C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation...

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Published inNature communications Vol. 14; no. 1; p. 5898
Main Authors Vahsen, Björn F., Nalluru, Sumedha, Morgan, Georgia R., Farrimond, Lucy, Carroll, Emily, Xu, Yinyan, Cramb, Kaitlyn M. L., Amein, Benazir, Scaber, Jakub, Katsikoudi, Antigoni, Candalija, Ana, Carcolé, Mireia, Dafinca, Ruxandra, Isaacs, Adrian M., Wade-Martins, Richard, Gray, Elizabeth, Turner, Martin R., Cowley, Sally A., Talbot, Kevin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 22.09.2023
Nature Publishing Group
Nature Portfolio
Subjects
13/100
13/106
14/19
38/91
631/378/1689/1285
631/378/2596/1953
631/532/2064/2158
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - genetics
C9orf72 Protein - genetics
Cell activation
Cell culture
Chemokines
Coculture Techniques
Gelatinase B
Gene sequencing
Genetic diversity
Genetic variance
Humanities and Social Sciences
Humans
Immune system
Induced Pluripotent Stem Cells
Inflammation
Lipopolysaccharides
Matrix metalloproteinase
Matrix Metalloproteinase 9 - genetics
Matrix metalloproteinases
Metalloproteinase
Microglia
Motor Neurons
multidisciplinary
Mutants
Neurodegenerative Diseases
Neurons
Pathophysiology
Priming
Regulatory sequences
Science
Science (multidisciplinary)
Therapeutic targets
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Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation in C9orf72 . Here, we study its consequences for microglial function using human iPSC-derived microglia. By RNA-sequencing, we identify enrichment of pathways associated with immune cell activation and cyto-/chemokines in C9orf72 HRE mutant microglia versus healthy controls, most prominently after LPS priming. Specifically, LPS-primed C9orf72 HRE mutant microglia show consistently increased expression and release of matrix metalloproteinase-9 (MMP9). LPS-primed C9orf72 HRE mutant microglia are toxic to co-cultured healthy motor neurons, which is ameliorated by concomitant application of an MMP9 inhibitor. Finally, we identify release of dipeptidyl peptidase-4 (DPP4) as a marker for MMP9-dependent microglial dysregulation in co-culture. These results demonstrate cellular dysfunction of C9orf72 HRE mutant microglia, and a non-cell-autonomous role in driving C9orf72-ALS pathophysiology in motor neurons through MMP9 signaling. The role of microglia in amyotrophic lateral sclerosis (ALS) is unclear. Here, the authors show that iPSC microglia from C9orf72-ALS patients are toxic to motor neurons and identify microglial MMP9 as a potential therapeutic target.
AbstractList Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation in C9orf72 . Here, we study its consequences for microglial function using human iPSC-derived microglia. By RNA-sequencing, we identify enrichment of pathways associated with immune cell activation and cyto-/chemokines in C9orf72 HRE mutant microglia versus healthy controls, most prominently after LPS priming. Specifically, LPS-primed C9orf72 HRE mutant microglia show consistently increased expression and release of matrix metalloproteinase-9 (MMP9). LPS-primed C9orf72 HRE mutant microglia are toxic to co-cultured healthy motor neurons, which is ameliorated by concomitant application of an MMP9 inhibitor. Finally, we identify release of dipeptidyl peptidase-4 (DPP4) as a marker for MMP9-dependent microglial dysregulation in co-culture. These results demonstrate cellular dysfunction of C9orf72 HRE mutant microglia, and a non-cell-autonomous role in driving C9orf72-ALS pathophysiology in motor neurons through MMP9 signaling.