TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma

• Published in: Cell death & disease Vol. 15; no. 1; pp. 26 - 14
• Main Authors: Kang, Donghee, Hwang, Hyun Jung, Baek, Yurim, Sung, Jee Young, Kim, KyeongJin, Park, Heon Joo, Ko, Young-Gyu, Kim, Yong-Nyun, Lee, Jae-Seon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.01.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/109; 13/51; 13/89; 13/95; 14/1; 38; 45/44; 631/67/1244; 631/80/509; AKT protein; Antibodies; Apoptosis; Biochemistry; Biomedical and Life Sciences; Carcinoma, Hepatocellular - genetics; Cell Biology; Cell Culture; Cell cycle; Cell differentiation; Cellular Senescence - genetics; Degradation; Hepatocellular carcinoma; Humans; Immunology; Ionizing radiation; Life Sciences; Liver cancer; Liver Neoplasms - genetics; Minor Histocompatibility Antigens; Neurodegenerative diseases; p53 Protein; Phosphoprotein Phosphatases - genetics; Phosphorylation; Proteasome Endopeptidase Complex; Proteasomes; Proto-Oncogene Proteins c-akt; Repressor Proteins; Senescence; Therapeutic targets; Tripartite Motif Proteins - genetics; Tumor Suppressor Protein p53 - genetics; Ubiquitin-protein ligase; Ubiquitins; Vascular diseases

The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression, apoptosis, and differentiation. Dysregulation of this system has been implicated in numerous diseases, including cancer, vascular disease, and neurode...