The diversified role of mitochondria in ferroptosis in cancer

• Published in: Cell death & disease Vol. 14; no. 8; pp. 519 - 12
• Main Authors: Liu, Yu’e, Lu, Shiping, Wu, Lei-lei, Yang, Liang, Yang, Lixue, Wang, Jinghan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.08.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/2; 631/80/82; 692/420/755; Antibodies; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cancer; Cell Biology; Cell Culture; Cell death; Cristae; Drug resistance; Energy metabolism; Ferroptosis; Glycolysis; Immunology; Iron; Life Sciences; Lipid peroxidation; Membrane fusion; Membrane potential; Metabolism; Metastases; Mitochondria; Oxidative phosphorylation; Oxidative stress; Phosphorylation; Review; Review Article; Sex hormones; Tumor cells

Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS accumulation, ferroptosis is modulated by various cellular metabolic and signaling pathways. The GSH-GPX4 path...