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation in C9orf72. Here, we study its consequences for microglial function using human iPSC-derived microglia. By RNA-sequencing, we identify enrichment of pathways associated with immune cell activation and cyto-/chemokines in C9orf72 HRE mutant microglia versus healthy controls, most prominently after LPS priming. Specifically, LPS-primed C9orf72 HRE mutant microglia show consistently increased expression and release of matrix metalloproteinase-9 (MMP9). LPS-primed C9orf72 HRE mutant microglia are toxic to co-cultured healthy motor neurons, which is ameliorated by concomitant application of an MMP9 inhibitor. Finally, we identify release of dipeptidyl peptidase-4 (DPP4) as a marker for MMP9-dependent microglial dysregulation in co-culture. These results demonstrate cellular dysfunction of C9orf72 HRE mutant microglia, and a non-cell-autonomous role in driving C9orf72-ALS pathophysiology in motor neurons through MMP9 signaling.The role of microglia in amyotrophic lateral sclerosis (ALS) is unclear. Here, the authors show that iPSC microglia from C9orf72-ALS patients are toxic to motor neurons and identify microglial MMP9 as a potential therapeutic target.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation in C9orf72. Here, we study its consequences for microglial function using human iPSC-derived microglia. By RNA-sequencing, we identify enrichment of pathways associated with immune cell activation and cyto-/chemokines in C9orf72 HRE mutant microglia versus healthy controls, most prominently after LPS priming. Specifically, LPS-primed C9orf72 HRE mutant microglia show consistently increased expression and release of matrix metalloproteinase-9 (MMP9). LPS-primed C9orf72 HRE mutant microglia are toxic to co-cultured healthy motor neurons, which is ameliorated by concomitant application of an MMP9 inhibitor. Finally, we identify release of dipeptidyl peptidase-4 (DPP4) as a marker for MMP9-dependent microglial dysregulation in co-culture. These results demonstrate cellular dysfunction of C9orf72 HRE mutant microglia, and a non-cell-autonomous role in driving C9orf72-ALS pathophysiology in motor neurons through MMP9 signaling.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation in C9orf72 . Here, we study its consequences for microglial function using human iPSC-derived microglia. By RNA-sequencing, we identify enrichment of pathways associated with immune cell activation and cyto-/chemokines in C9orf72 HRE mutant microglia versus healthy controls, most prominently after LPS priming. Specifically, LPS-primed C9orf72 HRE mutant microglia show consistently increased expression and release of matrix metalloproteinase-9 (MMP9). LPS-primed C9orf72 HRE mutant microglia are toxic to co-cultured healthy motor neurons, which is ameliorated by concomitant application of an MMP9 inhibitor. Finally, we identify release of dipeptidyl peptidase-4 (DPP4) as a marker for MMP9-dependent microglial dysregulation in co-culture. These results demonstrate cellular dysfunction of C9orf72 HRE mutant microglia, and a non-cell-autonomous role in driving C9orf72-ALS pathophysiology in motor neurons through MMP9 signaling. The role of microglia in amyotrophic lateral sclerosis (ALS) is unclear. Here, the authors show that iPSC microglia from C9orf72-ALS patients are toxic to motor neurons and identify microglial MMP9 as a potential therapeutic target.
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation in C9orf72. Here, we study its consequences for microglial function using human iPSC-derived microglia. By RNA-sequencing, we identify enrichment of pathways associated with immune cell activation and cyto-/chemokines in C9orf72 HRE mutant microglia versus healthy controls, most prominently after LPS priming. Specifically, LPS-primed C9orf72 HRE mutant microglia show consistently increased expression and release of matrix metalloproteinase-9 (MMP9). LPS-primed C9orf72 HRE mutant microglia are toxic to co-cultured healthy motor neurons, which is ameliorated by concomitant application of an MMP9 inhibitor. Finally, we identify release of dipeptidyl peptidase-4 (DPP4) as a marker for MMP9-dependent microglial dysregulation in co-culture. These results demonstrate cellular dysfunction of C9orf72 HRE mutant microglia, and a non-cell-autonomous role in driving C9orf72-ALS pathophysiology in motor neurons through MMP9 signaling.
ArticleNumber 5898
Author Katsikoudi, Antigoni
Xu, Yinyan
Gray, Elizabeth
Nalluru, Sumedha
Isaacs, Adrian M.
Scaber, Jakub
Cramb, Kaitlyn M. L.
Morgan, Georgia R.
Carroll, Emily
Wade-Martins, Richard
Turner, Martin R.
Farrimond, Lucy
Vahsen, Björn F.
Carcolé, Mireia
Cowley, Sally A.
