Quiescence enables unrestricted cell fate in naive embryonic stem cells

• Published in: Nature communications Vol. 15; no. 1; pp. 1721 - 19
• Main Authors: Khoa, Le Tran Phuc, Yang, Wentao, Shan, Mengrou, Zhang, Li, Mao, Fengbiao, Zhou, Bo, Li, Qiang, Malcore, Rebecca, Harris, Clair, Zhao, Lili, Rao, Rajesh C., Iwase, Shigeki, Kalantry, Sundeep, Bielas, Stephanie L., Lyssiotis, Costas A., Dou, Yali
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/100; 13/106; 13/109; 13/31; 13/89; 14; 14/1; 14/19; 38; 38/91; 45; 45/15; 45/23; 45/77; 631/136/2444; 631/136/532/2443; 631/532/2117; Adenosylmethionine; Animals; Cell Differentiation; Cell fate; Chromatin; Chromatin - metabolism; Diapause; Dormancy; Embryo cells; Embryonic Stem Cells - metabolism; Endogenous retroviruses; Humanities and Social Sciences; Metabolism; Metabolites; Methionine; Methionine adenosyltransferase; Mice; Mouse Embryonic Stem Cells - metabolism; multidisciplinary; Myc protein; Oxidation; Polycomb group proteins; Polycomb Repressive Complex 2 - metabolism; S-Adenosylmethionine; S-Adenosylmethionine - metabolism; Science; Science (multidisciplinary); Stem cells

Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinnin...