Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved - Simões Pires, Elisa Nicoloso; Frozza, Rudimar Luiz; Hoppe, Juliana Bender; Menezes, Bruna de Melo; Salbego, Christianne Gazzana (Brain research, 2014)
Keywords: Akt/GSK3β/ERK; Animals; Apoptosis - drug effects; Apoptosis - physiology; Berberine; Berberine - pharmacology; Berberis; Biological and medical sciences; Brain Ischemia - drug therapy; Brain Ischemia - physiopathology; Caspase 3 - metabolism; Caspase-3; Cell Survival - drug effects; Cell Survival - physiology; Disease Models, Animal; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Glucose - deficiency; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; Hippocampus - drug effects; Hippocampus - physiopathology; Hypoxia - drug therapy; Hypoxia - physiopathology; In Vitro Techniques; JNK; Male; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - physiology; Medical sciences; Neurology; Neuroprotection; Neuroprotective Agents - pharmacology; Oxygen and glucose deprivation; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Wistar; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs; Berberine; Neuroprotection; Akt/GSK3β/ERK; Oxygen and glucose deprivation; Caspase-3; JNK; Extracellular signal-regulated protein kinase; Cysteine endopeptidases; Central nervous system; Cardiovascular disease; Glucose; Encephalon; Vascular disease; Glycogen synthase kinase-3β; Cerebrovascular disease; Nervous system diseases; Oxygen; Deprivation; Enzyme; Transferases; In vitro; Survival; Cerebral disorder; Peptidases; Cell death; Central nervous system disease; Brain ischemia; Hydrolases; Models; Apoptosis