Estimating glutamate and Glx from GABA-optimized MEGA-PRESS: Off-resonance but not difference spectra values correspond to PRESS values

• Published in: Psychiatry research. Neuroimaging Vol. 279; pp. 22 - 30
• Main Authors: Maddock, Richard J., Caton, Michael D., Ragland, J. Daniel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.09.2018
• Subjects: Adolescent; Adult; Brain; Female; GABA; gamma-Aminobutyric Acid - metabolism; Glutamate; Glutamic Acid - metabolism; Healthy Volunteers; Humans; Magnetic Resonance Spectroscopy - methods; Male; Measurement; Metabolites; MRS; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - metabolism; Proton Magnetic Resonance Spectroscopy - methods; Simultaneous; Young Adult; Measurement; Brain; Metabolites; GABA; Glutamate; Simultaneous; MRS

•Glutamate can be measured two ways during a GABA-optimized MEGA-PRESS scan.•These glutamate measurements have not been directly compared to conventional methods.•MEGA-PRESS off-resonance glutamate values correspond well to PRESS values.•MEGA-PRESS difference spectra glutamate values correspond poor...