De novo synthesis of a sunscreen compound in vertebrates

• Published in: eLife Vol. 4
• Main Authors: Osborn, Andrew R, Almabruk, Khaled H, Holzwarth, Garrett, Asamizu, Shumpei, LaDu, Jane, Kean, Kelsey M, Karplus, P Andrew, Tanguay, Robert L, Bakalinsky, Alan T, Mahmud, Taifo
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 12.05.2015; eLife Sciences Publications, Ltd
• Subjects: 2-epi-5-epi-valiolone synthase; Algae; Amino Acids - biosynthesis; Amino Acids - genetics; Amino Acids - metabolism; Anabaena variabilis; Animals; Antioxidants; Bacteria; Biochemistry; Biosynthesis; Coral reefs; Corals; Cosmetics; Cyanobacteria; Cyclohexanols - chemistry; Cyclohexanols - metabolism; E coli; Ecology; Enzymes; Fishes; Fungi; gadusol; Genes; Genomes; Marine organisms; mycosporine; Mycosporine-like amino acids; Natural products; Organisms, Genetically Modified; Phylogenetics; Plasmids; Proteins; Radiation-Protective Agents - chemistry; Reptiles & amphibians; Saccharomyces cerevisiae; Short Report; Sunscreen; Transcription factors; Ultraviolet radiation; Ultraviolet Rays; vertebrate; Vertebrates; Zebrafish; ecology; sunscreen; mycosporine; gadusol; biochemistry; zebrafish; 2-epi-5-epi-valiolone synthase; E. coli; S. cerevisiae; vertebrates

Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds hav...