Programmable synthetic receptors: the next-generation of cell and gene therapies

• Published in: Signal transduction and targeted therapy Vol. 9; no. 1; pp. 7 - 25
• Main Authors: Teng, Fei, Cui, Tongtong, Zhou, Li, Gao, Qingqin, Zhou, Qi, Li, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.01.2024; Nature Publishing Group
• Subjects: 631/61; 631/80; Antigens; Biomarkers; Cancer Research; Cell Biology; Chimeric antigen receptors; Cytokines; FDA approval; Gene therapy; Genes; Internal Medicine; Medical research; Medicine; Medicine & Public Health; Oncology; Pathology; Proteins; R&D; Receptor mechanisms; Research & development; Review; Review Article; Sensors; Signal processing; Signal transduction; Stem cells; Synthetic biology; Therapeutic applications

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat diseases. However, concerns over the safety and efficacy require to be further addressed in order to realize their full potential. Synthetic receptors, a synthetic biology tool that can precisely control the f...