Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis

Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profil...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 14; no. 1; pp. 3620 - 17
Main Authors Fetahu, Irfete S., Esser-Skala, Wolfgang, Dnyansagar, Rohit, Sindelar, Samuel, Rifatbegovic, Fikret, Bileck, Andrea, Skos, Lukas, Bozsaky, Eva, Lazic, Daria, Shaw, Lisa, Tötzl, Marcus, Tarlungeanu, Dora, Bernkopf, Marie, Rados, Magdalena, Weninger, Wolfgang, Tomazou, Eleni M., Bock, Christoph, Gerner, Christopher, Ladenstein, Ruth, Farlik, Matthias, Fortelny, Nikolaus, Taschner-Mandl, Sabine
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.06.2023
Nature Publishing Group
Nature Portfolio
Subjects
13/106
13/21
13/31
14/1
14/63
38/39
42/47
631/337/100/101
631/337/176
631/337/2019
631/67/327
631/67/68
82/79
82/80
Bone cancer
Bone marrow
Bone Marrow - pathology
Bone Marrow Neoplasms - genetics
Bone Marrow Neoplasms - metabolism
Bone Marrow Neoplasms - pathology
Cancer
Cell interactions
Child
Children
Epigenomics
Humanities and Social Sciences
Humans
Inflammation
Macrophages
Metastases
Metastasis
Microenvironments
Midkine
Monocytes
Monocytes - metabolism
multidisciplinary
Neuroblastoma
Neuroblastoma - metabolism
Plastic foam
Plastic properties
Plasticity
Science
Science (multidisciplinary)
Tissue analysis
Transcriptome
Transcriptomics
Tumor cells
Tumor Microenvironment - genetics
Tumors
Online AccessGet full text

Cover

Abstract Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and cell-cell interactions, as well as functional validation. We show that cellular plasticity of NB tumor cells is conserved upon metastasis and tumor cell type composition is NB subtype-dependent. NB cells signal to the BM microenvironment, rewiring via macrophage mgration inhibitory factor and midkine signaling specifically monocytes, which exhibit M1 and M2 features, are marked by activation of pro- and anti-inflammatory programs, and express tumor-promoting factors, reminiscent of tumor-associated macrophages. The interactions and pathways characterized in our study provide the basis for therapeutic approaches that target tumor-to-microenvironment interactions. The bone marrow is a common site of metastasis for neuroblastoma patients. Here, the authors perform single cell RNA-seq and ATAC-seq of bone marrow aspirates from 16 subjects and show conservation of tumor cell plasticity in metastases and identify tumor-to-bone marrow cell signals that trigger tumor promoting monocytes.
AbstractList Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and cell-cell interactions, as well as functional validation. We show that cellular plasticity of NB tumor cells is conserved upon metastasis and tumor cell type composition is NB subtype-dependent. NB cells signal to the BM microenvironment, rewiring via macrophage mgration inhibitory factor and midkine signaling specifically monocytes, which exhibit M1 and M2 features, are marked by activation of pro- and anti-inflammatory programs, and express tumor-promoting factors, reminiscent of tumor-associated macrophages. The interactions and pathways characterized in our study provide the basis for therapeutic approaches that target tumor-to-microenvironment interactions.
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and cell-cell interactions, as well as functional validation. We show that cellular plasticity of NB tumor cells is conserved upon metastasis and tumor cell type composition is NB subtype-dependent. NB cells signal to the BM microenvironment, rewiring via macrophage mgration inhibitory factor and midkine signaling specifically monocytes, which exhibit M1 and M2 features, are marked by activation of pro- and anti-inflammatory programs, and express tumor-promoting factors, reminiscent of tumor-associated macrophages. The interactions and pathways characterized in our study provide the basis for therapeutic approaches that target tumor-to-microenvironment interactions.Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and cell-cell interactions, as well as functional validation. We show that cellular plasticity of NB tumor cells is conserved upon metastasis and tumor cell type composition is NB subtype-dependent. NB cells signal to the BM microenvironment, rewiring via macrophage mgration inhibitory factor and midkine signaling specifically monocytes, which exhibit M1 and M2 features, are marked by activation of pro- and anti-inflammatory programs, and express tumor-promoting factors, reminiscent of tumor-associated macrophages. The interactions and pathways characterized in our study provide the basis for therapeutic approaches that target tumor-to-microenvironment interactions.
Abstract Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and cell-cell interactions, as well as functional validation. We show that cellular plasticity of NB tumor cells is conserved upon metastasis and tumor cell type composition is NB subtype-dependent. NB cells signal to the BM microenvironment, rewiring via macrophage mgration inhibitory factor and midkine signaling specifically monocytes, which exhibit M1 and M2 features, are marked by activation of pro- and anti-inflammatory programs, and express tumor-promoting factors, reminiscent of tumor-associated macrophages. The interactions and pathways characterized in our study provide the basis for therapeutic approaches that target tumor-to-microenvironment interactions.
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and cell-cell interactions, as well as functional validation. We show that cellular plasticity of NB tumor cells is conserved upon metastasis and tumor cell type composition is NB subtype-dependent. NB cells signal to the BM microenvironment, rewiring via macrophage mgration inhibitory factor and midkine signaling specifically monocytes, which exhibit M1 and M2 features, are marked by activation of pro- and anti-inflammatory programs, and express tumor-promoting factors, reminiscent of tumor-associated macrophages. The interactions and pathways characterized in our study provide the basis for therapeutic approaches that target tumor-to-microenvironment interactions. The bone marrow is a common site of metastasis for neuroblastoma patients. Here, the authors perform single cell RNA-seq and ATAC-seq of bone marrow aspirates from 16 subjects and show conservation of tumor cell plasticity in metastases and identify tumor-to-bone marrow cell signals that trigger tumor promoting monocytes.
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and cell-cell interactions, as well as functional validation. We show that cellular plasticity of NB tumor cells is conserved upon metastasis and tumor cell type composition is NB subtype-dependent. NB cells signal to the BM microenvironment, rewiring via macrophage mgration inhibitory factor and midkine signaling specifically monocytes, which exhibit M1 and M2 features, are marked by activation of pro- and anti-inflammatory programs, and express tumor-promoting factors, reminiscent of tumor-associated macrophages. The interactions and pathways characterized in our study provide the basis for therapeutic approaches that target tumor-to-microenvironment interactions.The bone marrow is a common site of metastasis for neuroblastoma patients. Here, the authors perform single cell RNA-seq and ATAC-seq of bone marrow aspirates from 16 subjects and show conservation of tumor cell plasticity in metastases and identify tumor-to-bone marrow cell signals that trigger tumor promoting monocytes.
ArticleNumber 3620
Author Bernkopf, Marie
Tötzl, Marcus
Bock, Christoph
Rifatbegovic, Fikret
Bozsaky, Eva
Dnyansagar, Rohit
Tarlungeanu, Dora
Tomazou, Eleni M.
Bileck, Andrea
Esser-Skala, Wolfgang
Fetahu, Irfete S.
Lazic, Daria
Gerner, Christopher
Ladenstein, Ruth
Skos, Lukas
Shaw, Lisa
Sindelar, Samuel
Weninger, Wolfgang
Fortelny, Nikolaus
Taschner-Mandl, Sabine
Rados, Magdalena
Farlik, Matthias
Author_xml – sequence: 1
  givenname: Irfete S.
  orcidid: 0000-0002-0468-7458
  surname: Fetahu
  fullname: Fetahu, Irfete S.
  email: irfete.fetahu@ccri.at
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 2
  givenname: Wolfgang
  surname: Esser-Skala
  fullname: Esser-Skala, Wolfgang
  organization: Department of Biosciences and Medical Biology, University of Salzburg
– sequence: 3
  givenname: Rohit
  surname: Dnyansagar
  fullname: Dnyansagar, Rohit
  organization: Department of Biosciences and Medical Biology, University of Salzburg
– sequence: 4
  givenname: Samuel
  surname: Sindelar
  fullname: Sindelar, Samuel
  organization: Department of Biosciences and Medical Biology, University of Salzburg
– sequence: 5
  givenname: Fikret
  orcidid: 0000-0002-9956-2382
  surname: Rifatbegovic
  fullname: Rifatbegovic, Fikret
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 6
  givenname: Andrea
  orcidid: 0000-0002-7053-8856
  surname: Bileck
  fullname: Bileck, Andrea
  organization: University of Vienna, Department of Analytical Chemistry, Faculty of Chemistry, Joint Metabolomics Facility, University of Vienna and Medical University of Vienna
– sequence: 7
  givenname: Lukas
  orcidid: 0000-0003-3983-1736
  surname: Skos
  fullname: Skos, Lukas
  organization: University of Vienna, Department of Analytical Chemistry, Faculty of Chemistry
– sequence: 8
  givenname: Eva
  orcidid: 0000-0001-6208-368X
  surname: Bozsaky
  fullname: Bozsaky, Eva
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 9
  givenname: Daria
  surname: Lazic
  fullname: Lazic, Daria
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 10
  givenname: Lisa
  orcidid: 0000-0003-2273-7655
  surname: Shaw
  fullname: Shaw, Lisa
  organization: Medical University of Vienna, Department of Dermatology
– sequence: 11
  givenname: Marcus
  orcidid: 0000-0003-0321-5835
  surname: Tötzl
  fullname: Tötzl, Marcus
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 12
  givenname: Dora
  surname: Tarlungeanu
  fullname: Tarlungeanu, Dora
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 13
  givenname: Marie
  orcidid: 0000-0001-6650-4592
  surname: Bernkopf
  fullname: Bernkopf, Marie
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 14
  givenname: Magdalena
  surname: Rados
  fullname: Rados, Magdalena
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 15
  givenname: Wolfgang
  surname: Weninger
  fullname: Weninger, Wolfgang
  organization: Medical University of Vienna, Department of Dermatology
– sequence: 16
  givenname: Eleni M.
