The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants

• Published in: Scientific reports Vol. 13; no. 1; pp. 13078 - 11
• Main Authors: Naushad, Shaik Mohammad, Mandadapu, Gowtham, Ramaiah, Mekala Janaki, Almajhdi, Fahad N., Hussain, Tajamul
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.08.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/154; 631/208; 631/250; 631/326; Acetylcysteine; Adaptor Proteins, Signal Transducing - metabolism; Adjuvants, Immunologic; Affinity; Agonists; COVID-19; COVID-19 - genetics; Humanities and Social Sciences; Humans; Male; multidisciplinary; Mutation; MyD88 protein; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - metabolism; RNA, Viral; SARS-CoV-2 - genetics; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; TLR7 protein; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 7 - metabolism; Toll-like receptors

We investigate the mechanism associated with the severity of COVID-19 in men with TLR7 mutation. Men with loss-of-function (LOF) mutations in TLR7 had severe COVID-19. LOF mutations in TLR7 increased the risk of critical COVID by 16.00-fold (95% confidence interval 2.40–106.73). The deleterious muta...