Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression
Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues. Here, we investigate systems-level changes in the integrin adhesome in patient-derived cutane...
Saved in:
| Published in | Nature communications Vol. 14; no. 1; p. 1602 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
23.03.2023
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues. Here, we investigate systems-level changes in the integrin adhesome in patient-derived cutaneous squamous cell carcinoma cells and identify the actin regulatory protein Mena as a key node in the adhesion complex network. Mena is connected within a subnetwork of actin-binding proteins to the LINC complex component nesprin-2, with which it interacts and co-localises at the nuclear envelope. Moreover, Mena potentiates the interactions of nesprin-2 with the actin cytoskeleton and the nuclear lamina. CRISPR-mediated Mena depletion causes altered nuclear morphology, reduces tyrosine phosphorylation of the nuclear membrane protein emerin and downregulates expression of the immunomodulatory gene
PTX3
via the recruitment of its enhancer to the nuclear periphery. We uncover an unexpected role for Mena at the nuclear membrane, where it controls nuclear architecture, chromatin repositioning and gene expression. Our findings identify an adhesion protein that regulates gene transcription via direct signalling across the nuclear envelope.
Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene expression. |
|---|---|
| AbstractList | Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues. Here, we investigate systems-level changes in the integrin adhesome in patient-derived cutaneous squamous cell carcinoma cells and identify the actin regulatory protein Mena as a key node in the adhesion complex network. Mena is connected within a subnetwork of actin-binding proteins to the LINC complex component nesprin-2, with which it interacts and co-localises at the nuclear envelope. Moreover, Mena potentiates the interactions of nesprin-2 with the actin cytoskeleton and the nuclear lamina. CRISPR-mediated Mena depletion causes altered nuclear morphology, reduces tyrosine phosphorylation of the nuclear membrane protein emerin and downregulates expression of the immunomodulatory gene
PTX3
via the recruitment of its enhancer to the nuclear periphery. We uncover an unexpected role for Mena at the nuclear membrane, where it controls nuclear architecture, chromatin repositioning and gene expression. Our findings identify an adhesion protein that regulates gene transcription via direct signalling across the nuclear envelope.
Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene expression. Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues. Here, we investigate systems-level changes in the integrin adhesome in patient-derived cutaneous squamous cell carcinoma cells and identify the actin regulatory protein Mena as a key node in the adhesion complex network. Mena is connected within a subnetwork of actin-binding proteins to the LINC complex component nesprin-2, with which it interacts and co-localises at the nuclear envelope. Moreover, Mena potentiates the interactions of nesprin-2 with the actin cytoskeleton and the nuclear lamina. CRISPR-mediated Mena depletion causes altered nuclear morphology, reduces tyrosine phosphorylation of the nuclear membrane protein emerin and downregulates expression of the immunomodulatory gene PTX3 via the recruitment of its enhancer to the nuclear periphery. We uncover an unexpected role for Mena at the nuclear membrane, where it controls nuclear architecture, chromatin repositioning and gene expression. Our findings identify an adhesion protein that regulates gene transcription via direct signalling across the nuclear envelope. Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene expression. Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues. Here, we investigate systems-level changes in the integrin adhesome in patient-derived cutaneous squamous cell carcinoma cells and identify the actin regulatory protein Mena as a key node in the adhesion complex network. Mena is connected within a subnetwork of actin-binding proteins to the LINC complex component nesprin-2, with which it interacts and co-localises at the nuclear envelope. Moreover, Mena potentiates the interactions of nesprin-2 with the actin cytoskeleton and the nuclear lamina. CRISPR-mediated Mena depletion causes altered nuclear morphology, reduces tyrosine phosphorylation of the nuclear membrane protein emerin and downregulates expression of the immunomodulatory gene PTX3 via the recruitment of its enhancer to the nuclear periphery. We uncover an unexpected role for Mena at the nuclear membrane, where it controls nuclear architecture, chromatin repositioning and gene expression. Our findings identify an adhesion protein that regulates gene transcription via direct signalling across the nuclear envelope. Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including the sensing and transduction of mechanical cues. Here, we investigate systems-level changes in the integrin adhesome in patient-derived cutaneous squamous cell carcinoma cells and identify the actin regulatory protein Mena as a key node in the adhesion complex network. Mena is connected within a subnetwork of actin-binding proteins to the LINC complex component nesprin-2, with which it interacts and co-localises at the nuclear envelope. Moreover, Mena potentiates the interactions of nesprin-2 with the actin cytoskeleton and the nuclear lamina. CRISPR-mediated Mena depletion causes altered nuclear morphology, reduces tyrosine phosphorylation of the nuclear membrane protein emerin and downregulates expression of the immunomodulatory gene PTX3 via the recruitment of its enhancer to the nuclear periphery. We uncover an unexpected role for Mena at the nuclear membrane, where it controls nuclear architecture, chromatin repositioning and gene expression. Our findings identify an adhesion protein that regulates gene transcription via direct signalling across the nuclear envelope.Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene expression. |
| ArticleNumber | 1602 |
| Author | Wills, Jimi C. Armstrong, J. Douglas Bickmore, Wendy A. Loftus, Alexander E. P. Parsons, Maddy Griffith, Billie G. C. von Kriegsheim, Alex Beernaert, Bruno Frame, Margaret C. Lee, Martin Leigh, Irene M. Byron, Adam Wheeler, Ann P. Valli, Jessica Li Mow Chee, Frederic Kumar, Yatendra Proby, Charlotte M. |
| Author_xml | – sequence: 1 givenname: Frederic orcidid: 0000-0003-4838-1028 surname: Li Mow Chee fullname: Li Mow Chee, Frederic organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh – sequence: 2 givenname: Bruno orcidid: 0000-0002-6219-6163 surname: Beernaert fullname: Beernaert, Bruno organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Department of Oncology, Medical Sciences Division, University of Oxford – sequence: 3 givenname: Billie G. C. surname: Griffith fullname: Griffith, Billie G. C. organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh – sequence: 4 givenname: Alexander E. P. surname: Loftus fullname: Loftus, Alexander E. P. organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh – sequence: 5 givenname: Yatendra surname: Kumar fullname: Kumar, Yatendra organization: MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh – sequence: 6 givenname: Jimi C. surname: Wills fullname: Wills, Jimi C. organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh – sequence: 7 givenname: Martin orcidid: 0000-0001-6529-5784 surname: Lee fullname: Lee, Martin organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh – sequence: 8 givenname: Jessica orcidid: 0000-0003-4346-0317 surname: Valli fullname: Valli, Jessica organization: Edinburgh Super Resolution Imaging Consortium, Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University – sequence: 9 givenname: Ann P. surname: Wheeler fullname: Wheeler, Ann P. organization: Advanced Imaging Resource, Institute of Genetics and Cancer, University of Edinburgh – sequence: 10 givenname: J. Douglas surname: Armstrong fullname: Armstrong, J. Douglas organization: Simons Initiative for the Developing Brain, School of Informatics, University of Edinburgh – sequence: 11 givenname: Maddy orcidid: 0000-0002-2021-8379 surname: Parsons fullname: Parsons, Maddy organization: Randall Centre for Cell and Molecular Biophysics, King’s College London – sequence: 12 givenname: Irene M. surname: Leigh fullname: Leigh, Irene M. organization: Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London – sequence: 13 givenname: Charlotte M. orcidid: 0000-0002-3292-4836 surname: Proby fullname: Proby, Charlotte M. organization: Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee – sequence: 14 givenname: Alex orcidid: 0000-0002-4952-8573 surname: von Kriegsheim fullname: von Kriegsheim, Alex organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh – sequence: 15 givenname: Wendy A. orcidid: 0000-0001-6660-7735 surname: Bickmore fullname: Bickmore, Wendy A. organization: MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh – sequence: 16 givenname: Margaret C. orcidid: 0000-0001-5882-1942 surname: Frame fullname: Frame, Margaret C. organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh – sequence: 17 givenname: Adam orcidid: 0000-0002-5939-9883 surname: Byron fullname: Byron, Adam email: adam.byron@manchester.ac.uk organization: Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36959177$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kstu1TAQhiNUREvpC7BAkdiwIOBb4niFUFWgUhEbWFu-jIOPEvtgJ-iwQbxD35AnwT1pS8sCb2yNv_k9M_4fVwchBqiqpxi9woj2rzPDrOMNIrShHBHc7B5URwQx3GBO6MGd82F1kvMGlUUF7hl7VB3STrQCc35U_fwIQdUJhmVUM-Q6QN4mHxpSz7E2McwpjrUysw-_f12GxYygUj2qyZcslXM0Xs0-hvyynpMKublBJph0CUCd_RDUOPow1CrYeoASg902Qc4l70n10Kkxw8n1flx9eXf2-fRDc_Hp_fnp24vGtAzPjTCOIuAct4TpXlilBDBOe4e7Hnpqe0sMopxZy5zpOg1ad4JCC-CY1YjT4-p81bVRbWTpcFLph4zKy30gpkGqNPtSuzS0I44ZI1qrGSJMIUtBM00xcs4pU7TerFrbRU9gDZQhqfGe6P2b4L_KIX6XuPxA1zJWFF5cK6T4bYE8y8lnA-NYBhaXLAkXuHwqo11Bn_-DbuKSykSvqF70grSCFIqslEkx5wTuthqM5JVd5GoXWewi93aRu5L07G4ftyk35igAXYG9JQZIf9_-j-wfl7nRyg |
| CitedBy_id | crossref_primary_10_1242_dmm_050361 crossref_primary_10_1038_s41420_023_01763_w crossref_primary_10_1016_j_cobme_2023_100494 crossref_primary_10_1016_j_ebiom_2024_105003 crossref_primary_10_1186_s13046_023_02934_4 crossref_primary_10_1016_j_sbi_2023_102728 crossref_primary_10_1136_jitc_2023_006913 crossref_primary_10_1080_19424396_2024_2358554 |
| Cites_doi | 10.1002/cpcb.113 10.1016/j.humpath.2016.06.020 10.1016/j.cell.2017.04.022 10.1093/bioinformatics/btw069 10.1038/ncb2216 10.1093/bioinformatics/bth078 10.1073/pnas.0908686106 10.1016/j.ceb.2017.01.003 10.1101/gad.322404 10.1016/j.ceb.2018.08.004 10.1186/1471-2105-13-S16-S6 10.1016/j.ceb.2006.08.006 10.1007/978-1-4939-7759-8_13 10.1242/jcs.048397 10.1101/gr.212308.116 10.1007/978-1-0716-0962-0_10 10.1042/BST0361359 10.1038/ncb3257 10.1038/ncb2747 10.1083/jcb.202003038 10.1007/978-1-61779-080-5_14 10.1083/jcb.200506083 10.1038/ncomms10997 10.1038/35011540 10.1101/gad.190413.112 10.1088/2050-6120/4/4/044008 10.18632/oncotarget.17265 10.1038/nrm.2017.101 10.1073/pnas.1214394109 10.1083/jcb.201701039 10.1021/pr101065j 10.1083/jcb.201502039 10.1093/bioinformatics/btn161 10.1002/0471143030.cb0908s66 10.1101/gr.1239303 10.1016/j.ceb.2016.02.013 10.1093/nar/gkab1038 10.1016/j.devcel.2008.09.003 10.1038/embor.2011.5 10.1126/scisignal.2005329 10.1002/pmic.201100487 10.1016/j.cell.2015.01.004 10.1007/978-1-61779-166-6_19 10.1007/978-1-4939-7154-1_15 10.1093/nar/30.1.207 10.1093/nar/gkz401 10.1038/s41467-018-04404-4 10.1371/journal.pone.0063633 10.1038/ncb0807-858 10.1038/nrg3552 10.1158/2159-8290.CD-15-1183 10.18637/jss.v045.i03 10.1155/2012/494902 10.1021/pr401264n 10.1093/bioinformatics/btr406 10.1038/nrm3769 10.1038/s41467-018-06027-1 10.1093/bioinformatics/btv386 10.1038/ncomms7265 10.1016/j.devcel.2015.09.018 10.1093/nar/gkz433 10.1093/bioinformatics/bth349 10.1038/nature06947 10.1038/nprot.2007.148 10.1093/bioinformatics/btq562 10.1038/nrm1499 10.1155/2018/4578373 10.1038/ncb2927 10.1093/bioinformatics/btq089 10.1038/ncb2981 10.1073/pnas.2032324100 10.1038/s41580-019-0134-2 10.1126/scisignal.2001896 10.1242/jcs.01642 10.1038/nrc2748 10.1016/j.yexcr.2009.11.003 10.1126/scisignal.aan8355 10.1038/nmeth.1923 10.1038/srep02930 10.1371/journal.pbio.3000202 10.1016/j.molmed.2016.04.007 10.1016/j.yexcr.2019.03.011 10.1038/nmeth.2019 10.1038/ncb3387 10.1158/0008-5472.CAN-06-1997 10.12688/f1000research.6767.1 10.3390/ijms20143428 10.1038/nmeth.2688 10.1038/nrm2594 10.1016/j.cell.2015.09.001 10.1146/annurev.cellbio.19.050103.103356 10.1073/pnas.1800621115 10.1038/nrg2918 10.1016/j.yexcr.2015.10.025 10.1126/scisignal.2000396 10.1126/science.1257601 10.1093/nar/gkv007 10.1101/cshperspect.a005033 10.1242/jcs.01639 10.1080/19491034.2016.1267093 10.1016/S0167-4889(02)00349-X 10.1016/j.cub.2010.10.059 10.1016/j.ceb.2015.03.005 10.1034/j.1600-0625.2000.009002104.x 10.1016/j.devcel.2016.07.021 10.1371/journal.pone.0040098 10.1074/jbc.M111.325308 10.1038/s41556-018-0038-y 10.1038/nbt.1511 10.1158/1078-0432.CCR-05-2027 10.1145/1054972.1055031 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023 2023. The Author(s). The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2023 – notice: 2023. The Author(s). – notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PIMPY PQEST PQQKQ PQUKI RC3 SOI 7X8 5PM DOA |
| DOI | 10.1038/s41467-023-37021-x |
| DatabaseName | SpringerOpen Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection ProQuest Central Essentials Biological Science Collection ProQuest Databases Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Natural Science Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Technology Collection Technology Research Database ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef MEDLINE Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2041-1723 |
| EndPage | 1602 |
| ExternalDocumentID | oai_doaj_org_article_c362f4cc95db4024a0d3eb4b310fffac 10_1038_s41467_023_37021_x 36959177 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Cancer Research UK (CRUK) grantid: A13044; A13044; C157/A24837; C157/A15703 funderid: https://doi.org/10.13039/501100000289 – fundername: RCUK | Medical Research Council (MRC) grantid: MR/R008264/1; MC_UU_00007/2 funderid: https://doi.org/10.13039/501100000265 – fundername: EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) grantid: 945539 funderid: https://doi.org/10.13039/100010661 – fundername: Cancer Research UK grantid: A13044 – fundername: Cancer Research UK grantid: 24837 – fundername: Wellcome Trust – fundername: Medical Research Council grantid: MC_UU_00007/2 – fundername: Medical Research Council grantid: MR/R008264/1 – fundername: Cancer Research UK grantid: C157/A24837 – fundername: Cancer Research UK grantid: 15703 – fundername: ; grantid: A13044; A13044; C157/A24837; C157/A15703 – fundername: ; grantid: 945539 – fundername: ; grantid: MR/R008264/1; MC_UU_00007/2 |
| GroupedDBID | --- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADRAZ AENEX AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PQEST PQUKI RC3 SOI 7X8 5PM |
| ID | FETCH-LOGICAL-c541t-9cf30e771524b89daa9e4738f168e83d8d2c0374dd4fc66bebb693e5eef4db073 |
| IEDL.DBID | RPM |
| ISSN | 2041-1723 |
| IngestDate | Tue Oct 22 14:47:34 EDT 2024 Tue Sep 17 21:31:40 EDT 2024 Sat Oct 26 05:26:16 EDT 2024 Thu Oct 10 21:10:21 EDT 2024 Thu Nov 21 23:11:43 EST 2024 Sat Nov 02 12:25:40 EDT 2024 Fri Oct 11 20:46:35 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2023. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c541t-9cf30e771524b89daa9e4738f168e83d8d2c0374dd4fc66bebb693e5eef4db073 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-4838-1028 0000-0002-6219-6163 0000-0001-6660-7735 0000-0001-5882-1942 0000-0002-4952-8573 0000-0003-4346-0317 0000-0001-6529-5784 0000-0002-2021-8379 0000-0002-5939-9883 0000-0002-3292-4836 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036544/ |
| PMID | 36959177 |
| PQID | 2789892592 |
| PQPubID | 546298 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c362f4cc95db4024a0d3eb4b310fffac pubmedcentral_primary_oai_pubmedcentral_nih_gov_10036544 proquest_miscellaneous_2791370436 proquest_journals_2789892592 crossref_primary_10_1038_s41467_023_37021_x pubmed_primary_36959177 springer_journals_10_1038_s41467_023_37021_x |
| PublicationCentury | 2000 |
| PublicationDate | 2023-03-23 |
| PublicationDateYYYYMMDD | 2023-03-23 |
| PublicationDate_xml | – month: 03 year: 2023 text: 2023-03-23 day: 23 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2023 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Kuo, Han, Hsiao, Yates, Waterman (CR15) 2011; 13 Oudin (CR67) 2016; 6 Perez-Riverol (CR110) 2022; 50 Postma, Goedhart (CR109) 2019; 17 Uhler, Shivashankar (CR73) 2017; 18 Winograd-Katz, Fässler, Geiger, Legate (CR7) 2014; 15 Langmead, Salzberg (CR105) 2012; 9 Byron (CR12) 2018; 1764 Di Modugno (CR59) 2007; 67 Robson (CR70) 2017; 27 Wilhelmsen (CR37) 2005; 171 Kassel (CR51) 2004; 18 Serrels (CR77) 2017; 10 Barton, Soshnev, Geyer (CR74) 2015; 34 Kuo, Han, Yates, Waterman (CR9) 2012; 757 Kirby, Lammerding (CR36) 2018; 20 Cox, Mann (CR86) 2008; 26 Montojo (CR98) 2010; 26 Woroniuk (CR63) 2018; 9 Bonavita (CR69) 2015; 160 Buenrostro, Giresi, Zaba, Chang, Greenleaf (CR104) 2013; 10 Molania, Gagnon-Bartsch, Dobrovic, Speed (CR102) 2019; 47 van Steensel, Belmont (CR66) 2017; 169 Schiller (CR18) 2013; 15 Wu (CR23) 2005; 118 Clough, Thaminy, Ragg, Aebersold, Vitek (CR89) 2012; 13 Bodenhofer, Kothmeier, Hochreiter (CR92) 2011; 27 Brackley, Grantham (CR53) 2010; 316 Liao, Wang, Jaehnig, Shi, Zhang (CR91) 2019; 47 Geiger, Yamada (CR3) 2011; 3 Khatau (CR60) 2009; 106 Byron, Humphries, Bass, Knight, Humphries (CR8) 2011; 4 Inman (CR71) 2018; 9 de Hoon, Imoto, Nolan, Miyano (CR100) 2004; 20 Simpson, Roberts (CR57) 2008; 36 Humphries, Chastney, Askari, Humphries (CR4) 2019; 56 Tifft, Bradbury, Wilson (CR65) 2009; 122 Maziveyi, Alahari (CR29) 2017; 8 Cox (CR87) 2011; 10 Mitra, Carvunis, Ramesh, Ideker (CR45) 2013; 14 Jayo (CR26) 2016; 38 Kechagia, Ivaska, Roca-Cusachs (CR5) 2019; 20 D’Alessandro (CR56) 2015; 35 Robertson (CR11) 2017; 1636 Serrels (CR78) 2015; 163 Robertson (CR44) 2015; 6 Traag, Krings, Van Dooren (CR95) 2013; 3 Demmerle, Koch, Holaska (CR75) 2012; 287 Freese, Norris, Loraine (CR107) 2016; 32 Beisser, Klau, Dandekar, Muller, Dittrich (CR50) 2010; 26 Zhou (CR24) 2018; 115 Thomas (CR61) 2015; 210 Katz (CR52) 2012; 26 Vogel, Peric-Hupkes, van Steensel (CR103) 2007; 2 Zhang (CR55) 2005; 118 Desgrosellier, Cheresh (CR28) 2010; 10 Le (CR64) 2016; 18 Shannon (CR96) 2003; 13 Horton (CR20) 2015; 17 Hensley, Zetter, Horbinski, Strup, Kyprianou (CR25) 2016; 57 Hassan (CR43) 2019; 20 Humphries (CR14) 2009; 2 Guilluy (CR40) 2014; 16 Di Modugno (CR81) 2012; 109 Byron, Frame (CR31) 2016; 39 Zaidel-Bar, Itzkovitz, Ma’ayan, Iyengar, Geiger (CR6) 2007; 9 Schiller, Friedel, Boulegue, Fässler (CR16) 2011; 12 Chastney (CR19) 2020; 219 Spirin, Mirny (CR47) 2003; 100 Broders-Bondon, Ho-Bouldoires, Fernandez-Sanchez, Farge (CR39) 2018; 217 Wang, Tytell, Ingber (CR35) 2009; 10 Hartwell, Hopfield, Leibler, Murray (CR46) 1999; 402 Krause, Dent, Bear, Loureiro, Gertler (CR72) 2003; 19 Chawade, Alexandersson, Levander (CR88) 2014; 13 Menche (CR49) 2015; 347 Ono, Muetze, Kolishovski, Shannon, Demchak (CR97) 2015; 4 Chastney, Lawless, Humphries (CR13) 2020; 88 Kumeta, Yoshimura, Hejna, Takeyasu (CR22) 2012; 2012 Byron, Morgan, Humphries (CR1) 2010; 20 Hervy, Hoffman, Beckerle (CR32) 2006; 18 Kleinschmidt, Schlaepfer (CR34) 2017; 45 Edgar, Domrachev, Lash (CR111) 2002; 30 Pfisterer, Jayo, Parsons (CR42) 2017; 8 Kadrmas, Beckerle (CR30) 2004; 5 Barabási, Gulbahce, Loscalzo (CR48) 2011; 12 Autore (CR58) 2013; 8 Green, Brown (CR2) 2019; 378 Pignatelli (CR82) 2014; 7 Saldanha (CR101) 2004; 20 Rajgor, Mellad, Autore, Zhang, Shanahan (CR54) 2012; 7 Schindelin (CR85) 2012; 9 CR99 Jones (CR10) 2015; 66 Magrini, Mantovani, Garlanda (CR76) 2016; 22 Wang, Gilmore (CR33) 2003; 1593 Thiam (CR27) 2016; 7 Di Modugno (CR79) 2006; 12 Proby (CR83) 2000; 9 Izdebska, Zielinska, Grzanka, Gagat (CR41) 2018; 2018 Dittrich, Klau, Rosenwald, Dandekar, Müller (CR94) 2008; 24 Byron, Humphries, Craig, Knight, Humphries (CR17) 2012; 12 Kutscheidt (CR38) 2014; 16 Kumar, Shivashankar (CR62) 2016; 4 Philippar (CR80) 2008; 15 van Buuren, Groothuis-Oudshoorn (CR90) 2011; 45 Li Mow Chee, Byron (CR93) 2021; 2217 Ritchie (CR108) 2015; 43 Marshall, Brand (CR106) 2015; 31 Guelen (CR68) 2008; 453 Horton, Astudillo, Humphries, Humphries (CR21) 2016; 343 Purdie, Pourreyron, South (CR84) 2011; 731 Y Liao (37021_CR91) 2019; 47 S van Buuren (37021_CR90) 2011; 45 A-L Barabási (37021_CR48) 2011; 12 D Rajgor (37021_CR54) 2012; 7 HQ Le (37021_CR64) 2016; 18 K Ono (37021_CR97) 2015; 4 F Autore (37021_CR58) 2013; 8 J Demmerle (37021_CR75) 2012; 287 SE Winograd-Katz (37021_CR7) 2014; 15 J-C Kuo (37021_CR15) 2011; 13 F Di Modugno (37021_CR59) 2007; 67 OJ Marshall (37021_CR106) 2015; 31 GJ Inman (37021_CR71) 2018; 9 E Magrini (37021_CR76) 2016; 22 JD Humphries (37021_CR4) 2019; 56 DG Thomas (37021_CR61) 2015; 210 JD Humphries (37021_CR14) 2009; 2 B Serrels (37021_CR77) 2017; 10 MC Jones (37021_CR10) 2015; 66 ME Ritchie (37021_CR108) 2015; 43 J Menche (37021_CR49) 2015; 347 A Chawade (37021_CR88) 2014; 13 E Bonavita (37021_CR69) 2015; 160 A Woroniuk (37021_CR63) 2018; 9 LH Hartwell (37021_CR46) 1999; 402 C Wu (37021_CR23) 2005; 118 A Byron (37021_CR31) 2016; 39 TJ Kirby (37021_CR36) 2018; 20 ER Horton (37021_CR20) 2015; 17 HR Thiam (37021_CR27) 2016; 7 JL Zhou (37021_CR24) 2018; 115 KI Brackley (37021_CR53) 2010; 316 F Broders-Bondon (37021_CR39) 2018; 217 SB Khatau (37021_CR60) 2009; 106 C Uhler (37021_CR73) 2017; 18 F Di Modugno (37021_CR79) 2006; 12 CM Proby (37021_CR83) 2000; 9 J Robertson (37021_CR44) 2015; 6 HB Schiller (37021_CR18) 2013; 15 MJ Vogel (37021_CR103) 2007; 2 JZ Kechagia (37021_CR5) 2019; 20 MJ Oudin (37021_CR67) 2016; 6 JG Simpson (37021_CR57) 2008; 36 MJL de Hoon (37021_CR100) 2004; 20 LJ Barton (37021_CR74) 2015; 34 Y Perez-Riverol (37021_CR110) 2022; 50 V Spirin (37021_CR47) 2003; 100 U Bodenhofer (37021_CR92) 2011; 27 K Mitra (37021_CR45) 2013; 14 AJ Saldanha (37021_CR101) 2004; 20 M Izdebska (37021_CR41) 2018; 2018 J Montojo (37021_CR98) 2010; 26 B van Steensel (37021_CR66) 2017; 169 S Hassan (37021_CR43) 2019; 20 A Byron (37021_CR1) 2010; 20 A Jayo (37021_CR26) 2016; 38 A Byron (37021_CR17) 2012; 12 37021_CR99 J-C Kuo (37021_CR9) 2012; 757 Y Wang (37021_CR33) 2003; 1593 D Beisser (37021_CR50) 2010; 26 A Byron (37021_CR8) 2011; 4 M Maziveyi (37021_CR29) 2017; 8 U Philippar (37021_CR80) 2008; 15 ZB Katz (37021_CR52) 2012; 26 J Schindelin (37021_CR85) 2012; 9 T Clough (37021_CR89) 2012; 13 QP Zhang (37021_CR55) 2005; 118 A Serrels (37021_CR78) 2015; 163 F Di Modugno (37021_CR81) 2012; 109 S Kutscheidt (37021_CR38) 2014; 16 R Zaidel-Bar (37021_CR6) 2007; 9 VA Traag (37021_CR95) 2013; 3 EG Kleinschmidt (37021_CR34) 2017; 45 L Guelen (37021_CR68) 2008; 453 M Kumeta (37021_CR22) 2012; 2012 C Guilluy (37021_CR40) 2014; 16 PJ Hensley (37021_CR25) 2016; 57 M D’Alessandro (37021_CR56) 2015; 35 F Li Mow Chee (37021_CR93) 2021; 2217 M Postma (37021_CR109) 2019; 17 ER Horton (37021_CR21) 2016; 343 R Molania (37021_CR102) 2019; 47 B Langmead (37021_CR105) 2012; 9 JD Buenrostro (37021_CR104) 2013; 10 R Edgar (37021_CR111) 2002; 30 J Cox (37021_CR86) 2008; 26 P Shannon (37021_CR96) 2003; 13 J Robertson (37021_CR11) 2017; 1636 N Wang (37021_CR35) 2009; 10 HJ Green (37021_CR2) 2019; 378 MI Robson (37021_CR70) 2017; 27 M Hervy (37021_CR32) 2006; 18 J Pignatelli (37021_CR82) 2014; 7 NH Freese (37021_CR107) 2016; 32 HB Schiller (37021_CR16) 2011; 12 B Geiger (37021_CR3) 2011; 3 K Wilhelmsen (37021_CR37) 2005; 171 MR Chastney (37021_CR13) 2020; 88 JS Desgrosellier (37021_CR28) 2010; 10 MR Chastney (37021_CR19) 2020; 219 A Kumar (37021_CR62) 2016; 4 M Krause (37021_CR72) 2003; 19 KE Tifft (37021_CR65) 2009; 122 A Byron (37021_CR12) 2018; 1764 MT Dittrich (37021_CR94) 2008; 24 O Kassel (37021_CR51) 2004; 18 KJ Purdie (37021_CR84) 2011; 731 JL Kadrmas (37021_CR30) 2004; 5 K Pfisterer (37021_CR42) 2017; 8 J Cox (37021_CR87) 2011; 10 |
| References_xml | – volume: 88 start-page: e113 year: 2020 ident: CR13 article-title: Multiplexed proximity biotinylation coupled to mass spectrometry for defining integrin adhesion complexes publication-title: Curr. Protoc. Cell Biol. doi: 10.1002/cpcb.113 contributor: fullname: Humphries – volume: 57 start-page: 68 year: 2016 end-page: 77 ident: CR25 article-title: Association of epithelial-mesenchymal transition and nuclear cofilin with advanced urothelial cancer publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2016.06.020 contributor: fullname: Kyprianou – volume: 169 start-page: 780 year: 2017 end-page: 791 ident: CR66 article-title: Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression publication-title: Cell doi: 10.1016/j.cell.2017.04.022 contributor: fullname: Belmont – volume: 32 start-page: 2089 year: 2016 end-page: 2095 ident: CR107 article-title: Integrated genome browser: visual analytics platform for genomics publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw069 contributor: fullname: Loraine – volume: 13 start-page: 383 year: 2011 end-page: 393 ident: CR15 article-title: Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation publication-title: Nat. Cell Biol. doi: 10.1038/ncb2216 contributor: fullname: Waterman – volume: 20 start-page: 1453 year: 2004 end-page: 1454 ident: CR100 article-title: Open source clustering software publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth078 contributor: fullname: Miyano – volume: 106 start-page: 19017 year: 2009 end-page: 19022 ident: CR60 article-title: A perinuclear actin cap regulates nuclear shape publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0908686106 contributor: fullname: Khatau – volume: 45 start-page: 24 year: 2017 end-page: 30 ident: CR34 article-title: Focal adhesion kinase signaling in unexpected places publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2017.01.003 contributor: fullname: Schlaepfer – volume: 18 start-page: 2518 year: 2004 end-page: 2528 ident: CR51 article-title: A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters publication-title: Genes Dev. doi: 10.1101/gad.322404 contributor: fullname: Kassel – volume: 56 start-page: 14 year: 2019 end-page: 21 ident: CR4 article-title: Signal transduction via integrin adhesion complexes publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2018.08.004 contributor: fullname: Humphries – volume: 13 year: 2012 ident: CR89 article-title: Statistical protein quantification and significance analysis in label-free LC-MS experiments with complex designs publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-13-S16-S6 contributor: fullname: Vitek – volume: 18 start-page: 524 year: 2006 end-page: 532 ident: CR32 article-title: From the membrane to the nucleus and back again: bifunctional focal adhesion proteins publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2006.08.006 contributor: fullname: Beckerle – volume: 1764 start-page: 193 year: 2018 end-page: 236 ident: CR12 article-title: Proteomic profiling of integrin adhesion complex assembly publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-7759-8_13 contributor: fullname: Byron – volume: 122 start-page: 3780 year: 2009 end-page: 3790 ident: CR65 article-title: Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases publication-title: J. Cell Sci. doi: 10.1242/jcs.048397 contributor: fullname: Wilson – volume: 27 start-page: 1126 year: 2017 end-page: 1138 ident: CR70 article-title: Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments publication-title: Genome Res. doi: 10.1101/gr.212308.116 contributor: fullname: Robson – volume: 2217 start-page: 149 year: 2021 end-page: 179 ident: CR93 article-title: Network analysis of integrin adhesion complexes publication-title: Methods Mol. Biol. doi: 10.1007/978-1-0716-0962-0_10 contributor: fullname: Byron – volume: 36 start-page: 1359 year: 2008 end-page: 1367 ident: CR57 article-title: Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0361359 contributor: fullname: Roberts – volume: 17 start-page: 1577 year: 2015 end-page: 1587 ident: CR20 article-title: Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly publication-title: Nat. Cell Biol. doi: 10.1038/ncb3257 contributor: fullname: Horton – volume: 15 start-page: 625 year: 2013 end-page: 636 ident: CR18 article-title: β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments publication-title: Nat. Cell Biol. doi: 10.1038/ncb2747 contributor: fullname: Schiller – volume: 219 start-page: e202003038 year: 2020 ident: CR19 article-title: Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation publication-title: J. Cell Biol. doi: 10.1083/jcb.202003038 contributor: fullname: Chastney – volume: 731 start-page: 151 year: 2011 end-page: 159 ident: CR84 article-title: Isolation and culture of squamous cell carcinoma lines publication-title: Methods Mol. Biol. doi: 10.1007/978-1-61779-080-5_14 contributor: fullname: South – volume: 171 start-page: 799 year: 2005 end-page: 810 ident: CR37 article-title: Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin publication-title: J. Cell Biol. doi: 10.1083/jcb.200506083 contributor: fullname: Wilhelmsen – volume: 7 year: 2016 ident: CR27 article-title: Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments publication-title: Nat. Commun. doi: 10.1038/ncomms10997 contributor: fullname: Thiam – volume: 402 start-page: C47 year: 1999 end-page: C52 ident: CR46 article-title: From molecular to modular cell biology publication-title: Nature doi: 10.1038/35011540 contributor: fullname: Murray – volume: 26 start-page: 1885 year: 2012 end-page: 1890 ident: CR52 article-title: β-Actin mRNA compartmentalization enhances focal adhesion stability and directs cell migration publication-title: Genes Dev. doi: 10.1101/gad.190413.112 contributor: fullname: Katz – volume: 4 start-page: 044008 year: 2016 ident: CR62 article-title: Dynamic interaction between actin and nesprin2 maintain the cell nucleus in a prestressed state publication-title: Methods Appl. Fluoresc. doi: 10.1088/2050-6120/4/4/044008 contributor: fullname: Shivashankar – volume: 8 start-page: 48471 year: 2017 end-page: 48487 ident: CR29 article-title: Cell matrix adhesions in cancer: the proteins that form the glue publication-title: Oncotarget doi: 10.18632/oncotarget.17265 contributor: fullname: Alahari – volume: 18 start-page: 717 year: 2017 end-page: 727 ident: CR73 article-title: Regulation of genome organization and gene expression by nuclear mechanotransduction publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2017.101 contributor: fullname: Shivashankar – volume: 109 start-page: 19280 year: 2012 end-page: 19285 ident: CR81 article-title: Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1214394109 contributor: fullname: Di Modugno – volume: 217 start-page: 1571 year: 2018 end-page: 1587 ident: CR39 article-title: Mechanotransduction in tumor progression: the dark side of the force publication-title: J. Cell Biol. doi: 10.1083/jcb.201701039 contributor: fullname: Farge – volume: 10 start-page: 1794 year: 2011 end-page: 1805 ident: CR87 article-title: Andromeda: a peptide search engine integrated into the MaxQuant environment publication-title: J. Proteome Res. doi: 10.1021/pr101065j contributor: fullname: Cox – volume: 210 start-page: 583 year: 2015 end-page: 594 ident: CR61 article-title: Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion publication-title: J. Cell. Biol. doi: 10.1083/jcb.201502039 contributor: fullname: Thomas – volume: 24 start-page: i223 year: 2008 end-page: i231 ident: CR94 article-title: Identifying functional modules in protein–protein interaction networks: an integrated exact approach publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn161 contributor: fullname: Müller – volume: 66 start-page: 9.8.1 year: 2015 end-page: 9.8.15 ident: CR10 article-title: Isolation of integrin-based adhesion complexes publication-title: Curr. Protoc. Cell Biol. doi: 10.1002/0471143030.cb0908s66 contributor: fullname: Jones – volume: 13 start-page: 2498 year: 2003 end-page: 2504 ident: CR96 article-title: Cytoscape: a software environment for integrated models of biomolecular interaction networks publication-title: Genome Res. doi: 10.1101/gr.1239303 contributor: fullname: Shannon – volume: 39 start-page: 93 year: 2016 end-page: 100 ident: CR31 article-title: Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2016.02.013 contributor: fullname: Frame – volume: 50 start-page: D543 year: 2022 end-page: D552 ident: CR110 article-title: The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkab1038 contributor: fullname: Perez-Riverol – volume: 15 start-page: 813 year: 2008 end-page: 828 ident: CR80 article-title: A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis publication-title: Dev. Cell doi: 10.1016/j.devcel.2008.09.003 contributor: fullname: Philippar – volume: 12 start-page: 259 year: 2011 end-page: 266 ident: CR16 article-title: Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins publication-title: EMBO Rep. doi: 10.1038/embor.2011.5 contributor: fullname: Fässler – volume: 7 start-page: ra112 year: 2014 ident: CR82 article-title: Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration publication-title: Sci. Signal. doi: 10.1126/scisignal.2005329 contributor: fullname: Pignatelli – volume: 12 start-page: 2107 year: 2012 end-page: 2114 ident: CR17 article-title: Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment publication-title: Proteomics doi: 10.1002/pmic.201100487 contributor: fullname: Humphries – volume: 160 start-page: 700 year: 2015 end-page: 714 ident: CR69 article-title: PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer publication-title: Cell doi: 10.1016/j.cell.2015.01.004 contributor: fullname: Bonavita – volume: 757 start-page: 297 year: 2012 end-page: 323 ident: CR9 article-title: Isolation of focal adhesion proteins for biochemical and proteomic analysis publication-title: Methods Mol. Biol. doi: 10.1007/978-1-61779-166-6_19 contributor: fullname: Waterman – volume: 1636 start-page: 235 year: 2017 end-page: 251 ident: CR11 article-title: Characterization of the phospho-adhesome by mass spectrometry-based proteomics publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-7154-1_15 contributor: fullname: Robertson – volume: 30 start-page: 207 year: 2002 end-page: 210 ident: CR111 article-title: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository publication-title: Nucleic Acids Res. doi: 10.1093/nar/30.1.207 contributor: fullname: Lash – volume: 47 start-page: W199 year: 2019 end-page: W205 ident: CR91 article-title: WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz401 contributor: fullname: Zhang – volume: 9 year: 2018 ident: CR63 article-title: STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap publication-title: Nat. Commun. doi: 10.1038/s41467-018-04404-4 contributor: fullname: Woroniuk – volume: 8 start-page: e63633 year: 2013 ident: CR58 article-title: Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins publication-title: PLoS One doi: 10.1371/journal.pone.0063633 contributor: fullname: Autore – volume: 9 start-page: 858 year: 2007 end-page: 867 ident: CR6 article-title: Functional atlas of the integrin adhesome publication-title: Nat. Cell Biol. doi: 10.1038/ncb0807-858 contributor: fullname: Geiger – volume: 14 start-page: 719 year: 2013 end-page: 732 ident: CR45 article-title: Integrative approaches for finding modular structure in biological networks publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3552 contributor: fullname: Ideker – volume: 6 start-page: 516 year: 2016 end-page: 531 ident: CR67 article-title: Tumor cell-driven extracellular matrix remodeling drives haptotaxis during metastatic progression publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-15-1183 contributor: fullname: Oudin – volume: 45 start-page: 1 year: 2011 end-page: 67 ident: CR90 article-title: mice: multivariate imputation by chained equations in R publication-title: J. Stat. Softw. doi: 10.18637/jss.v045.i03 contributor: fullname: Groothuis-Oudshoorn – volume: 2012 start-page: 494902 year: 2012 ident: CR22 article-title: Nucleocytoplasmic shuttling of cytoskeletal proteins: molecular mechanism and biological significance publication-title: Int. J. Cell Biol. doi: 10.1155/2012/494902 contributor: fullname: Takeyasu – volume: 13 start-page: 3114 year: 2014 end-page: 3120 ident: CR88 article-title: Normalyzer: a tool for rapid evaluation of normalization methods for omics data sets publication-title: J. Proteome Res. doi: 10.1021/pr401264n contributor: fullname: Levander – volume: 27 start-page: 2463 year: 2011 end-page: 2464 ident: CR92 article-title: APCluster: an R package for affinity propagation clustering publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr406 contributor: fullname: Hochreiter – volume: 15 start-page: 273 year: 2014 end-page: 288 ident: CR7 article-title: The integrin adhesome: from genes and proteins to human disease publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3769 contributor: fullname: Legate – volume: 9 year: 2018 ident: CR71 article-title: The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature publication-title: Nat. Commun. doi: 10.1038/s41467-018-06027-1 contributor: fullname: Inman – volume: 31 start-page: 3371 year: 2015 end-page: 3373 ident: CR106 article-title: damidseq_pipeline: an automated pipeline for processing DamID sequencing datasets publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv386 contributor: fullname: Brand – volume: 6 year: 2015 ident: CR44 article-title: Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling publication-title: Nat. Commun. doi: 10.1038/ncomms7265 contributor: fullname: Robertson – volume: 35 start-page: 186 year: 2015 end-page: 198 ident: CR56 article-title: Amphiphysin 2 orchestrates nucleus positioning and shape by linking the nuclear envelope to the actin and microtubule cytoskeleton publication-title: Dev. Cell doi: 10.1016/j.devcel.2015.09.018 contributor: fullname: D’Alessandro – volume: 47 start-page: 6073 year: 2019 end-page: 6083 ident: CR102 article-title: A new normalization for Nanostring nCounter gene expression data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz433 contributor: fullname: Speed – volume: 20 start-page: 3246 year: 2004 end-page: 3248 ident: CR101 article-title: Java Treeview—extensible visualization of microarray data publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth349 contributor: fullname: Saldanha – volume: 453 start-page: 948 year: 2008 end-page: 951 ident: CR68 article-title: Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions publication-title: Nature doi: 10.1038/nature06947 contributor: fullname: Guelen – volume: 2 start-page: 1467 year: 2007 end-page: 1478 ident: CR103 article-title: Detection of in vivo protein-DNA interactions using DamID in mammalian cells publication-title: Nat. Protoc. doi: 10.1038/nprot.2007.148 contributor: fullname: van Steensel – volume: 26 start-page: 2927 year: 2010 end-page: 2928 ident: CR98 article-title: GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq562 contributor: fullname: Montojo – volume: 5 start-page: 920 year: 2004 end-page: 931 ident: CR30 article-title: The LIM domain: from the cytoskeleton to the nucleus publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1499 contributor: fullname: Beckerle – volume: 2018 start-page: 4578373 year: 2018 ident: CR41 article-title: The role of actin dynamics and actin-binding proteins expression in epithelial-to-mesenchymal transition and its association with cancer progression and evaluation of possible therapeutic targets publication-title: Biomed. Res. Int. doi: 10.1155/2018/4578373 contributor: fullname: Gagat – volume: 16 start-page: 376 year: 2014 end-page: 381 ident: CR40 article-title: Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus publication-title: Nat. Cell Biol. doi: 10.1038/ncb2927 contributor: fullname: Guilluy – volume: 26 start-page: 1129 year: 2010 end-page: 1130 ident: CR50 article-title: BioNet: an R-package for the functional analysis of biological networks publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq089 contributor: fullname: Dittrich – volume: 16 start-page: 708 year: 2014 end-page: 715 ident: CR38 article-title: FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement publication-title: Nat. Cell Biol. doi: 10.1038/ncb2981 contributor: fullname: Kutscheidt – volume: 100 start-page: 12123 year: 2003 end-page: 12128 ident: CR47 article-title: Protein complexes and functional modules in molecular networks publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2032324100 contributor: fullname: Mirny – volume: 20 start-page: 457 year: 2019 end-page: 473 ident: CR5 article-title: Integrins as biomechanical sensors of the microenvironment publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-019-0134-2 contributor: fullname: Roca-Cusachs – volume: 4 start-page: pt2 year: 2011 ident: CR8 article-title: Proteomic analysis of integrin adhesion complexes publication-title: Sci. Signal. doi: 10.1126/scisignal.2001896 contributor: fullname: Humphries – volume: 118 start-page: 673 year: 2005 end-page: 687 ident: CR55 article-title: Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle publication-title: J. Cell Sci. doi: 10.1242/jcs.01642 contributor: fullname: Zhang – volume: 10 start-page: 9 year: 2010 end-page: 22 ident: CR28 article-title: Integrins in cancer: biological implications and therapeutic opportunities publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2748 contributor: fullname: Cheresh – volume: 316 start-page: 543 year: 2010 end-page: 553 ident: CR53 article-title: Subunits of the chaperonin CCT interact with F-actin and influence cell shape and cytoskeletal assembly publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2009.11.003 contributor: fullname: Grantham – ident: CR99 – volume: 10 start-page: eaan8355 year: 2017 ident: CR77 article-title: IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks publication-title: Sci. Signal. doi: 10.1126/scisignal.aan8355 contributor: fullname: Serrels – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: CR105 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 contributor: fullname: Salzberg – volume: 3 year: 2013 ident: CR95 article-title: Significant scales in community structure publication-title: Sci. Rep. doi: 10.1038/srep02930 contributor: fullname: Van Dooren – volume: 17 start-page: e3000202 year: 2019 ident: CR109 article-title: PlotsOfData—a web app for visualizing data together with their summaries publication-title: PLoS Biol. doi: 10.1371/journal.pbio.3000202 contributor: fullname: Goedhart – volume: 22 start-page: 497 year: 2016 end-page: 510 ident: CR76 article-title: The dual complexity of PTX3 in health and disease: a balancing act publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2016.04.007 contributor: fullname: Garlanda – volume: 378 start-page: 226 year: 2019 end-page: 231 ident: CR2 article-title: Integrin intracellular machinery in action publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2019.03.011 contributor: fullname: Brown – volume: 9 start-page: 676 year: 2012 end-page: 682 ident: CR85 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat. Methods doi: 10.1038/nmeth.2019 contributor: fullname: Schindelin – volume: 18 start-page: 864 year: 2016 end-page: 875 ident: CR64 article-title: Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment publication-title: Nat. Cell Biol. doi: 10.1038/ncb3387 contributor: fullname: Le – volume: 67 start-page: 2657 year: 2007 end-page: 2665 ident: CR59 article-title: Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-06-1997 contributor: fullname: Di Modugno – volume: 4 start-page: 478 year: 2015 ident: CR97 article-title: CyREST: turbocharging Cytoscape access for external tools via a RESTful API publication-title: F1000Res doi: 10.12688/f1000research.6767.1 contributor: fullname: Demchak – volume: 20 start-page: 3428 year: 2019 ident: CR43 article-title: A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20143428 contributor: fullname: Hassan – volume: 10 start-page: 1213 year: 2013 end-page: 1218 ident: CR104 article-title: Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position publication-title: Nat. Methods doi: 10.1038/nmeth.2688 contributor: fullname: Greenleaf – volume: 10 start-page: 75 year: 2009 end-page: 82 ident: CR35 article-title: Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2594 contributor: fullname: Ingber – volume: 163 start-page: 160 year: 2015 end-page: 173 ident: CR78 article-title: Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity publication-title: Cell doi: 10.1016/j.cell.2015.09.001 contributor: fullname: Serrels – volume: 19 start-page: 541 year: 2003 end-page: 564 ident: CR72 article-title: Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.19.050103.103356 contributor: fullname: Gertler – volume: 115 start-page: E6760 year: 2018 end-page: E6769 ident: CR24 article-title: Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1800621115 contributor: fullname: Zhou – volume: 12 start-page: 56 year: 2011 end-page: 68 ident: CR48 article-title: Network medicine: a network-based approach to human disease publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2918 contributor: fullname: Loscalzo – volume: 343 start-page: 7 year: 2016 end-page: 13 ident: CR21 article-title: Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2015.10.025 contributor: fullname: Humphries – volume: 2 start-page: ra51 year: 2009 ident: CR14 article-title: Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6 publication-title: Sci. Signal. doi: 10.1126/scisignal.2000396 contributor: fullname: Humphries – volume: 347 start-page: 1257601 year: 2015 