Small molecule metabolites: discovery of biomarkers and therapeutic targets

• Published in: Signal transduction and targeted therapy Vol. 8; no. 1; pp. 132 - 37
• Main Authors: Qiu, Shi, Cai, Ying, Yao, Hong, Lin, Chunsheng, Xie, Yiqiang, Tang, Songqi, Zhang, Aihua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.03.2023; Nature Publishing Group
• Subjects: 631/154/1435; 631/154/555; 631/45/535; Biomarkers; Cancer Research; Cell Biology; Diagnosis; Drug screening; Humans; Internal Medicine; Medicine; Medicine & Public Health; Metabolic networks; Metabolic Networks and Pathways; Metabolic pathways; Metabolism; Metabolites; Metabolome; Metabolomics; Metabolomics - methods; Oncology; Pathology; Phenotypic variations; Prognosis; Review; Review Article; Therapeutic applications; Therapeutic targets
• ISSN: 2059-3635; 2095-9907; 2059-3635
• DOI: 10.1038/s41392-023-01399-3

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and progn...