Quiescence enables unrestricted cell fate in naive embryonic stem cells

Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinnin...

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Published inNature communications Vol. 15; no. 1; pp. 1721 - 19
Main Authors Khoa, Le Tran Phuc, Yang, Wentao, Shan, Mengrou, Zhang, Li, Mao, Fengbiao, Zhou, Bo, Li, Qiang, Malcore, Rebecca, Harris, Clair, Zhao, Lili, Rao, Rajesh C., Iwase, Shigeki, Kalantry, Sundeep, Bielas, Stephanie L., Lyssiotis, Costas A., Dou, Yali
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Published London Nature Publishing Group UK 26.02.2024
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Abstract Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinning and developmental potential of quiescent ESCs (qESCs) are relatively unexplored. Here we show that qESCs possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types (e.g., trophoblast stem cells). These cells have a divergent metabolic landscape comparing to the cycling ESCs, with a notable decrease of the one-carbon metabolite S -adenosylmethionine. The metabolic changes are accompanied by a global reduction of H3K27me3, an increase of chromatin accessibility, as well as the de-repression of endogenous retrovirus MERVL and trophoblast master regulators. Depletion of methionine adenosyltransferase Mat2a or deletion of Eed in the polycomb repressive complex 2 results in removal of the developmental constraints towards the extraembryonic lineages. Our findings suggest that quiescent ESCs are not dormant but rather undergo an active transition towards an unrestricted cell fate. Stem cell quiescence is generally considered as an inactive state with poised potential. Here, Khoa et al. find that quiescent embryonic stem cells actively maintain a dynamic reservoir of cells with unrestricted cell fate that converges on S -adenosylmethionine and H3K27me3 status.
AbstractList Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinning and developmental potential of quiescent ESCs (qESCs) are relatively unexplored. Here we show that qESCs possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types (e.g., trophoblast stem cells). These cells have a divergent metabolic landscape comparing to the cycling ESCs, with a notable decrease of the one-carbon metabolite S -adenosylmethionine. The metabolic changes are accompanied by a global reduction of H3K27me3, an increase of chromatin accessibility, as well as the de-repression of endogenous retrovirus MERVL and trophoblast master regulators. Depletion of methionine adenosyltransferase Mat2a or deletion of Eed in the polycomb repressive complex 2 results in removal of the developmental constraints towards the extraembryonic lineages. Our findings suggest that quiescent ESCs are not dormant but rather undergo an active transition towards an unrestricted cell fate.
Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinning and developmental potential of quiescent ESCs (qESCs) are relatively unexplored. Here we show that qESCs possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types (e.g., trophoblast stem cells). These cells have a divergent metabolic landscape comparing to the cycling ESCs, with a notable decrease of the one-carbon metabolite S -adenosylmethionine. The metabolic changes are accompanied by a global reduction of H3K27me3, an increase of chromatin accessibility, as well as the de-repression of endogenous retrovirus MERVL and trophoblast master regulators. Depletion of methionine adenosyltransferase Mat2a or deletion of Eed in the polycomb repressive complex 2 results in removal of the developmental constraints towards the extraembryonic lineages. Our findings suggest that quiescent ESCs are not dormant but rather undergo an active transition towards an unrestricted cell fate. Stem cell quiescence is generally considered as an inactive state with poised potential. Here, Khoa et al. find that quiescent embryonic stem cells actively maintain a dynamic reservoir of cells with unrestricted cell fate that converges on S -adenosylmethionine and H3K27me3 status.
Abstract Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinning and developmental potential of quiescent ESCs (qESCs) are relatively unexplored. Here we show that qESCs possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types (e.g., trophoblast stem cells). These cells have a divergent metabolic landscape comparing to the cycling ESCs, with a notable decrease of the one-carbon metabolite S-adenosylmethionine. The metabolic changes are accompanied by a global reduction of H3K27me3, an increase of chromatin accessibility, as well as the de-repression of endogenous retrovirus MERVL and trophoblast master regulators. Depletion of methionine adenosyltransferase Mat2a or deletion of Eed in the polycomb repressive complex 2 results in removal of the developmental constraints towards the extraembryonic lineages. Our findings suggest that quiescent ESCs are not dormant but rather undergo an active transition towards an unrestricted cell fate.
Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinning and developmental potential of quiescent ESCs (qESCs) are relatively unexplored. Here we show that qESCs possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types (e.g., trophoblast stem cells). These cells have a divergent metabolic landscape comparing to the cycling ESCs, with a notable decrease of the one-carbon metabolite S-adenosylmethionine. The metabolic changes are accompanied by a global reduction of H3K27me3, an increase of chromatin accessibility, as well as the de-repression of endogenous retrovirus MERVL and trophoblast master regulators. Depletion of methionine adenosyltransferase Mat2a or deletion of Eed in the polycomb repressive complex 2 results in removal of the developmental constraints towards the extraembryonic lineages. Our findings suggest that quiescent ESCs are not dormant but rather undergo an active transition towards an unrestricted cell fate.Stem cell quiescence is generally considered as an inactive state with poised potential. Here, Khoa et al. find that quiescent embryonic stem cells actively maintain a dynamic reservoir of cells with unrestricted cell fate that converges on S-adenosylmethionine and H3K27me3 status.
Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinning and developmental potential of quiescent ESCs (qESCs) are relatively unexplored. Here we show that qESCs possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types (e.g., trophoblast stem cells). These cells have a divergent metabolic landscape comparing to the cycling ESCs, with a notable decrease of the one-carbon metabolite S-adenosylmethionine. The metabolic changes are accompanied by a global reduction of H3K27me3, an increase of chromatin accessibility, as well as the de-repression of endogenous retrovirus MERVL and trophoblast master regulators. Depletion of methionine adenosyltransferase Mat2a or deletion of Eed in the polycomb repressive complex 2 results in removal of the developmental constraints towards the extraembryonic lineages. Our findings suggest that quiescent ESCs are not dormant but rather undergo an active transition towards an unrestricted cell fate.
Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinning and developmental potential of quiescent ESCs (qESCs) are relatively unexplored. Here we show that qESCs possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types (e.g., trophoblast stem cells). These cells have a divergent metabolic landscape comparing to the cycling ESCs, with a notable decrease of the one-carbon metabolite S-adenosylmethionine. The metabolic changes are accompanied by a global reduction of H3K27me3, an increase of chromatin accessibility, as well as the de-repression of endogenous retrovirus MERVL and trophoblast master regulators. Depletion of methionine adenosyltransferase Mat2a or deletion of Eed in the polycomb repressive complex 2 results in removal of the developmental constraints towards the extraembryonic lineages. Our findings suggest that quiescent ESCs are not dormant but rather undergo an active transition towards an unrestricted cell fate.Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo. The molecular underpinning and developmental potential of quiescent ESCs (qESCs) are relatively unexplored. Here we show that qESCs possess an expanded or unrestricted cell fate, capable of generating both embryonic and extraembryonic cell types (e.g., trophoblast stem cells). These cells have a divergent metabolic landscape comparing to the cycling ESCs, with a notable decrease of the one-carbon metabolite S-adenosylmethionine. The metabolic changes are accompanied by a global reduction of H3K27me3, an increase of chromatin accessibility, as well as the de-repression of endogenous retrovirus MERVL and trophoblast master regulators. Depletion of methionine adenosyltransferase Mat2a or deletion of Eed in the polycomb repressive complex 2 results in removal of the developmental constraints towards the extraembryonic lineages. Our findings suggest that quiescent ESCs are not dormant but rather undergo an active transition towards an unrestricted cell fate.
ArticleNumber 1721
Author Yang, Wentao
Kalantry, Sundeep
Zhang, Li
Dou, Yali
Zhao, Lili
Khoa, Le Tran Phuc
Shan, Mengrou
Malcore, Rebecca
Lyssiotis, Costas A.
Li, Qiang
Zhou, Bo
Harris, Clair
Mao, Fengbiao
Rao, Rajesh C.
Iwase, Shigeki
Bielas, Stephanie L.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/38409226$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/nature06968
10.1016/j.celrep.2016.08.087
10.1038/s41556-019-0453-8
10.1093/nar/gkac194
10.1038/s41467-019-13668-3
10.1038/s41576-020-0270-8
10.1016/j.molcel.2020.03.004
10.1038/ng.3844
10.1101/gad.268821.115
10.1038/nature13255
10.1038/s41580-021-00341-1
10.1016/j.stem.2018.10.017
10.1038/ncb1351
10.1186/gb-2013-14-4-r36
10.1016/j.taap.2008.08.013
10.1021/acs.jmedchem.2c00395
10.1016/j.cell.2016.12.026
10.1038/s41580-022-00457-y
10.1038/nbt.2931
10.1038/nature20578
10.1002/stem.590
10.1038/nature18606
10.1093/bib/bbs017
10.1242/dev.189845
10.1093/nar/gkp335
10.1038/nrm3591
10.1038/s41568-019-0187-8
10.1038/nmeth.2089
10.1038/nbt.1630
10.1093/nar/gkw257
10.1093/bioinformatics/btr167
10.1038/s41589-021-00925-0
10.1016/j.xpro.2020.100136
10.1038/nature729
10.1186/s13059-017-1211-5
10.1038/s41556-022-00916-w
10.1186/s13059-014-0550-8
10.1093/bib/bbs037
10.1093/bioinformatics/btp340
10.1038/nmeth.3065
10.1016/j.stem.2019.01.001
10.1016/j.ccell.2020.12.002
10.1093/nar/gkab382
10.1038/s41556-020-00609-2
10.1016/j.stem.2013.06.002
10.1016/j.stem.2020.01.004
10.1016/j.cell.2006.02.041
10.1038/ncb1786
10.1007/s11306-019-1564-8
10.1093/dnares/dsv013
10.1016/j.molcel.2010.05.004
10.1093/bioinformatics/btp616
10.1093/nar/gkv1252
10.1093/bioinformatics/btt656
10.1038/nature11244
10.1038/s41556-022-00932-w
10.1002/0471250953.bi1107s32
10.1038/ncb3264
10.1016/j.cell.2015.12.033
10.1242/dev.189688
10.1038/s42255-019-0032-0
10.1038/sj.emboj.7601187
10.1038/s41586-020-2076-4
10.1038/s41586-020-2682-1
10.1016/j.ab.2017.07.009
10.1016/j.cmet.2018.01.008
10.1016/j.stem.2017.12.011
10.1038/nsmb.3066
10.1016/j.cell.2020.11.018
10.1016/j.stem.2020.01.013
10.1016/j.cmet.2016.08.009
10.1093/nar/gku365
10.1093/bioinformatics/btp352
10.1016/j.stem.2020.06.005
10.15698/cst2022.01.261
10.1038/nmeth.1212
10.1016/j.devcel.2020.09.029
10.1016/j.cell.2012.03.026
10.1101/496521
10.1093/nar/gkz1138
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References Dhimolea (CR8) 2021; 39
Fessler (CR20) 2020; 579
Zijlmans (CR52) 2022; 24
Zhang (CR11) 2018; 27
Sherman (CR82) 2022; 50
Dykens (CR21) 2008; 233
Risso, Ngai, Speed, Dudoit (CR71) 2014; 32
Martinez-Reyes, Chandel (CR16) 2020; 11
CR78
CR76
Langmead (CR75) 2010; 32
Whitaker, Chen, Wang (CR80) 2015; 12
Liang (CR13) 2020; 26
Ng (CR35) 2008; 10
CR74
Fueyo, Judd, Feschotte, Wysocka (CR44) 2022; 23
Sperber (CR54) 2015; 17
Yates (CR66) 2020; 48
Piunti, Shilatifard (CR42) 2021; 22
Hu (CR30) 2020; 22
Benaglia, Chauveau, Hunter, Young (CR57) 2010; 32
Pang (CR61) 2021; 49
McLean (CR83) 2010; 28
van Velthoven, Rando (CR2) 2019; 24
Li (CR63) 2009; 25
Akiyama (CR26) 2015; 22
Genet, Torres-Padilla (CR31) 2020; 147
Mandal, Lindgren, Srivastava, Clark, Banerjee (CR24) 2011; 29
Rodgers (CR14) 2014; 510
Zhao (CR67) 2016; 44
Haws (CR55) 2020; 78
Krueger, Andrews (CR58) 2011; 27
Schoeftner (CR50) 2006; 25
Sanderson, Gao, Dai, Locasale (CR46) 2019; 19
van Mierlo (CR41) 2019; 24
Yang (CR29) 2020; 26
Habibi (CR49) 2013; 13
Li (CR45) 2022; 65
Marescal, Cheeseman (CR3) 2020; 55
Sun, Locasale (CR38) 2022; 6
Riveiro, Brickman (CR32) 2020; 147
Kim (CR62) 2013; 14
Bailey (CR81) 2009; 37
Hendrickson (CR28) 2017; 49
Zorova (CR17) 2018; 552
Robinson, McCarthy, Smyth (CR70) 2010; 26
Ying, Nichols, Evans, Smith (CR22) 2002; 416
Kalantry (CR56) 2006; 8
Maclary (CR47) 2017; 18
Liao, Smyth, Shi (CR69) 2014; 30
Rehman (CR9) 2021; 184
Love, Huber, Anders (CR72) 2014; 15
Khoa (CR5) 2020; 27
Posfai (CR34) 2021; 23
Zang (CR77) 2009; 25
Dai, Ramesh, Locasale (CR39) 2020; 21
Thorvaldsdottir, Robinson, Mesirov (CR64) 2013; 14
Schneider, Rasband, Eliceiri (CR59) 2012; 9
Latos (CR43) 2015; 29
Nagaraj (CR10) 2017; 168
Scognamiglio (CR6) 2016; 164
Marks (CR40) 2012; 149
Dey (CR12) 2022; 18
Ying (CR4) 2008; 453
Macfarlan (CR19) 2012; 487
Wu (CR25) 2016; 534
Ramirez (CR65) 2016; 44
Ducker, Rabinowitz (CR36) 2017; 25
Ishiuchi (CR23) 2015; 22
Lee, Kremer, Sajjakulnukit, Zhang, Lyssiotis (CR60) 2019; 15
Gutscher (CR18) 2008; 5
Intlekofer, Finley (CR53) 2019; 1
Bian (CR37) 2020; 585
Bernstein (CR48) 2006; 125
Heinz (CR68) 2010; 38
Lazar (CR73) 2013; 14
Baker, Pera (CR33) 2018; 22
Cheung, Rando (CR1) 2013; 14
Bulut-Karslioglu (CR7) 2016; 540
Khoa, Dou (CR15) 2020; 1
Kumar (CR51) 2022; 24
Eckersley-Maslin (CR27) 2016; 17
Ramírez, Dündar, Diehl, Grüning, Manke (CR79) 2014; 42
BT Sherman (46121_CR82) 2022; 50
F Ramírez (46121_CR79) 2014; 42
CA Schneider (46121_CR59) 2012; 9
H Thorvaldsdottir (46121_CR64) 2013; 14
GS Ducker (46121_CR36) 2017; 25
B Langmead (46121_CR75) 2010; 32
LTP Khoa (46121_CR5) 2020; 27
R Nagaraj (46121_CR10) 2017; 168
E Fessler (46121_CR20) 2020; 579
AM Intlekofer (46121_CR53) 2019; 1
S Heinz (46121_CR68) 2010; 38
Y Zhao (46121_CR67) 2016; 44
J Zhang (46121_CR11) 2018; 27
I Martinez-Reyes (46121_CR16) 2020; 11
Y Sun (46121_CR38) 2022; 6
SA Haws (46121_CR55) 2020; 78
J Wu (46121_CR25) 2016; 534
T Akiyama (46121_CR26) 2015; 22
R Liang (46121_CR13) 2020; 26
RK Ng (46121_CR35) 2008; 10
D Risso (46121_CR71) 2014; 32
LD Zorova (46121_CR17) 2018; 552
PG Hendrickson (46121_CR28) 2017; 49
46121_CR78
MA Eckersley-Maslin (46121_CR27) 2016; 17
A Bulut-Karslioglu (46121_CR7) 2016; 540
A Piunti (46121_CR42) 2021; 22
SK Rehman (46121_CR9) 2021; 184
E Posfai (46121_CR34) 2021; 23
CTJ van Velthoven (46121_CR2) 2019; 24
R Scognamiglio (46121_CR6) 2016; 164
JA Dykens (46121_CR21) 2008; 233
G van Mierlo (46121_CR41) 2019; 24
H Sperber (46121_CR54) 2015; 17
E Dhimolea (46121_CR8) 2021; 39
TS Macfarlan (46121_CR19) 2012; 487
E Habibi (46121_CR49) 2013; 13
DW Zijlmans (46121_CR52) 2022; 24
M Genet (46121_CR31) 2020; 147
C Li (46121_CR45) 2022; 65
Y Bian (46121_CR37) 2020; 585
B Kumar (46121_CR51) 2022; 24
F Krueger (46121_CR58) 2011; 27
S Schoeftner (46121_CR50) 2006; 25
Y Liao (46121_CR69) 2014; 30
S Kalantry (46121_CR56) 2006; 8
SM Sanderson (46121_CR46) 2019; 19
H Marks (46121_CR40) 2012; 149
C Lazar (46121_CR73) 2013; 14
M Gutscher (46121_CR18) 2008; 5
T Ishiuchi (46121_CR23) 2015; 22
Z Pang (46121_CR61) 2021; 49
H Li (46121_CR63) 2009; 25
JW Whitaker (46121_CR80) 2015; 12
F Yang (46121_CR29) 2020; 26
CY McLean (46121_CR83) 2010; 28
AR Riveiro (46121_CR32) 2020; 147
C Zang (46121_CR77) 2009; 25
S Mandal (46121_CR24) 2011; 29
LTP Khoa (46121_CR15) 2020; 1
46121_CR76
BE Bernstein (46121_CR48) 2006; 125
46121_CR74
T Benaglia (46121_CR57) 2010; 32
Z Dai (46121_CR39) 2020; 21
AD Yates (46121_CR66) 2020; 48
PA Latos (46121_CR43) 2015; 29
F Ramirez (46121_CR65) 2016; 44
QL Ying (46121_CR22) 2002; 416
CL Baker (46121_CR33) 2018; 22
Z Hu (46121_CR30) 2020; 22
QL Ying (46121_CR4) 2008; 453
HJ Lee (46121_CR60) 2019; 15
O Marescal (46121_CR3) 2020; 55
MI Love (46121_CR72) 2014; 15
TL Bailey (46121_CR81) 2009; 37
R Fueyo (46121_CR44) 2022; 23
D Kim (46121_CR62) 2013; 14
MD Robinson (46121_CR70) 2010; 26
JT Rodgers (46121_CR14) 2014; 510
E Maclary (46121_CR47) 2017; 18
SK Dey (46121_CR12) 2022; 18
TH Cheung (46121_CR1) 2013; 14
References_xml – volume: 453
  start-page: 519
  year: 2008
  end-page: 523
  ident: CR4
  article-title: The ground state of embryonic stem cell self-renewal
  publication-title: Nature
  doi: 10.1038/nature06968
  contributor:
    fullname: Ying
– volume: 17
  start-page: 179
  year: 2016
  end-page: 192
  ident: CR27
  article-title: MERVL/Zscan4 network activation results in transient genome-wide DNA demethylation of mESCs
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.08.087
  contributor:
    fullname: Eckersley-Maslin
– volume: 22
  start-page: 175
  year: 2020
  end-page: 186
  ident: CR30
  article-title: Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0453-8
  contributor:
    fullname: Hu
– volume: 50
  start-page: W216
  year: 2022
  end-page: W221
  ident: CR82
  article-title: DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac194
  contributor:
    fullname: Sherman
– volume: 11
  year: 2020
  ident: CR16
  article-title: Mitochondrial TCA cycle metabolites control physiology and disease
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-13668-3
  contributor:
    fullname: Chandel
– volume: 21
  start-page: 737
  year: 2020
  end-page: 753
  ident: CR39
  article-title: The evolving metabolic landscape of chromatin biology and epigenetics
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-020-0270-8
  contributor:
    fullname: Locasale
– ident: CR74
– volume: 78
  start-page: 210
  year: 2020
  end-page: 223 e218
  ident: CR55
  article-title: Methyl-metabolite depletion elicits adaptive responses to support heterochromatin stability and epigenetic persistence
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2020.03.004
  contributor:
    fullname: Haws
– volume: 49
  start-page: 925
  year: 2017
  end-page: 934
  ident: CR28
  article-title: Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3844
  contributor:
    fullname: Hendrickson
– volume: 29
  start-page: 2435
  year: 2015
  end-page: 2448
  ident: CR43
  article-title: Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks
  publication-title: Genes Dev.
  doi: 10.1101/gad.268821.115
  contributor:
    fullname: Latos
– volume: 510
  start-page: 393
  year: 2014
  end-page: 396
  ident: CR14
  article-title: mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)
  publication-title: Nature
  doi: 10.1038/nature13255
  contributor:
    fullname: Rodgers
– volume: 22
  start-page: 326
  year: 2021
  end-page: 345
  ident: CR42
  article-title: The roles of Polycomb repressive complexes in mammalian development and cancer
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-021-00341-1
  contributor:
    fullname: Shilatifard
– volume: 24
  start-page: 123
  year: 2019
  end-page: 137 e128
  ident: CR41
  article-title: Integrative proteomic profiling reveals PRC2-dependent epigenetic crosstalk maintains ground-state pluripotency
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.10.017
  contributor:
    fullname: van Mierlo
– volume: 8
  start-page: 195
  year: 2006
  end-page: 202
  ident: CR56
  article-title: The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1351
  contributor:
    fullname: Kalantry
– volume: 14
  year: 2013
  ident: CR62
  article-title: TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
  publication-title: Genome Biol.
  doi: 10.1186/gb-2013-14-4-r36
  contributor:
    fullname: Kim
– volume: 233
  start-page: 203
  year: 2008
  end-page: 210
  ident: CR21
  article-title: Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2008.08.013
  contributor:
    fullname: Dykens
– volume: 65
  start-page: 9531
  year: 2022
  end-page: 9547
  ident: CR45
  article-title: Overview of methionine adenosyltransferase 2A (MAT2A) as an anticancer target: structure, function, and inhibitors
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.2c00395
  contributor:
    fullname: Li
– volume: 168
  start-page: 210
  year: 2017
  end-page: 223.e211
  ident: CR10
  article-title: Nuclear localization of mitochondrial TCA cycle enzymes as a critical step in mammalian zygotic genome activation
  publication-title: Cell
  doi: 10.1016/j.cell.2016.12.026
  contributor:
    fullname: Nagaraj
– volume: 23
  start-page: 481
  year: 2022
  end-page: 497
  ident: CR44
  article-title: Roles of transposable elements in the regulation of mammalian transcription
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-022-00457-y
  contributor:
    fullname: Wysocka
– volume: 32
  start-page: 896
  year: 2014
  end-page: 902
  ident: CR71
  article-title: Normalization of RNA-seq data using factor analysis of control genes or samples
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2931
  contributor:
    fullname: Dudoit
– volume: 540
  start-page: 119
  year: 2016
  end-page: 123
  ident: CR7
  article-title: Inhibition of mTOR induces a paused pluripotent state
  publication-title: Nature
  doi: 10.1038/nature20578
  contributor:
    fullname: Bulut-Karslioglu
– volume: 29
  start-page: 486
  year: 2011
  end-page: 495
  ident: CR24
  article-title: Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells
  publication-title: Stem Cells
  doi: 10.1002/stem.590
  contributor:
    fullname: Banerjee
– volume: 534
  start-page: 652
  year: 2016
  end-page: 657
  ident: CR25
  article-title: The landscape of accessible chromatin in mammalian preimplantation embryos
  publication-title: Nature
  doi: 10.1038/nature18606
  contributor:
    fullname: Wu
– volume: 14
  start-page: 178
  year: 2013
  end-page: 192
  ident: CR64
  article-title: Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
  publication-title: Brief. Bioinform.
  doi: 10.1093/bib/bbs017
  contributor:
    fullname: Mesirov
– volume: 147
  start-page: dev189845
  year: 2020
  ident: CR32
  article-title: From pluripotency to totipotency: an experimentalist’s guide to cellular potency
  publication-title: Development
  doi: 10.1242/dev.189845
  contributor:
    fullname: Brickman
– volume: 37
  start-page: W202
  year: 2009
  end-page: W208
  ident: CR81
  article-title: MEME SUITE: tools for motif discovery and searching
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkp335
  contributor:
    fullname: Bailey
– volume: 14
  start-page: 329
  year: 2013
  end-page: 340
  ident: CR1
  article-title: Molecular regulation of stem cell quiescence
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3591
  contributor:
    fullname: Rando
– volume: 19
  start-page: 625
  year: 2019
  end-page: 637
  ident: CR46
  article-title: Methionine metabolism in health and cancer: a nexus of diet and precision medicine
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0187-8
  contributor:
    fullname: Locasale
– volume: 9
  start-page: 671
  year: 2012
  end-page: 675
  ident: CR59
  article-title: NIH Image to ImageJ: 25 years of image analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2089
  contributor:
    fullname: Eliceiri
– volume: 28
  start-page: 495
  year: 2010
  end-page: 501
  ident: CR83
  article-title: GREAT improves functional interpretation of cis-regulatory regions
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
  contributor:
    fullname: McLean
– volume: 44
  start-page: W160
  year: 2016
  end-page: W165
  ident: CR65
  article-title: deepTools2: a next generation web server for deep-sequencing data analysis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw257
  contributor:
    fullname: Ramirez
– volume: 27
  start-page: 1571
  year: 2011
  end-page: 1572
  ident: CR58
  article-title: Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr167
  contributor:
    fullname: Andrews
– volume: 18
  start-page: 180
  year: 2022
  end-page: 190
  ident: CR12
  article-title: Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-021-00925-0
  contributor:
    fullname: Dey
– volume: 1
  year: 2020
  ident: CR15
  article-title: In vitro derivation of quiescent mouse embryonic stem cells based on distinct mitochondrial activity
  publication-title: STAR Protoc.
  doi: 10.1016/j.xpro.2020.100136
  contributor:
    fullname: Dou
– ident: CR78
– volume: 416
  start-page: 545
  year: 2002
  end-page: 548
  ident: CR22
  article-title: Changing potency by spontaneous fusion
  publication-title: Nature
  doi: 10.1038/nature729
  contributor:
    fullname: Smith
– volume: 18
  year: 2017
  ident: CR47
  article-title: PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice
  publication-title: Genome Biol.
  doi: 10.1186/s13059-017-1211-5
  contributor:
    fullname: Maclary
– volume: 24
  start-page: 845
  year: 2022
  end-page: 857
  ident: CR51
  article-title: Polycomb repressive complex 2 shields naive human pluripotent cells from trophectoderm differentiation
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-022-00916-w
  contributor:
    fullname: Kumar
– volume: 15
  year: 2014
  ident: CR72
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
  contributor:
    fullname: Anders
– volume: 14
  start-page: 469
  year: 2013
  end-page: 490
  ident: CR73
  article-title: Batch effect removal methods for microarray gene expression data integration: a survey
  publication-title: Brief. Bioinform.
  doi: 10.1093/bib/bbs037
  contributor:
    fullname: Lazar
– volume: 25
  start-page: 1952
  year: 2009
  end-page: 1958
  ident: CR77
  article-title: A clustering approach for identification of enriched domains from histone modification ChIP-Seq data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp340
  contributor:
    fullname: Zang
– volume: 12
  start-page: 265
  year: 2015
  end-page: 272
  ident: CR80
  article-title: Predicting the human epigenome from DNA motifs
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3065
  contributor:
    fullname: Wang
– volume: 24
  start-page: 213
  year: 2019
  end-page: 225
  ident: CR2
  article-title: Stem cell quiescence: dynamism, restraint, and cellular idling
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2019.01.001
  contributor:
    fullname: Rando
– volume: 39
  start-page: 240
  year: 2021
  end-page: 256.e211
  ident: CR8
  article-title: An embryonic diapause-like adaptation with suppressed Myc activity enables tumor treatment persistence
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2020.12.002
  contributor:
    fullname: Dhimolea
– volume: 49
  start-page: W388
  year: 2021
  end-page: W396
  ident: CR61
  article-title: MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab382
  contributor:
    fullname: Pang
– volume: 23
  start-page: 49
  year: 2021
  end-page: 60
  ident: CR34
  article-title: Evaluating totipotency using criteria of increasing stringency
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-020-00609-2
  contributor:
    fullname: Posfai
– volume: 13
  start-page: 360
  year: 2013
  end-page: 369
  ident: CR49
  article-title: Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.002
  contributor:
    fullname: Habibi
– volume: 32
  start-page: 1
  year: 2010
  end-page: 29
  ident: CR57
  article-title: S. mixtools: an R package for analyzing mixture models
  publication-title: J. Stat. Softw.
  contributor:
    fullname: Young
– volume: 26
  start-page: 234
  year: 2020
  end-page: 250.e237
  ident: CR29
  article-title: DUX-miR-344-ZMYM2-mediated activation of MERVL LTRs induces a totipotent 2C-like state
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.01.004
  contributor:
    fullname: Yang
– volume: 125
  start-page: 315
  year: 2006
  end-page: 326
  ident: CR48
  article-title: A bivalent chromatin structure marks key developmental genes in embryonic stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2006.02.041
  contributor:
    fullname: Bernstein
– volume: 10
  start-page: 1280
  year: 2008
  end-page: 1290
  ident: CR35
  article-title: Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1786
  contributor:
    fullname: Ng
– volume: 15
  year: 2019
  ident: CR60
  article-title: A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics
  publication-title: Metabolomics
  doi: 10.1007/s11306-019-1564-8
  contributor:
    fullname: Lyssiotis
– volume: 22
  start-page: 307
  year: 2015
  end-page: 318
  ident: CR26
  article-title: Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells
  publication-title: DNA Res.
  doi: 10.1093/dnares/dsv013
  contributor:
    fullname: Akiyama
– volume: 38
  start-page: 576
  year: 2010
  end-page: 589
  ident: CR68
  article-title: Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.05.004
  contributor:
    fullname: Heinz
– volume: 26
  start-page: 139
  year: 2010
  end-page: 140
  ident: CR70
  article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
  contributor:
    fullname: Smyth
– volume: 44
  start-page: D203
  year: 2016
  end-page: 208,
  ident: CR67
  article-title: NONCODE 2016: an informative and valuable data source of long non-coding RNAs
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1252
  contributor:
    fullname: Zhao
– volume: 30
  start-page: 923
  year: 2014
  end-page: 930
  ident: CR69
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
  contributor:
    fullname: Shi
– volume: 487
  start-page: 57
  year: 2012
  end-page: 63
  ident: CR19
  article-title: Embryonic stem cell potency fluctuates with endogenous retrovirus activity
  publication-title: Nature
  doi: 10.1038/nature11244
  contributor:
    fullname: Macfarlan
– volume: 24
  start-page: 858
  year: 2022
  end-page: 871
  ident: CR52
  article-title: Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-022-00932-w
  contributor:
    fullname: Zijlmans
– volume: 32
  start-page: 11.17. 11
  year: 2010
  end-page: 11.17. 14
  ident: CR75
  article-title: Aligning short sequencing reads with Bowtie
  publication-title: Curr. Protoc. Bioinform.
  doi: 10.1002/0471250953.bi1107s32
  contributor:
    fullname: Langmead
– volume: 17
  start-page: 1523
  year: 2015
  end-page: 1535
  ident: CR54
  article-title: The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3264
  contributor:
    fullname: Sperber
– volume: 164
  start-page: 668
  year: 2016
  end-page: 680
  ident: CR6
  article-title: Myc depletion induces a pluripotent dormant state mimicking diapause
  publication-title: Cell
  doi: 10.1016/j.cell.2015.12.033
  contributor:
    fullname: Scognamiglio
– volume: 147
  start-page: dev189688
  year: 2020
  ident: CR31
  article-title: The molecular and cellular features of 2-cell-like cells: a reference guide
  publication-title: Development
  doi: 10.1242/dev.189688
  contributor:
    fullname: Torres-Padilla
– volume: 1
  start-page: 177
  year: 2019
  end-page: 188
  ident: CR53
  article-title: Metabolic signatures of cancer cells and stem cells
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-019-0032-0
  contributor:
    fullname: Finley
– volume: 25
  start-page: 3110
  year: 2006
  end-page: 3122
  ident: CR50
  article-title: Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601187
  contributor:
    fullname: Schoeftner
– volume: 48
  start-page: D682
  year: 2020
  end-page: D688
  ident: CR66
  article-title: Ensembl 2020
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Yates
– volume: 579
  start-page: 433
  year: 2020
  end-page: 437
  ident: CR20
  article-title: A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol
  publication-title: Nature
  doi: 10.1038/s41586-020-2076-4
  contributor:
    fullname: Fessler
– volume: 585
  start-page: 277
  year: 2020
  end-page: 282
  ident: CR37
  article-title: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
  publication-title: Nature
  doi: 10.1038/s41586-020-2682-1
  contributor:
    fullname: Bian
– volume: 552
  start-page: 50
  year: 2018
  end-page: 59
  ident: CR17
  article-title: Mitochondrial membrane potential
  publication-title: Anal. Biochem.
  doi: 10.1016/j.ab.2017.07.009
  contributor:
    fullname: Zorova
– volume: 27
  start-page: 332
  year: 2018
  end-page: 338
  ident: CR11
  article-title: Metabolism in pluripotent stem cells and early mammalian development
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2018.01.008
  contributor:
    fullname: Zhang
– volume: 22
  start-page: 25
  year: 2018
  end-page: 34
  ident: CR33
  article-title: Capturing totipotent stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.12.011
  contributor:
    fullname: Pera
– ident: CR76
– volume: 22
  start-page: 662
  year: 2015
  end-page: 671
  ident: CR23
  article-title: Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3066
  contributor:
    fullname: Ishiuchi
– volume: 184
  start-page: 226
  year: 2021
  end-page: 242 e221
  ident: CR9
  article-title: Colorectal cancer cells enter a diapause-like DTP state to survive chemotherapy
  publication-title: Cell
  doi: 10.1016/j.cell.2020.11.018
  contributor:
    fullname: Rehman
– volume: 26
  start-page: 359
  year: 2020
  end-page: 376.e357
  ident: CR13
  article-title: Restraining lysosomal activity preserves hematopoietic stem cell quiescence and potency
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.01.013
  contributor:
    fullname: Liang
– volume: 25
  start-page: 27
  year: 2017
  end-page: 42
  ident: CR36
  article-title: One-carbon metabolism in health and disease
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.08.009
  contributor:
    fullname: Rabinowitz
– volume: 42
  start-page: W187
  year: 2014
  end-page: W191
  ident: CR79
  article-title: deepTools: a flexible platform for exploring deep-sequencing data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku365
  contributor:
    fullname: Manke
– volume: 25
  start-page: 2078
  year: 2009
  end-page: 2079
  ident: CR63
  article-title: The sequence alignment/map format And SAMtools
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp352
  contributor:
    fullname: Li
– volume: 27
  start-page: 441
  year: 2020
  end-page: 458.e410
  ident: CR5
  article-title: Histone acetyltransferase MOF blocks acquisition of quiescence in ground-state escs through activating fatty acid oxidation
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.06.005
  contributor:
    fullname: Khoa
– volume: 6
  start-page: 1
  year: 2022
  end-page: 5
  ident: CR38
  article-title: Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine
  publication-title: Cell Stress
  doi: 10.15698/cst2022.01.261
  contributor:
    fullname: Locasale
– volume: 5
  start-page: 553
  year: 2008
  end-page: 559
  ident: CR18
  article-title: Real-time imaging of the intracellular glutathione redox potential
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1212
  contributor:
    fullname: Gutscher
– volume: 55
  start-page: 259
  year: 2020
  end-page: 271
  ident: CR3
  article-title: Cellular mechanisms and regulation of quiescence
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2020.09.029
  contributor:
    fullname: Cheeseman
– volume: 149
  start-page: 590
  year: 2012
  end-page: 604
  ident: CR40
  article-title: The transcriptional and epigenomic foundations of ground state pluripotency
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.026
  contributor:
    fullname: Marks
– volume: 39
  start-page: 240
  year: 2021
  ident: 46121_CR8
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2020.12.002
  contributor:
    fullname: E Dhimolea
– volume: 534
  start-page: 652
  year: 2016
  ident: 46121_CR25
  publication-title: Nature
  doi: 10.1038/nature18606
  contributor:
    fullname: J Wu
– volume: 17
  start-page: 179
  year: 2016
  ident: 46121_CR27
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.08.087
  contributor:
    fullname: MA Eckersley-Maslin
– volume: 21
  start-page: 737
  year: 2020
  ident: 46121_CR39
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-020-0270-8
  contributor:
    fullname: Z Dai
– volume: 168
  start-page: 210
  year: 2017
  ident: 46121_CR10
  publication-title: Cell
  doi: 10.1016/j.cell.2016.12.026
  contributor:
    fullname: R Nagaraj
– volume: 552
  start-page: 50
  year: 2018
  ident: 46121_CR17
  publication-title: Anal. Biochem.
  doi: 10.1016/j.ab.2017.07.009
  contributor:
    fullname: LD Zorova
– volume: 149
  start-page: 590
  year: 2012
  ident: 46121_CR40
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.026
  contributor:
    fullname: H Marks
– ident: 46121_CR78
– volume: 26
  start-page: 139
  year: 2010
  ident: 46121_CR70
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
  contributor:
    fullname: MD Robinson
– volume: 19
  start-page: 625
  year: 2019
  ident: 46121_CR46
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0187-8
  contributor:
    fullname: SM Sanderson
– volume: 37
  start-page: W202
  year: 2009
  ident: 46121_CR81
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkp335
  contributor:
    fullname: TL Bailey
– volume: 233
  start-page: 203
  year: 2008
  ident: 46121_CR21
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2008.08.013
  contributor:
    fullname: JA Dykens
– volume: 184
  start-page: 226
  year: 2021
  ident: 46121_CR9
  publication-title: Cell
  doi: 10.1016/j.cell.2020.11.018
  contributor:
    fullname: SK Rehman
– volume: 29
  start-page: 486
  year: 2011
  ident: 46121_CR24
  publication-title: Stem Cells
  doi: 10.1002/stem.590
  contributor:
    fullname: S Mandal
– volume: 8
  start-page: 195
  year: 2006
  ident: 46121_CR56
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1351
  contributor:
    fullname: S Kalantry
– volume: 453
  start-page: 519
  year: 2008
  ident: 46121_CR4
  publication-title: Nature
  doi: 10.1038/nature06968
  contributor:
    fullname: QL Ying
– volume: 22
  start-page: 175
  year: 2020
  ident: 46121_CR30
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0453-8
  contributor:
    fullname: Z Hu
– ident: 46121_CR74
– volume: 6
  start-page: 1
  year: 2022
  ident: 46121_CR38
  publication-title: Cell Stress
  doi: 10.15698/cst2022.01.261
  contributor:
    fullname: Y Sun
– volume: 32
  start-page: 11.17. 11
  year: 2010
  ident: 46121_CR75
  publication-title: Curr. Protoc. Bioinform.
  doi: 10.1002/0471250953.bi1107s32
  contributor:
    fullname: B Langmead
– volume: 13
  start-page: 360
  year: 2013
  ident: 46121_CR49
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.002
  contributor:
    fullname: E Habibi
– volume: 49
  start-page: W388
  year: 2021
  ident: 46121_CR61
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab382
  contributor:
    fullname: Z Pang
– volume: 44
  start-page: W160
  year: 2016
  ident: 46121_CR65
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw257
  contributor:
    fullname: F Ramirez
– volume: 12
  start-page: 265
  year: 2015
  ident: 46121_CR80
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3065
  contributor:
    fullname: JW Whitaker
– volume: 25
  start-page: 3110
  year: 2006
  ident: 46121_CR50
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601187
  contributor:
    fullname: S Schoeftner
– volume: 17
  start-page: 1523
  year: 2015
  ident: 46121_CR54
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3264
  contributor:
    fullname: H Sperber
– volume: 1
  start-page: 177
  year: 2019
  ident: 46121_CR53
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-019-0032-0
  contributor:
    fullname: AM Intlekofer
– volume: 28
  start-page: 495
  year: 2010
  ident: 46121_CR83
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
  contributor:
    fullname: CY McLean
– volume: 416
  start-page: 545
  year: 2002
  ident: 46121_CR22
  publication-title: Nature
  doi: 10.1038/nature729
  contributor:
    fullname: QL Ying
– volume: 5
  start-page: 553
  year: 2008
  ident: 46121_CR18
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1212
  contributor:
    fullname: M Gutscher
– volume: 540
  start-page: 119
  year: 2016
  ident: 46121_CR7
  publication-title: Nature
  doi: 10.1038/nature20578
  contributor:
    fullname: A Bulut-Karslioglu
– volume: 42
  start-page: W187
  year: 2014
  ident: 46121_CR79
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku365
  contributor:
    fullname: F Ramírez
– volume: 1
  year: 2020
  ident: 46121_CR15
  publication-title: STAR Protoc.
  doi: 10.1016/j.xpro.2020.100136
  contributor:
    fullname: LTP Khoa
– volume: 164
  start-page: 668
  year: 2016
  ident: 46121_CR6
  publication-title: Cell
  doi: 10.1016/j.cell.2015.12.033
  contributor:
    fullname: R Scognamiglio
– ident: 46121_CR76
  doi: 10.1101/496521
– volume: 25
  start-page: 1952
  year: 2009
  ident: 46121_CR77
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp340
  contributor:
    fullname: C Zang
– volume: 27
  start-page: 441
  year: 2020
  ident: 46121_CR5
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.06.005
  contributor:
    fullname: LTP Khoa
– volume: 26
  start-page: 359
  year: 2020
  ident: 46121_CR13
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.01.013
  contributor:
    fullname: R Liang
– volume: 27
  start-page: 332
  year: 2018
  ident: 46121_CR11
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2018.01.008
  contributor:
    fullname: J Zhang
– volume: 15
  year: 2019
  ident: 46121_CR60
  publication-title: Metabolomics
  doi: 10.1007/s11306-019-1564-8
  contributor:
    fullname: HJ Lee
– volume: 22
  start-page: 662
  year: 2015
  ident: 46121_CR23
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3066
  contributor:
    fullname: T Ishiuchi
– volume: 14
  year: 2013
  ident: 46121_CR62
  publication-title: Genome Biol.
  doi: 10.1186/gb-2013-14-4-r36
  contributor:
    fullname: D Kim
– volume: 44
  start-page: D203
  year: 2016
  ident: 46121_CR67
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1252
  contributor:
    fullname: Y Zhao
– volume: 24
  start-page: 858
  year: 2022
  ident: 46121_CR52
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-022-00932-w
  contributor:
    fullname: DW Zijlmans
– volume: 24
  start-page: 213
  year: 2019
  ident: 46121_CR2
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2019.01.001
  contributor:
    fullname: CTJ van Velthoven
– volume: 55
  start-page: 259
  year: 2020
  ident: 46121_CR3
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2020.09.029
  contributor:
    fullname: O Marescal
– volume: 25
  start-page: 2078
  year: 2009
  ident: 46121_CR63
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp352
  contributor:
    fullname: H Li
– volume: 10
  start-page: 1280
  year: 2008
  ident: 46121_CR35
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1786
  contributor:
    fullname: RK Ng
– volume: 14
  start-page: 178
  year: 2013
  ident: 46121_CR64
  publication-title: Brief. Bioinform.
  doi: 10.1093/bib/bbs017
  contributor:
    fullname: H Thorvaldsdottir
– volume: 18
  start-page: 180
  year: 2022
  ident: 46121_CR12
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-021-00925-0
  contributor:
    fullname: SK Dey
– volume: 9
  start-page: 671
  year: 2012
  ident: 46121_CR59
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2089
  contributor:
    fullname: CA Schneider
– volume: 147
  start-page: dev189845
  year: 2020
  ident: 46121_CR32
  publication-title: Development
  doi: 10.1242/dev.189845
  contributor:
    fullname: AR Riveiro
– volume: 579
  start-page: 433
  year: 2020
  ident: 46121_CR20
  publication-title: Nature
  doi: 10.1038/s41586-020-2076-4
  contributor:
    fullname: E Fessler
– volume: 14
  start-page: 469
  year: 2013
  ident: 46121_CR73
  publication-title: Brief. Bioinform.
  doi: 10.1093/bib/bbs037
  contributor:
    fullname: C Lazar
– volume: 23
  start-page: 481
  year: 2022
  ident: 46121_CR44
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-022-00457-y
  contributor:
    fullname: R Fueyo
– volume: 25
  start-page: 27
  year: 2017
  ident: 46121_CR36
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.08.009
  contributor:
    fullname: GS Ducker
– volume: 22
  start-page: 326
  year: 2021
  ident: 46121_CR42
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-021-00341-1
  contributor:
    fullname: A Piunti
– volume: 32
  start-page: 896
  year: 2014
  ident: 46121_CR71
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2931
  contributor:
    fullname: D Risso
– volume: 15
  year: 2014
  ident: 46121_CR72
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
  contributor:
    fullname: MI Love
– volume: 48
  start-page: D682
  year: 2020
  ident: 46121_CR66
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz1138
  contributor:
    fullname: AD Yates
– volume: 147
  start-page: dev189688
  year: 2020
  ident: 46121_CR31
  publication-title: Development
  doi: 10.1242/dev.189688
  contributor:
    fullname: M Genet
– volume: 65
  start-page: 9531
  year: 2022
  ident: 46121_CR45
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.2c00395
  contributor:
    fullname: C Li
– volume: 585
  start-page: 277
  year: 2020
  ident: 46121_CR37
  publication-title: Nature
  doi: 10.1038/s41586-020-2682-1
  contributor:
    fullname: Y Bian
– volume: 11
  year: 2020
  ident: 46121_CR16
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-13668-3
  contributor:
    fullname: I Martinez-Reyes
– volume: 14
  start-page: 329
  year: 2013
  ident: 46121_CR1
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3591
  contributor:
    fullname: TH Cheung
– volume: 49
  start-page: 925
  year: 2017
  ident: 46121_CR28
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3844
  contributor:
    fullname: PG Hendrickson
– volume: 26
  start-page: 234
  year: 2020
  ident: 46121_CR29
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.01.004
  contributor:
    fullname: F Yang
– volume: 78
  start-page: 210
  year: 2020
  ident: 46121_CR55
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2020.03.004
  contributor:
    fullname: SA Haws
– volume: 22
  start-page: 25
  year: 2018
  ident: 46121_CR33
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.12.011
  contributor:
    fullname: CL Baker
– volume: 38
  start-page: 576
  year: 2010
  ident: 46121_CR68
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.05.004
  contributor:
    fullname: S Heinz
– volume: 24
  start-page: 845
  year: 2022
  ident: 46121_CR51
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-022-00916-w
  contributor:
    fullname: B Kumar
– volume: 27
  start-page: 1571
  year: 2011
  ident: 46121_CR58
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr167
  contributor:
    fullname: F Krueger
– volume: 487
  start-page: 57
  year: 2012
  ident: 46121_CR19
  publication-title: Nature
  doi: 10.1038/nature11244
  contributor:
    fullname: TS Macfarlan
– volume: 510
  start-page: 393
  year: 2014
  ident: 46121_CR14
  publication-title: Nature
  doi: 10.1038/nature13255
  contributor:
    fullname: JT Rodgers
– volume: 18
  year: 2017
  ident: 46121_CR47
  publication-title: Genome Biol.
  doi: 10.1186/s13059-017-1211-5
  contributor:
    fullname: E Maclary
– volume: 32
  start-page: 1
  year: 2010
  ident: 46121_CR57
  publication-title: J. Stat. Softw.
  contributor:
    fullname: T Benaglia
– volume: 50
  start-page: W216
  year: 2022
  ident: 46121_CR82
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac194
  contributor:
    fullname: BT Sherman
– volume: 125
  start-page: 315
  year: 2006
  ident: 46121_CR48
  publication-title: Cell
  doi: 10.1016/j.cell.2006.02.041
  contributor:
    fullname: BE Bernstein
– volume: 29
  start-page: 2435
  year: 2015
  ident: 46121_CR43
  publication-title: Genes Dev.
  doi: 10.1101/gad.268821.115
  contributor:
    fullname: PA Latos
– volume: 30
  start-page: 923
  year: 2014
  ident: 46121_CR69
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
  contributor:
    fullname: Y Liao
– volume: 23
  start-page: 49
  year: 2021
  ident: 46121_CR34
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-020-00609-2
  contributor:
    fullname: E Posfai
– volume: 24
  start-page: 123
  year: 2019
  ident: 46121_CR41
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.10.017
  contributor:
    fullname: G van Mierlo
– volume: 22
  start-page: 307
  year: 2015
  ident: 46121_CR26
  publication-title: DNA Res.
  doi: 10.1093/dnares/dsv013
  contributor:
    fullname: T Akiyama
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Snippet Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can...
Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can...
Abstract Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs)...
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Adenosylmethionine
Animals
Cell Differentiation
Cell fate
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Embryonic Stem Cells - metabolism
Endogenous retroviruses
Humanities and Social Sciences
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Mouse Embryonic Stem Cells - metabolism
multidisciplinary
Myc protein
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Polycomb group proteins
Polycomb Repressive Complex 2 - metabolism
S-Adenosylmethionine
S-Adenosylmethionine - metabolism
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Science (multidisciplinary)
Stem cells
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Title Quiescence enables unrestricted cell fate in naive embryonic stem cells
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