Dafinca, Ruxandra
Talbot, Kevin
Amein, Benazir
Candalija, Ana
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37736756$$D View this record in MEDLINE/PubMed
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Cites_doi 10.3389/fncel.2021.653688
10.1038/s41593-018-0083-7
10.1016/j.febslet.2014.08.029
10.1523/ENEURO.0266-18.2018
10.1007/s00415-018-8983-8
10.1038/s41598-022-16896-8
10.1016/j.stemcr.2017.05.017
10.1083/jcb.200908164
10.1016/j.neuron.2021.05.020
10.1097/00001756-200011090-00003
10.1186/s13059-014-0550-8
10.1002/stem.2758
10.1126/science.aaf1064
10.1038/nrn2038
10.1371/journal.pone.0071098
10.1016/j.exphem.2008.04.009
10.1093/bioinformatics/btt656
10.1016/j.nbd.2018.11.013
10.7554/eLife.48363
10.1146/annurev-immunol-051116-052358
10.15252/emmm.201707850
10.1016/j.stemcr.2020.03.023
10.1111/jnc.13415
10.1016/j.neuron.2011.09.011
10.1016/j.neuron.2018.02.027
10.1002/cne.24040
10.1038/s41587-019-0201-4
10.1016/j.jbc.2021.100963
10.21037/atm.2018.04.41
10.1016/j.neuron.2013.12.009
10.1038/s41582-021-00487-8
10.1038/nm.4490
10.3389/fncel.2015.00280
10.1038/s41418-018-0060-4
10.1126/sciadv.abq0651
10.1016/j.jns.2010.04.005
10.1080/15548627.2021.1872189
10.1038/nmeth.2019
10.3389/fncel.2023.1179796
10.1093/hmg/ddaa106
10.1126/science.1232927
10.1371/journal.pone.0039216
10.1007/s00401-011-0932-x
10.1038/s41586-020-2625-x
10.1089/omi.2011.0118
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References Serio, Patani (CR3) 2018; 36
Vahsen (CR4) 2021; 17
Banerjee (CR28) 2023; 9
Laflamme (CR29) 2019; 8
Nicolas (CR21) 2018; 97
Kaplan (CR22) 2014; 81
Mori (CR11) 2013; 339
Haenseler (CR16) 2017; 8
Fang (CR36) 2010; 294
Dafinca (CR39) 2020; 14
Ilieva, Polymenidou, Cleveland (CR1) 2009; 187
Vahsen (CR17) 2022; 12
Simone (CR20) 2018; 10
Rohrborn, Eckel, Sell (CR26) 2014; 588
Vafadari, Salamian, Kaczmarek (CR34) 2016; 139
Schindelin (CR45) 2012; 9
Love, Huber, Anders (CR43) 2014; 15
van Wilgenburg, Browne, Vowles, Cowley (CR15) 2013; 8
Talbot, Feneberg, Scaber, Thompson, Turner (CR7) 2018; 265
Beckers, Tharkeshwar, Van Damme (CR31) 2021; 17
Beuche (CR35) 2000; 11
Block, Zecca, Hong (CR6) 2007; 8
Liao, Smyth, Shi (CR42) 2014; 30
DeJesus-Hernandez (CR10) 2011; 72
Brettschneider (CR9) 2012; 123
Dafinca, Barbagallo, Talbot (CR32) 2021; 15
Angelopoulou, Piperi (CR37) 2018; 6
Lall (CR14) 2021; 109
Colonna, Butovsky (CR5) 2017; 35
York, LeDue, Bernier, MacVicar (CR19) 2018; 5
Shi (CR30) 2018; 24
Reinhard, Razak, Ethell (CR33) 2015; 9
O’Rourke (CR12) 2016; 351
Spiller (CR23) 2019; 124
Brettschneider (CR8) 2012; 7
McCauley (CR13) 2020; 585
Spiller (CR38) 2018; 21
Kim, Paggi, Park, Bennett, Salzberg (CR41) 2019; 37
Valverde (CR25) 2021; 297
Karlsson (CR40) 2008; 36
von Bartheld, Bahney, Herculano-Houzel (CR24) 2016; 524
