Morphological and molecular-biological features of glioblastoma progression in tolerant and susceptible to hypoxia Wistar rats

• Published in: Scientific reports Vol. 13; no. 1; pp. 12694 - 13
• Main Authors: Dzhalilova, D. Sh, Zolotova, N. A., Mkhitarov, V. A., Kosyreva, A. M., Tsvetkov, I. S., Khalansky, A. S., Alekseeva, A. I., Fatkhudinov, T. H., Makarova, O. V.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.08.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/256; 631/67/2329; 692/308/1426; 692/499; Animals; Body weight; Brain cancer; Decompression; Glioblastoma; Glioblastoma cells; Humanities and Social Sciences; Hypoxia; Hypoxia-inducible factor 1a; IL-1β; Inoculation; multidisciplinary; Science; Science (multidisciplinary); Serum levels; Survival; Tumor necrosis factor-α; Tumorigenesis; Tumors

Hypoxia is a major pathogenetic factor in many cancers. Individual resistance to suboptimal oxygen availability is subject to broad variation and its possible role in tumorigenesis remains underexplored. This study aimed at specific characterization of glioblastoma progression in male tolerant and s...