Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved

• Published in: Brain research Vol. 1557; pp. 26 - 33
• Main Authors: Simões Pires, Elisa Nicoloso, Frozza, Rudimar Luiz, Hoppe, Juliana Bender, Menezes, Bruna de Melo, Salbego, Christianne Gazzana
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 04.04.2014; Elsevier
• Subjects: Akt/GSK3β/ERK; Animals; Apoptosis - drug effects; Apoptosis - physiology; Berberine; Berberine - pharmacology; Berberis; Biological and medical sciences; Brain Ischemia - drug therapy; Brain Ischemia - physiopathology; Caspase 3 - metabolism; Caspase-3; Cell Survival - drug effects; Cell Survival - physiology; Disease Models, Animal; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Glucose - deficiency; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; Hippocampus - drug effects; Hippocampus - physiopathology; Hypoxia - drug therapy; Hypoxia - physiopathology; In Vitro Techniques; JNK; Male; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - physiology; Medical sciences; Neurology; Neuroprotection; Neuroprotective Agents - pharmacology; Oxygen and glucose deprivation; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Wistar; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs; Berberine; Neuroprotection; Akt/GSK3β/ERK; Oxygen and glucose deprivation; Caspase-3; JNK; Extracellular signal-regulated protein kinase; Cysteine endopeptidases; Central nervous system; Cardiovascular disease; Glucose; Encephalon; Vascular disease; Glycogen synthase kinase-3β; Cerebrovascular disease; Nervous system diseases; Oxygen; Deprivation; Enzyme; Transferases; In vitro; Survival; Cerebral disorder; Peptidases; Cell death; Central nervous system disease; Brain ischemia; Hydrolases; Models; Apoptosis

Berberine is an alkaloid derived from herb the Berberis sp. and has long-term use in Oriental medicine. Studies along the years have demonstrated its beneficial effect in various neurodegenerative and neuropsychiatric disorders. The subject of this study was to evaluate whether berberine protects ag...