Lorenzini (CR27) 2023; 17
Ababneh (CR18) 2020; 29
Yu, Wang, Han, He (CR44) 2012; 16
Chen, Kankel, Su, Han, Ofengeim (CR2) 2018; 25
R Dafinca (41603_CR39) 2020; 14
ME McCauley (41603_CR13) 2020; 585
Y Liao (41603_CR42) 2014; 30
M DeJesus-Hernandez (41603_CR10) 2011; 72
A Kaplan (41603_CR22) 2014; 81
JG O’Rourke (41603_CR12) 2016; 351
W Haenseler (41603_CR16) 2017; 8
J Schindelin (41603_CR45) 2012; 9
J Brettschneider (41603_CR9) 2012; 123
KJ Spiller (41603_CR38) 2018; 21
A Serio (41603_CR3) 2018; 36
L Fang (41603_CR36) 2010; 294
H Ilieva (41603_CR1) 2009; 187
P Banerjee (41603_CR28) 2023; 9
B Vafadari (41603_CR34) 2016; 139
Y Shi (41603_CR30) 2018; 24
K Mori (41603_CR11) 2013; 339
C Laflamme (41603_CR29) 2019; 8
J Brettschneider (41603_CR8) 2012; 7
J Beckers (41603_CR31) 2021; 17
SM Reinhard (41603_CR33) 2015; 9
MI Love (41603_CR43) 2014; 15
BF Vahsen (41603_CR17) 2022; 12
I Lorenzini (41603_CR27) 2023; 17
NA Ababneh (41603_CR18) 2020; 29
ML Block (41603_CR6) 2007; 8
M Colonna (41603_CR5) 2017; 35
R Simone (41603_CR20) 2018; 10
D Lall (41603_CR14) 2021; 109
KJ Spiller (41603_CR23) 2019; 124
R Dafinca (41603_CR32) 2021; 15
D Kim (41603_CR41) 2019; 37
E Angelopoulou (41603_CR37) 2018; 6
BF Vahsen (41603_CR4) 2021; 17
KR Karlsson (41603_CR40) 2008; 36
G Yu (41603_CR44) 2012; 16
EM York (41603_CR19) 2018; 5
A Valverde (41603_CR25) 2021; 297
B van Wilgenburg (41603_CR15) 2013; 8
K Talbot (41603_CR7) 2018; 265
A Nicolas (41603_CR21) 2018; 97
D Rohrborn (41603_CR26) 2014; 588
W Beuche (41603_CR35) 2000; 11
H Chen (41603_CR2) 2018; 25
CS von Bartheld (41603_CR24) 2016; 524
References_xml – volume: 15
  start-page: 653688
  year: 2021
  ident: CR32
  article-title: The role of mitochondrial dysfunction and ER stress in TDP-43 and C9ORF72 ALS
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2021.653688
  contributor:
    fullname: Talbot
– volume: 21
  start-page: 329
  year: 2018
  end-page: 340
  ident: CR38
  article-title: Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-018-0083-7
  contributor:
    fullname: Spiller
– volume: 588
  start-page: 3870
  year: 2014
  end-page: 3877
  ident: CR26
  article-title: Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2014.08.029
  contributor:
    fullname: Sell
– volume: 5
  start-page: ENEURO.0266-0218.2018
  year: 2018
  ident: CR19
  article-title: 3DMorph automatic analysis of microglial morphology in three dimensions from ex vivo and in vivo imaging
  publication-title: eNeuro
  doi: 10.1523/ENEURO.0266-18.2018
  contributor:
    fullname: MacVicar
– volume: 265
  start-page: 2454
  year: 2018
  end-page: 2462
  ident: CR7
  article-title: Amyotrophic lateral sclerosis: the complex path to precision medicine
  publication-title: J. Neurol.
  doi: 10.1007/s00415-018-8983-8
  contributor:
    fullname: Turner
– volume: 12
  year: 2022
  ident: CR17
  article-title: Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-022-16896-8
  contributor:
    fullname: Vahsen
– volume: 8
  start-page: 1727
  year: 2017
  end-page: 1742
  ident: CR16
  article-title: A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2017.05.017
  contributor:
    fullname: Haenseler
– volume: 187
  start-page: 761
  year: 2009
  end-page: 772
  ident: CR1
  article-title: Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200908164
  contributor:
    fullname: Cleveland
– volume: 109
  start-page: 2275
  year: 2021
  end-page: 2291.e2278
  ident: CR14
  article-title: C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
  publication-title: Neuron
  doi: 10.1016/j.neuron.2021.05.020
  contributor:
    fullname: Lall
– volume: 11
  start-page: 3419
  year: 2000
  end-page: 3422
  ident: CR35
  article-title: Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis
  publication-title: Neuroreport
  doi: 10.1097/00001756-200011090-00003
  contributor:
    fullname: Beuche
– volume: 15
  year: 2014
  ident: CR43
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
  contributor:
    fullname: Anders
– volume: 36
  start-page: 293
  year: 2018
  end-page: 303
  ident: CR3
  article-title: Concise review: the cellular conspiracy of amyotrophic lateral sclerosis
  publication-title: Stem Cells
  doi: 10.1002/stem.2758
  contributor:
    fullname: Patani
– volume: 351
  start-page: 1324
  year: 2016
  end-page: 1329
  ident: CR12
  article-title: C9orf72 is required for proper macrophage and microglial function in mice
  publication-title: Science
  doi: 10.1126/science.aaf1064
  contributor:
    fullname: O’Rourke
– volume: 8
  start-page: 57
  year: 2007
  end-page: 69
  ident: CR6
  article-title: Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2038
  contributor:
    fullname: Hong
– volume: 8
  start-page: e71098
  year: 2013
  ident: CR15
  article-title: Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0071098
  contributor:
    fullname: Cowley
– volume: 36
  start-page: 1167
  year: 2008
  end-page: 1175
  ident: CR40
  article-title: Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2008.04.009
  contributor:
    fullname: Karlsson
– volume: 30
  start-page: 923
  year: 2014
  end-page: 930
  ident: CR42
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
  contributor:
    fullname: Shi
– volume: 124
  start-page: 133
  year: 2019
  end-page: 140
  ident: CR23
  article-title: Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2018.11.013
  contributor:
    fullname: Spiller
– volume: 8
  start-page: e48363
  year: 2019
  ident: CR29
  article-title: Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72
  publication-title: elife
  doi: 10.7554/eLife.48363
  contributor:
    fullname: Laflamme
– volume: 35
  start-page: 441
  year: 2017
  end-page: 468
  ident: CR5
  article-title: Microglia function in the central nervous system during health and neurodegeneration
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-051116-052358
  contributor:
    fullname: Butovsky
– volume: 10
  start-page: 22
  year: 2018
  end-page: 31
  ident: CR20
  article-title: G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201707850
  contributor:
    fullname: Simone
– volume: 14
  start-page: 892
  year: 2020
  end-page: 908
  ident: CR39
  article-title: Impairment of mitochondrial calcium buffering links mutations in C9ORF72 and TARDBP in iPS-derived motor neurons from patients with ALS/FTD
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2020.03.023
  contributor:
    fullname: Dafinca
– volume: 139
  start-page: 91
  year: 2016
  end-page: 114
  ident: CR34
  article-title: MMP-9 in translation: from molecule to brain physiology, pathology, and therapy
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.13415
  contributor:
    fullname: Kaczmarek
– volume: 72
  start-page: 245
  year: 2011
  end-page: 256
  ident: CR10
  article-title: Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.09.011
  contributor:
    fullname: DeJesus-Hernandez
– volume: 97
  start-page: 1268
  year: 2018
  end-page: 1283.e1266
  ident: CR21
  article-title: Genome-wide analyses identify KIF5A as a novel ALS gene
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.02.027
  contributor:
    fullname: Nicolas
– volume: 524
  start-page: 3865
  year: 2016
  end-page: 3895
  ident: CR24
  article-title: The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.24040
  contributor:
    fullname: Herculano-Houzel
– volume: 37
  start-page: 907
  year: 2019
  end-page: 915
  ident: CR41
  article-title: Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-019-0201-4
  contributor:
    fullname: Salzberg
– volume: 297
  start-page: 100963
  year: 2021
  ident: CR25
  article-title: Dipeptidyl peptidase 4 contributes to Alzheimer’s disease-like defects in a mouse model and is increased in sporadic Alzheimer’s disease brains
  publication-title: J. Biol. Chem.
  doi: 10.1016/j.jbc.2021.100963
  contributor:
    fullname: Valverde
– volume: 6
  start-page: 255
  year: 2018
  ident: CR37
  article-title: DPP-4 inhibitors: a promising therapeutic approach against Alzheimer’s disease
  publication-title: Ann. Transl. Med.
  doi: 10.21037/atm.2018.04.41
  contributor:
    fullname: Piperi
– volume: 81
  start-page: 333
  year: 2014
  end-page: 348
  ident: CR22
  article-title: Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.12.009
  contributor:
    fullname: Kaplan
– volume: 17
  start-page: 333
  year: 2021
  end-page: 348
  ident: CR4
  article-title: Non-neuronal cells in amyotrophic lateral sclerosis - from pathogenesis to biomarkers
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/s41582-021-00487-8
  contributor:
    fullname: Vahsen
– volume: 24
  start-page: 313
  year: 2018
  end-page: 325
  ident: CR30
  article-title: Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
  publication-title: Nat. Med.
  doi: 10.1038/nm.4490
  contributor:
    fullname: Shi
– volume: 9
  start-page: 280
  year: 2015
  ident: CR33
  article-title: A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2015.00280
  contributor:
    fullname: Ethell
– volume: 25
  start-page: 648
  year: 2018
  end-page: 662
  ident: CR2
  article-title: Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-018-0060-4
  contributor:
    fullname: Ofengeim
– volume: 9
  start-page: eabq0651
  year: 2023
  ident: CR28
  article-title: Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abq0651
  contributor:
    fullname: Banerjee
– volume: 294
  start-page: 51
  year: 2010
  end-page: 56
  ident: CR36
  article-title: MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS
  publication-title: J. Neurol. Sci.
  doi: 10.1016/j.jns.2010.04.005
  contributor:
    fullname: Fang
– volume: 17
  start-page: 3306
  year: 2021
  end-page: 3322
  ident: CR31
  article-title: C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels
  publication-title: Autophagy
  doi: 10.1080/15548627.2021.1872189
  contributor:
    fullname: Van Damme
– volume: 9
  start-page: 676
  year: 2012
  end-page: 682
  ident: CR45
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: Schindelin
– volume: 17
  start-page: 1179796
  year: 2023
  ident: CR27
  article-title: Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2023.1179796
  contributor:
    fullname: Lorenzini
– volume: 29
  start-page: 2200
  year: 2020
  end-page: 2217
  ident: CR18
  article-title: Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddaa106
  contributor:
    fullname: Ababneh
– volume: 339
  start-page: 1335
  year: 2013
  end-page: 1338
  ident: CR11
  article-title: The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS
  publication-title: Science
  doi: 10.1126/science.1232927
  contributor:
    fullname: Mori
– volume: 7
  start-page: e39216
  year: 2012
  ident: CR8
  article-title: Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0039216
  contributor:
    fullname: Brettschneider
– volume: 123
  start-page: 395
  year: 2012
  end-page: 407
  ident: CR9
  article-title: Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-011-0932-x
  contributor:
    fullname: Brettschneider
– volume: 585
  start-page: 96
  year: 2020
  end-page: 101
  ident: CR13
  article-title: C9orf72 in myeloid cells suppresses STING-induced inflammation
  publication-title: Nature
  doi: 10.1038/s41586-020-2625-x
  contributor:
    fullname: McCauley
– volume: 16
  start-page: 284
  year: 2012
  end-page: 287
  ident: CR44
  article-title: clusterProfiler: an R package for comparing biological themes among gene clusters
  publication-title: OMICS
  doi: 10.1089/omi.2011.0118
  contributor:
    fullname: He
– volume: 124
  start-page: 133
  year: 2019
  ident: 41603_CR23
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2018.11.013
  contributor:
    fullname: KJ Spiller
– volume: 588
  start-page: 3870
  year: 2014
  ident: 41603_CR26
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2014.08.029
  contributor:
    fullname: D Rohrborn
– volume: 24
  start-page: 313
  year: 2018
  ident: 41603_CR30
  publication-title: Nat. Med.
  doi: 10.1038/nm.4490
  contributor:
    fullname: Y Shi
– volume: 37
  start-page: 907
  year: 2019
  ident: 41603_CR41
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-019-0201-4
  contributor:
    fullname: D Kim
– volume: 17
  start-page: 1179796
  year: 2023
  ident: 41603_CR27
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2023.1179796
  contributor:
    fullname: I Lorenzini
– volume: 265
  start-page: 2454
  year: 2018
  ident: 41603_CR7
  publication-title: J. Neurol.
  doi: 10.1007/s00415-018-8983-8
  contributor:
    fullname: K Talbot
– volume: 5
  start-page: ENEURO.0266-021
  year: 2018
  ident: 41603_CR19
  publication-title: eNeuro
  doi: 10.1523/ENEURO.0266-18.2018
  contributor:
    fullname: EM York
– volume: 524
  start-page: 3865
  year: 2016
  ident: 41603_CR24
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.24040
  contributor:
    fullname: CS von Bartheld
– volume: 109
  start-page: 2275
  year: 2021
  ident: 41603_CR14
  publication-title: Neuron
  doi: 10.1016/j.neuron.2021.05.020
  contributor:
    fullname: D Lall
– volume: 10
  start-page: 22
  year: 2018
  ident: 41603_CR20
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201707850
  contributor:
    fullname: R Simone
– volume: 9
  start-page: 676
  year: 2012
  ident: 41603_CR45
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: J Schindelin
– volume: 294
  start-page: 51
  year: 2010
  ident: 41603_CR36
  publication-title: J. Neurol. Sci.
  doi: 10.1016/j.jns.2010.04.005
  contributor:
    fullname: L Fang
– volume: 14
  start-page: 892
  year: 2020
  ident: 41603_CR39
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2020.03.023
  contributor:
    fullname: R Dafinca
– volume: 8
  start-page: 57
  year: 2007
  ident: 41603_CR6
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2038
  contributor:
    fullname: ML Block
– volume: 6
  start-page: 255
  year: 2018
  ident: 41603_CR37
  publication-title: Ann. Transl. Med.
  doi: 10.21037/atm.2018.04.41
  contributor:
    fullname: E Angelopoulou
– volume: 97
  start-page: 1268
  year: 2018
  ident: 41603_CR21
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.02.027
  contributor:
    fullname: A Nicolas
– volume: 17
  start-page: 3306
  year: 2021
  ident: 41603_CR31
  publication-title: Autophagy
  doi: 10.1080/15548627.2021.1872189
  contributor:
    fullname: J Beckers
– volume: 36
  start-page: 293
  year: 2018
  ident: 41603_CR3
  publication-title: Stem Cells
  doi: 10.1002/stem.2758
  contributor:
    fullname: A Serio
– volume: 21
  start-page: 329
  year: 2018
  ident: 41603_CR38
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-018-0083-7
  contributor:
    fullname: KJ Spiller
– volume: 81
  start-page: 333
  year: 2014
  ident: 41603_CR22
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.12.009
  contributor:
    fullname: A Kaplan
– volume: 139
  start-page: 91
  year: 2016
  ident: 41603_CR34
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.13415
  contributor:
    fullname: B Vafadari
– volume: 11
  start-page: 3419
  year: 2000
  ident: 41603_CR35
  publication-title: Neuroreport
  doi: 10.1097/00001756-200011090-00003
  contributor:
    fullname: W Beuche
– volume: 187
  start-page: 761
  year: 2009
  ident: 41603_CR1
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200908164
  contributor:
    fullname: H Ilieva
– volume: 8
  start-page: e71098
  year: 2013
  ident: 41603_CR15
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0071098
  contributor:
    fullname: B van Wilgenburg
– volume: 15
  start-page: 653688
  year: 2021
  ident: 41603_CR32
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2021.653688
  contributor:
    fullname: R Dafinca
– volume: 351
  start-page: 1324
  year: 2016
  ident: 41603_CR12
  publication-title: Science
  doi: 10.1126/science.aaf1064
  contributor:
    fullname: JG O’Rourke
– volume: 72
  start-page: 245
  year: 2011
  ident: 41603_CR10
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.09.011
  contributor:
    fullname: M DeJesus-Hernandez
– volume: 12
  year: 2022
  ident: 41603_CR17
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-022-16896-8
  contributor:
    fullname: BF Vahsen
– volume: 339
  start-page: 1335
  year: 2013
  ident: 41603_CR11
  publication-title: Science
  doi: 10.1126/science.1232927
  contributor:
    fullname: K Mori
– volume: 16
  start-page: 284
  year: 2012
  ident: 41603_CR44
  publication-title: OMICS
  doi: 10.1089/omi.2011.0118
  contributor:
    fullname: G Yu
– volume: 25
  start-page: 648
  year: 2018
  ident: 41603_CR2
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-018-0060-4
  contributor:
    fullname: H Chen
– volume: 297
  start-page: 100963
  year: 2021
  ident: 41603_CR25
  publication-title: J. Biol. Chem.
  doi: 10.1016/j.jbc.2021.100963
  contributor:
    fullname: A Valverde
– volume: 15
  year: 2014
  ident: 41603_CR43
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
  contributor:
    fullname: MI Love
– volume: 8
  start-page: 1727
  year: 2017
  ident: 41603_CR16
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2017.05.017
  contributor:
    fullname: W Haenseler
– volume: 8
  start-page: e48363
  year: 2019
  ident: 41603_CR29
  publication-title: elife
  doi: 10.7554/eLife.48363
  contributor:
    fullname: C Laflamme
– volume: 585
  start-page: 96
  year: 2020
  ident: 41603_CR13
  publication-title: Nature
  doi: 10.1038/s41586-020-2625-x
  contributor:
    fullname: ME McCauley
– volume: 9
  start-page: eabq0651
  year: 2023
  ident: 41603_CR28
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abq0651
  contributor:
    fullname: P Banerjee
– volume: 30
  start-page: 923
  year: 2014
  ident: 41603_CR42
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
  contributor:
    fullname: Y Liao
– volume: 17
  start-page: 333
  year: 2021
  ident: 41603_CR4
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/s41582-021-00487-8
  contributor:
    fullname: BF Vahsen
– volume: 36
  start-page: 1167
  year: 2008
  ident: 41603_CR40
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2008.04.009
  contributor:
    fullname: KR Karlsson
– volume: 7
  start-page: e39216
  year: 2012
  ident: 41603_CR8
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0039216
  contributor:
    fullname: J Brettschneider
– volume: 29
  start-page: 2200
  year: 2020
  ident: 41603_CR18
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddaa106
  contributor:
    fullname: NA Ababneh
– volume: 35
  start-page: 441
  year: 2017
  ident: 41603_CR5
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-051116-052358
  contributor:
    fullname: M Colonna
– volume: 123
  start-page: 395
  year: 2012
  ident: 41603_CR9
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-011-0932-x
  contributor:
    fullname: J Brettschneider
– volume: 9
  start-page: 280
  year: 2015
  ident: 41603_CR33
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2015.00280
  contributor:
    fullname: SM Reinhard
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Snippet Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological...
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological...
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological...
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SubjectTerms 13/100
13/106
14/19
38/91
631/378/1689/1285
631/378/2596/1953
631/532/2064/2158
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - genetics
C9orf72 Protein - genetics
Cell activation
Cell culture
Chemokines
Coculture Techniques
Gelatinase B
Gene sequencing
Genetic diversity
Genetic variance
Humanities and Social Sciences
Humans
Immune system
Induced Pluripotent Stem Cells
Inflammation
Lipopolysaccharides
Matrix metalloproteinase
Matrix Metalloproteinase 9 - genetics
Matrix metalloproteinases
Metalloproteinase
Microglia
Motor Neurons
multidisciplinary
Mutants
Neurodegenerative Diseases
Neurons
Pathophysiology
Priming
Regulatory sequences
Science
Science (multidisciplinary)
Therapeutic targets
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Title C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
URI https://link.springer.com/article/10.1038/s41467-023-41603-0
https://www.ncbi.nlm.nih.gov/pubmed/37736756
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Volume 14
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