Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration

• Published in: Nature communications Vol. 14; no. 1; pp. 7771 - 14
• Main Authors: Yang, Yuxuan, Zhao, Xiaodan, Wang, Shuang, Zhang, Yanfeng, Yang, Aiming, Cheng, Yilong, Chen, Xuesi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 147/135; 631/61/54/990; 639/166/985; 639/301/54/993; 639/301/923/1027; 64/86; 96/100; Arthritis; Body temperature; Bone marrow; Cartilage; Cartilage - physiology; Cartilage diseases; Chondrocytes; Chondrogenesis; Crosslinking; Drug Liberation; Humanities and Social Sciences; Humans; Hydrogels; Hydrogels - chemistry; Hydrogen bonds; Inflammation; Mechanical properties; Mesenchymal stem cells; Microenvironments; Minimally invasive surgery; multidisciplinary; Osteoarthritis; Oxidative stress; Regeneration; Scaffolds; Science; Science (multidisciplinary); Shape memory; Stem cells; Tannic acid; Unloading

Osteoarthritis is a worldwide prevalent disease that imposes a significant socioeconomic burden on individuals and healthcare systems. Achieving cartilage regeneration in patients with osteoarthritis remains challenging clinically. In this work, we construct a multiple hydrogen-bond crosslinked hydr...