ident: CR49 article-title: Uncovering disease-disease relationships through the incomplete interactome publication-title: Science doi: 10.1126/science.1257601 contributor: fullname: Menche – volume: 43 start-page: e47 year: 2015 ident: CR108 article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv007 contributor: fullname: Ritchie – volume: 3 start-page: a005033 year: 2011 ident: CR3 article-title: Molecular architecture and function of matrix adhesions publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a005033 contributor: fullname: Yamada – volume: 118 start-page: 659 year: 2005 end-page: 664 ident: CR23 article-title: Migfilin and its binding partners: from cell biology to human diseases publication-title: J. Cell Sci. doi: 10.1242/jcs.01639 contributor: fullname: Wu – volume: 8 start-page: 126 year: 2017 end-page: 133 ident: CR42 article-title: Control of nuclear organization by F-actin binding proteins publication-title: Nucleus doi: 10.1080/19491034.2016.1267093 contributor: fullname: Parsons – volume: 1593 start-page: 115 year: 2003 end-page: 120 ident: CR33 article-title: Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear publication-title: Biochim. Biophys. Acta doi: 10.1016/S0167-4889(02)00349-X contributor: fullname: Gilmore – volume: 20 start-page: R1063 year: 2010 end-page: R1067 ident: CR1 article-title: Adhesion signalling complexes publication-title: Curr. Biol. doi: 10.1016/j.cub.2010.10.059 contributor: fullname: Humphries – volume: 34 start-page: 1 year: 2015 end-page: 8 ident: CR74 article-title: Networking in the nucleus: a spotlight on LEM-domain proteins publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2015.03.005 contributor: fullname: Geyer – volume: 9 start-page: 104 year: 2000 end-page: 117 ident: CR83 article-title: Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis publication-title: Exp. Dermatol. doi: 10.1034/j.1600-0625.2000.009002104.x contributor: fullname: Proby – volume: 38 start-page: 371 year: 2016 end-page: 383 ident: CR26 article-title: Fascin regulates nuclear movement and deformation in migrating cells publication-title: Dev. Cell doi: 10.1016/j.devcel.2016.07.021 contributor: fullname: Jayo – volume: 7 start-page: e40098 year: 2012 ident: CR54 article-title: Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds publication-title: PLoS One doi: 10.1371/journal.pone.0040098 contributor: fullname: Shanahan – volume: 287 start-page: 22080 year: 2012 end-page: 22088 ident: CR75 article-title: The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.325308 contributor: fullname: Holaska – volume: 20 start-page: 373 year: 2018 end-page: 381 ident: CR36 article-title: Emerging views of the nucleus as a cellular mechanosensor publication-title: Nat. Cell Biol. doi: 10.1038/s41556-018-0038-y contributor: fullname: Lammerding – volume: 26 start-page: 1367 year: 2008 end-page: 1372 ident: CR86 article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1511 contributor: fullname: Mann – volume: 12 start-page: 1470 year: 2006 end-page: 1478 ident: CR79 article-title: The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-05-2027 contributor: fullname: Di Modugno – volume: 22 start-page: 497 year: 2016 ident: 37021_CR76 publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2016.04.007 contributor: fullname: E Magrini – volume: 13 start-page: 2498 year: 2003 ident: 37021_CR96 publication-title: Genome Res. doi: 10.1101/gr.1239303 contributor: fullname: P Shannon – volume: 118 start-page: 659 year: 2005 ident: 37021_CR23 publication-title: J. Cell Sci. doi: 10.1242/jcs.01639 contributor: fullname: C Wu – volume: 210 start-page: 583 year: 2015 ident: 37021_CR61 publication-title: J. Cell. Biol. doi: 10.1083/jcb.201502039 contributor: fullname: DG Thomas – volume: 4 start-page: 478 year: 2015 ident: 37021_CR97 publication-title: F1000Res doi: 10.12688/f1000research.6767.1 contributor: fullname: K Ono – volume: 4 start-page: 044008 year: 2016 ident: 37021_CR62 publication-title: Methods Appl. Fluoresc. doi: 10.1088/2050-6120/4/4/044008 contributor: fullname: A Kumar – volume: 57 start-page: 68 year: 2016 ident: 37021_CR25 publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2016.06.020 contributor: fullname: PJ Hensley – volume: 47 start-page: W199 year: 2019 ident: 37021_CR91 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz401 contributor: fullname: Y Liao – volume: 757 start-page: 297 year: 2012 ident: 37021_CR9 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-61779-166-6_19 contributor: fullname: J-C Kuo – volume: 8 start-page: e63633 year: 2013 ident: 37021_CR58 publication-title: PLoS One doi: 10.1371/journal.pone.0063633 contributor: fullname: F Autore – volume: 316 start-page: 543 year: 2010 ident: 37021_CR53 publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2009.11.003 contributor: fullname: KI Brackley – volume: 30 start-page: 207 year: 2002 ident: 37021_CR111 publication-title: Nucleic Acids Res. doi: 10.1093/nar/30.1.207 contributor: fullname: R Edgar – volume: 15 start-page: 273 year: 2014 ident: 37021_CR7 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3769 contributor: fullname: SE Winograd-Katz – volume: 1764 start-page: 193 year: 2018 ident: 37021_CR12 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-7759-8_13 contributor: fullname: A Byron – volume: 47 start-page: 6073 year: 2019 ident: 37021_CR102 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz433 contributor: fullname: R Molania – volume: 453 start-page: 948 year: 2008 ident: 37021_CR68 publication-title: Nature doi: 10.1038/nature06947 contributor: fullname: L Guelen – volume: 50 start-page: D543 year: 2022 ident: 37021_CR110 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkab1038 contributor: fullname: Y Perez-Riverol – volume: 24 start-page: i223 year: 2008 ident: 37021_CR94 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn161 contributor: fullname: MT Dittrich – volume: 15 start-page: 625 year: 2013 ident: 37021_CR18 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2747 contributor: fullname: HB Schiller – volume: 19 start-page: 541 year: 2003 ident: 37021_CR72 publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.19.050103.103356 contributor: fullname: M Krause – volume: 18 start-page: 864 year: 2016 ident: 37021_CR64 publication-title: Nat. Cell Biol. doi: 10.1038/ncb3387 contributor: fullname: HQ Le – volume: 13 start-page: 383 year: 2011 ident: 37021_CR15 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2216 contributor: fullname: J-C Kuo – volume: 217 start-page: 1571 year: 2018 ident: 37021_CR39 publication-title: J. Cell Biol. doi: 10.1083/jcb.201701039 contributor: fullname: F Broders-Bondon – volume: 67 start-page: 2657 year: 2007 ident: 37021_CR59 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-06-1997 contributor: fullname: F Di Modugno – volume: 378 start-page: 226 year: 2019 ident: 37021_CR2 publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2019.03.011 contributor: fullname: HJ Green – volume: 66 start-page: 9.8.1 year: 2015 ident: 37021_CR10 publication-title: Curr. Protoc. Cell Biol. doi: 10.1002/0471143030.cb0908s66 contributor: fullname: MC Jones – volume: 1636 start-page: 235 year: 2017 ident: 37021_CR11 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-4939-7154-1_15 contributor: fullname: J Robertson – volume: 36 start-page: 1359 year: 2008 ident: 37021_CR57 publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0361359 contributor: fullname: JG Simpson – volume: 45 start-page: 1 year: 2011 ident: 37021_CR90 publication-title: J. Stat. Softw. doi: 10.18637/jss.v045.i03 contributor: fullname: S van Buuren – volume: 31 start-page: 3371 year: 2015 ident: 37021_CR106 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv386 contributor: fullname: OJ Marshall – volume: 26 start-page: 1129 year: 2010 ident: 37021_CR50 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq089 contributor: fullname: D Beisser – volume: 9 year: 2018 ident: 37021_CR71 publication-title: Nat. Commun. doi: 10.1038/s41467-018-06027-1 contributor: fullname: GJ Inman – volume: 13 start-page: 3114 year: 2014 ident: 37021_CR88 publication-title: J. Proteome Res. doi: 10.1021/pr401264n contributor: fullname: A Chawade – volume: 18 start-page: 717 year: 2017 ident: 37021_CR73 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2017.101 contributor: fullname: C Uhler – volume: 9 start-page: 357 year: 2012 ident: 37021_CR105 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 contributor: fullname: B Langmead – volume: 17 start-page: 1577 year: 2015 ident: 37021_CR20 publication-title: Nat. Cell Biol. doi: 10.1038/ncb3257 contributor: fullname: ER Horton – volume: 100 start-page: 12123 year: 2003 ident: 37021_CR47 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2032324100 contributor: fullname: V Spirin – volume: 1593 start-page: 115 year: 2003 ident: 37021_CR33 publication-title: Biochim. Biophys. Acta doi: 10.1016/S0167-4889(02)00349-X contributor: fullname: Y Wang – volume: 287 start-page: 22080 year: 2012 ident: 37021_CR75 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.325308 contributor: fullname: J Demmerle – volume: 343 start-page: 7 year: 2016 ident: 37021_CR21 publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2015.10.025 contributor: fullname: ER Horton – volume: 20 start-page: 373 year: 2018 ident: 37021_CR36 publication-title: Nat. Cell Biol. doi: 10.1038/s41556-018-0038-y contributor: fullname: TJ Kirby – volume: 7 start-page: ra112 year: 2014 ident: 37021_CR82 publication-title: Sci. Signal. doi: 10.1126/scisignal.2005329 contributor: fullname: J Pignatelli – volume: 2 start-page: 1467 year: 2007 ident: 37021_CR103 publication-title: Nat. Protoc. doi: 10.1038/nprot.2007.148 contributor: fullname: MJ Vogel – volume: 171 start-page: 799 year: 2005 ident: 37021_CR37 publication-title: J. Cell Biol. doi: 10.1083/jcb.200506083 contributor: fullname: K Wilhelmsen – volume: 8 start-page: 126 year: 2017 ident: 37021_CR42 publication-title: Nucleus doi: 10.1080/19491034.2016.1267093 contributor: fullname: K Pfisterer – volume: 27 start-page: 2463 year: 2011 ident: 37021_CR92 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr406 contributor: fullname: U Bodenhofer – volume: 10 start-page: 9 year: 2010 ident: 37021_CR28 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2748 contributor: fullname: JS Desgrosellier – volume: 27 start-page: 1126 year: 2017 ident: 37021_CR70 publication-title: Genome Res. doi: 10.1101/gr.212308.116 contributor: fullname: MI Robson – volume: 2 start-page: ra51 year: 2009 ident: 37021_CR14 publication-title: Sci. Signal. doi: 10.1126/scisignal.2000396 contributor: fullname: JD Humphries – volume: 402 start-page: C47 year: 1999 ident: 37021_CR46 publication-title: Nature doi: 10.1038/35011540 contributor: fullname: LH Hartwell – volume: 56 start-page: 14 year: 2019 ident: 37021_CR4 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2018.08.004 contributor: fullname: JD Humphries – volume: 45 start-page: 24 year: 2017 ident: 37021_CR34 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2017.01.003 contributor: fullname: EG Kleinschmidt – volume: 13 year: 2012 ident: 37021_CR89 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-13-S16-S6 contributor: fullname: T Clough – volume: 17 start-page: e3000202 year: 2019 ident: 37021_CR109 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.3000202 contributor: fullname: M Postma – volume: 731 start-page: 151 year: 2011 ident: 37021_CR84 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-61779-080-5_14 contributor: fullname: KJ Purdie – volume: 219 start-page: e202003038 year: 2020 ident: 37021_CR19 publication-title: J. Cell Biol. doi: 10.1083/jcb.202003038 contributor: fullname: MR Chastney – volume: 20 start-page: 1453 year: 2004 ident: 37021_CR100 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth078 contributor: fullname: MJL de Hoon – volume: 10 start-page: 1794 year: 2011 ident: 37021_CR87 publication-title: J. Proteome Res. doi: 10.1021/pr101065j contributor: fullname: J Cox – ident: 37021_CR99 doi: 10.1145/1054972.1055031 – volume: 38 start-page: 371 year: 2016 ident: 37021_CR26 publication-title: Dev. Cell doi: 10.1016/j.devcel.2016.07.021 contributor: fullname: A Jayo – volume: 122 start-page: 3780 year: 2009 ident: 37021_CR65 publication-title: J. Cell Sci. doi: 10.1242/jcs.048397 contributor: fullname: KE Tifft – volume: 32 start-page: 2089 year: 2016 ident: 37021_CR107 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw069 contributor: fullname: NH Freese – volume: 106 start-page: 19017 year: 2009 ident: 37021_CR60 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0908686106 contributor: fullname: SB Khatau – volume: 9 start-page: 676 year: 2012 ident: 37021_CR85 publication-title: Nat. Methods doi: 10.1038/nmeth.2019 contributor: fullname: J Schindelin – volume: 26 start-page: 2927 year: 2010 ident: 37021_CR98 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq562 contributor: fullname: J Montojo – volume: 9 start-page: 104 year: 2000 ident: 37021_CR83 publication-title: Exp. Dermatol. doi: 10.1034/j.1600-0625.2000.009002104.x contributor: fullname: CM Proby – volume: 7 year: 2016 ident: 37021_CR27 publication-title: Nat. Commun. doi: 10.1038/ncomms10997 contributor: fullname: HR Thiam – volume: 20 start-page: 3246 year: 2004 ident: 37021_CR101 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth349 contributor: fullname: AJ Saldanha – volume: 10 start-page: 75 year: 2009 ident: 37021_CR35 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2594 contributor: fullname: N Wang – volume: 34 start-page: 1 year: 2015 ident: 37021_CR74 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2015.03.005 contributor: fullname: LJ Barton – volume: 10 start-page: eaan8355 year: 2017 ident: 37021_CR77 publication-title: Sci. Signal. doi: 10.1126/scisignal.aan8355 contributor: fullname: B Serrels – volume: 35 start-page: 186 year: 2015 ident: 37021_CR56 publication-title: Dev. Cell doi: 10.1016/j.devcel.2015.09.018 contributor: fullname: M D’Alessandro – volume: 160 start-page: 700 year: 2015 ident: 37021_CR69 publication-title: Cell doi: 10.1016/j.cell.2015.01.004 contributor: fullname: E Bonavita – volume: 2217 start-page: 149 year: 2021 ident: 37021_CR93 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-0716-0962-0_10 contributor: fullname: F Li Mow Chee – volume: 20 start-page: R1063 year: 2010 ident: 37021_CR1 publication-title: Curr. Biol. doi: 10.1016/j.cub.2010.10.059 contributor: fullname: A Byron – volume: 26 start-page: 1885 year: 2012 ident: 37021_CR52 publication-title: Genes Dev. doi: 10.1101/gad.190413.112 contributor: fullname: ZB Katz – volume: 3 start-page: a005033 year: 2011 ident: 37021_CR3 publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a005033 contributor: fullname: B Geiger – volume: 115 start-page: E6760 year: 2018 ident: 37021_CR24 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1800621115 contributor: fullname: JL Zhou – volume: 2012 start-page: 494902 year: 2012 ident: 37021_CR22 publication-title: Int. J. Cell Biol. doi: 10.1155/2012/494902 contributor: fullname: M Kumeta – volume: 3 year: 2013 ident: 37021_CR95 publication-title: Sci. Rep. doi: 10.1038/srep02930 contributor: fullname: VA Traag – volume: 7 start-page: e40098 year: 2012 ident: 37021_CR54 publication-title: PLoS One doi: 10.1371/journal.pone.0040098 contributor: fullname: D Rajgor – volume: 43 start-page: e47 year: 2015 ident: 37021_CR108 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv007 contributor: fullname: ME Ritchie – volume: 347 start-page: 1257601 year: 2015 ident: 37021_CR49 publication-title: Science doi: 10.1126/science.1257601 contributor: fullname: J Menche – volume: 26 start-page: 1367 year: 2008 ident: 37021_CR86 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1511 contributor: fullname: J Cox – volume: 2018 start-page: 4578373 year: 2018 ident: 37021_CR41 publication-title: Biomed. Res. Int. doi: 10.1155/2018/4578373 contributor: fullname: M Izdebska – volume: 20 start-page: 3428 year: 2019 ident: 37021_CR43 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20143428 contributor: fullname: S Hassan – volume: 16 start-page: 376 year: 2014 ident: 37021_CR40 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2927 contributor: fullname: C Guilluy – volume: 20 start-page: 457 year: 2019 ident: 37021_CR5 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-019-0134-2 contributor: fullname: JZ Kechagia – volume: 14 start-page: 719 year: 2013 ident: 37021_CR45 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3552 contributor: fullname: K Mitra – volume: 118 start-page: 673 year: 2005 ident: 37021_CR55 publication-title: J. Cell Sci. doi: 10.1242/jcs.01642 contributor: fullname: QP Zhang – volume: 9 year: 2018 ident: 37021_CR63 publication-title: Nat. Commun. doi: 10.1038/s41467-018-04404-4 contributor: fullname: A Woroniuk – volume: 12 start-page: 56 year: 2011 ident: 37021_CR48 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2918 contributor: fullname: A-L Barabási – volume: 12 start-page: 1470 year: 2006 ident: 37021_CR79 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-05-2027 contributor: fullname: F Di Modugno – volume: 6 start-page: 516 year: 2016 ident: 37021_CR67 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-15-1183 contributor: fullname: MJ Oudin – volume: 16 start-page: 708 year: 2014 ident: 37021_CR38 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2981 contributor: fullname: S Kutscheidt – volume: 109 start-page: 19280 year: 2012 ident: 37021_CR81 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1214394109 contributor: fullname: F Di Modugno – volume: 18 start-page: 2518 year: 2004 ident: 37021_CR51 publication-title: Genes Dev. doi: 10.1101/gad.322404 contributor: fullname: O Kassel – volume: 163 start-page: 160 year: 2015 ident: 37021_CR78 publication-title: Cell doi: 10.1016/j.cell.2015.09.001 contributor: fullname: A Serrels – volume: 169 start-page: 780 year: 2017 ident: 37021_CR66 publication-title: Cell doi: 10.1016/j.cell.2017.04.022 contributor: fullname: B van Steensel – volume: 9 start-page: 858 year: 2007 ident: 37021_CR6 publication-title: Nat. Cell Biol. doi: 10.1038/ncb0807-858 contributor: fullname: R Zaidel-Bar – volume: 5 start-page: 920 year: 2004 ident: 37021_CR30 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1499 