD 2012-09-01
PublicationDate_xml – month: 09
  year: 2012
  text: 2012-09-01
  day: 01
PublicationDecade 2010
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
– name: 1752 N St., N.W., Washington, DC
PublicationTitle Journal of Virology
PublicationTitleAlternate J Virol
PublicationYear 2012
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References 5355242 - Am J Trop Med Hyg. 1969 Nov;18(6):954-71
20404274 - J Immunol. 2010 May 15;184(10):5903-13
11070172 - Immunity. 2000 Oct;13(4):539-48
15546885 - J Biol Chem. 2005 Feb 11;280(6):4037-47
20179353 - J Clin Invest. 2010 Mar;120(3):894-906
17357045 - J Infect Dis. 2007 Apr 15;195(8):1097-107
18287573 - J Child Neurol. 2008 Sep;23(9):1028-35
21223583 - Arthritis Res Ther. 2011;13(1):R3
19200759 - Immunity. 2009 Feb 20;30(2):242-53
10608747 - J Infect Dis. 2000 Jan;181(1):27-34
19802576 - Curr Top Microbiol Immunol. 2010;338:35-44
20551973 - Nat Rev Microbiol. 2010 Jul;8(7):491-500
5849867 - Indian J Med Res. 1965 Oct;53(10):921-5
20123960 - J Exp Med. 2010 Feb 15;207(2):429-42
22565316 - Nat Rev Rheumatol. 2012 Jul;8(7):420-9
20519386 - J Virol. 2010 Aug;84(16):8021-32
16785313 - J Exp Med. 2006 Jul 10;203(7):1795-803
5637015 - Am J Trop Med Hyg. 1968 Jan;17(1):107-11
10428302 - Atherosclerosis. 1999 Jul;145(1):115-23
19620305 - J Immunol. 2009 Aug 15;183(4):2810-7
21182504 - Int J Dermatol. 2011 Jan;50(1):61-9
19802579 - Curr Top Microbiol Immunol. 2010;338:67-82
12855817 - Science. 2003 Aug 1;301(5633):640-3
4282477 - Bull World Health Organ. 1974;51(3):227-35
20883967 - Lancet Infect Dis. 2010 Oct;10(10):712-22
16378976 - J Virol. 2006 Jan;80(2):737-49
9012836 - Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):634-9
15711573 - Nature. 2005 Feb 24;433(7028):887-92
20404278 - J Immunol. 2010 May 15;184(10):5914-27
15800576 - Nature. 2005 Apr 7;434(7034):772-7
10496320 - J Leukoc Biol. 1999 Sep;66(3):489-94
9822609 - EMBO J. 1998 Nov 16;17(22):6660-9
20962078 - J Virol. 2011 Jan;85(1):606-20
18200500 - Eur J Immunol. 2008 Feb;38(2):507-17
20032806 - Pediatr Infect Dis J. 2010 Mar;29(3):238-42
16597286 - Crit Care Resusc. 2000 Mar;2(1):66-84
9065478 - J Biol Chem. 1997 Mar 21;272(12):8050-6
20154210 - J Immunol. 2010 Mar 15;184(6):3072-8
21411525 - J Virol. 2011 Jun;85(11):5664-8
12697441 - Trends Immunol. 2003 Apr;24(4):165-8
22371392 - J Immunol. 2012 Apr 1;188(7):2967-71
17130899 - Immunol Cell Biol. 2007 Jan;85(1):43-5
21307205 - J Virol. 2011 Apr;85(8):3708-16
17098977 - J Gen Virol. 2006 Dec;87(Pt 12):3623-30
20686047 - J Virol. 2010 Oct;84(20):10877-87
16586382 - Clin Infect Dis. 2006 May 1;42(9):1241-6
9877175 - FEBS Lett. 1998 Dec 11;441(1):106-10
14962089 - J Invest Dermatol. 2004 Jan;122(1):51-60
20943967 - J Virol. 2010 Dec;84(24):12982-94
21402764 - Infect Immun. 2011 May;79(5):2112-9
12370359 - J Immunol. 2002 Oct 15;169(8):4279-87
