Acute administration of oxycodone, alcohol, and their combination on simulated driving—preliminary outcomes in healthy adults

• Published in: Psychopharmacology Vol. 238; no. 2; pp. 539 - 549
• Main Authors: Babalonis, Shanna, Coe, Marion A., Nuzzo, Paul A., Lofwall, Michelle R., Ali, Nur, Sloan, Paul A., Fanucchi, Laura C., Walsh, Sharon L.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2021; Springer; Springer Nature B.V
• Subjects: Acuity; Adult; Alcohol; Alcohols; Analysis; Biomedical and Life Sciences; Biomedicine; Blindness; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Driving ability; Driving Under the Influence - psychology; Drug dosages; Drug Synergism; Drunk driving; Epidemiology; Ethanol - administration & dosage; Ethanol - adverse effects; Evaluation; Female; Humans; Male; Models, Psychological; Narcotics; Neurosciences; Opioid-Related Disorders - psychology; Opioids; Original Investigation; Oxycodone; Oxycodone - administration & dosage; Oxycodone - adverse effects; Pharmacology/Toxicology; Placebos; Psychiatry; Psychomotor Performance - drug effects; United States; Human; Drugged driving; Driving simulator; Ethanol; Oxycodone; Impairment; Opioid; Alcohol

Rationale Epidemiological data indicate that drivers testing positive for an opioid drug are twice as likely to cause a fatal car crash; however, there are limited controlled data available. Objectives The primary aim of this study was to assess the effects of a therapeutic dose range of oxycodone a...