Muscle synergies in Parkinson’s disease before and after the deep brain stimulation of the bilateral subthalamic nucleus

The aim of this study is to quantitatively assess motor control changes in Parkinson’s disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surge...

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Published inScientific reports Vol. 13; no. 1; pp. 6997 - 13
Main Authors Ghislieri, Marco, Lanotte, Michele, Knaflitz, Marco, Rizzi, Laura, Agostini, Valentina
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 28.04.2023
Nature Publishing Group
Nature Portfolio
Subjects
631/378/1689/1718
631/378/2632
639/166/985
692/699/375/365/1718
Deep Brain Stimulation
Electrical stimuli
Electromyography
Gait
Humanities and Social Sciences
Humans
Motor task performance
Movement disorders
multidisciplinary
Muscles
Neurodegenerative diseases
Parkinson Disease - surgery
Parkinson's disease
Science
Science (multidisciplinary)
Solitary tract nucleus
Subthalamic nucleus
Subthalamic Nucleus - physiology
Surgery
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Abstract The aim of this study is to quantitatively assess motor control changes in Parkinson’s disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surgery, T 0 ), at 3 months (T 1 ), and at 12 months (T 2 ) after STN-DBS surgery, as well as a group of 20 age-matched healthy control subjects, underwent an instrumented gait analysis, including surface electromyography recordings from 12 muscles. A smaller number of muscle synergies was found in PD patients (4 muscle synergies, at each time point) compared to control subjects (5 muscle synergies). The neuromuscular robustness of PD patients—that at T 0 was smaller with respect to controls (PD T 0 : 69.3 ± 2.2% vs. Controls: 77.6 ± 1.8%, p  = 0.004)—increased at T 1 (75.8 ± 1.8%), becoming not different from that of controls at T 2 (77.5 ± 1.9%). The muscle synergies analysis may offer clinicians new knowledge on the neuromuscular structure underlying PD motor types of behavior and how they can improve after electroceutical STN-DBS therapy.
AbstractList The aim of this study is to quantitatively assess motor control changes in Parkinson’s disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surgery, T 0 ), at 3 months (T 1 ), and at 12 months (T 2 ) after STN-DBS surgery, as well as a group of 20 age-matched healthy control subjects, underwent an instrumented gait analysis, including surface electromyography recordings from 12 muscles. A smaller number of muscle synergies was found in PD patients (4 muscle synergies, at each time point) compared to control subjects (5 muscle synergies). The neuromuscular robustness of PD patients—that at T 0 was smaller with respect to controls (PD T 0 : 69.3 ± 2.2% vs. Controls: 77.6 ± 1.8%, p  = 0.004)—increased at T 1 (75.8 ± 1.8%), becoming not different from that of controls at T 2 (77.5 ± 1.9%). The muscle synergies analysis may offer clinicians new knowledge on the neuromuscular structure underlying PD motor types of behavior and how they can improve after electroceutical STN-DBS therapy.
The aim of this study is to quantitatively assess motor control changes in Parkinson's disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surgery, T0), at 3 months (T1), and at 12 months (T2) after STN-DBS surgery, as well as a group of 20 age-matched healthy control subjects, underwent an instrumented gait analysis, including surface electromyography recordings from 12 muscles. A smaller number of muscle synergies was found in PD patients (4 muscle synergies, at each time point) compared to control subjects (5 muscle synergies). The neuromuscular robustness of PD patients-that at T0 was smaller with respect to controls (PD T0: 69.3 ± 2.2% vs. Controls: 77.6 ± 1.8%, p = 0.004)-increased at T1 (75.8 ± 1.8%), becoming not different from that of controls at T2 (77.5 ± 1.9%). The muscle synergies analysis may offer clinicians new knowledge on the neuromuscular structure underlying PD motor types of behavior and how they can improve after electroceutical STN-DBS therapy.The aim of this study is to quantitatively assess motor control changes in Parkinson's disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surgery, T0), at 3 months (T1), and at 12 months (T2) after STN-DBS surgery, as well as a group of 20 age-matched healthy control subjects, underwent an instrumented gait analysis, including surface electromyography recordings from 12 muscles. A smaller number of muscle synergies was found in PD patients (4 muscle synergies, at each time point) compared to control subjects (5 muscle synergies). The neuromuscular robustness of PD patients-that at T0 was smaller with respect to controls (PD T0: 69.3 ± 2.2% vs. Controls: 77.6 ± 1.8%, p = 0.004)-increased at T1 (75.8 ± 1.8%), becoming not different from that of controls at T2 (77.5 ± 1.9%). The muscle synergies analysis may offer clinicians new knowledge on the neuromuscular structure underlying PD motor types of behavior and how they can improve after electroceutical STN-DBS therapy.
The aim of this study is to quantitatively assess motor control changes in Parkinson’s disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surgery, T0), at 3 months (T1), and at 12 months (T2) after STN-DBS surgery, as well as a group of 20 age-matched healthy control subjects, underwent an instrumented gait analysis, including surface electromyography recordings from 12 muscles. A smaller number of muscle synergies was found in PD patients (4 muscle synergies, at each time point) compared to control subjects (5 muscle synergies). The neuromuscular robustness of PD patients—that at T0 was smaller with respect to controls (PD T0: 69.3 ± 2.2% vs. Controls: 77.6 ± 1.8%, p = 0.004)—increased at T1 (75.8 ± 1.8%), becoming not different from that of controls at T2 (77.5 ± 1.9%). The muscle synergies analysis may offer clinicians new knowledge on the neuromuscular structure underlying PD motor types of behavior and how they can improve after electroceutical STN-DBS therapy.
Abstract The aim of this study is to quantitatively assess motor control changes in Parkinson’s disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surgery, T0), at 3 months (T1), and at 12 months (T2) after STN-DBS surgery, as well as a group of 20 age-matched healthy control subjects, underwent an instrumented gait analysis, including surface electromyography recordings from 12 muscles. A smaller number of muscle synergies was found in PD patients (4 muscle synergies, at each time point) compared to control subjects (5 muscle synergies). The neuromuscular robustness of PD patients—that at T0 was smaller with respect to controls (PD T0: 69.3 ± 2.2% vs. Controls: 77.6 ± 1.8%, p = 0.004)—increased at T1 (75.8 ± 1.8%), becoming not different from that of controls at T2 (77.5 ± 1.9%). The muscle synergies analysis may offer clinicians new knowledge on the neuromuscular structure underlying PD motor types of behavior and how they can improve after electroceutical STN-DBS therapy.
The aim of this study is to quantitatively assess motor control changes in Parkinson's disease (PD) patients after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS), based on a novel muscle synergy evaluation approach. A group of 20 PD patients evaluated at baseline (before surgery, T ), at 3 months (T ), and at 12 months (T ) after STN-DBS surgery, as well as a group of 20 age-matched healthy control subjects, underwent an instrumented gait analysis, including surface electromyography recordings from 12 muscles. A smaller number of muscle synergies was found in PD patients (4 muscle synergies, at each time point) compared to control subjects (5 muscle synergies). The neuromuscular robustness of PD patients-that at T was smaller with respect to controls (PD T : 69.3 ± 2.2% vs. Controls: 77.6 ± 1.8%, p = 0.004)-increased at T (75.8 ± 1.8%), becoming not different from that of controls at T (77.5 ± 1.9%). The muscle synergies analysis may offer clinicians new knowledge on the neuromuscular structure underlying PD motor types of behavior and how they can improve after electroceutical STN-DBS therapy.
ArticleNumber 6997
Author Lanotte, Michele
Ghislieri, Marco
Knaflitz, Marco
Rizzi, Laura
Agostini, Valentina
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  surname: Agostini
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  organization: Department of Electronics and Telecommunications, Politecnico di Torino, PolitoBIOMed Lab, Politecnico di Torino
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37117317$$D View this record in MEDLINE/PubMed
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Snippet The aim of this study is to quantitatively assess motor control changes in Parkinson’s disease (PD) patients after bilateral deep brain stimulation of the...
The aim of this study is to quantitatively assess motor control changes in Parkinson's disease (PD) patients after bilateral deep brain stimulation of the...
Abstract The aim of this study is to quantitatively assess motor control changes in Parkinson’s disease (PD) patients after bilateral deep brain stimulation of...
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StartPage 6997
SubjectTerms 631/378/1689/1718
631/378/2632
639/166/985
692/699/375/365/1718
Deep Brain Stimulation
Electrical stimuli
Electromyography
Gait
Humanities and Social Sciences
Humans
Motor task performance
Movement disorders
multidisciplinary
Muscles
Neurodegenerative diseases
Parkinson Disease - surgery
Parkinson's disease
Science
Science (multidisciplinary)
Solitary tract nucleus
Subthalamic nucleus
Subthalamic Nucleus - physiology
Surgery
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Title Muscle synergies in Parkinson’s disease before and after the deep brain stimulation of the bilateral subthalamic nucleus
URI https://link.springer.com/article/10.1038/s41598-023-34151-6
https://www.ncbi.nlm.nih.gov/pubmed/37117317
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https://www.proquest.com/docview/2807915662
https://pubmed.ncbi.nlm.nih.gov/PMC10147693
https://doaj.org/article/84c528a25e9049efbc4c4959ccaedd52
Volume 13
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