1571018 - Arch Virol. 1992;124(1-2):21-30
20581669 - Curr Opin Infect Dis. 2010 Oct;23(5):438-44
10982376 - J Virol. 2000 Oct;74(19):9294-9
7539444 - J Virol Methods. 1995 Mar;52(1-2):51-4
20123961 - J Exp Med. 2010 Feb 15;207(2):327-37
17604450 - PLoS Pathog. 2007 Jun;3(6):e89
17565380 - PLoS One. 2007;2(6):e527
18695288 - Indian Pediatr. 2008 Jul;45(7):605
21847628 - Inflamm Res. 2011 Nov;60(11):1031-7
6319580 - J Gen Virol. 1984 Feb;65 ( Pt 2):377-90
21722754 - Infect Genet Evol. 2011 Oct;11(7):1664-73
21734047 - J Virol. 2011 Sep;85(18):9478-85
19798431 - PLoS Pathog. 2009 Oct;5(10):e1000607
18351797 - PLoS Med. 2008 Mar 18;5(3):e60
21493895 - Circ Res. 2011 May 27;108(11):1358-66
19808647 - Am J Pathol. 2009 Nov;175(5):2023-33
17457344 - Nat Rev Immunol. 2007 May;7(5):379-90
e_1_3_3_50_2
e_1_3_3_71_2
Sarkar JK (e_1_3_3_48_2) 1965; 53
e_1_3_3_16_2
Teik OC (e_1_3_3_62_2) 2001; 25
e_1_3_3_18_2
e_1_3_3_39_2
e_1_3_3_12_2
e_1_3_3_58_2
e_1_3_3_14_2
e_1_3_3_35_2
e_1_3_3_56_2
e_1_3_3_33_2
e_1_3_3_54_2
e_1_3_3_10_2
e_1_3_3_31_2
e_1_3_3_52_2
e_1_3_3_40_2
e_1_3_3_61_2
Nair PM (e_1_3_3_38_2) 2008; 45
Khai Ming C (e_1_3_3_25_2) 1974; 51
Srikiatkhachorn A (e_1_3_3_57_2) 2010; 338
e_1_3_3_5_2
e_1_3_3_7_2
e_1_3_3_9_2
e_1_3_3_27_2
e_1_3_3_29_2
e_1_3_3_23_2
e_1_3_3_69_2
e_1_3_3_46_2
e_1_3_3_67_2
e_1_3_3_44_2
e_1_3_3_65_2
e_1_3_3_3_2
e_1_3_3_21_2
e_1_3_3_42_2
e_1_3_3_63_2
e_1_3_3_51_2
e_1_3_3_70_2
e_1_3_3_17_2
e_1_3_3_19_2
e_1_3_3_13_2
e_1_3_3_36_2
e_1_3_3_59_2
e_1_3_3_15_2
e_1_3_3_34_2
e_1_3_3_32_2
e_1_3_3_55_2
e_1_3_3_11_2
e_1_3_3_30_2
e_1_3_3_53_2
e_1_3_3_60_2
e_1_3_3_6_2
e_1_3_3_8_2
e_1_3_3_28_2
e_1_3_3_49_2
e_1_3_3_24_2
e_1_3_3_47_2
e_1_3_3_26_2
e_1_3_3_45_2
Worthley LI (e_1_3_3_68_2) 2000; 2
e_1_3_3_2_2
e_1_3_3_20_2
Munoz-Jordan JL (e_1_3_3_37_2) 2010; 338
e_1_3_3_43_2
Weber C (e_1_3_3_66_2) 1999; 145
e_1_3_3_4_2
e_1_3_3_22_2
e_1_3_3_41_2
e_1_3_3_64_2
References_xml – ident: e_1_3_3_59_2
  doi: 10.1016/S1471-4906(03)00065-6
– ident: e_1_3_3_22_2
  doi: 10.4049/jimmunol.0900255
– ident: e_1_3_3_24_2
  doi: 10.1074/jbc.M411569200
– volume: 145
  start-page: 115
  year: 1999
  ident: e_1_3_3_66_2
  article-title: Downregulation by tumor necrosis factor-alpha of monocyte CCR2 expression and monocyte chemotactic protein-1-induced transendothelial migration is antagonized by oxidized low-density lipoprotein: a potential mechanism of monocyte retention in atherosclerotic lesions
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(99)00021-0
  contributor:
    fullname: Weber C
– ident: e_1_3_3_27_2
  doi: 10.1007/BF01314622
– ident: e_1_3_3_61_2
  doi: 10.1074/jbc.272.12.8050
– volume: 51
  start-page: 227
  year: 1974
  ident: e_1_3_3_25_2
  article-title: Clinical and laboratory studies on haemorrhagic fever in Burma, 1970–72
  publication-title: Bull. World Health Organ.
  contributor:
    fullname: Khai Ming C
– ident: e_1_3_3_19_2
  doi: 10.1128/JVI.74.19.9294-9299.2000
– ident: e_1_3_3_29_2
  doi: 10.1016/0166-0934(94)00136-5
– ident: e_1_3_3_69_2
  doi: 10.1126/science.1087262
– ident: e_1_3_3_55_2
  doi: 10.1086/512162
– ident: e_1_3_3_12_2
  doi: 10.1128/JVI.05008-11
– ident: e_1_3_3_31_2
  doi: 10.1099/vir.0.82093-0
– ident: e_1_3_3_6_2
  doi: 10.1097/QCO.0b013e32833c1d16
– ident: e_1_3_3_63_2
  doi: 10.1016/j.immuni.2008.11.012
– ident: e_1_3_3_30_2
  doi: 10.2353/ajpath.2009.090328
– ident: e_1_3_3_39_2
  doi: 10.4049/jimmunol.169.8.4279
– ident: e_1_3_3_42_2
  doi: 10.1111/j.1365-4632.2010.04644.x
– ident: e_1_3_3_15_2
  doi: 10.1128/JVI.00949-10
– ident: e_1_3_3_51_2
  doi: 10.4049/jimmunol.1103185
– ident: e_1_3_3_60_2
  doi: 10.1016/j.meegid.2011.06.009
– ident: e_1_3_3_5_2
  doi: 10.1128/JVI.02133-10
– ident: e_1_3_3_13_2
  doi: 10.1002/eji.200737760
– volume: 338
  start-page: 67
  year: 2010
  ident: e_1_3_3_57_2
  article-title: Markers of dengue disease severity
  publication-title: Curr. Top. Microbiol. Immunol.
  contributor:
    fullname: Srikiatkhachorn A
– ident: e_1_3_3_43_2
  doi: 10.1038/sj.icb.7100008
– volume: 338
  start-page: 35
  year: 2010
  ident: e_1_3_3_37_2
  article-title: Subversion of interferon by dengue virus
  publication-title: Curr. Top. Microbiol. Immunol.
  contributor:
    fullname: Munoz-Jordan JL
– ident: e_1_3_3_46_2
  doi: 10.1177/0883073808314151
– ident: e_1_3_3_2_2
  doi: 10.1186/ar3221
– ident: e_1_3_3_14_2
  doi: 10.4269/ajtmh.1968.17.107
– ident: e_1_3_3_20_2
  doi: 10.4049/jimmunol.0904181
– ident: e_1_3_3_70_2
  doi: 10.1007/s00011-011-0364-z
– ident: e_1_3_3_10_2
  doi: 10.1128/JVI.00232-11
– ident: e_1_3_3_17_2
  doi: 10.1371/journal.pmed.0050060
– ident: e_1_3_3_49_2
  doi: 10.1016/S0014-5793(98)01514-2
– volume: 25
  start-page: 45
  year: 2001
  ident: e_1_3_3_62_2
  article-title: A guide to DHF/DSS management—the Singapore experience
  publication-title: Dengue Bull.
  contributor:
    fullname: Teik OC
– ident: e_1_3_3_11_2
  doi: 10.1371/journal.ppat.1000607
– ident: e_1_3_3_32_2
  doi: 10.1038/nri2075
– ident: e_1_3_3_18_2
  doi: 10.1016/S1473-3099(10)70166-3
– ident: e_1_3_3_52_2
  doi: 10.1084/jem.20090851
– ident: e_1_3_3_71_2
  doi: 10.1161/CIRCRESAHA.111.243246
– ident: e_1_3_3_35_2
  doi: 10.1128/JVI.80.2.737-749.2006
– ident: e_1_3_3_54_2
  doi: 10.1038/nrmicro2368
– ident: e_1_3_3_50_2
  doi: 10.1016/S1074-7613(00)00053-4
– ident: e_1_3_3_23_2
  doi: 10.1038/nature03464
– ident: e_1_3_3_28_2
  doi: 10.1172/JCI40104
– ident: e_1_3_3_40_2
  doi: 10.4269/ajtmh.1969.18.954
– ident: e_1_3_3_33_2
  doi: 10.1086/315164
– volume: 2
  start-page: 66
  year: 2000
  ident: e_1_3_3_68_2
  article-title: Shock: a review of pathophysiology and management
  publication-title: Part II. Crit. Care Resusc.
  contributor:
    fullname: Worthley LI
– ident: e_1_3_3_36_2
  doi: 10.1099/0022-1317-65-2-377
– ident: e_1_3_3_9_2
  doi: 10.4049/jimmunol.0900205
– ident: e_1_3_3_44_2
  doi: 10.1084/jem.20091746
– ident: e_1_3_3_58_2
  doi: 10.1038/nrrheum.2012.64
– ident: e_1_3_3_34_2
  doi: 10.1093/emboj/17.22.6660
– ident: e_1_3_3_64_2
  doi: 10.1046/j.0022-202X.2003.22113.x
– volume: 53
  start-page: 921
  year: 1965
  ident: e_1_3_3_48_2
  article-title: Chikungunya virus infection with haemorrhagic manifestations
  publication-title: Indian J. Med. Res.
  contributor:
    fullname: Sarkar JK
– ident: e_1_3_3_53_2
  doi: 10.1038/nature03326
– ident: e_1_3_3_16_2
  doi: 10.1128/JVI.02603-09
– ident: e_1_3_3_65_2
  doi: 10.1002/jlb.66.3.489
– ident: e_1_3_3_7_2
  doi: 10.1128/IAI.01176-10
– ident: e_1_3_3_4_2
  doi: 10.4049/jimmunol.0902947
– ident: e_1_3_3_8_2
  doi: 10.1073/pnas.94.2.634
– ident: e_1_3_3_41_2
  doi: 10.1371/journal.pone.0000527
– volume: 45
  start-page: 605
  year: 2008
  ident: e_1_3_3_38_2
  article-title: Correspondence; Chikungunya in neonates
  publication-title: Indian Pediatr.
  contributor:
    fullname: Nair PM
– ident: e_1_3_3_56_2
  doi: 10.1371/journal.ppat.0030089
– ident: e_1_3_3_26_2
  doi: 10.1084/jem.20060792
– ident: e_1_3_3_47_2
  doi: 10.1097/INF.0b013e3181bc3c5b
– ident: e_1_3_3_67_2
  doi: 10.1128/JVI.00767-10
– ident: e_1_3_3_3_2
  doi: 10.5580/647
– ident: e_1_3_3_45_2
  doi: 10.1086/501355
– ident: e_1_3_3_21_2
  doi: 10.1128/JVI.01224-10
SSID ssj0014464
Score 2.499867
Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we show that CHIKV infection of adult mice deficient in interferon response...
SourceID pubmedcentral
hal
crossref
pubmed
pascalfrancis
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 9888
SubjectTerms Adaptor Proteins, Vesicular Transport - deficiency
Adaptor Proteins, Vesicular Transport - genetics
Adaptor Proteins, Vesicular Transport - physiology
Alphavirus Infections - immunology
Alphavirus Infections - pathology
Alphavirus Infections - prevention & control
Animals
Biological and medical sciences
Chikungunya Fever
Chikungunya virus - immunology
Chikungunya virus - pathogenicity
Chikungunya virus - physiology
Fundamental and applied biological sciences. Psychology
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humans
Interferon Regulatory Factor-3 - deficiency
Interferon Regulatory Factor-3 - genetics
Interferon Regulatory Factor-3 - physiology
Interferon Regulatory Factor-7 - deficiency
Interferon Regulatory Factor-7 - genetics
Interferon Regulatory Factor-7 - physiology
Interferon-alpha - biosynthesis
Interferon-alpha - pharmacology
Interferon-beta - biosynthesis
Life Sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbiology
Miscellaneous
Myeloid Differentiation Factor 88 - deficiency
Myeloid Differentiation Factor 88 - genetics
Myeloid Differentiation Factor 88 - physiology
Pathogenesis and Immunity
Receptor, Interferon alpha-beta - deficiency
Receptor, Interferon alpha-beta - genetics
Receptor, Interferon alpha-beta - physiology
Santé publique et épidémiologie
Shock, Hemorrhagic - immunology
Shock, Hemorrhagic - prevention & control
Virology
Virus Replication - drug effects
Title Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock
URI http://jvi.asm.org/content/86/18/9888.abstract
https://www.ncbi.nlm.nih.gov/pubmed/22761364
https://hal.science/hal-01191139
https://pubmed.ncbi.nlm.nih.gov/PMC3446587
Volume 86
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwELVYpEq9VNDPAF1ZiB6zm9iO4xzRqquFAkJtQXuz7NghadmA9gOJf884Trbk2mtsR5Zn7DeTPL9B6IQYAD1LeJhqSFEYVQb2XKrDBGJxnimVs8LdHb684rMbdj5P5jso6e7CNKT9XFej-n4xqquy4VY-LvJxxxMbX19OqFP5Eul4gAYAv12K3v46gDbWSYTDbp53bHcixue3Z6PIK--5KjaEQA5POetB0qB0hMitWLDjSqoVLFfh61y8Aqo-ifIVKk330Ls2nMSnftr7aMfW79EbX2Dy-QNSzQe_wi4favzTs2EtnvoSO5hiVRuc4msv1YDVnaogWMSTsvoLR8Cmflb4tlpuVnjm6LjLUsEpiacWnL8Z-auEs_Qjupl-_z2ZhW1RhTBPWLwOFaVUxzQ3JhUckMqyHCCaa8Gt1hwekliblLtbhDzKVJELmwmTAM6RjJk8op_Qbv1Q2y8IJ4oSw1mkY10wpq02hESkEAWLLWR9JEDfunWVj147QzY5BxESTCEbU8gY-h3Dom-7OMHr2emFdM-cIl0MQepTHKDDziZSrRbyz1MlBYwWMoMkPkDDnpm2L3Ny9AkjaYA-e3P9a2mtH6C0Z8jePPot4I-NAHfrfwf_PfIQvYXAi3iu2hHaXS839isEN2s9hLD-7MewcekX2Nv4JA
link.rule.ids 230,314,727,780,784,885,27924,27925,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELXaIgQXxDehUCwEx-wmtuM4x2rFKi27VQVttTfLjp0mwKbVflTqv2ccJ0tz5RrbkeU39swkz28Q-kIMOD1LeJhqSFEYVQb2XKrDBGJxnilVsNLdHZ6f8fySnS6SxR5K-rswLWm_0PWo-bMcNXXVcitvl8W454mNz-cT6lS-RDreR48SmmZxn6R3Pw-glfUi4bCfFz3fnYjx6dXJKPLae66ODSGQxVPOBk5pv3KUyJ1csGNLqjUsWOkrXTxwVUMa5QO_NH2OnnUBJT72E3-B9mzzEj32JSbvXyHVfvIr7eqmwT88H9biqS-ygylWjcEpPvdiDVhdqxrCRTyp6t9wCGybe4Wv6tV2jXNHyF1VCs5JPLVg_u3InxWcpq_R5fTbxSQPu7IKYZGweBMqSqmOaWFMKjj4KssKcNJcC2615vCQxNqk3N0j5FGmykLYTJgEPB3JmCki-gYdNDeNfYdwoigxnEU61iVj2mpDSERKUbLYQt5HAvS1X1d569UzZJt1ECEBCtlCIWPo9xkWfdfFSV7nxzPpnjlNuhjC1Ls4QIc9JlKtl_LXXS0FjBYygzQ-QEcDmHYvc4L0CSNpgN56uP61dOgHKB0AOZjHsAUsspXg7izw_X-P_ISe5BfzmZydnH0_RE8hDCOeufYBHWxWW_sRQp2NPmoN-y80xvqA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELVoEYgL4ptQKBaCY3YT23GcY7UQbUtbrYBWe7Ps2CEBNl3tR6X-e8ZxsmyuXGM7svzGnpnk-Q1CH4kBp2cJD1MNKQqjysCeS3WYQCzOM6UKVrq7wxeXfHrFzubJfK_UV0vaL3Q9av4sRk1dtdzK5aIY9zyx8exiQp3Kl0jHS1OOD9D9hIKR9Yl69wMBerBeKBz29LznvBMxPrs-HUVef8_VsiEEMnnK2cAxHVSOFrmTDHaMSbWGRSt9tYs9dzWkUu75pvwJetwFlfjET_4pumebZ-iBLzN59xyp9rNfaVc3Df7mObEW577QDqZYNQaneOYFG7D6qWoIGfGkqn_DQbBt7hS-rlfbNZ46Uu6qUnBW4tzCFmhHfq_gRH2BrvIvPybTsCutEBYJizehopTqmBbGpIKDv7KsAEfNteBWaw4PSaxNyt1dQh5lqiyEzYRJwNuRjJkioi_RYXPT2NcIJ4oSw1mkY10ypq02hESkFCWLLeR-JECf-nWVS6-gIdvMgwgJUMgWChlDvw-w6LsuTvZ6enIu3TOnSxdDqHobB-iox0Sq9UL-uq2lgNFCZpDKB-h4ANPuZU6UPmEkDdArD9e_lg79AKUDIAfzGLaAVbYy3J0Vvvnvke_Rw9nnXJ6fXn49Qo8gEiOevPYWHW5WW_sOop2NPm7t-i_b3fuT
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interferon+Response+Factors+3+and+7+Protect+against+Chikungunya+Virus+Hemorrhagic+Fever+and+Shock&rft.jtitle=Journal+of+Virology&rft.au=Penny+A.+Rudd&rft.au=Jane+Wilson&rft.au=Joy+Gardner&rft.au=Thibaut+Larcher&rft.date=2012-09-01&rft.pub=American+Society+for+Microbiology&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=86&rft.issue=18&rft.spage=9888&rft_id=info:doi/10.1128%2FJVI.00956-12&rft_id=info%3Apmid%2F22761364&rft.externalDBID=n%2Fa&rft.externalDocID=jvi_86_18_9888
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon