Bone marrow niches in haematological malignancies

• Published in: Nature reviews. Cancer Vol. 20; no. 5; pp. 285 - 298
• Main Authors: Méndez-Ferrer, Simón, Bonnet, Dominique, Steensma, David P., Hasserjian, Robert P., Ghobrial, Irene M., Gribben, John G., Andreeff , Michael, Krause, Daniela S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2020; Nature Publishing Group
• Subjects: 631/136/532/2139; 631/532/71; 631/67/1990; 631/67/327; Angiogenesis; Animals; Biomedical and Life Sciences; Biomedicine; Blood cancer; Bone composition; Bone marrow; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Bone remodeling; Cancer; Cancer Research; Cell survival; Chemoresistance; Chemotherapy; Development and progression; Epigenetics; Hematologic Neoplasms - genetics; Hematologic Neoplasms - metabolism; Hematologic Neoplasms - physiopathology; Hematological diseases; Hematology; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Humans; Hypoxia; Inflammation; Malignancy; Mutation; Neoplastic Stem Cells - cytology; Neoplastic Stem Cells - metabolism; Perspective; Reactive oxygen species; Stem cells; Therapeutic applications; Therapeutic targets; Wildlife conservation; United Kingdom; Germany

Haematological malignancies were previously thought to be driven solely by genetic or epigenetic lesions within haematopoietic cells. However, the niches that maintain and regulate daily production of blood and immune cells are now increasingly being recognized as having an important role in the pat...