Oral administration of coenzyme Q10 ameliorates memory impairment induced by nicotine-ethanol abstinence through restoration of biochemical changes in male rat hippocampal tissues

• Published in: Scientific reports Vol. 14; no. 1; pp. 11413 - 12
• Main Authors: Ahmadi-Soleimani, S. Mohammad, Ghasemi, Seyedalireza, Rahmani, Mohamad Amin, Gharaei, Moein, Mohammadi Bezanaj, Maryam, Beheshti, Farimah
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/136; 631/136/334/1874/486; 631/45; Abstinence; Administration, Oral; Adolescence; Adolescents; Alcohol Abstinence; Alzheimer's disease; Animals; Bupropion; Coenzyme Q10; Diabetes mellitus; Drug abuse; Drug dependence; Drug dosages; Ethanol; Ethanol - administration & dosage; Ethanol - adverse effects; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Humanities and Social Sciences; Impulsive behavior; Inflammation; Male; Maze Learning - drug effects; Memory; Memory Disorders - drug therapy; Memory Disorders - etiology; Memory Disorders - metabolism; multidisciplinary; Naloxone; Neurodegenerative diseases; Nicotine; Nicotine - administration & dosage; Nicotine - adverse effects; Oral administration; Oxidative Stress - drug effects; Pattern recognition; Rats; Rats, Wistar; Risk taking; Science; Science (multidisciplinary); Side effects; Teenagers; Ubiquinone - administration & dosage; Ubiquinone - analogs & derivatives; Ubiquinone - pharmacology; β-Amyloid; Adolescence; Ethanol; Coenzyme Q10; Memory; Abstinence; Nicotine

Substance abuse among adolescents has become a growing issue throughout the world. The significance of research on this life period is based on the occurrence of neurobiological changes in adolescent brain which makes the individual more susceptible for risk-taking and impulsive behaviors. Alcohol a...