contributor: fullname: JL Kadrmas – volume: 88 start-page: e113 year: 2020 ident: 37021_CR13 publication-title: Curr. Protoc. Cell Biol. doi: 10.1002/cpcb.113 contributor: fullname: MR Chastney – volume: 6 year: 2015 ident: 37021_CR44 publication-title: Nat. Commun. doi: 10.1038/ncomms7265 contributor: fullname: J Robertson – volume: 10 start-page: 1213 year: 2013 ident: 37021_CR104 publication-title: Nat. Methods doi: 10.1038/nmeth.2688 contributor: fullname: JD Buenrostro – volume: 18 start-page: 524 year: 2006 ident: 37021_CR32 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2006.08.006 contributor: fullname: M Hervy – volume: 4 start-page: pt2 year: 2011 ident: 37021_CR8 publication-title: Sci. Signal. doi: 10.1126/scisignal.2001896 contributor: fullname: A Byron – volume: 15 start-page: 813 year: 2008 ident: 37021_CR80 publication-title: Dev. Cell doi: 10.1016/j.devcel.2008.09.003 contributor: fullname: U Philippar – volume: 12 start-page: 2107 year: 2012 ident: 37021_CR17 publication-title: Proteomics doi: 10.1002/pmic.201100487 contributor: fullname: A Byron – volume: 8 start-page: 48471 year: 2017 ident: 37021_CR29 publication-title: Oncotarget doi: 10.18632/oncotarget.17265 contributor: fullname: M Maziveyi – volume: 12 start-page: 259 year: 2011 ident: 37021_CR16 publication-title: EMBO Rep. doi: 10.1038/embor.2011.5 contributor: fullname: HB Schiller – volume: 39 start-page: 93 year: 2016 ident: 37021_CR31 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2016.02.013 contributor: fullname: A Byron |
| SSID | ssj0000391844 |
| Score | 2.5178351 |
| Snippet | Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes, play key roles in fundamental cellular processes, including... Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the... |
| SourceID | doaj pubmedcentral proquest crossref pubmed springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 1602 |
| SubjectTerms | 13/106 14/19 14/35 38 38/23 38/39 38/77 631/80/128 631/80/386 631/80/79 82/58 96/95 Actin Actins - genetics Actins - metabolism Adhesion Carcinoma, Squamous Cell - metabolism Cell Nucleus - metabolism Chromatin CRISPR Cytoskeleton Depletion Extracellular matrix Gene Expression Humanities and Social Sciences Humans Immunomodulation Integrins - metabolism Kinases Membrane proteins Membranes Microfilament Proteins - metabolism multidisciplinary Nuclear Envelope - metabolism Nuclear Lamina - metabolism Phosphorylation Proteins Science Science (multidisciplinary) Signal transduction Signaling Skin Neoplasms - metabolism Squamous cell carcinoma Tyrosine |
| SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LaxRBEG4kIHgR344m0oI3M2R2uqan-2hCQhDiyUBuTT8xh_TK7gTWi_gf_If-Eqt6ZjdZH3jxOtO7FFVfvaarv2bsDX3M907pGpzEBgWCrHVoAT1eY3UrvG0UnR0--yBPz-H9RXdx66ovmgkb6YFHxR14jLAJvNddcNjrgG2CiA4cliUpJetL9G3aW81UicFCY-sC0ymZRqiDJZSYgCkKfYrmElZbmagQ9v-pyvx9WPKXHdOSiE4esPtTBcnfjZI_ZHdifsTujndKfnnMvp7FbPlivGI-LjmGMvqjuuXDnE-D6ZxOM-Qf375nYjO2C46wuMRf2RtbLff5QGmsXi-5ilfYWOfIaeLDFiZvbnPgCMDI42qap81P2PnJ8cej03q6ZKH2HcyGWvskmtj3mMcBbRas1RF6odJMqqhEUKH1xFETAiQvpYvOSS1iF2OC4DBAPGU7eZ7jc8b71qqOOkSs-iA0woGCoJqYGkc5UVXs7Vrh5vPIpWHKHrhQZjSPQfOYYh6zqtgh2WSzkniwywNEh5nQYf6Fjortri1qJudcGjr8qzT2fW3FXm9eo1vRXgkqcn5Na_QMBQEhK_ZsBMBGEiF1h11uXzG1BY0tUbff5MtPhbp7Rvw_HUDF9tcoupHr77p48T908ZLdawn-jahbsct2hsV13MOKanCvivP8BPr6IRM priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k2gICNxo1Gz8cSxTwgQS4VUTlTqzfIr0EOTskml5YL4D_xDfgkzTrKr5XWNncjxvMfjbxh7Tsl875TOwUkMUCDIXIcSUOI1erfC20LR3eHjD_LoBN6fVqdTwq2fyipnnZgUdeg85cgP6cam0uisly8vvuTUNYpOV6cWGlfZtUVZSyrpU8t3mxwLoZ8rgOmuTCHUYQ9JM6ChQsmi6oT1jj1KsP1_8zX_LJn87dw0maPlLXZz8iP5q5Hwt9mV2N5h18fOkl_vsm_HsbV8NTaajz1HhUYfyks-dHwqT-d0p6H9-f1HS5jGdsWROc7wLbulWH_ABzJm-TzlPJ5jeN1GTnUfNuF5c9sGjmwYeVxPVbXtPXayfPvxzVE-tVrIfQWLIde-EUWsa7TmgJQL1uoItVDNQqqoRFCh9IRUEwI0XkoXnZNaxCrGBoJDNXGf7bVdGx8yXpdWVRQnou8HoRAOFARVxKZwZBlVxl7MG24uRkQNk07ChTIjeQySxyTymHXGXhNNNjMJDTs96FafzCRcxqMVbsB7XQWH8TDYIojowKHr2jSN9RnbnylqJhHtzZahMvZsM4zCRScmuJHdJc3RC1wICJmxByMDbFYipK4w1q0zpnZYY2epuyPt2ecE4L0gFKAKIGMHMxdt1_XvvXj0_994zG6UxNiFyEuxz_aG1WV8gh7T4J4msfgFdeAXVA priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3da9RAEB9KRemL-G20ygq-2WguO0l2H0RULEU4nzzo27Jf0UK7p7kUruAf7-wmuXJ6fU12wzAfOzPZmd8AvI4_860RMkdTU4KCrs6lK5EsXlJ0y60uROwdnn-rTxb49bQ63YNp3NHIwNXO1C7Ok1p052_Xv68-kMG_H1rGxbsVJnMn70PmEksOKKa8VZJnjCVe8zHcTyczl5TQ4Ng7s3vrAdzhtawoi2m2XFVC9N8Vhv5fTfnPlWryVMf34O4YYrKPg07chz0fHsDtYejk1UP4M_dBs26YQe9XjM66-KG8ZP2SjZXrLLY7hDxEsGPdMdKaM9qjr0W5OmJ99HKbJRf-gvLu4FksCNEJ6Jvp4Bjpp2d-PZbbhkewOP7y_fNJPs5gyG2Fsz6XtuWFbxpy80gidVpLjw0X7awWXnAnXGkjhI1z2Nq6Nt6YWnJfed-iM3R-PIb9sAz-KbCm1KKKCSQFhegKblCgE4VvCxNdpsjgzcRu9WuA2lDpipwLNchJkZxUkpNaZ_ApSmSzMsJkpwfL7ocarU5Zcs8tWisrZyhRRl047g0aimnbttU2g8NJnmpSPRV7g4WktLDM4NXmNVldvEohRi4v4xo5I0KQ1xk8GcS_oWRSnwzElmJskbr9Jpz9TMjeswgPVCFmcDTp0DVdN_Pi2Y00PIeDMip3wfOSH8J-3136FxRF9eZlMo2_RewYww priority: 102 providerName: Scholars Portal – databaseName: SpringerOpen dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NbhQxDI5QERIXxD8DBQWJGx0xO_FkkiOsqCqkcqJSb1F-RQ_Not2p1F4Q78Ab8iTYmdmtBsqB6yQZWbEd27H9hbE3dJnvndI1OIkBCgRZ69ACarxG71Z42yjqHT7-LI9O4NNpdzrB5FAvzCx_L9S7DRRVRsuCqkDlBOgv3kYb3JM0L-Vyd59CSOcKYOqLuXnpzPYUiP6b_Mq_yyP_yJEW03N4n92bfEb-fmTyA3Yr5ofszviK5NUj9v04ZsvX46PyccPx8KIf1S0fVnwqRefUv5B__fiZCb_YrjkKwhmustfc2RzwgQxXvZ1yHs8xlM6RU42HLdjd3ObAUeQij5dTBW1-zE4OP35ZHtXTswq172Ax1Non0cS-R8sNyKVgrY7QC5UWUkUlggqtJ1SaECB5KV10TmoRuxgTBIdHwhO2l1c5PmO8b63qKCZEPw9CIxwoCKqJqXFkBVXF3m433Hwb0TNMyXoLZUb2GGSPKewxlxX7QDzZzSTk6_IBBcJMimQ8WtwE3usuOIx9wTZBRAcO3dSUkvUV299y1EzquDHU7qs0RnptxV7vhlGRKDuCG7m6oDl6gYSAkBV7OgrAjhIhdYdxbV8xNRONGanzkXz2tYB1LwjxpwOo2MFWiq7p-vdePP-_6S_Y3ZYEvRF1K_bZ3rC-iC_RWxrcq6ImvwHbTBCN priority: 102 providerName: Springer Nature |
| Title | Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression |
| URI | https://link.springer.com/article/10.1038/s41467-023-37021-x https://www.ncbi.nlm.nih.gov/pubmed/36959177 https://www.proquest.com/docview/2789892592 https://search.proquest.com/docview/2791370436 https://pubmed.ncbi.nlm.nih.gov/PMC10036544 https://doaj.org/article/c362f4cc95db4024a0d3eb4b310fffac |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF61RUhcEG8MJVokbtSN4x2vd49p1FBVSlUBlXKz9uUSiWyqJJXKBfEf-If8EmbXdkp4XLg4kr1JRjvf7Mx4Z74l5E14mW-0kClojgkKWJ5KmwNavMTolhmVidA7PDnjJxdwOi2mO4R3vTCxaN_o2aH_PD_0s0-xtvJqbvpdnVj_fDIaBBaVAqC_S3bR__6So8f1l0lMW6DtkMmY6K8grgfontCeQk1CYJ9mXBaYq5RbDiny9v8t2PyzZvK3jdPoj8YPyP02kKTDRuCHZMf5R-Ruc7Tkl8fk68R5RZfNSfNuRXFFCz-U5nS9oG19Og1NDf7Ht-8-kBqrJUV0zPBb6lZlqwO6Dt4s7YbM3Rzza-9oKPxQkdCbKm8p4tBRd9OW1fon5GJ8_HF0krZnLaSmgME6laZmmStLdOeAqrNKSQclE_WACyeYFTY3garGWqgN59ppzSVzhXM1WI3rxFOy5xfePSe0zJUoQqKIwR_YjGkQYEXm6kwH1ygS8rab8OqqodSo4lY4E1WjqQo1VUVNVTcJOQo62YwMdNjxxmJ5WbWgqAy64RqMkYXVmBCDyixzGjTGrnVdK5OQ_U6jVWujqyr0AAuJ6V-ekNebx2hdYcsEJ3JxHcbIAQoCjCfkWQOAjSQdgBIitqCxJer2EwR0ZPDuAJyQgw5Ft3L9ey5e_P8_vST38oD_jKU52yd76-W1e4Xh1Fr30IamJV7F-F2P3BkOTz-c4ufR8dn5e7w74qNefFGB1wmIXrS1n5EQKCU |
| link.rule.ids | 230,314,727,780,784,864,885,2102,12056,12765,21388,24318,27924,27925,31719,31720,33373,33374,33744,33745,41120,42189,43310,43600,43805,51576,53791,53793,73745,74035,74302 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEB5BKkQviDeGAovEjVp1vGNnfUIUtQrQRAi1Um-rfRl6qNMmqRQuiP_AP-SXMGNvEoXX1bu21jvv2dlvAF5yMt9ZVaVoSwpQ0Jdp5XMkia_Iu5XOZIrvDo_G5fAE358WpzHhNotllUud2CpqP3GcI9_jG5uqImc9f31xmXLXKD5djS00rsMWI6cXPdjaPxh__LTKsjD-uUKMt2UyqfZm2OoGMlUkW1yfsNiwSC1w_9-8zT-LJn87OW0N0uFtuBU9SfGmI_0duBaau3Cj6y359R58G4XGiGnXaj7MBKk0_lCai_lExAJ1wbcamp_ffzSMamymgtjjjN4ya5rNdsWczVm6nHIezinAboLgyg_TInoL03hBjBhEWMS62uY-nBweHL8dprHZQuoK7M_TytUyC4MB2XMk2nljqoADqep-qYKSXvncMVaN91i7srTB2rKSoQihRm9JUTyAXjNpwiMQg9yogiNF8v7QZ9KiQq-yUGeWbaNK4NVyw_VFh6mh27NwqXRHHk3k0S159CKBfabJaibjYbcPJtPPOoqXdmSHa3SuKryliBhN5mWwaMl5revauAR2lhTVUUhnes1SCbxYDZN48ZkJbeTkiudUfVoIyjKBhx0DrFYiy6qgaHeQgNpgjY2lbo40Z19aCO8-4wAViAnsLrlova5_78Xj___Gc7g5PB4d6aN34w9PYDtnJs9kmssd6M2nV-Ep-U9z-ywKyS9iIxul |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEB5BKlAviDeGAovEjVpxvGNnfUIUGpVHowpRqbfVvgw91GmTVAoXxH_gH_JLmLE3icLr6l1b6533zuw3AM_5MN9ZVaVoSwpQ0Jdp5XMkia_Iu5XOZIrvDh-Oy4NjfHdSnMT6p1ksq1zqxFZR-4njM_I-39hUFTnreb-OZRFHb0Yvzy9S7iDFmdbYTuMqbJFVzPIebO3tj48-rk5cGAtdIcabM5lU_Rm2eoLMFskZ1yosNqxTC-L_N8_zzwLK37KorXEa3YQb0asUrzo2uAVXQnMbrnV9Jr_egW-HoTFi2rWdDzNB6o0_lOZiPhGxWF3wDYfm5_cfDSMcm6kgVjmlt8yafrNdMWfTli6nnIUzCrabILgKxLTo3sI0XhBTBhEWsca2uQvHo_1Prw_S2HghdQUO5mnlapmF4ZBsOxIdvTFVwKFU9aBUQUmvfO4Yt8Z7rF1Z2mBtWclQhFCjt6Q07kGvmTThAYhhblTBUSN5gugzaVGhV1moM8t2UiXwYrnh-rzD19BtXlwq3ZFHE3l0Sx69SGCPabKaydjY7YPJ9LOOoqYd2eQanasKbyk6RpN5GSxacmTrujYugZ0lRXUU2Jles1cCz1bDJGqcP6GNnFzynGpAC0FZJnC_Y4DVSmRZFRT5DhNQG6yxsdTNkeb0SwvnPWBMoAIxgd0lF63X9e-9ePj_33gK10k-9Ie34_ePYDtnHs9kmssd6M2nl-ExuVJz-yTKyC-Aax_S |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mena+regulates+nesprin-2+to+control+actin-nuclear+lamina+associations%2C+trans-nuclear+membrane+signalling+and+gene+expression&rft.jtitle=Nature+communications&rft.au=Li+Mow+Chee%2C+Frederic&rft.au=Beernaert%2C+Bruno&rft.au=Griffith%2C+Billie+G+C&rft.au=Loftus%2C+Alexander+E+P&rft.date=2023-03-23&rft.eissn=2041-1723&rft.volume=14&rft.issue=1&rft.spage=1602&rft_id=info:doi/10.1038%2Fs41467-023-37021-x&rft_id=info%3Apmid%2F36959177&rft.externalDocID=36959177 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |