CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis

• Published in: Nature communications Vol. 15; no. 1; pp. 3263 - 21
• Main Authors: Yin, Chengyu, Liu, Boyu, Dong, Zishan, Shi, Sai, Peng, Chenxing, Pan, Yushuang, Bi, Xiaochen, Nie, Huimin, Zhang, Yunwen, Tai, Yan, Hu, Qimiao, Wang, Xuan, Shao, Xiaomei, An, Hailong, Fang, Jianqiao, Wang, Chuan, Liu, Boyi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/95; 14/32; 38; 49; 49/91; 631/250/371; 631/378/2607; 631/378/371; 82/51; 82/80; 9/74; 96; 96/31; Animal models; Animals; Ankle; Arthralgia; Arthritis; Arthritis, Gouty; Calcitonin gene-related peptide; Chemokine CXCL5 - genetics; Chemokine CXCL5 - metabolism; Chemotaxis; CXCR2 protein; Dorsal root ganglia; Extravasation; Gout; Humanities and Social Sciences; Humans; Immunomodulation; Inflammation; Joint diseases; Joints (anatomy); Leukocytes (neutrophilic); Male; Mice; multidisciplinary; Neurons; Neutrophils; Nociception; Nociceptors - metabolism; Pain; Pain perception; Rheumatism; Science; Science (multidisciplinary); Sensory neurons; Substance P; Vasodilation

Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of go...