  orcidid: 0000-0002-7497-4567
  surname: Tomazou
  fullname: Tomazou, Eleni M.
  organization: St. Anna Children’s Cancer Research Institute
– sequence: 17
  givenname: Christoph
  orcidid: 0000-0001-6091-3088
  surname: Bock
  fullname: Bock, Christoph
  organization: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Medical University of Vienna, Institute of Artificial Intelligence, Center for Medical Data Science
– sequence: 18
  givenname: Christopher
  orcidid: 0000-0003-4964-0642
  surname: Gerner
  fullname: Gerner, Christopher
  organization: University of Vienna, Department of Analytical Chemistry, Faculty of Chemistry, Joint Metabolomics Facility, University of Vienna and Medical University of Vienna
– sequence: 19
  givenname: Ruth
  orcidid: 0000-0001-6548-3873
  surname: Ladenstein
  fullname: Ladenstein, Ruth
  organization: St. Anna Children’s Hospital and St. Anna Children’s Cancer Research Institute, Department of Studies and Statistics for Integrated Research and Projects, Medical University of Vienna, Department of Pediatrics
– sequence: 20
  givenname: Matthias
  orcidid: 0000-0003-0698-2992
  surname: Farlik
  fullname: Farlik, Matthias
  organization: Medical University of Vienna, Department of Dermatology
– sequence: 21
  givenname: Nikolaus
  orcidid: 0000-0003-4025-9968
  surname: Fortelny
  fullname: Fortelny, Nikolaus
  email: nikolaus.fortelny@plus.ac.at
  organization: Department of Biosciences and Medical Biology, University of Salzburg
– sequence: 22
  givenname: Sabine
  orcidid: 0000-0002-1439-5301
  surname: Taschner-Mandl
  fullname: Taschner-Mandl, Sabine
  email: sabine.taschner@ccri.at
  organization: St. Anna Children’s Cancer Research Institute
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37365178$$D View this record in MEDLINE/PubMed
BookMark eNp9Uk1v1TAQjFARLaV_gAOyxIVLwF9J7BNCFR-VKnEAztbG3rz6KbFf7aRV_z1-TQttD_XF9npmNN6d19VBiAGr6i2jHxkV6lOWTLZdTbmoheaM1vRFdcSpZDXruDh4cD6sTnLe0rKEZkrKV9Wh6ETbsE4dVZe_fNiMWFscRzInCNkmv5vj5G0mEBzBnd9gWO9LSHCFBXeBJMURSRzIFEO0NzNm4gMJuKTYj5CLAJC-OCYTpBSvyYRzqUL2-U31coAx48ndflz9-fb19-mP-vzn97PTL-e1bSSba20HNvCW0QYcl1Y7jtIJJqTjAzTUtaLVDlAolL1Ep7TkQEWvXWOR970Tx9XZqusibM0u-eLkxkTw5rYQ08ZAmr0d0TDWMSGg5wNn0lmlbOcaNQDvEATYvdbnVWu39BM6i6G0anwk-vgl-AuziVeGUa4FV01R-HCnkOLlgnk2k8_7pkPAuGTDlaC8_K7TBfr-CXQblxRKrwqK65bJMu-CevfQ0j8v96MtALUCbIo5JxyM9TPMPu4d-rFYM_sgmTVIpgTJ3AbJ0ELlT6j36s-SxErKBRw2mP7bfob1F-6Q3UA
CitedBy_id crossref_primary_10_1038_s41467_025_57185_y
crossref_primary_10_1007_s11684_024_1081_7
crossref_primary_10_1080_1744666X_2024_2438721
crossref_primary_10_1038_s41467_024_47945_7
crossref_primary_10_1038_s41423_024_01216_z
crossref_primary_10_1016_j_celrep_2024_114804
crossref_primary_10_1038_s41467_024_45802_1
crossref_primary_10_1038_s41467_024_53776_3
crossref_primary_10_1016_j_ejca_2025_115263
crossref_primary_10_1002_advs_202308986
crossref_primary_10_1016_j_xgen_2024_100739
crossref_primary_10_1016_j_gendis_2024_101511
crossref_primary_10_1007_s00431_024_05896_7
crossref_primary_10_1016_j_bcp_2023_115696
crossref_primary_10_1038_s41467_024_51337_2
crossref_primary_10_1186_s13046_023_02913_9
crossref_primary_10_1016_j_csbj_2024_04_024
crossref_primary_10_1007_s00508_024_02328_2
crossref_primary_10_1007_s10555_024_10212_8
crossref_primary_10_1177_15330338241290386
crossref_primary_10_1016_j_ejcped_2024_100161
crossref_primary_10_3390_cancers16091735
Cites_doi 10.1038/s41467-021-21859-0
10.1038/ng.3899
10.1016/j.csbj.2021.06.043
10.1038/ng.3921
10.1038/s41467-021-24870-7
10.18632/oncotarget.19664
10.1126/science.aat6768
10.1038/nature14980
10.3389/fnmol.2019.00009
10.1186/1471-2164-14-632
10.1038/bjc.2011.472
10.1038/nrdp.2016.78
10.1038/nature25480
10.1016/j.cell.2019.01.031
10.1038/s41587-022-01284-4
10.1016/j.celrep.2022.111455
10.21105/joss.03021
10.1038/s41467-020-19781-y
10.1038/nature21350
10.1007/s00109-022-02228-w
10.3389/fonc.2020.601076
10.1093/bioinformatics/btw313
10.1038/s41467-023-38239-5
10.1007/s00383-017-4189-x
10.1080/2162402X.2017.1320626
10.1038/s41590-018-0276-y
10.1038/nrc.2016.54
10.1038/s41592-021-01282-5
10.1021/acs.analchem.6b04433
10.1158/2159-8290.CD-21-1059
10.1038/s41467-021-26870-z
10.1038/s41586-019-0969-x
10.1038/s41588-021-00818-x
10.1038/s41586-021-03651-8
10.1038/ng.2529
10.1056/NEJMoa0911123
10.1038/nri3865
10.1200/JCO.2011.40.9169
10.1038/s41598-019-41695-z
10.1038/nbt.4091
10.1093/bioinformatics/btv145
10.1016/j.cell.2017.10.044
10.1016/j.cell.2021.04.048
10.3389/fimmu.2018.02542
10.1080/2162402X.2015.1019981
10.1038/s41467-021-26530-2
10.1093/carcin/bgt009
10.1038/ng.3333
10.1038/onc.2015.139
10.1038/s41467-021-21246-9
10.1038/s41416-018-0098-6
10.1038/s41588-021-00806-1
10.1038/s42003-021-02146-6
10.3389/fimmu.2017.01473
10.1038/sj.onc.1207490
10.1016/j.ccell.2021.09.005
10.1038/nature11247
10.1038/nature20123
10.1038/s41598-020-76157-4
10.1097/PAS.0000000000000398
10.1038/s41467-021-21247-8
10.1038/s41598-020-79378-9
10.3389/fonc.2022.817069
10.1186/s13104-020-05357-y
10.1016/j.cell.2018.10.022
10.3324/haematol.2013.094243
10.1186/s13059-019-1642-2
10.1046/j.1440-1797.2003.00152.x
10.3389/fimmu.2018.02380
10.1016/j.ccell.2020.08.014
10.3389/fphar.2019.00727
10.1158/1078-0432.CCR-16-2082
10.1093/bioinformatics/bty723
10.1016/j.celrep.2019.01.041
10.1002/pmic.201300553
10.1038/s41467-020-19894-4
10.1038/nrclinonc.2016.217
10.1016/j.cell.2019.04.040
10.1002/ijc.31053
10.1016/j.xcrm.2022.100657
10.1016/j.cell.2011.01.004
10.1200/JCO.2008.16.6785
10.1158/1078-0432.CCR-15-1912
10.1016/j.molcel.2010.05.004
10.1002/path.4769
10.1200/JCO.21.00086
10.1126/science.aad0501
10.1093/bioinformatics/btz698
10.1038/s41591-020-1073-3
10.1136/jitc-2022-004807
10.3390/cancers13174311
10.5281/zenodo.7867892
10.3390/ijms222312828
10.1093/nar/gkaa516
10.1126/science.aal3753
10.1007/978-3-319-24277-4
10.1093/database/baz046
10.1126/science.aas9536
10.1182/bloodadvances.2022008303
10.1093/gigascience/giaa151
10.5281/zenodo.7707614
10.5281/zenodo.6621045
10.1002/cpz1.90
10.1172/jci.insight.124928
ContentType Journal Article
Copyright The Author(s) 2023
2023. The Author(s).
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2023
– notice: 2023. The Author(s).
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-023-39210-0
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Database
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Biological Science Database
ProQuest advanced technologies & aerospace journals
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Publicly Available Content
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic


CrossRef

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 17
ExternalDocumentID oai_doaj_org_article_117133ab2f214dc88c7d58fa27ea3acd
PMC10293285
37365178
10_1038_s41467_023_39210_0
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Vienna Science and Technology Fund (Wiener Wissenschafts-, Forschungs- und Technologiefonds)
  grantid: WWTF#LS18-111; WWTF#LS18-111; WWTF#LS18-111
  funderid: https://doi.org/10.13039/501100001821
– fundername: Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung)
  grantid: FWF#I4162; FWF#P35841-B; FWF#P35072
  funderid: https://doi.org/10.13039/501100002428
– fundername: Austrian Science Fund FWF
  grantid: P 35072
– fundername: Austrian Science Fund FWF
  grantid: TAI 592
– fundername: Austrian Science Fund FWF
  grantid: I 4162
– fundername: Austrian Science Fund FWF
  grantid: P 34958
– fundername: Austrian Science Fund FWF
  grantid: P 35841
– fundername: ;
  grantid: FWF#I4162; FWF#P35841-B; FWF#P35072
– fundername: ;
  grantid: WWTF#LS18-111; WWTF#LS18-111; WWTF#LS18-111
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
RC3
SOI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c541t-9cf1f26105ad24c9d2e4d3134d2fa50d6369dae38e4b4ed8942a03b9d5ce2bbd3
IEDL.DBID M48
ISSN 2041-1723
IngestDate Wed Aug 27 01:26:51 EDT 2025
Thu Aug 21 18:37:28 EDT 2025
Fri Jul 11 01:56:02 EDT 2025
Wed Aug 13 11:12:24 EDT 2025
Mon Jul 21 06:07:08 EDT 2025
Tue Jul 01 00:58:56 EDT 2025
Thu Apr 24 22:53:03 EDT 2025
Fri Feb 21 02:38:09 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2023. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c541t-9cf1f26105ad24c9d2e4d3134d2fa50d6369dae38e4b4ed8942a03b9d5ce2bbd3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-7053-8856
0000-0003-3983-1736
0000-0003-4025-9968
0000-0003-0321-5835
0000-0001-6091-3088
0000-0002-1439-5301
0000-0003-2273-7655
0000-0001-6548-3873
0000-0003-4964-0642
0000-0002-0468-7458
0000-0002-9956-2382
0000-0001-6208-368X
0000-0002-7497-4567
0000-0001-6650-4592
0000-0003-0698-2992
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41467-023-39210-0
PMID 37365178
PQID 2829614921
PQPubID 546298
PageCount 17
ParticipantIDs doaj_primary_oai_doaj_org_article_117133ab2f214dc88c7d58fa27ea3acd
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10293285
proquest_miscellaneous_2830213479
proquest_journals_2829614921
pubmed_primary_37365178
crossref_citationtrail_10_1038_s41467_023_39210_0
crossref_primary_10_1038_s41467_023_39210_0
springer_journals_10_1038_s41467_023_39210_0
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-06-26
PublicationDateYYYYMMDD 2023-06-26
PublicationDate_xml – month: 06
  year: 2023
  text: 2023-06-26
  day: 26
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Mina (CR26) 2015; 4
Hishiki (CR27) 2018; 34
Novershtern (CR91) 2011; 144
Berbegall (CR8) 2018; 118
Boeva (CR48) 2017; 49
Thirant (CR58) 2023; 14
CR38
Yu (CR60) 2010; 363
Zougman, Selby, Banks (CR72) 2014; 14
CR35
CR33
van Groningen (CR49) 2017; 49
Ackermann (CR9) 2018; 362
Paul (CR64) 2017; 8
Abbasi (CR4) 2017; 23
Schmelz (CR6) 2021; 12
Eleveld (CR12) 2015; 47
Xie (CR98) 2021; 1
Cao (CR82) 2019; 566
Popitsch (CR69) 2019; 35
Stuart (CR99) 2021; 18
Hashimoto (CR31) 2016; 240
Johnsen, Dyberg, Wickström (CR24) 2019; 12
Mao (CR30) 2016; 22
CR47
Asgharzadeh (CR32) 2012; 30
Matthay (CR2) 2016; 2
Verhoeven (CR37) 2022; 3
Anderson (CR40) 2020; 10
Melaiu (CR25) 2020; 11
Puram (CR44) 2017; 171
Casanova-Acebes (CR54) 2021; 595
Engblom, Pfirschke, Pittet (CR59) 2016; 16
Traag, Waltman, van Eck (CR85) 2019; 9
Bellini (CR13) 2021; 39
Guo (CR51) 2016; 35
Hao (CR79) 2021; 184
Cao, Gao (CR106) 2022; 40
Hartlieb (CR10) 2021; 12
Tirosh (CR43) 2016; 352
Li (CR105) 2019; 20
Pugh (CR15) 2013; 45
Schmiedel (CR90) 2018; 175
Dong (CR20) 2020; 38
Gu, Eils, Schlesner (CR78) 2016; 32
Bedoya-Reina (CR23) 2021; 12
Mantovani (CR53) 2017; 14
Yuan (CR57) 2022; 41
Miettinen (CR46) 2015; 39
Waskom (CR75) 2021; 6
CR68
Andreatta, Carmona (CR94) 2021; 19
Platanitis, Decker (CR55) 2018; 9
CR63
Tahir (CR70) 2017; 89
Zhao (CR39) 2020; 13
Mabbott (CR87) 2013; 14
Rifatbegovic (CR3) 2018; 142
Zhang (CR29) 2017; 8
Ren (CR67) 2004; 23
Hanahan (CR5) 2022; 12
Blom (CR61) 2020; 10
CR77
CR76
CR74
Li (CR100) 2021; 12
Haghverdi (CR83) 2018; 36
Cai, Chen (CR56) 2022; 12
Gröbner (CR14) 2018; 555
Jin (CR50) 2021; 12
Crowell (CR95) 2020; 11
Martens, Stunnenberg (CR88) 2013; 98
Yangngam (CR52) 2022; 100
CR84
CR81
He (CR96) 2021; 4
Cohn (CR1) 2009; 27
Baryawno (CR101) 2019; 177
Yu, Wang, He (CR103) 2015; 31
CR19
CR18
CR17
van Galen (CR41) 2019; 176
Fornes (CR102) 2020; 48
Cerezo-Wallis (CR65) 2020; 26
(CR89) 2012; 489
CR97
Kfoury (CR42) 2021; 39
Tanay, Regev (CR36) 2017; 541
Bais, Kostka (CR80) 2020; 36
Layer (CR28) 2017; 6
Schleiermacher (CR16) 2011; 105
Aran (CR86) 2019; 20
Swiecki, Colonna (CR45) 2015; 15
Richards, Sotillo, Majzner (CR62) 2018; 9
Rice (CR66) 2003; 8
Tirosh (CR93) 2016; 539
Gerner (CR71) 2019; 10
Peifer (CR11) 2015; 526
Jansky (CR21) 2021; 53
Weiss (CR7) 2021; 12
CR108
Kameneva (CR22) 2021; 53
Monaco (CR92) 2019; 26
CR109
Carlson (CR34) 2013; 34
Seiser (CR73) 2021; 11
Heinz (CR104) 2010; 38
CR107
TF Eleveld (39210_CR12) 2015; 47
P Kameneva (39210_CR22) 2021; 53
KK Matthay (39210_CR2) 2016; 2
39210_CR38
39210_CR35
M Swiecki (39210_CR45) 2015; 15
39210_CR33
BM Verhoeven (39210_CR37) 2022; 3
S Yangngam (39210_CR52) 2022; 100
M Mina (39210_CR26) 2015; 4
G Monaco (39210_CR92) 2019; 26
A Bellini (39210_CR13) 2021; 39
T Blom (39210_CR61) 2020; 10
G Yu (39210_CR103) 2015; 31
L Haghverdi (39210_CR83) 2018; 36
Y Mao (39210_CR30) 2016; 22
C Thirant (39210_CR58) 2023; 14
AP Berbegall (39210_CR8) 2018; 118
SL Cohn (39210_CR1) 2009; 27
T van Groningen (39210_CR49) 2017; 49
M Casanova-Acebes (39210_CR54) 2021; 595
G Schleiermacher (39210_CR16) 2011; 105
ZJ Cao (39210_CR106) 2022; 40
D Hanahan (39210_CR5) 2022; 12
M Miettinen (39210_CR46) 2015; 39
HL Crowell (39210_CR95) 2020; 11
MC Gerner (39210_CR71) 2019; 10
D Anderson (39210_CR40) 2020; 10
P Paul (39210_CR64) 2017; 8
N Popitsch (39210_CR69) 2019; 35
C Engblom (39210_CR59) 2016; 16
S Jansky (39210_CR21) 2021; 53
SN Gröbner (39210_CR14) 2018; 555
T Stuart (39210_CR99) 2021; 18
SV Puram (39210_CR44) 2017; 171
P Zhang (39210_CR29) 2017; 8
X Zhao (39210_CR39) 2020; 13
Z Gu (39210_CR78) 2016; 32
Consortium, E.P. (39210_CR89) 2012; 489
K Schmelz (39210_CR6) 2021; 12
OC Bedoya-Reina (39210_CR23) 2021; 12
39210_CR47
R Dong (39210_CR20) 2020; 38
AL Yu (39210_CR60) 2010; 363
N Novershtern (39210_CR91) 2011; 144
AS Bais (39210_CR80) 2020; 36
Z Li (39210_CR105) 2019; 20
S Seiser (39210_CR73) 2021; 11
JP Layer (39210_CR28) 2017; 6
39210_CR74
39210_CR77
39210_CR76
39210_CR81
39210_CR84
I Tirosh (39210_CR93) 2016; 539
A Tanay (39210_CR36) 2017; 541
Z Xie (39210_CR98) 2021; 1
S Heinz (39210_CR104) 2010; 38
Y Ren (39210_CR67) 2004; 23
O Fornes (39210_CR102) 2020; 48
A Mantovani (39210_CR53) 2017; 14
M Cai (39210_CR56) 2022; 12
X Yuan (39210_CR57) 2022; 41
D Aran (39210_CR86) 2019; 20
A Tahir (39210_CR70) 2017; 89
39210_CR68
T Hishiki (39210_CR27) 2018; 34
TJ Pugh (39210_CR15) 2013; 45
39210_CR63
JH Martens (39210_CR88) 2013; 98
F Guo (39210_CR51) 2016; 35
E Platanitis (39210_CR55) 2018; 9
M Peifer (39210_CR11) 2015; 526
RM Richards (39210_CR62) 2018; 9
I Tirosh (39210_CR43) 2016; 352
M Andreatta (39210_CR94) 2021; 19
Y Hao (39210_CR79) 2021; 184
NA Mabbott (39210_CR87) 2013; 14
P van Galen (39210_CR41) 2019; 176
O Hashimoto (39210_CR31) 2016; 240
D Cerezo-Wallis (39210_CR65) 2020; 26
JI Johnsen (39210_CR24) 2019; 12
39210_CR17
39210_CR19
O Melaiu (39210_CR25) 2020; 11
S Ackermann (39210_CR9) 2018; 362
39210_CR18
39210_CR97
L He (39210_CR96) 2021; 4
MR Abbasi (39210_CR4) 2017; 23
VA Traag (39210_CR85) 2019; 9
V Boeva (39210_CR48) 2017; 49
S Asgharzadeh (39210_CR32) 2012; 30
J Cao (39210_CR82) 2019; 566
ML Waskom (39210_CR75) 2021; 6
39210_CR108
39210_CR109
LM Carlson (39210_CR34) 2013; 34
39210_CR107
A Zougman (39210_CR72) 2014; 14
EK Rice (39210_CR66) 2003; 8
S Jin (39210_CR50) 2021; 12
SA Hartlieb (39210_CR10) 2021; 12
BJ Schmiedel (39210_CR90) 2018; 175
Y Kfoury (39210_CR42) 2021; 39
F Rifatbegovic (39210_CR3) 2018; 142
T Weiss (39210_CR7) 2021; 12
N Baryawno (39210_CR101) 2019; 177
Z Li (39210_CR100) 2021; 12
References_xml – volume: 12
  year: 2021
  ident: CR7
  article-title: Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21859-0
– volume: 49
  start-page: 1261
  year: 2017
  end-page: 1266
  ident: CR49
  article-title: Neuroblastoma is composed of two super-enhancer-associated differentiation states
  publication-title: Nat. Genet
  doi: 10.1038/ng.3899
– ident: CR97
– ident: CR68
– ident: CR74
– volume: 19
  start-page: 3796
  year: 2021
  end-page: 3798
  ident: CR94
  article-title: UCell: robust and scalable single-cell gene signature scoring
  publication-title: Comput Struct. Biotechnol. J.
  doi: 10.1016/j.csbj.2021.06.043
– volume: 49
  start-page: 1408
  year: 2017
  end-page: 1413
  ident: CR48
  article-title: Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries
  publication-title: Nat. Genet
  doi: 10.1038/ng.3921
– volume: 12
  year: 2021
  ident: CR23
  article-title: Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-24870-7
– ident: CR77
– volume: 8
  start-page: 82609
  year: 2017
  end-page: 82620
  ident: CR64
  article-title: Elevated TIMP-1 expression is associated with a prometastatic phenotype, disease relapse, and poor survival in neuroblastoma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.19664
– volume: 362
  start-page: 1165
  year: 2018
  end-page: 1170
  ident: CR9
  article-title: A mechanistic classification of clinical phenotypes in neuroblastoma
  publication-title: Science
  doi: 10.1126/science.aat6768
– volume: 526
  start-page: 700
  year: 2015
  end-page: 704
  ident: CR11
  article-title: Telomerase activation by genomic rearrangements in high-risk neuroblastoma
  publication-title: Nature
  doi: 10.1038/nature14980
– volume: 12
  start-page: 9
  year: 2019
  ident: CR24
  article-title: Neuroblastoma-a neural crest derived embryonal malignancy
  publication-title: Front Mol. Neurosci.
  doi: 10.3389/fnmol.2019.00009
– volume: 14
  year: 2013
  ident: CR87
  article-title: An expression atlas of human primary cells: inference of gene function from coexpression networks
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-632
– ident: CR19
– volume: 105
  start-page: 1940
  year: 2011
  end-page: 1948
  ident: CR16
  article-title: Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study)
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2011.472
– volume: 2
  start-page: 16078
  year: 2016
  ident: CR2
  article-title: Neuroblastoma
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/nrdp.2016.78
– volume: 555
  start-page: 321
  year: 2018
  end-page: 327
  ident: CR14
  article-title: The landscape of genomic alterations across childhood cancers
  publication-title: Nature
  doi: 10.1038/nature25480
– volume: 176
  start-page: 1265
  year: 2019
  end-page: 1281.e24
  ident: CR41
  article-title: Single-cell RNA-seq reveals AML hierarchies relevant to disease progression and immunity
  publication-title: Cell
  doi: 10.1016/j.cell.2019.01.031
– volume: 40
  start-page: 1458
  year: 2022
  end-page: 1466
  ident: CR106
  article-title: Multi-omics single-cell data integration and regulatory inference with graph-linked embedding
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-022-01284-4
– volume: 41
  start-page: 111455
  year: 2022
  ident: CR57
  article-title: Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2022.111455
– volume: 6
  start-page: 3021
  year: 2021
  ident: CR75
  article-title: Seaborn: statistical data visualization
  publication-title: J. Open Source Softw.
  doi: 10.21105/joss.03021
– ident: CR109
– volume: 11
  year: 2020
  ident: CR25
  article-title: Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19781-y
– volume: 541
  start-page: 331
  year: 2017
  end-page: 338
  ident: CR36
  article-title: Scaling single-cell genomics from phenomenology to mechanism
  publication-title: Nature
  doi: 10.1038/nature21350
– ident: CR18
– volume: 100
  start-page: 1145
  year: 2022
  end-page: 1157
  ident: CR52
  article-title: Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis
  publication-title: J. Mol. Med.
  doi: 10.1007/s00109-022-02228-w
– ident: CR47
– volume: 10
  start-page: 601076
  year: 2020
  ident: CR61
  article-title: Treatment-related toxicities during anti-GD2 immunotherapy in high-risk neuroblastoma patients
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2020.601076
– volume: 32
  start-page: 2847
  year: 2016
  end-page: 2849
  ident: CR78
  article-title: Complex heatmaps reveal patterns and correlations in multidimensional genomic data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw313
– volume: 14
  year: 2023
  ident: CR58
  article-title: Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-38239-5
– volume: 34
  start-page: 195
  year: 2018
  end-page: 201
  ident: CR27
  article-title: Invariant natural killer T infiltration in neuroblastoma with favorable outcome
  publication-title: Pediatr. Surg. Int.
  doi: 10.1007/s00383-017-4189-x
– volume: 6
  start-page: e1320626
  year: 2017
  ident: CR28
  article-title: Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2017.1320626
– volume: 20
  start-page: 163
  year: 2019
  end-page: 172
  ident: CR86
  article-title: Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0276-y
– volume: 16
  start-page: 447
  year: 2016
  end-page: 462
  ident: CR59
  article-title: The role of myeloid cells in cancer therapies
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.54
– ident: CR33
– volume: 18
  start-page: 1333
  year: 2021
  end-page: 1341
  ident: CR99
  article-title: Single-cell chromatin state analysis with Signac
  publication-title: Nat. Methods
  doi: 10.1038/s41592-021-01282-5
– volume: 48
  start-page: D87
  year: 2020
  end-page: D92
  ident: CR102
  article-title: JASPAR 2020: update of the open-access database of transcription factor binding profiles
  publication-title: Nucleic Acids Res.
– volume: 89
  start-page: 1945
  year: 2017
  end-page: 1954
  ident: CR70
  article-title: Combined proteome and eicosanoid profiling approach for revealing implications of human fibroblasts in chronic inflammation
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.6b04433
– ident: CR63
– volume: 12
  start-page: 31
  year: 2022
  end-page: 46
  ident: CR5
  article-title: Hallmarks of cancer: new dimensions
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-21-1059
– volume: 12
  year: 2021
  ident: CR6
  article-title: Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26870-z
– ident: CR108
– volume: 566
  start-page: 496
  year: 2019
  end-page: 502
  ident: CR82
  article-title: The single-cell transcriptional landscape of mammalian organogenesis
  publication-title: Nature
  doi: 10.1038/s41586-019-0969-x
– volume: 53
  start-page: 694
  year: 2021
  end-page: 706
  ident: CR22
  article-title: Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin
  publication-title: Nat. Genet
  doi: 10.1038/s41588-021-00818-x
– volume: 595
  start-page: 578
  year: 2021
  end-page: 584
  ident: CR54
  article-title: Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
  publication-title: Nature
  doi: 10.1038/s41586-021-03651-8
– volume: 45
  start-page: 279
  year: 2013
  end-page: 284
  ident: CR15
  article-title: The genetic landscape of high-risk neuroblastoma
  publication-title: Nat. Genet
  doi: 10.1038/ng.2529
– volume: 363
  start-page: 1324
  year: 2010
  end-page: 1334
  ident: CR60
  article-title: Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0911123
– volume: 15
  start-page: 471
  year: 2015
  end-page: 485
  ident: CR45
  article-title: The multifaceted biology of plasmacytoid dendritic cells
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3865
– ident: CR38
– volume: 30
  start-page: 3525
  year: 2012
  end-page: 3532
  ident: CR32
  article-title: Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2011.40.9169
– volume: 9
  year: 2019
  ident: CR85
  article-title: From Louvain to Leiden: guaranteeing well-connected communities
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-41695-z
– volume: 36
  start-page: 421
  year: 2018
  end-page: 427
  ident: CR83
  article-title: Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4091
– volume: 31
  start-page: 2382
  year: 2015
  end-page: 2383
  ident: CR103
  article-title: ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv145
– volume: 171
  start-page: 1611
  year: 2017
  end-page: 1624.e24
  ident: CR44
  article-title: Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2017.10.044
– volume: 184
  start-page: 3573
  year: 2021
  end-page: 3587.e29
  ident: CR79
  article-title: Integrated analysis of multimodal single-cell data
  publication-title: Cell
  doi: 10.1016/j.cell.2021.04.048
– volume: 9
  start-page: 2542
  year: 2018
  ident: CR55
  article-title: Regulatory networks involving STATs, IRFs, and NFκB in inflammation
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2018.02542
– volume: 4
  start-page: e1019981
  year: 2015
  ident: CR26
  article-title: Tumor-infiltrating T lymphocytes improve clinical outcome of therapy-resistant neuroblastoma
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2015.1019981
– volume: 12
  year: 2021
  ident: CR100
  article-title: Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26530-2
– volume: 34
  start-page: 1081
  year: 2013
  end-page: 1088
  ident: CR34
  article-title: Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgt009
– volume: 47
  start-page: 864
  year: 2015
  end-page: 871
  ident: CR12
  article-title: Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
  publication-title: Nat. Genet
  doi: 10.1038/ng.3333
– volume: 35
  start-page: 816
  year: 2016
  end-page: 826
  ident: CR51
  article-title: CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks
  publication-title: Oncogene
  doi: 10.1038/onc.2015.139
– volume: 12
  year: 2021
  ident: CR50
  article-title: Inference and analysis of cell-cell communication using CellChat
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21246-9
– volume: 118
  start-page: 1502
  year: 2018
  end-page: 1512
  ident: CR8
  article-title: Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-018-0098-6
– volume: 53
  start-page: 683
  year: 2021
  end-page: 693
  ident: CR21
  article-title: Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma
  publication-title: Nat. Genet
  doi: 10.1038/s41588-021-00806-1
– volume: 4
  start-page: 629
  year: 2021
  ident: CR96
  article-title: NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-021-02146-6
– ident: CR35
– ident: CR84
– volume: 8
  start-page: 1473
  year: 2017
  ident: CR29
  article-title: Amplification is associated with repressed cellular immunity in neuroblastoma: an in silico immunological analysis of TARGET database
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.01473
– volume: 23
  start-page: 4146
  year: 2004
  end-page: 4154
  ident: CR67
  article-title: Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207490
– volume: 39
  start-page: 1464
  year: 2021
  end-page: 1478.e8
  ident: CR42
  article-title: Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2021.09.005
– volume: 489
  start-page: 57
  year: 2012
  end-page: 74
  ident: CR89
  article-title: An integrated encyclopedia of DNA elements in the human genome
  publication-title: Nature
  doi: 10.1038/nature11247
– volume: 539
  start-page: 309
  year: 2016
  end-page: 313
  ident: CR93
  article-title: Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
  publication-title: Nature
  doi: 10.1038/nature20123
– volume: 10
  year: 2020
  ident: CR40
  article-title: The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-76157-4
– volume: 39
  start-page: 826
  year: 2015
  end-page: 835
  ident: CR46
  article-title: Sox10–a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors
  publication-title: Am. J. Surg. Pathol.
  doi: 10.1097/PAS.0000000000000398
– volume: 12
  year: 2021
  ident: CR10
  article-title: Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21247-8
– volume: 11
  year: 2021
  ident: CR73
  article-title: Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-79378-9
– volume: 12
  start-page: 817069
  year: 2022
  ident: CR56
  article-title: The roles of IRF-8 in regulating IL-9-mediated immunologic mechanisms in the development of DLBCL: a State-of-the-Art literature review
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2022.817069
– volume: 13
  year: 2020
  ident: CR39
  article-title: Comprehensive analysis of single-cell RNA sequencing data from healthy human marrow hematopoietic cells
  publication-title: BMC Res. Notes
  doi: 10.1186/s13104-020-05357-y
– volume: 175
  start-page: 1701
  year: 2018
  end-page: 1715.e16
  ident: CR90
  article-title: Impact of genetic polymorphisms on human immune cell gene expression
  publication-title: Cell
  doi: 10.1016/j.cell.2018.10.022
– volume: 98
  start-page: 1487
  year: 2013
  end-page: 1489
  ident: CR88
  article-title: BLUEPRINT: mapping human blood cell epigenomes
  publication-title: Haematologica
  doi: 10.3324/haematol.2013.094243
– volume: 20
  year: 2019
  ident: CR105
  article-title: Identification of transcription factor binding sites using ATAC-seq
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1642-2
– volume: 8
  start-page: 156
  year: 2003
  end-page: 161
  ident: CR66
  article-title: Interferon-gamma induces macrophage migration inhibitory factor synthesis and secretion by tubular epithelial cells
  publication-title: Nephrology
  doi: 10.1046/j.1440-1797.2003.00152.x
– ident: CR81
– volume: 9
  start-page: 2380
  year: 2018
  ident: CR62
  article-title: CAR T cell therapy for neuroblastoma
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02380
– volume: 38
  start-page: 716
  year: 2020
  end-page: 733.e6
  ident: CR20
  article-title: Single-cell characterization of malignant phenotypes and developmental trajectories of adrenal neuroblastoma
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2020.08.014
– volume: 10
  start-page: 727
  year: 2019
  ident: CR71
  article-title: Proteome analysis reveals distinct mitochondrial functions linked to interferon response patterns in activated CD4+ and CD8+ T cells
  publication-title: Front. Pharm.
  doi: 10.3389/fphar.2019.00727
– volume: 23
  start-page: 4224
  year: 2017
  end-page: 4232
  ident: CR4
  article-title: Impact of disseminated neuroblastoma cells on the identification of the relapse-seeding clone
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-2082
– volume: 35
  start-page: 868
  year: 2019
  end-page: 870
  ident: CR69
  article-title: VARAN-GIE: curation of genomic interval sets
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bty723
– volume: 26
  start-page: 1627
  year: 2019
  end-page: 1640.e7
  ident: CR92
  article-title: RNA-seq signatures normalized by mRNA abundance allow absolute deconvolution of human immune cell types
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.01.041
– volume: 14
  start-page: 1006
  year: 2014
  end-page: 0
  ident: CR72
  article-title: Suspension trapping (STrap) sample preparation method for bottom-up proteomics analysis
  publication-title: Proteomics
  doi: 10.1002/pmic.201300553
– volume: 11
  year: 2020
  ident: CR95
  article-title: muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19894-4
– volume: 14
  start-page: 399
  year: 2017
  end-page: 416
  ident: CR53
  article-title: Tumour-associated macrophages as treatment targets in oncology
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2016.217
– volume: 177
  start-page: 1915
  year: 2019
  end-page: 1932.e16
  ident: CR101
  article-title: A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia
  publication-title: Cell
  doi: 10.1016/j.cell.2019.04.040
– volume: 142
  start-page: 297
  year: 2018
  end-page: 307
  ident: CR3
  article-title: Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression
  publication-title: Int J. Cancer
  doi: 10.1002/ijc.31053
– volume: 1
  start-page: e90
  year: 2021
  ident: CR98
  article-title: Gene set knowledge discovery with Enrichr
  publication-title: Curr. Protoc.
– volume: 3
  start-page: 100657
  year: 2022
  ident: CR37
  article-title: The immune cell atlas of human neuroblastoma
  publication-title: Cell Rep. Med.
  doi: 10.1016/j.xcrm.2022.100657
– volume: 144
  start-page: 296
  year: 2011
  end-page: 309
  ident: CR91
  article-title: Densely interconnected transcriptional circuits control cell states in human hematopoiesis
  publication-title: Cell
  doi: 10.1016/j.cell.2011.01.004
– volume: 27
  start-page: 289
  year: 2009
  end-page: 297
  ident: CR1
  article-title: The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2008.16.6785
– volume: 22
  start-page: 3849
  year: 2016
  end-page: 3859
  ident: CR30
  article-title: Targeting suppressive myeloid cells potentiates checkpoint inhibitors to control spontaneous neuroblastoma
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-15-1912
– volume: 38
  start-page: 576
  year: 2010
  end-page: 589
  ident: CR104
  article-title: Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.05.004
– volume: 240
  start-page: 211
  year: 2016
  end-page: 223
  ident: CR31
  article-title: Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development
  publication-title: J. Pathol.
  doi: 10.1002/path.4769
– volume: 39
  start-page: 3377
  year: 2021
  end-page: 3390
  ident: CR13
  article-title: Frequency and prognostic impact of amplifications and mutations in the European Neuroblastoma Study Group (SIOPEN) high-risk neuroblastoma trial (HR-NBL1)
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.21.00086
– volume: 352
  start-page: 189
  year: 2016
  end-page: 196
  ident: CR43
  article-title: Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  publication-title: Science
  doi: 10.1126/science.aad0501
– ident: CR17
– volume: 36
  start-page: 1150
  year: 2020
  end-page: 1158
  ident: CR80
  article-title: scds: computational annotation of doublets in single-cell RNA sequencing data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btz698
– ident: CR76
– ident: CR107
– volume: 26
  start-page: 1865
  year: 2020
  end-page: 1877
  ident: CR65
  article-title: Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state
  publication-title: Nat. Med.
  doi: 10.1038/s41591-020-1073-3
– volume: 12
  year: 2021
  ident: 39210_CR6
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26870-z
– volume: 23
  start-page: 4224
  year: 2017
  ident: 39210_CR4
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-2082
– volume: 175
  start-page: 1701
  year: 2018
  ident: 39210_CR90
  publication-title: Cell
  doi: 10.1016/j.cell.2018.10.022
– volume: 4
  start-page: 629
  year: 2021
  ident: 39210_CR96
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-021-02146-6
– volume: 39
  start-page: 826
  year: 2015
  ident: 39210_CR46
  publication-title: Am. J. Surg. Pathol.
  doi: 10.1097/PAS.0000000000000398
– ident: 39210_CR33
  doi: 10.1136/jitc-2022-004807
– volume: 8
  start-page: 82609
  year: 2017
  ident: 39210_CR64
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.19664
– volume: 142
  start-page: 297
  year: 2018
  ident: 39210_CR3
  publication-title: Int J. Cancer
  doi: 10.1002/ijc.31053
– ident: 39210_CR35
  doi: 10.3390/cancers13174311
– volume: 9
  start-page: 2380
  year: 2018
  ident: 39210_CR62
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02380
– volume: 144
  start-page: 296
  year: 2011
  ident: 39210_CR91
  publication-title: Cell
  doi: 10.1016/j.cell.2011.01.004
– volume: 39
  start-page: 3377
  year: 2021
  ident: 39210_CR13
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.21.00086
– volume: 11
  year: 2020
  ident: 39210_CR95
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19894-4
– volume: 12
  start-page: 31
  year: 2022
  ident: 39210_CR5
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-21-1059
– volume: 8
  start-page: 1473
  year: 2017
  ident: 39210_CR29
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.01473
– volume: 9
  start-page: 2542
  year: 2018
  ident: 39210_CR55
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2018.02542
– volume: 18
  start-page: 1333
  year: 2021
  ident: 39210_CR99
  publication-title: Nat. Methods
  doi: 10.1038/s41592-021-01282-5
– volume: 555
  start-page: 321
  year: 2018
  ident: 39210_CR14
  publication-title: Nature
  doi: 10.1038/nature25480
– volume: 53
  start-page: 683
  year: 2021
  ident: 39210_CR21
  publication-title: Nat. Genet
  doi: 10.1038/s41588-021-00806-1
– volume: 35
  start-page: 816
  year: 2016
  ident: 39210_CR51
  publication-title: Oncogene
  doi: 10.1038/onc.2015.139
– volume: 49
  start-page: 1261
  year: 2017
  ident: 39210_CR49
  publication-title: Nat. Genet
  doi: 10.1038/ng.3899
– volume: 41
  start-page: 111455
  year: 2022
  ident: 39210_CR57
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2022.111455
– ident: 39210_CR109
  doi: 10.5281/zenodo.7867892
– volume: 36
  start-page: 421
  year: 2018
  ident: 39210_CR83
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4091
– volume: 12
  start-page: 817069
  year: 2022
  ident: 39210_CR56
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2022.817069
– volume: 49
  start-page: 1408
  year: 2017
  ident: 39210_CR48
  publication-title: Nat. Genet
  doi: 10.1038/ng.3921
– volume: 12
  year: 2021
  ident: 39210_CR23
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-24870-7
– volume: 26
  start-page: 1865
  year: 2020
  ident: 39210_CR65
  publication-title: Nat. Med.
  doi: 10.1038/s41591-020-1073-3
– volume: 14
  start-page: 1006
  year: 2014
  ident: 39210_CR72
  publication-title: Proteomics
  doi: 10.1002/pmic.201300553
– volume: 47
  start-page: 864
  year: 2015
  ident: 39210_CR12
  publication-title: Nat. Genet
  doi: 10.1038/ng.3333
– volume: 20
  start-page: 163
  year: 2019
  ident: 39210_CR86
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0276-y
– ident: 39210_CR63
  doi: 10.3390/ijms222312828
– volume: 48
  start-page: D87
  year: 2020
  ident: 39210_CR102
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa516
– volume: 53
  start-page: 694
  year: 2021
  ident: 39210_CR22
  publication-title: Nat. Genet
  doi: 10.1038/s41588-021-00818-x
– ident: 39210_CR18
  doi: 10.1126/science.aal3753
– volume: 16
  start-page: 447
  year: 2016
  ident: 39210_CR59
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.54
– volume: 240
  start-page: 211
  year: 2016
  ident: 39210_CR31
  publication-title: J. Pathol.
  doi: 10.1002/path.4769
– volume: 26
  start-page: 1627
  year: 2019
  ident: 39210_CR92
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.01.041
– volume: 566
  start-page: 496
  year: 2019
  ident: 39210_CR82
  publication-title: Nature
  doi: 10.1038/s41586-019-0969-x
– volume: 541
  start-page: 331
  year: 2017
  ident: 39210_CR36
  publication-title: Nature
  doi: 10.1038/nature21350
– volume: 27
  start-page: 289
  year: 2009
  ident: 39210_CR1
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2008.16.6785
– ident: 39210_CR84
– volume: 12
  year: 2021
  ident: 39210_CR100
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26530-2
– volume: 23
  start-page: 4146
  year: 2004
  ident: 39210_CR67
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207490
– volume: 14
  year: 2013
  ident: 39210_CR87
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-632
– volume: 10
  start-page: 601076
  year: 2020
  ident: 39210_CR61
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2020.601076
– volume: 100
  start-page: 1145
  year: 2022
  ident: 39210_CR52
  publication-title: J. Mol. Med.
  doi: 10.1007/s00109-022-02228-w
– ident: 39210_CR77
  doi: 10.1007/978-3-319-24277-4
– ident: 39210_CR47
  doi: 10.1093/database/baz046
– volume: 39
  start-page: 1464
  year: 2021
  ident: 39210_CR42
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2021.09.005
– volume: 526
  start-page: 700
  year: 2015
  ident: 39210_CR11
  publication-title: Nature
  doi: 10.1038/nature14980
– volume: 9
  year: 2019
  ident: 39210_CR85
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-41695-z
– ident: 39210_CR76
– volume: 38
  start-page: 576
  year: 2010
  ident: 39210_CR104
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.05.004
– ident: 39210_CR17
  doi: 10.1126/science.aas9536
– volume: 35
  start-page: 868
  year: 2019
  ident: 39210_CR69
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bty723
– volume: 36
  start-page: 1150
  year: 2020
  ident: 39210_CR80
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btz698
– ident: 39210_CR68
  doi: 10.1182/bloodadvances.2022008303
– volume: 177
  start-page: 1915
  year: 2019
  ident: 39210_CR101
  publication-title: Cell
  doi: 10.1016/j.cell.2019.04.040
– volume: 539
  start-page: 309
  year: 2016
  ident: 39210_CR93
  publication-title: Nature
  doi: 10.1038/nature20123
– volume: 3
  start-page: 100657
  year: 2022
  ident: 39210_CR37
  publication-title: Cell Rep. Med.
  doi: 10.1016/j.xcrm.2022.100657
– volume: 30
  start-page: 3525
  year: 2012
  ident: 39210_CR32
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2011.40.9169
– volume: 184
  start-page: 3573
  year: 2021
  ident: 39210_CR79
  publication-title: Cell
  doi: 10.1016/j.cell.2021.04.048
– volume: 11
  year: 2020
  ident: 39210_CR25
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19781-y
– volume: 14
  year: 2023
  ident: 39210_CR58
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-38239-5
– volume: 2
  start-page: 16078
  year: 2016
  ident: 39210_CR2
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/nrdp.2016.78
– volume: 15
  start-page: 471
  year: 2015
  ident: 39210_CR45
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3865
– volume: 32
  start-page: 2847
  year: 2016
  ident: 39210_CR78
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw313
– volume: 8
  start-page: 156
  year: 2003
  ident: 39210_CR66
  publication-title: Nephrology
  doi: 10.1046/j.1440-1797.2003.00152.x
– volume: 19
  start-page: 3796
  year: 2021
  ident: 39210_CR94
  publication-title: Comput Struct. Biotechnol. J.
  doi: 10.1016/j.csbj.2021.06.043
– volume: 595
  start-page: 578
  year: 2021
  ident: 39210_CR54
  publication-title: Nature
  doi: 10.1038/s41586-021-03651-8
– volume: 362
  start-page: 1165
  year: 2018
  ident: 39210_CR9
  publication-title: Science
  doi: 10.1126/science.aat6768
– volume: 13
  year: 2020
  ident: 39210_CR39
  publication-title: BMC Res. Notes
  doi: 10.1186/s13104-020-05357-y
– volume: 118
  start-page: 1502
  year: 2018
  ident: 39210_CR8
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-018-0098-6
– volume: 6
  start-page: e1320626
  year: 2017
  ident: 39210_CR28
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2017.1320626
– ident: 39210_CR81
  doi: 10.1093/gigascience/giaa151
– volume: 352
  start-page: 189
  year: 2016
  ident: 39210_CR43
  publication-title: Science
  doi: 10.1126/science.aad0501
– volume: 40
  start-page: 1458
  year: 2022
  ident: 39210_CR106
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-022-01284-4
– ident: 39210_CR108
  doi: 10.5281/zenodo.7707614
– volume: 12
  year: 2021
  ident: 39210_CR7
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21859-0
– volume: 14
  start-page: 399
  year: 2017
  ident: 39210_CR53
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2016.217
– volume: 12
  start-page: 9
  year: 2019
  ident: 39210_CR24
  publication-title: Front Mol. Neurosci.
  doi: 10.3389/fnmol.2019.00009
– volume: 38
  start-page: 716
  year: 2020
  ident: 39210_CR20
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2020.08.014
– ident: 39210_CR19
– volume: 11
  year: 2021
  ident: 39210_CR73
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-79378-9
– ident: 39210_CR74
– volume: 45
  start-page: 279
  year: 2013
  ident: 39210_CR15
  publication-title: Nat. Genet
  doi: 10.1038/ng.2529
– ident: 39210_CR107
  doi: 10.5281/zenodo.6621045
– volume: 105
  start-page: 1940
  year: 2011
  ident: 39210_CR16
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2011.472
– volume: 22
  start-page: 3849
  year: 2016
  ident: 39210_CR30
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-15-1912
– volume: 10
  start-page: 727
  year: 2019
  ident: 39210_CR71
  publication-title: Front. Pharm.
  doi: 10.3389/fphar.2019.00727
– volume: 363
  start-page: 1324
  year: 2010
  ident: 39210_CR60
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0911123
– volume: 4
  start-page: e1019981
  year: 2015
  ident: 39210_CR26
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2015.1019981
– volume: 10
  year: 2020
  ident: 39210_CR40
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-76157-4
– volume: 34
  start-page: 1081
  year: 2013
  ident: 39210_CR34
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgt009
– volume: 176
  start-page: 1265
  year: 2019
  ident: 39210_CR41
  publication-title: Cell
  doi: 10.1016/j.cell.2019.01.031
– volume: 1
  start-page: e90
  year: 2021
  ident: 39210_CR98
  publication-title: Curr. Protoc.
  doi: 10.1002/cpz1.90
– ident: 39210_CR97
– volume: 98
  start-page: 1487
  year: 2013
  ident: 39210_CR88
  publication-title: Haematologica
  doi: 10.3324/haematol.2013.094243
– volume: 12
  year: 2021
  ident: 39210_CR10
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21247-8
– volume: 171
  start-page: 1611
  year: 2017
  ident: 39210_CR44
  publication-title: Cell
  doi: 10.1016/j.cell.2017.10.044
– volume: 6
  start-page: 3021
  year: 2021
  ident: 39210_CR75
  publication-title: J. Open Source Softw.
  doi: 10.21105/joss.03021
– ident: 39210_CR38
  doi: 10.1172/jci.insight.124928
– volume: 12
  year: 2021
  ident: 39210_CR50
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21246-9
– volume: 89
  start-page: 1945
  year: 2017
  ident: 39210_CR70
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.6b04433
– volume: 20
  year: 2019
  ident: 39210_CR105
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1642-2
– volume: 31
  start-page: 2382
  year: 2015
  ident: 39210_CR103
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv145
– volume: 489
  start-page: 57
  year: 2012
  ident: 39210_CR89
  publication-title: Nature
  doi: 10.1038/nature11247
– volume: 34
  start-page: 195
  year: 2018
  ident: 39210_CR27
  publication-title: Pediatr. Surg. Int.
  doi: 10.1007/s00383-017-4189-x
SSID ssj0000391844
Score 2.5587773
Snippet Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however,...
Abstract Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site,...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3620
SubjectTerms 13/106
13/21
13/31
14/1
14/63
38/39
42/47
631/337/100/101
631/337/176
631/337/2019
631/67/327
631/67/68
82/79
82/80
Bone cancer
Bone marrow
Bone Marrow - pathology
Bone Marrow Neoplasms - genetics
Bone Marrow Neoplasms - metabolism
Bone Marrow Neoplasms - pathology
Cancer
Cell interactions
Child
Children
Epigenomics
Humanities and Social Sciences
Humans
Inflammation
Macrophages
Metastases
Metastasis
Microenvironments
Midkine
Monocytes
Monocytes - metabolism
multidisciplinary
Neuroblastoma
Neuroblastoma - metabolism
Plastic foam
Plastic properties
Plasticity
Science
Science (multidisciplinary)
Tissue analysis
Transcriptome
Transcriptomics
Tumor cells
Tumor Microenvironment - genetics
Tumors
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuiFIeaQsyEjewmvgV-wiIqkKCC1TqzfIr6kpttpDsof--M0526fLqhUukOH7JM_Z8E9vfEPI6yQ5PBmkmlYjwsDULAMyZkRnQg5Ame_w18PmLPjmVn87U2a1QX3gmbKIHngbuqGnQjfKBd7yRKRoT26RM53kLtfiYcPUFm3fLmSprsLDgusj5lkwtzNEgy5oAJooBJMAd4C1LVAj7_4Qyfz8s-cuOaTFEx4_IwxlB0ndTz3fJvdw_JvenmJLXe-T7Vyh1kRn-kacjWqKyLuDl44H6PtF8VYhZy_uqx-hDkO88UzxnSJcdBb1cxmtAoHTR00J3GQBhQwWehmWf6WWhbaSXeYRUPyyGJ-T0-OO3DydsjqvAopLNyGzsmg48p1r5xGW0iWeZRCNk4p1XddJC2-SzMFkGmZOxkvtaBJtUzDyEJJ6SnR4afE6oUOBfR4ss8Elqn73VrU8iG6Uz1GEr0qzH2MWZdBxjX1y4svktjJvk4kAursjF1RV5sylzNVFu_DP3exTdJifSZZcEUCI3K5G7S4kqcrgWvJvn8OBwjxnACzRTkVebzzD7UIC-z8sV5hE1L7dxK_Js0pNNT0QrtGpaUxGzpUFbXd3-0i_OC8M3oD7A1UZV5O1a2X726-9jsf8_xuKAPOA4S2rNuD4kO-OPVX4BwGsML8scuwGcwys4
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4t1AWxmJG1hN_Ip9QlCxrZDgApV6ixzboSu1ybbJHvrvmXGyqZZHLytt4iROZuz5PDP-hpB3QTaYGaSZVMLDj81ZDcCcGRkBPQhpokPXwLfv-uRUfj1TZ5PDrZ_SKjdzYpqoQ-fRR36IET8wJZYXH1dXDKtGYXR1KqFxnzwowNJgSpdZHM8-FmQ_N1JOe2VyYQ57mWYGMFQMgAHGgbfsUaLt_xfW_Dtl8o-4aTJHiyfk8YQj6adR8E_Jvdg-Iw_HypI3z8nVD7jqIjL0y9MB7VGaHXALck9dG2hcJXrW9H_dYg0iaHceKWYb0q6h8LqdvwEcSpctTaSXNeBsuIGjdddGepnIG-llHOCo65f9C3K6-PLz6IRN1RWYV7IYmPVN0cD6KVcucOlt4FEGUQgZeONUHrTQNrgoTJS1jMFYyV0uahuUj7yug3hJdlp44C6hQsEq21vkgg9Su-isLl0Q0Sgd4R42I8XmG1d-oh7HChgXVQqBC1ONcqlALlWSS5Vn5P18zWok3riz9WcU3dwSSbPTge76VzWNQeQ1hxW5q3nDCxm8Mb4MyjSOl6CQzoeM7G0EX00jua9u9S4jb-fTMAZRgK6N3RrbiJynPbkZeTXqydwTUQqtitJkxGxp0FZXt8-0y_PE8w3YD9C1URn5sFG22379_1u8vvs13pBHHPU_14zrPbIzXK_jPgCroT5Io-c3FMIh_g
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VVkhcEG8CBRmJG0QkfsU5LoiqWgkupVJvkWM7dKU2KU320H_PjPNACwWJS6TE49jKzGQ-2-PPAG-9bCgzSKdSCYeXMktrBOapkQHRg5AmWJoa-PJVH5_K9Zk62wM-74WJSfuR0jL-pufssA-9jC6NESbFiE4LuHfggKja0bYPVqv1yXqZWSHOcyPltEMmE-aWyjtRKJL134Yw_0yU_G21NAahowdwf0KPbDX29yHshfYR3B3Pk7x5DD9OsNZFSGk2ng0UheI_gTYe98y2noWrSMoa77ctnTyEcueBUY4h6xqGNtm5G0SfbNOySHVZI7rGF1hWd21gl5GykV2GAZ_aftM_gdOjz98-HafTmQqpUzIf0tI1eYOjpkxZz6UrPQ_Si1xIzxurMq-FLr0NwgRZy-BNKbnNRF165QKvay-ewn6LDT4HJhSOrV1JDPBeahtsqQvrRTBKB3xHmUA-f-PKTYTjdO7FRRUXvoWpRr1UqJcq6qXKEni31Lka6Tb-Kf2RVLdIElV2fNBdf68m0yE2cxyH25o3PJfeGeMKr0xjeYFmaJ1P4HBWfDX5b1_R-jICF2wmgTdLMXoeKdC2oduSjMh43ImbwLPRTpaeiEJolRcmAbNjQTtd3S1pN-eR3RsRH2JqoxJ4Pxvbr379_Vu8-D_xl3CPkz9kOuX6EPaH6214hfBqqF9P_vQT_DAhDQ
  priority: 102
  providerName: Springer Nature
Title Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis
URI https://link.springer.com/article/10.1038/s41467-023-39210-0
https://www.ncbi.nlm.nih.gov/pubmed/37365178
https://www.proquest.com/docview/2829614921
https://www.proquest.com/docview/2830213479
https://pubmed.ncbi.nlm.nih.gov/PMC10293285
https://doaj.org/article/117133ab2f214dc88c7d58fa27ea3acd
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9swED_6wWAvo_v22gUN9rZ5s_Vl-WGMNDQrgZaxLpA3I0tyG0idNh-w_Pc7yU5GtmzsxSHyWRa6O9_vdNIdwFvLK78zSMZcMIOXPIlLBOax4g7RA-PKab80cHEpz4d8MBKjPViXO2oncL7TtfP1pIazyYcf96vPqPCfmiPj6uOcB3VH6xOjtffB3X04RMuU-YoGFy3cD19mlqND4wPNNOFpjASsPUezu5stWxVS-u_CoX9up_wtphpMVf8IHrUYk3QboXgMe65-Ag-aqpOrp3B_hU9NXOzX7MnC26rw5fDHk-dE15a4u5C6Nfxf1r4-EdLdOOJ3IpJpRVByp2aFGJWMaxISYpaIwbEDTcpp7chtSOxIbt0CW_V8PH8Gw_7Z99553FZeiI3g6SLOTZVW6FslQlvKTW6p45aljFtaaZFYyWRutWPK8ZI7q3JOdcLK3ArjaFla9hwOanzhSyBMoAducp8n3nKpnc5lpi1zSkiHfeQRpOs5LkybltxXx5gUITzOVNHwpUC-FIEvRRLBu80zd01Sjn9Sn3rWbSh9Qu3QMJ1dF61--pzn6K3rklY05dYoZTIrVKVphsKqjY3gZM34Yi2khY9CI7zB10TwZnMb9dMzUNduuvQ0LKHhvG4ELxo52YyEZUyKNFMRqC0J2hrq9p16fBNygCMuROStRATv18L2a1x_n4tX_zHOY3hIvRIkMqbyBA4Ws6V7jchrUXZgPxtleFX9Lx047HYHVwP8PT27_PoNW3uy1wlrGp2gdj8BuAgvuw
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgQXxJtAASPBCaImtpN1DgjxWrb0caGVeksd26Ertcm22RXaP8VvZMZ5VMujt14iJXG8Xs_rs8czA_DKypJOBqWhTITBSxaFBQLzUEmH6EFI5TRtDezupZMD-e0wOVyDX30sDB2r7HWiV9S2NrRHvkkePzQlGY_fz85CqhpF3tW-hEbLFttu-ROXbM27rc9I39ecj7_sf5qEXVWB0CQynoeZKeMS1w1Roi2XJrPcSStiIS0vdRLZVKSZ1U4oJwvprMok15EoMpsYx4vCCuz3GlyXAi05RaaPvw57OpRtXUnZxeZEQm020msiNIwhAhHyO6_YP18m4F_Y9u8jmn_4ab35G9-B2x1uZR9aRrsLa666BzfaSpbL-3D2Hb86cSH5Adic7J_XRhTy3DBdWeZmPh2sv19UVPMI2x07RqcbWV0ynN7aLBH3smnFfJLNAnE9dqBZUVeOnfpkkezUzfGpbqbNAzi4knl_COsV_uBjYCLBVb3JKPe8lal2OktH2gqnktRhH1kAcT_HuelSnVPFjZPcu9yFylu65EiX3NMljwJ4M3wzaxN9XNr6I5FuaElJuv2D-vxH3sk85VGPhdAFL3ksrVHKjGyiSs1HKADa2AA2esLnneZo8gs-D-Dl8BplngioK1cvqI2IuI8BDuBRyyfDSMRIpEk8UgGoFQ5aGerqm2p67POKI9ZENK-SAN72zHYxrv_PxZPL_8YLuDnZ393Jd7b2tp_CLU6yEKUhTzdgfX6-cM8Q1M2L516SGBxdtej-BpT5YAw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTiBeEN8EBhgJniBqYjup84AQY5s2BtUETNpbcGyHVdqSbmmF-q_x13HnJJ3Kx972EimJ47q-r5995zuAl1aWFBmUhjIRBi9ZFBYIzEMlHaIHIZXTtDXweZzuHsqPR8nRGvzqz8JQWGWvE72itrWhPfIhefzQlGQ8HpZdWMTB1s676VlIFaTI09qX02hZZN8tfuLyrXm7t4W0fsX5zva3D7thV2EgNImMZ2FmyrjENUSUaMulySx30opYSMtLnUQ2FWlmtRPKyUI6qzLJdSSKzCbG8aKwAvu9BusjWhUNYH1ze3zwZbnDQ7nXlZTdSZ1IqGEjvV5CMxkiLCEv9Io19EUD_oV0_w7Y_MNr643hzm241aFY9r5luzuw5qq7cL2ta7m4B2df8asTF5JXgM3IGnrdRAegG6Yry9zUJ4f19_OKKiBhu2PHKNaR1SXDCa7NAlEwm1TMp9wsEOVjB5oVdeXYqU8dyU7dDJ_qZtLch8MrmfkHMKjwBx8BEwmu8U1GmeitTLXTWTrSVjiVpA77yAKI-znOTZf4nOpvnOTeAS9U3tIlR7rkni55FMDr5TfTNu3Hpa03iXTLlpSy2z-oz3_knQagrOqxELrgJY-lNUqZkU1UqfkIxUEbG8BGT_i80yNNfsH1AbxYvkYNQATUlavn1EZE3J8IDuBhyyfLkYiRSJN4pAJQKxy0MtTVN9Xk2GcZR-SJ2F4lAbzpme1iXP-fi8eX_43ncAPFNv-0N95_Ajc5iUKUhjzdgMHsfO6eIsKbFc86UWLw_aql9zfEsWWe
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Single-cell+transcriptomics+and+epigenomics+unravel+the+role+of+monocytes+in+neuroblastoma+bone+marrow+metastasis&rft.jtitle=Nature+communications&rft.au=Fetahu%2C+Irfete+S&rft.au=Esser-Skala%2C+Wolfgang&rft.au=Dnyansagar%2C+Rohit&rft.au=Sindelar%2C+Samuel&rft.date=2023-06-26&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=14&rft.issue=1&rft.spage=3620&rft_id=info:doi/10.1038%2Fs41467-023-39210-0&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon