CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis

Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of go...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 15; no. 1; pp. 3263 - 21
Main Authors Yin, Chengyu, Liu, Boyu, Dong, Zishan, Shi, Sai, Peng, Chenxing, Pan, Yushuang, Bi, Xiaochen, Nie, Huimin, Zhang, Yunwen, Tai, Yan, Hu, Qimiao, Wang, Xuan, Shao, Xiaomei, An, Hailong, Fang, Jianqiao, Wang, Chuan, Liu, Boyi
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.04.2024
Nature Publishing Group
Nature Portfolio
Subjects
13/95
14/32
38
49
49/91
631/250/371
631/378/2607
631/378/371
82/51
82/80
9/74
96
96/31
Animal models
Animals
Ankle
Arthralgia
Arthritis
Arthritis, Gouty
Calcitonin gene-related peptide
Chemokine CXCL5 - genetics
Chemokine CXCL5 - metabolism
Chemotaxis
CXCR2 protein
Dorsal root ganglia
Extravasation
Gout
Humanities and Social Sciences
Humans
Immunomodulation
Inflammation
Joint diseases
Joints (anatomy)
Leukocytes (neutrophilic)
Male
Mice
multidisciplinary
Neurons
Neutrophils
Nociception
Nociceptors - metabolism
Pain
Pain perception
Rheumatism
Science
Science (multidisciplinary)
Sensory neurons
Substance P
Vasodilation
Online AccessGet full text

Cover

Abstract Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons. Here, the authors demonstrate that CXCL5 expression is increased in ankle joints of gouty arthritis model mice. CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and joint inflammation.
AbstractList Abstract Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons.
Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons.Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons.
Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons. Here, the authors demonstrate that CXCL5 expression is increased in ankle joints of gouty arthritis model mice. CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and joint inflammation.
Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons.
Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons.Here, the authors demonstrate that CXCL5 expression is increased in ankle joints of gouty arthritis model mice. CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and joint inflammation.
Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation. CXCL5 expression was increased in ankle joints of gout arthritis model mice, whereas CXCR2 showed expression in joint-innervating sensory neurons. CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to trigger TRPA1 activation, resulting in hyperexcitability and pain. Neuronal CXCR2 coordinates with neutrophilic CXCR2 to contribute to CXCL5-induced neutrophil chemotaxis via triggering CGRP- and substance P-mediated vasodilation and plasma extravasation. Neuronal Cxcr2 deletion ameliorates joint pain, neutrophil infiltration and gait impairment in model mice. We confirmed CXCR2 expression in human dorsal root ganglion neurons and CXCL5 level upregulation in serum from male patients with gouty arthritis. Our study demonstrates CXCL5-neuronal CXCR2-TRPA1 axis contributes to gouty arthritis pain, neutrophil influx and inflammation that expands our knowledge of immunomodulation capability of nociceptive sensory neurons.
ArticleNumber 3263
Author Yin, Chengyu
Shi, Sai
An, Hailong
Pan, Yushuang
Bi, Xiaochen
Fang, Jianqiao
Peng, Chenxing
Liu, Boyu
Wang, Xuan
Tai, Yan
Shao, Xiaomei
Nie, Huimin
Dong, Zishan
Liu, Boyi
Zhang, Yunwen
Wang, Chuan
Hu, Qimiao
Author_xml – sequence: 1
  givenname: Chengyu
  orcidid: 0000-0001-5655-6292
  surname: Yin
  fullname: Yin, Chengyu
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
– sequence: 2
  givenname: Boyu
  orcidid: 0000-0002-8801-8760
  surname: Liu
  fullname: Liu, Boyu
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
– sequence: 3
  givenname: Zishan
  surname: Dong
  fullname: Dong, Zishan
  organization: Department of Pharmacology, Hebei Medical University
– sequence: 4
  givenname: Sai
  surname: Shi
  fullname: Shi, Sai
  organization: Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University
– sequence: 5
  givenname: Chenxing
  surname: Peng
  fullname: Peng, Chenxing
  organization: Department of Immunology and Rheumatology, the Second Hospital of Hebei Medical University
– sequence: 6
  givenname: Yushuang
  surname: Pan
  fullname: Pan, Yushuang
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
– sequence: 7
  givenname: Xiaochen
  surname: Bi
  fullname: Bi, Xiaochen
  organization: Department of Human Anatomy, School of Basic Medical Sciences, Zhejiang Chinese Medical University
– sequence: 8
  givenname: Huimin
  surname: Nie
  fullname: Nie, Huimin
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
– sequence: 9
  givenname: Yunwen
  surname: Zhang
  fullname: Zhang, Yunwen
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
– sequence: 10
  givenname: Yan
  surname: Tai
  fullname: Tai, Yan
  organization: Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University
– sequence: 11
  givenname: Qimiao
  surname: Hu
  fullname: Hu, Qimiao
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
– sequence: 12
  givenname: Xuan
  surname: Wang
  fullname: Wang, Xuan
  organization: Diagnostic Center of Infections, The Second Hospital of Hebei Medical University
– sequence: 13
  givenname: Xiaomei
  surname: Shao
  fullname: Shao, Xiaomei
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
– sequence: 14
  givenname: Hailong
  orcidid: 0000-0001-7947-357X
  surname: An
  fullname: An, Hailong
  email: hailong_an@hebut.edu.cn
  organization: Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology
– sequence: 15
  givenname: Jianqiao
  orcidid: 0000-0003-4499-0352
  surname: Fang
  fullname: Fang, Jianqiao
  email: fangjianqiao7532@163.com
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
– sequence: 16
  givenname: Chuan
  orcidid: 0000-0003-3144-7094
  surname: Wang
  fullname: Wang, Chuan
  email: wangchuan@hebmu.edu.cn
  organization: Department of Pharmacology, Hebei Medical University
– sequence: 17
  givenname: Boyi
  orcidid: 0000-0001-9870-4548
  surname: Liu
  fullname: Liu, Boyi
  email: boyi.liu@foxmail.com
  organization: Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38627393$$D View this record in MEDLINE/PubMed
BookMark eNp9Uk1v1DAQjVARLaV_gAOyxIVLwF-xnRNCKz4qrYSEQOJmTRxn61ViL7ZTdf893k0pbQ_1xfbMe2_e2POyOvHB26p6TfB7gpn6kDjhQtaY8ppLwXEtn1VnFHNSE0nZyb3zaXWR0haXxVqiOH9RnTIlqGQtO6v2q9-rdYPAZHcN2SZU7j8och75YJyxuxK3KFmfQtwjb-cYfEI5oD4eEtvgfEY7KHjwfaENI0wTZBf8QcPe7Gx0k_UZRrQJc94jiPkquuzSq-r5AGOyF7f7efXry-efq2_1-vvXy9WndW0aTnKtml52LaNdC6JnnRBGSsOHTgnWEwN26DhuWymFBcxNPzQgMe8FZUII0nWMnVeXi24fYKt3xQ7EvQ7g9DEQ4kYXT86MVjPSGZAGQIHharBq4IRZ4J1UFKuWFK2Pi9Zu7ibbm9JYhPGB6MOMd1d6E641IZgSrmhReHerEMOf2aasJ5eMHUfwNsxJM8wxo7g5Fnv7CLoNc_TlrQqKtYK2jKmCenPf0p2Xf19cAHQBmBhSina4gxCsD6Okl1HSZZT0cZS0LCT1iGRcPn5racuNT1PZQk2ljt_Y-N_2E6y_5Sjelg
CitedBy_id crossref_primary_10_1016_j_clinbiochem_2025_110878
crossref_primary_10_1186_s11658_024_00653_y
crossref_primary_10_1038_s41598_024_83513_1
crossref_primary_10_1186_s13020_024_00962_6
crossref_primary_10_1016_j_bbadis_2025_167671
crossref_primary_10_1038_s41598_025_86090_z
crossref_primary_10_1002_advs_202500406
crossref_primary_10_1111_cns_70302
crossref_primary_10_1002_adfm_202417307
crossref_primary_10_1016_j_it_2024_08_007
crossref_primary_10_1038_s41598_024_75532_9
crossref_primary_10_1186_s13020_024_01023_8
crossref_primary_10_1186_s40478_024_01856_2
Cites_doi 10.1038/nrrheum.2009.236
10.1136/ard.2009.109355
10.1111/febs.15605
10.1186/s11658-022-00316-w
10.1523/JNEUROSCI.2211-06.2006
10.1073/pnas.1606608113
10.1189/jlb.0806502
10.1016/S1297-319X(15)30005-1
10.1016/j.jpain.2020.01.007
10.1006/meth.2001.1262
10.1111/bph.14967
10.1007/s00018-016-2293-z
10.1016/j.brainresbull.2016.09.016
10.1016/j.jare.2020.12.009
10.1002/cne.902610211
10.1136/annrheumdis-2021-220295
10.1038/s41596-020-0312-x
10.1002/art.24185
10.1016/j.biopha.2023.115143
10.1002/art.33355
10.1186/s12974-023-02778-x
10.1056/NEJMra052723
10.1016/j.pain.2013.07.002
10.1111/febs.14466
10.1016/j.freeradbiomed.2013.10.814
10.1016/bs.ircmb.2018.02.008
10.1002/pro.3280
10.1136/annrheumdis-2016-209707
10.1016/j.freeradbiomed.2014.04.021
10.1007/s00281-013-0361-0
10.3390/ijms20235917
10.1002/(SICI)1521-4141(199801)28:01<164::AID-IMMU164>3.0.CO;2-S
10.1189/jlb.3MA0915-418R
10.1038/s41586-020-2480-9
10.1186/s12974-020-01834-0
10.1038/nn1095
10.1073/pnas.2001177117
10.1016/j.cellsig.2023.110630
10.1016/j.pain.2004.08.015
10.2165/00002018-200730100-00005
10.1097/BOR.0000000000000583
10.1016/j.cellsig.2018.11.004
10.1046/j.1523-1747.2000.00034.x
10.7150/thno.48028
10.1016/j.neuron.2015.05.044
10.1111/bph.13760
10.1002/art.1780200320
10.1016/j.jlr.2021.100117
10.1038/nn.2789
10.3389/fphar.2019.00453
10.1038/icb.2009.98
10.1038/s41467-023-38602-6
10.1016/j.npep.2016.06.001
10.1038/s41572-019-0115-y
10.1002/jlb.63.6.746
10.1073/pnas.0609598103
10.1053/j.ajkd.2020.03.023
10.1186/s12974-021-02131-0
10.1097/j.pain.0000000000000158
10.3389/fimmu.2020.01259
10.1126/scisignal.aax3053
10.1186/1744-8069-4-38
10.1097/AIA.0b013e318034194e
10.1126/scitranslmed.3002193
10.1016/j.bbamcr.2021.119046
10.1186/s13020-023-00800-1
10.2147/JPR.S358942
10.1186/s13075-016-1012-3
10.3389/fphar.2019.00229
10.1038/s41467-023-38241-x
10.1152/physrev.00034.2013
10.1172/JCI41084
10.1126/science.280.5367.1271
ContentType Journal Article
Copyright The Author(s) 2024
2024. The Author(s).
The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2024
– notice: 2024. The Author(s).
– notice: The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-024-47640-7
DatabaseName SpringerOpen
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni)
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic

CrossRef
Publicly Available Content Database
MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 21
ExternalDocumentID oai_doaj_org_article_31bca7caa8ac48fe8f413ea4b7820891
PMC11021482
38627393
10_1038_s41467_024_47640_7
Genre Journal Article
GrantInformation_xml – fundername: Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation)
  grantid: LZ23H270001; LQ21H270004
  funderid: https://doi.org/10.13039/501100004731
– fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81873365; 82305369
  funderid: https://doi.org/10.13039/501100001809
– fundername: Funder: National Key R&D Program of China, Grant reference number: (2022YFC3500604);
– fundername: Zhejiang Chinese Medical University (ZCMU)
  grantid: 2021JKZDZC07
  funderid: https://doi.org/10.13039/501100004863
– fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 82305369
– fundername: Zhejiang Chinese Medical University (ZCMU)
  grantid: 2021JKZDZC07
– fundername: Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation)
  grantid: LZ23H270001
– fundername: Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation)
  grantid: LQ21H270004
– fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81873365
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LGEZI
LK8
LOTEE
M1P
M48
M7P
M~E
NADUK
NAO
NXXTH
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c541t-85d7b932b9a6d3b66c77c4fb863d1caefb4099776ea04cdf5a704d6236661bb33
IEDL.DBID M48
ISSN 2041-1723
IngestDate Wed Aug 27 01:26:33 EDT 2025
Thu Aug 21 18:34:10 EDT 2025
Fri Jul 11 10:06:32 EDT 2025
Wed Aug 13 09:17:19 EDT 2025
Mon Jul 21 06:02:56 EDT 2025
Tue Jul 01 02:11:05 EDT 2025
Thu Apr 24 23:44:04 EDT 2025
Fri Feb 21 02:37:22 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2024. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c541t-85d7b932b9a6d3b66c77c4fb863d1caefb4099776ea04cdf5a704d6236661bb33
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-5655-6292
0000-0001-7947-357X
0000-0002-8801-8760
0000-0003-4499-0352
0000-0001-9870-4548
0000-0003-3144-7094
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41467-024-47640-7
PMID 38627393
PQID 3039629338
PQPubID 546298
PageCount 21
ParticipantIDs doaj_primary_oai_doaj_org_article_31bca7caa8ac48fe8f413ea4b7820891
pubmedcentral_primary_oai_pubmedcentral_nih_gov_11021482
proquest_miscellaneous_3040320591
proquest_journals_3039629338
pubmed_primary_38627393
crossref_primary_10_1038_s41467_024_47640_7
crossref_citationtrail_10_1038_s41467_024_47640_7
springer_journals_10_1038_s41467_024_47640_7
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-04-16
PublicationDateYYYYMMDD 2024-04-16
PublicationDate_xml – month: 04
  year: 2024
  text: 2024-04-16
  day: 16
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2024
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Obeidat (CR46) 2023; 14
Baker, Perazella (CR5) 2020; 76
Lukacs (CR27) 1998; 63
Fang (CR57) 2015; 156
Chen (CR62) 2020; 17
Zhang, Cao, Zhang, Ji, Gao (CR21) 2013; 154
Wang (CR59) 2023; 20
Ford (CR35) 1998; 280
Wilson (CR33) 2011; 14
Liu (CR65) 2010; 120
Liu (CR60) 2022; 27
Lan (CR11) 2021; 80
Yan, Tao, He, Huang (CR72) 2020; 15
Capucetti, Albano, Bonecchi (CR20) 2020; 11
Zamudio-Cuevas (CR29) 2016; 18
Cao, Qian, Zhang, Gao, Wu (CR31) 2016; 127
Senarath (CR41) 2018; 339
Popa-Nita, Naccache (CR53) 2010; 88
Wang (CR22) 2008; 4
Hughes, Nibbs (CR48) 2018; 285
Zhao, Lin King, Paulsen, Cheng, Julius (CR71) 2020; 585
Lin, Carlson, Diaconu, Pearlman (CR28) 2007; 81
Rafikov (CR30) 2014; 67
Hinman, Chuang, Bautista, Julius (CR39) 2006; 103
Yevenes (CR36) 2003; 6
Yin (CR24) 2020; 177
Russell, King, Smillie, Kodji, Brain (CR51) 2014; 94
Mashaghi (CR52) 2016; 73
Livak, Schmittgen (CR69) 2001; 25
Singh (CR4) 2019; 31
Amaral (CR15) 2012; 64
Basbaum, Menetrey (CR32) 1987; 261
Charo, Ransohoff (CR16) 2006; 354
Lopez-Santiago (CR43) 2006; 26
Richette (CR7) 2017; 76
Rajanala, Wedegaertner (CR38) 2023; 106
Stirling (CR45) 2005; 113
Martin, Walton, Harper (CR9) 2009; 60
Hu (CR63) 2020; 21
Topiwala (CR2) 2023; 14
Wang (CR66) 2021; 31
Bardin, van de Laar (CR8) 2015; 821
Li, Yu, Nie, Yin, Liu (CR13) 2023; 165
Dawes (CR19) 2011; 3
Wallace (CR58) 1977; 20
Rossaneis (CR68) 2019; 10
Dalbeth (CR1) 2019; 5
Ma (CR37) 2021; 1868
Schlereth (CR47) 2016; 59
Zhang, An (CR25) 2007; 45
Morita (CR34) 2015; 87
Hu (CR44) 2019; 10
Lee (CR26) 2021; 62
Rajarathnam, Schnoor, Richardson, Rajagopal (CR50) 2019; 54
Mitroulis, Kambas, Ritis (CR12) 2013; 35
Torres (CR23) 2009; 68
Li (CR64) 2019; 20
Liu (CR67) 2016; 113
Caceres (CR70) 2017; 174
Yin (CR14) 2020; 10
Chen, Yin, Fang, Liu (CR10) 2021; 18
Metzemaekers (CR18) 2021; 14
Wolf (CR17) 1998; 28
Chung, Wong (CR40) 2021; 288
Jurrus (CR73) 2018; 27
Devalaraja (CR54) 2000; 115
Wei (CR55) 2023; 18
Terkeltaub (CR3) 2010; 6
Trevisan (CR56) 2014; 72
Behrendt (CR42) 2020; 117
Galvao (CR49) 2016; 99
Xu (CR61) 2022; 15
Fardet, Kassar, Cabane, Flahault (CR6) 2007; 30
A Hinman (47640_CR39) 2006; 103
I Mitroulis (47640_CR12) 2013; 35
DL Cao (47640_CR31) 2016; 127
R Chen (47640_CR62) 2020; 17
JM Dawes (47640_CR19) 2011; 3
D Fang (47640_CR57) 2015; 156
Q Hu (47640_CR44) 2019; 10
B Liu (47640_CR67) 2016; 113
FA Amaral (47640_CR15) 2012; 64
AI Basbaum (47640_CR32) 1987; 261
SL Wallace (47640_CR58) 1977; 20
RM Devalaraja (47640_CR54) 2000; 115
YK Chung (47640_CR40) 2021; 288
JA Singh (47640_CR4) 2019; 31
M Lin (47640_CR28) 2007; 81
N Dalbeth (47640_CR1) 2019; 5
R Chen (47640_CR10) 2021; 18
ZJ Zhang (47640_CR21) 2013; 154
O Popa-Nita (47640_CR53) 2010; 88
T Morita (47640_CR34) 2015; 87
M Baker (47640_CR5) 2020; 76
M Metzemaekers (47640_CR18) 2021; 14
K Rajanala (47640_CR38) 2023; 106
GE Yevenes (47640_CR36) 2003; 6
T Schlereth (47640_CR47) 2016; 59
I Galvao (47640_CR49) 2016; 99
Q Wang (47640_CR66) 2021; 31
Q Hu (47640_CR63) 2020; 21
J Wang (47640_CR59) 2023; 20
KJ Livak (47640_CR69) 2001; 25
C Yin (47640_CR24) 2020; 177
G Trevisan (47640_CR56) 2014; 72
LC Stirling (47640_CR45) 2005; 113
H Wei (47640_CR55) 2023; 18
R Terkeltaub (47640_CR3) 2010; 6
JM Zhang (47640_CR25) 2007; 45
B Liu (47640_CR60) 2022; 27
L Fardet (47640_CR6) 2007; 30
JG Wang (47640_CR22) 2008; 4
LF Lopez-Santiago (47640_CR43) 2006; 26
FA Russell (47640_CR51) 2014; 94
B Liu (47640_CR65) 2010; 120
J Zhao (47640_CR71) 2020; 585
A Topiwala (47640_CR2) 2023; 14
K Senarath (47640_CR41) 2018; 339
K Rajarathnam (47640_CR50) 2019; 54
Q Ma (47640_CR37) 2021; 1868
AM Obeidat (47640_CR46) 2023; 14
A Capucetti (47640_CR20) 2020; 11
CE Hughes (47640_CR48) 2018; 285
R Torres (47640_CR23) 2009; 68
R Rafikov (47640_CR30) 2014; 67
M Behrendt (47640_CR42) 2020; 117
WJ Martin (47640_CR9) 2009; 60
E Jurrus (47640_CR73) 2018; 27
C Yin (47640_CR14) 2020; 10
Z Lan (47640_CR11) 2021; 80
NW Lukacs (47640_CR27) 1998; 63
CE Ford (47640_CR35) 1998; 280
A Mashaghi (47640_CR52) 2016; 73
P Li (47640_CR13) 2023; 165
Y Li (47640_CR64) 2019; 20
AC Rossaneis (47640_CR68) 2019; 10
R Xu (47640_CR61) 2022; 15
Y Yan (47640_CR72) 2020; 15
P Richette (47640_CR7) 2017; 76
IF Charo (47640_CR16) 2006; 354
SR Wilson (47640_CR33) 2011; 14
D Lee (47640_CR26) 2021; 62
Y Zamudio-Cuevas (47640_CR29) 2016; 18
T Bardin (47640_CR8) 2015; 821
M Wolf (47640_CR17) 1998; 28
AI Caceres (47640_CR70) 2017; 174
References_xml – volume: 6
  start-page: 30
  year: 2010
  end-page: 38
  ident: CR3
  article-title: Update on gout: new therapeutic strategies and options
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2009.236
– volume: 68
  start-page: 1602
  year: 2009
  end-page: 1608
  ident: CR23
  article-title: Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/ard.2009.109355
– volume: 288
  start-page: 2490
  year: 2021
  end-page: 2501
  ident: CR40
  article-title: Re-examining the ‘Dissociation Model’ of G protein activation from the perspective of Gβγ signaling
  publication-title: FEBS J.
  doi: 10.1111/febs.15605
– volume: 27
  start-page: 16
  year: 2022
  ident: CR60
  article-title: Exploring neuronal mechanisms involved in the scratching behavior of a mouse model of allergic contact dermatitis by transcriptomics
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00316-w
– volume: 26
  start-page: 7984
  year: 2006
  end-page: 7994
  ident: CR43
  article-title: Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2211-06.2006
– volume: 113
  start-page: E7572
  year: 2016
  end-page: E7579
  ident: CR67
  article-title: IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1606608113
– volume: 81
  start-page: 786
  year: 2007
  end-page: 792
  ident: CR28
  article-title: CXCL1/KC and CXCL5/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0806502
– volume: 821
  start-page: eS30
  year: 2015
  end-page: eS32
  ident: CR8
  article-title: The way forward: practical clinical considerations for the use of canakinumab in patients with difficult-to-treat gouty arthritis
  publication-title: Jt. Bone Spine
  doi: 10.1016/S1297-319X(15)30005-1
– volume: 21
  start-page: 1060
  year: 2020
  end-page: 1074
  ident: CR63
  article-title: Electroacupuncture alleviates mechanical allodynia in a rat model of complex regional pain syndrome type-I via suppressing spinal CXCL12/CXCR4 signaling
  publication-title: J. Pain.
  doi: 10.1016/j.jpain.2020.01.007
– volume: 25
  start-page: 402
  year: 2001
  end-page: 408
  ident: CR69
  article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
  publication-title: Methods
  doi: 10.1006/meth.2001.1262
– volume: 177
  start-page: 2042
  year: 2020
  end-page: 2057
  ident: CR24
  article-title: Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis
  publication-title: Br. J. Pharm.
  doi: 10.1111/bph.14967
– volume: 73
  start-page: 4249
  year: 2016
  end-page: 4264
  ident: CR52
  article-title: Neuropeptide substance P and the immune response
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-016-2293-z
– volume: 127
  start-page: 219
  year: 2016
  end-page: 225
  ident: CR31
  article-title: Chemokine receptor CXCR2 in dorsal root ganglion contributes to the maintenance of inflammatory pain
  publication-title: Brain Res Bull.
  doi: 10.1016/j.brainresbull.2016.09.016
– volume: 31
  start-page: 97
  year: 2021
  end-page: 111
  ident: CR66
  article-title: Fibroblast growth factor 13 stabilizes microtubules to promote Na(+) channel function in nociceptive DRG neurons and modulates inflammatory pain
  publication-title: J. Adv. Res.
  doi: 10.1016/j.jare.2020.12.009
– volume: 261
  start-page: 306
  year: 1987
  end-page: 318
  ident: CR32
  article-title: Wheat germ agglutinin-apoHRP gold: a new retrograde tracer for light- and electron-microscopic single- and double-label studies
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.902610211
– volume: 80
  start-page: 1604
  year: 2021
  end-page: 1614
  ident: CR11
  article-title: Mechanosensitive TRPV4 is required for crystal-induced inflammation
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2021-220295
– volume: 15
  start-page: 1829
  year: 2020
  end-page: 1852
  ident: CR72
  article-title: The HDOCK server for integrated protein-protein docking
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-020-0312-x
– volume: 60
  start-page: 281
  year: 2009
  end-page: 289
  ident: CR9
  article-title: Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.24185
– volume: 165
  year: 2023
  ident: CR13
  article-title: IL-33/ST2 signaling in pain and itch: cellular and molecular mechanisms and therapeutic potentials
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2023.115143
– volume: 64
  start-page: 474
  year: 2012
  end-page: 484
  ident: CR15
  article-title: NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.33355
– volume: 20
  year: 2023
  ident: CR59
  article-title: CXCL13 contributes to chronic pain of a mouse model of CRPS-I via CXCR5-mediated NF-kappaB activation and pro-inflammatory cytokine production in spinal cord dorsal horn
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-023-02778-x
– volume: 354
  start-page: 610
  year: 2006
  end-page: 621
  ident: CR16
  article-title: The many roles of chemokines and chemokine receptors in inflammation
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra052723
– volume: 154
  start-page: 2185
  year: 2013
  end-page: 2197
  ident: CR21
  article-title: Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons
  publication-title: Pain
  doi: 10.1016/j.pain.2013.07.002
– volume: 285
  start-page: 2944
  year: 2018
  end-page: 2971
  ident: CR48
  article-title: A guide to chemokines and their receptors
  publication-title: FEBS J.
  doi: 10.1111/febs.14466
– volume: 67
  start-page: 255
  year: 2014
  end-page: 264
  ident: CR30
  article-title: Endothelin-1 stimulates catalase activity through the PKCdelta-mediated phosphorylation of serine 167
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2013.10.814
– volume: 339
  start-page: 133
  year: 2018
  end-page: 191
  ident: CR41
  article-title: Regulation of G protein βγ signaling
  publication-title: Int. Rev. Cell Mol. Biol.
  doi: 10.1016/bs.ircmb.2018.02.008
– volume: 27
  start-page: 112
  year: 2018
  end-page: 128
  ident: CR73
  article-title: Improvements to the APBS biomolecular solvation software suite
  publication-title: Protein Sci.
  doi: 10.1002/pro.3280
– volume: 76
  start-page: 29
  year: 2017
  end-page: 42
  ident: CR7
  article-title: 2016 updated EULAR evidence-based recommendations for the management of gout
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2016-209707
– volume: 72
  start-page: 200
  year: 2014
  end-page: 209
  ident: CR56
  article-title: TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2014.04.021
– volume: 35
  start-page: 501
  year: 2013
  end-page: 512
  ident: CR12
  article-title: Neutrophils, IL-1beta, and gout: is there a link?
  publication-title: Semin. Immunopathol.
  doi: 10.1007/s00281-013-0361-0
– volume: 20
  start-page: 5917
  year: 2019
  ident: CR64
  article-title: Electroacupuncture alleviates paclitaxel-induced peripheral neuropathic pain in rats via suppressing TLR4 signaling and TRPV1 upregulation in sensory neurons
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms20235917
– volume: 28
  start-page: 164
  year: 1998
  end-page: 170
  ident: CR17
  article-title: Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2
  publication-title: Eur. J. Immunol.
  doi: 10.1002/(SICI)1521-4141(199801)28:01<164::AID-IMMU164>3.0.CO;2-S
– volume: 99
  start-page: 1035
  year: 2016
  end-page: 1043
  ident: CR49
  article-title: Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1beta production in a murine model of acute gout
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.3MA0915-418R
– volume: 585
  start-page: 141
  year: 2020
  end-page: 145
  ident: CR71
  article-title: Irritant-evoked activation and calcium modulation of the TRPA1 receptor
  publication-title: Nature
  doi: 10.1038/s41586-020-2480-9
– volume: 17
  year: 2020
  ident: CR62
  article-title: Expression profiling of spinal cord dorsal horn in a rat model of complex regional pain syndrome type-I uncovers potential mechanisms mediating pain and neuroinflammation responses
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-020-01834-0
– volume: 6
  start-page: 819
  year: 2003
  end-page: 824
  ident: CR36
  article-title: Modulation of glycine-activated ion channel function by G-protein betagamma subunits
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn1095
– volume: 117
  start-page: 29090
  year: 2020
  end-page: 29100
  ident: CR42
  article-title: The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2001177117
– volume: 106
  year: 2023
  ident: CR38
  article-title: Gβγ signaling regulates microtubule-dependent control of Golgi integrity
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2023.110630
– volume: 113
  start-page: 27
  year: 2005
  end-page: 36
  ident: CR45
  article-title: Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice
  publication-title: Pain
  doi: 10.1016/j.pain.2004.08.015
– volume: 30
  start-page: 861
  year: 2007
  end-page: 881
  ident: CR6
  article-title: Corticosteroid-induced adverse events in adults: frequency, screening and prevention
  publication-title: Drug Saf.
  doi: 10.2165/00002018-200730100-00005
– volume: 31
  start-page: 159
  year: 2019
  end-page: 166
  ident: CR4
  article-title: Patient perspectives in gout: a review
  publication-title: Curr. Opin. Rheumatol.
  doi: 10.1097/BOR.0000000000000583
– volume: 54
  start-page: 69
  year: 2019
  end-page: 80
  ident: CR50
  article-title: How do chemokines navigate neutrophils to the target site: dissecting the structural mechanisms and signaling pathways
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2018.11.004
– volume: 115
  start-page: 234
  year: 2000
  end-page: 244
  ident: CR54
  article-title: Delayed wound healing in CXCR2 knockout mice
  publication-title: J. Investig. Dermatol.
  doi: 10.1046/j.1523-1747.2000.00034.x
– volume: 10
  start-page: 12189
  year: 2020
  end-page: 12203
  ident: CR14
  article-title: IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain
  publication-title: Theranostics
  doi: 10.7150/thno.48028
– volume: 87
  start-page: 124
  year: 2015
  end-page: 138
  ident: CR34
  article-title: HTR7 mediates serotonergic acute and chronic itch
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.05.044
– volume: 174
  start-page: 867
  year: 2017
  end-page: 879
  ident: CR70
  article-title: Transient receptor potential cation channel subfamily M member 8 channels mediate the anti-inflammatory effects of eucalyptol
  publication-title: Br. J. Pharm.
  doi: 10.1111/bph.13760
– volume: 20
  start-page: 895
  year: 1977
  end-page: 900
  ident: CR58
  article-title: Preliminary criteria for the classification of the acute arthritis of primary gout
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.1780200320
– volume: 62
  year: 2021
  ident: CR26
  article-title: CXCL5 secreted from macrophages during cold exposure mediates white adipose tissue browning
  publication-title: J. Lipid Res.
  doi: 10.1016/j.jlr.2021.100117
– volume: 14
  start-page: 595
  year: 2011
  end-page: 602
  ident: CR33
  article-title: TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2789
– volume: 10
  start-page: 453
  year: 2019
  ident: CR44
  article-title: TRPV1 channel contributes to the behavioral hypersensitivity in a rat model of complex regional pain syndrome type 1
  publication-title: Front. Pharm.
  doi: 10.3389/fphar.2019.00453
– volume: 88
  start-page: 32
  year: 2010
  end-page: 40
  ident: CR53
  article-title: Crystal-induced neutrophil activation
  publication-title: Immunol. Cell Biol.
  doi: 10.1038/icb.2009.98
– volume: 14
  year: 2023
  ident: CR2
  article-title: Association of gout with brain reserve and vulnerability to neurodegenerative disease
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-38602-6
– volume: 59
  start-page: 57
  year: 2016
  end-page: 62
  ident: CR47
  article-title: Interaction of calcitonin gene related peptide (CGRP) and substance P (SP) in human skin
  publication-title: Neuropeptides
  doi: 10.1016/j.npep.2016.06.001
– volume: 5
  start-page: 69
  year: 2019
  ident: CR1
  article-title: Gout
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/s41572-019-0115-y
– volume: 63
  start-page: 746
  year: 1998
  end-page: 751
  ident: CR27
  article-title: Mast cells produce ENA-78, which can function as a potent neutrophil chemoattractant during allergic airway inflammation
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/jlb.63.6.746
– volume: 103
  start-page: 19564
  year: 2006
  end-page: 19568
  ident: CR39
  article-title: TRP channel activation by reversible covalent modification
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0609598103
– volume: 76
  start-page: 546
  year: 2020
  end-page: 557
  ident: CR5
  article-title: NSAIDs in CKD: Are They Safe?
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2020.03.023
– volume: 18
  year: 2021
  ident: CR10
  article-title: The NLRP3 inflammasome: an emerging therapeutic target for chronic pain
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-021-02131-0
– volume: 156
  start-page: 1124
  year: 2015
  end-page: 1144
  ident: CR57
  article-title: Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model
  publication-title: Pain
  doi: 10.1097/j.pain.0000000000000158
– volume: 11
  start-page: 1259
  year: 2020
  ident: CR20
  article-title: Multiple roles for chemokines in neutrophil biology
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.01259
– volume: 14
  start-page: eaax3053
  year: 2021
  ident: CR18
  article-title: Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aax3053
– volume: 4
  year: 2008
  ident: CR22
  article-title: The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons
  publication-title: Mol. Pain
  doi: 10.1186/1744-8069-4-38
– volume: 45
  start-page: 27
  year: 2007
  end-page: 37
  ident: CR25
  article-title: Cytokines, inflammation, and pain
  publication-title: Int. Anesthesiol. Clin.
  doi: 10.1097/AIA.0b013e318034194e
– volume: 3
  start-page: 90ra60
  year: 2011
  ident: CR19
  article-title: CXCL5 mediates UVB irradiation-induced pain
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3002193
– volume: 1868
  year: 2021
  ident: CR37
  article-title: Two naturally occurring mutations of human GPR103 define distinct G protein selection bias
  publication-title: Biochim. Biophys. Acta Mol. Cell Res.
  doi: 10.1016/j.bbamcr.2021.119046
– volume: 18
  year: 2023
  ident: CR55
  article-title: Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivation
  publication-title: Chin. Med.
  doi: 10.1186/s13020-023-00800-1
– volume: 15
  start-page: 985
  year: 2022
  end-page: 1001
  ident: CR61
  article-title: Genome-wide expression profiling by RNA-sequencing in spinal cord dorsal horn of a rat chronic postsurgical pain model to explore potential mechanisms involved in chronic pain
  publication-title: J. Pain Res.
  doi: 10.2147/JPR.S358942
– volume: 18
  start-page: 117
  year: 2016
  ident: CR29
  article-title: Monosodium urate crystals induce oxidative stress in human synoviocytes
  publication-title: Arthritis Res. Ther.
  doi: 10.1186/s13075-016-1012-3
– volume: 10
  start-page: 229
  year: 2019
  ident: CR68
  article-title: Ru(bpy)2(NO)SO3](PF6), a nitric oxide donating ruthenium complex, reduces gout arthritis in mice
  publication-title: Front. Pharm.
  doi: 10.3389/fphar.2019.00229
– volume: 14
  year: 2023
  ident: CR46
  article-title: Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-38241-x
– volume: 94
  start-page: 1099
  year: 2014
  end-page: 1142
  ident: CR51
  article-title: Calcitonin gene-related peptide: physiology and pathophysiology
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00034.2013
– volume: 120
  start-page: 1240
  year: 2010
  end-page: 1252
  ident: CR65
  article-title: The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca -activated Cl- channels
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI41084
– volume: 280
  start-page: 1271
  year: 1998
  end-page: 1274
  ident: CR35
  article-title: Molecular basis for interactions of G protein betagamma subunits with effectors
  publication-title: Science
  doi: 10.1126/science.280.5367.1271
– volume: 14
  year: 2023
  ident: 47640_CR46
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-38241-x
– volume: 3
  start-page: 90ra60
  year: 2011
  ident: 47640_CR19
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3002193
– volume: 28
  start-page: 164
  year: 1998
  ident: 47640_CR17
  publication-title: Eur. J. Immunol.
  doi: 10.1002/(SICI)1521-4141(199801)28:01<164::AID-IMMU164>3.0.CO;2-S
– volume: 10
  start-page: 453
  year: 2019
  ident: 47640_CR44
  publication-title: Front. Pharm.
  doi: 10.3389/fphar.2019.00453
– volume: 31
  start-page: 97
  year: 2021
  ident: 47640_CR66
  publication-title: J. Adv. Res.
  doi: 10.1016/j.jare.2020.12.009
– volume: 20
  start-page: 5917
  year: 2019
  ident: 47640_CR64
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms20235917
– volume: 5
  start-page: 69
  year: 2019
  ident: 47640_CR1
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/s41572-019-0115-y
– volume: 20
  year: 2023
  ident: 47640_CR59
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-023-02778-x
– volume: 27
  start-page: 112
  year: 2018
  ident: 47640_CR73
  publication-title: Protein Sci.
  doi: 10.1002/pro.3280
– volume: 165
  year: 2023
  ident: 47640_CR13
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2023.115143
– volume: 63
  start-page: 746
  year: 1998
  ident: 47640_CR27
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/jlb.63.6.746
– volume: 80
  start-page: 1604
  year: 2021
  ident: 47640_CR11
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2021-220295
– volume: 76
  start-page: 546
  year: 2020
  ident: 47640_CR5
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2020.03.023
– volume: 174
  start-page: 867
  year: 2017
  ident: 47640_CR70
  publication-title: Br. J. Pharm.
  doi: 10.1111/bph.13760
– volume: 4
  year: 2008
  ident: 47640_CR22
  publication-title: Mol. Pain
  doi: 10.1186/1744-8069-4-38
– volume: 1868
  year: 2021
  ident: 47640_CR37
  publication-title: Biochim. Biophys. Acta Mol. Cell Res.
  doi: 10.1016/j.bbamcr.2021.119046
– volume: 113
  start-page: E7572
  year: 2016
  ident: 47640_CR67
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1606608113
– volume: 339
  start-page: 133
  year: 2018
  ident: 47640_CR41
  publication-title: Int. Rev. Cell Mol. Biol.
  doi: 10.1016/bs.ircmb.2018.02.008
– volume: 18
  start-page: 117
  year: 2016
  ident: 47640_CR29
  publication-title: Arthritis Res. Ther.
  doi: 10.1186/s13075-016-1012-3
– volume: 10
  start-page: 229
  year: 2019
  ident: 47640_CR68
  publication-title: Front. Pharm.
  doi: 10.3389/fphar.2019.00229
– volume: 30
  start-page: 861
  year: 2007
  ident: 47640_CR6
  publication-title: Drug Saf.
  doi: 10.2165/00002018-200730100-00005
– volume: 62
  year: 2021
  ident: 47640_CR26
  publication-title: J. Lipid Res.
  doi: 10.1016/j.jlr.2021.100117
– volume: 26
  start-page: 7984
  year: 2006
  ident: 47640_CR43
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2211-06.2006
– volume: 113
  start-page: 27
  year: 2005
  ident: 47640_CR45
  publication-title: Pain
  doi: 10.1016/j.pain.2004.08.015
– volume: 10
  start-page: 12189
  year: 2020
  ident: 47640_CR14
  publication-title: Theranostics
  doi: 10.7150/thno.48028
– volume: 285
  start-page: 2944
  year: 2018
  ident: 47640_CR48
  publication-title: FEBS J.
  doi: 10.1111/febs.14466
– volume: 76
  start-page: 29
  year: 2017
  ident: 47640_CR7
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2016-209707
– volume: 17
  year: 2020
  ident: 47640_CR62
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-020-01834-0
– volume: 81
  start-page: 786
  year: 2007
  ident: 47640_CR28
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0806502
– volume: 14
  start-page: eaax3053
  year: 2021
  ident: 47640_CR18
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aax3053
– volume: 821
  start-page: eS30
  year: 2015
  ident: 47640_CR8
  publication-title: Jt. Bone Spine
  doi: 10.1016/S1297-319X(15)30005-1
– volume: 35
  start-page: 501
  year: 2013
  ident: 47640_CR12
  publication-title: Semin. Immunopathol.
  doi: 10.1007/s00281-013-0361-0
– volume: 14
  start-page: 595
  year: 2011
  ident: 47640_CR33
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2789
– volume: 27
  start-page: 16
  year: 2022
  ident: 47640_CR60
  publication-title: Cell. Mol. Biol. Lett.
  doi: 10.1186/s11658-022-00316-w
– volume: 72
  start-page: 200
  year: 2014
  ident: 47640_CR56
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2014.04.021
– volume: 68
  start-page: 1602
  year: 2009
  ident: 47640_CR23
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/ard.2009.109355
– volume: 106
  year: 2023
  ident: 47640_CR38
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2023.110630
– volume: 25
  start-page: 402
  year: 2001
  ident: 47640_CR69
  publication-title: Methods
  doi: 10.1006/meth.2001.1262
– volume: 59
  start-page: 57
  year: 2016
  ident: 47640_CR47
  publication-title: Neuropeptides
  doi: 10.1016/j.npep.2016.06.001
– volume: 99
  start-page: 1035
  year: 2016
  ident: 47640_CR49
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.3MA0915-418R
– volume: 585
  start-page: 141
  year: 2020
  ident: 47640_CR71
  publication-title: Nature
  doi: 10.1038/s41586-020-2480-9
– volume: 127
  start-page: 219
  year: 2016
  ident: 47640_CR31
  publication-title: Brain Res Bull.
  doi: 10.1016/j.brainresbull.2016.09.016
– volume: 88
  start-page: 32
  year: 2010
  ident: 47640_CR53
  publication-title: Immunol. Cell Biol.
  doi: 10.1038/icb.2009.98
– volume: 31
  start-page: 159
  year: 2019
  ident: 47640_CR4
  publication-title: Curr. Opin. Rheumatol.
  doi: 10.1097/BOR.0000000000000583
– volume: 20
  start-page: 895
  year: 1977
  ident: 47640_CR58
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.1780200320
– volume: 261
  start-page: 306
  year: 1987
  ident: 47640_CR32
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.902610211
– volume: 64
  start-page: 474
  year: 2012
  ident: 47640_CR15
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.33355
– volume: 120
  start-page: 1240
  year: 2010
  ident: 47640_CR65
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI41084
– volume: 6
  start-page: 30
  year: 2010
  ident: 47640_CR3
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2009.236
– volume: 18
  year: 2021
  ident: 47640_CR10
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-021-02131-0
– volume: 73
  start-page: 4249
  year: 2016
  ident: 47640_CR52
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-016-2293-z
– volume: 11
  start-page: 1259
  year: 2020
  ident: 47640_CR20
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.01259
– volume: 117
  start-page: 29090
  year: 2020
  ident: 47640_CR42
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2001177117
– volume: 354
  start-page: 610
  year: 2006
  ident: 47640_CR16
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra052723
– volume: 15
  start-page: 1829
  year: 2020
  ident: 47640_CR72
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-020-0312-x
– volume: 87
  start-page: 124
  year: 2015
  ident: 47640_CR34
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.05.044
– volume: 154
  start-page: 2185
  year: 2013
  ident: 47640_CR21
  publication-title: Pain
  doi: 10.1016/j.pain.2013.07.002
– volume: 94
  start-page: 1099
  year: 2014
  ident: 47640_CR51
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00034.2013
– volume: 18
  year: 2023
  ident: 47640_CR55
  publication-title: Chin. Med.
  doi: 10.1186/s13020-023-00800-1
– volume: 67
  start-page: 255
  year: 2014
  ident: 47640_CR30
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2013.10.814
– volume: 177
  start-page: 2042
  year: 2020
  ident: 47640_CR24
  publication-title: Br. J. Pharm.
  doi: 10.1111/bph.14967
– volume: 45
  start-page: 27
  year: 2007
  ident: 47640_CR25
  publication-title: Int. Anesthesiol. Clin.
  doi: 10.1097/AIA.0b013e318034194e
– volume: 21
  start-page: 1060
  year: 2020
  ident: 47640_CR63
  publication-title: J. Pain.
  doi: 10.1016/j.jpain.2020.01.007
– volume: 14
  year: 2023
  ident: 47640_CR2
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-38602-6
– volume: 288
  start-page: 2490
  year: 2021
  ident: 47640_CR40
  publication-title: FEBS J.
  doi: 10.1111/febs.15605
– volume: 156
  start-page: 1124
  year: 2015
  ident: 47640_CR57
  publication-title: Pain
  doi: 10.1097/j.pain.0000000000000158
– volume: 115
  start-page: 234
  year: 2000
  ident: 47640_CR54
  publication-title: J. Investig. Dermatol.
  doi: 10.1046/j.1523-1747.2000.00034.x
– volume: 54
  start-page: 69
  year: 2019
  ident: 47640_CR50
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2018.11.004
– volume: 15
  start-page: 985
  year: 2022
  ident: 47640_CR61
  publication-title: J. Pain Res.
  doi: 10.2147/JPR.S358942
– volume: 60
  start-page: 281
  year: 2009
  ident: 47640_CR9
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.24185
– volume: 6
  start-page: 819
  year: 2003
  ident: 47640_CR36
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn1095
– volume: 103
  start-page: 19564
  year: 2006
  ident: 47640_CR39
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0609598103
– volume: 280
  start-page: 1271
  year: 1998
  ident: 47640_CR35
  publication-title: Science
  doi: 10.1126/science.280.5367.1271
SSID ssj0000391844
Score 2.5387704
Snippet Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5...
Abstract Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3263
SubjectTerms 13/95
14/32
38
49
49/91
631/250/371
631/378/2607
631/378/371
82/51
82/80
9/74
96
96/31
Animal models
Animals
Ankle
Arthralgia
Arthritis
Arthritis, Gouty
Calcitonin gene-related peptide
Chemokine CXCL5 - genetics
Chemokine CXCL5 - metabolism
Chemotaxis
CXCR2 protein
Dorsal root ganglia
Extravasation
Gout
Humanities and Social Sciences
Humans
Immunomodulation
Inflammation
Joint diseases
Joints (anatomy)
Leukocytes (neutrophilic)
Male
Mice
multidisciplinary
Neurons
Neutrophils
Nociception
Nociceptors - metabolism
Pain
Pain perception
Rheumatism
Science
Science (multidisciplinary)
Sensory neurons
Substance P
Vasodilation
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA9yIPgifls9JYJvWq7tpEn6eLd4HCI-iAf7FpI09VYkPXa7B_vfO5N2110_X3xs88EwM8nMkJnfMPa6Buk9VC7vpCtyoaDNnVaQq66AUDY-lDYlyH6UF5fi_bye77X6opywER54ZNwJlM5b5a3V1gvdBd3htRuscAT0plPdeoU2by-YSncwNBi6iKlKpgB9shLpTkCThBRJSqM7sEQJsP93XuavyZI_vZgmQ3R-j92dPEh-OlJ-n90K8QG7PfaU3Dxkm9l89qHmVK9wQ34kx-9PFV9EHlEOKYnlJvAVRq_9csMTnGVc8aHn7ZIGvvaLOPBri_NtbHFZhyozljfSHvsNAfiXfj1sOLLwKiEjPWKX5-8-zy7yqb9C7mtRDrmuW-XQf3ONlS04Kb1SXnROS2hLb0PnBNXVKhlsIXzb1VYVokV_CUOe0jmAx-wo9jE8ZVwCXhSFb6wvrAhQNJW2GMzJoEAEASpj5ZbXxk_g49QD45tJj-CgzSgfg_IxST4G17zZrbkeoTf-OvuMRLibSbDZ6Qcqk5mUyfxLmTJ2vFUAM53llUEj30j0ikBn7NVuGE8hPa3YGPo1zRHUib6mLZ6M-rKjBDBoJNzBjOkDTTog9XAkLq4S0neZGq_rKmNvt0r3g64_8-LZ_-DFc3anotNCuJbymB0Ny3V4gQ7Y4F6ms_YdzqksbA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k1KQUbiBlGT2LGdE4IVS4UQB0SlvVm247RbIWfZZCvtv--Mk01ZHj0mtiPH87bH3xDypmTCOVbYtBE2S7lkdWqVZKlsMubzyvncxATZb-LklH9ZlItxw60b0yp3OjEq6rp1uEd-DKq2EmCbmHq_-pVi1Sg8XR1LaNwmd3KwNJjSpeafpz0WRD9XnI93ZTKmjjseNQMYJpiXwGS6PXsUYfv_5Wv-nTL5x7lpNEfzB-T-6EfSDwPhH5JbPjwid4fKktvHZDtbzL6WFG8tXKI3SeH5e0GXgQagRkxlufS0gxi2XW9pBLUMHe1bWq-x4aJdhp6uDPQ3oYZhDTDOcMkRv_F7WQB61m76LQUOPI_4SE_I6fzTj9lJOlZZSF3J8z5VZS0teHG2MqJmVggnpeONVYLVuTO-sRxv10rhTcZd3ZRGZrwGrwkCn9xaxp6Sg9AG_5xQwUBdZK4yLjPcs6wqlIGQTnjJuOdMJiTfrbV2IwQ5VsL4qeNROFN6oI8G-uhIHw1j3k5jVgMAx429PyIJp54Inh1ftOszPcqiZrl1RjpjlHFcNV41YMm94RaxA1WVJ-RoxwB6lOhOX_NfQl5PzSCLeMBigm832IdjPfoSP_Fs4JdpJgxCR0QfTIja46S9qe63hOV5xPvOY_l1VSTk3Y7pruf1_7U4vPk3XpB7BcoB4laKI3LQrzf-JThYvX0VpegK_HYjJA
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9QwDI_GJiRe0PguGyhIvEFF26RJ-nicmKYT4gGYdG9RkqbbIZROd71J999jpx9wMJB4bGNHUWzXTmP_TMjrkgnnWGHTRtgs5ZLVqVWSpbLJmM8r53MTE2Q_ifMLvliWywNSjLUwMWk_QlrGz_SYHfZuw6NJg0eBCQVmwd0hRwjVDrp9NJstviymPyuIea44HypkMqZuYd7zQhGs_7YI889Eyd9uS6MTOjsm94fokc769T4gBz48JHf7fpK7R2Q3X84_lhRrFW4whqTw_Lmgq0ADyCAmsNx4uoGTa7ve0QhlGTa0a2m9xoFv7Sp09NoAvQk1sDWgLn1pI87xazMAetluux2FjbuKqEiPycXZh6_z83TorZC6kuddqspaWojdbGVEzawQTkrHG6sEq3NnfGM51tRK4U3GXd2URma8hlgJjju5tYw9IYehDf4ZoYLBRyJzlXGZ4Z5lVaEMHOSEl4x7zmRC8nGvtRuAx7H_xXcdL8CZ0r18NMhHR_lo4Hkz8Vz3sBv_pH6PIpwoETI7vmjXl3pQIc1y64x0xijjuGq8asB_e8MtIgaqKk_I6agAerDjjQYHXwmIiJhKyKtpGCwQr1VM8O0WaTh2oS9xiqe9vkwrYXBgRMzBhKg9Tdpb6v5IWF1FlO88Nl1XRULejkr3c11_34vn_0d-Qu4VaBeIXilOyWG33voXEGZ19uVgVz8A8KUiSw
  priority: 102
  providerName: Springer Nature
Title CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis
URI https://link.springer.com/article/10.1038/s41467-024-47640-7
https://www.ncbi.nlm.nih.gov/pubmed/38627393
https://www.proquest.com/docview/3039629338
https://www.proquest.com/docview/3040320591
https://pubmed.ncbi.nlm.nih.gov/PMC11021482
https://doaj.org/article/31bca7caa8ac48fe8f413ea4b7820891
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELf2ISReEN_LGJWReINAEju284BQF61MFUxoUKlvke04W9GUbGk6kf-es5MUCgXxkirx2bV8d7m72Pc7hF7GhGlNIuUXTAU-5ST3leDE50VATJhoE0p3QPaMnc7odB7Pd9BQ7qhfwOXW0M7Wk5rVV2--37TvQeHfdSnj4u2SOnUHawN_xuwJuV20D5aJ24oGn3p3372ZSQIBjd1ojgIa-kBA-jya7cNs2CoH6b_ND_3zOOVve6rOVE3uo3u9j4nHnVA8QDumfIjudFUn20eoTefpxxjbjIZb62liuD-P8KLEJXDKHXO5NXgJ8W1Vt9gBXpZL3FQ4r23Dt2pRNvhaAr0sc-hWgFB1CZB2jF9LBuCLatW0GKTz0mEnPUazycnX9NTvKzD4OqZh44s45wo8PJVIlhPFmOZc00IJRvJQS1MoajNvOTMyoDovYskDmoNHBUFRqBQhT9BeWZXmAGFG4FUS6ETqQFJDgiQSEsI9ZjihhhLuoXBY60z38OS2SsZV5rbJicg6_mTAn8zxJ4M-r9Z9rjtwjn9SH1sWriktsLZ7UNUXWa-nGQmVllxLKaSmojCiACtvJFUWV1AkoYeOBgHIBmHNwA1IGPhNRHjoxboZ9NRuvsjSVCtLQ22t-tgO8bSTl_VMCISVFpnQQ2JDkjamutlSLi4dFnjoSrOLyEOvB6H7Oa-_r8Xhf8zzGbobWWWwwJbsCO019co8Bw-sUSO0y-ccrmLyYYT2x-Pplyn8Hp-cfT6HpylLR-7bxsip3w8vkTDf
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Nb9MwFLemIQQXxPcCA4wEJ4iWxI7tHBCCQulY2QFtUm_BdpytCCWlTYf6T_E38p6TdJSP3XZMbEeO36ft936PkGcpE9ayxISlMFHIJStCoyQLZRkxF2fWxdoHyB6K0TH_OEknW-RnnwuDYZW9TvSKuqgtnpHvgarNBNgmpl7PvodYNQpvV_sSGi1bHLjVD9iyLV7tvwP6Pk-S4fujwSjsqgqENuVxE6q0kAa8FpNpUTAjhJXS8tIowYrYalcajtmkUjgdcVuUqZYRL8BLAEc_NgYPQEHlX-EMLDlmpg8_rM90EG1dcd7l5kRM7S2410RgCGEdBAbvbdg_XybgX77t3yGaf9zTevM3vEludH4rfdMy2i2y5arb5GpbyXJ1h6wGk8E4pZglcYbeK4XnzwmdVrQC6vvQmTNHF7Bnrucr6kE0qwVtalrMseFrPa0aOtPQX1cFDCuBUdukSvzG72UI6Em9bFYUOP7U4zHdJceXsv73yHZVV26HUMFAPUU20zbS3LEoS5SGLaRwknHHmQxI3K91bjvIc6y88S33V-9M5S19cqBP7umTw5gX6zGzFvDjwt5vkYTrngjW7V_U85O8k_2cxcZqabVW2nJVOlWC5-A0N4hVqLI4ILs9A-SdBlnk5_wekKfrZpB9vNDRlauX2IdHLAEHGT5xv-WX9UwYbFUR7TAgaoOTNqa62VJNTz2-eOzLvaskIC97pjuf1__X4sHFv_GEXBsdfRrn4_3Dg4fkeoIygZiZYpdsN_OlewTOXWMee4mi5Mtli_AvgBFgRA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELemTiBeEN8rDDASPEG0JHZs5wEh1q3a2FRNE5P6FmzH2YpQUtp0qP8afx13TtJRPva2x8R25Ph-Pt_Z598R8jphwloWm6AQJgy4ZHlglGSBLELmotS6SPsA2ZE4OOOfxsl4g_zs7sJgWGWnE72iziuLe-Q7oGpTAWsTUztFGxZxsjf8MP0eYAYpPGnt0mk0EDlyyx_gvs3fH-6BrN_E8XD_8-AgaDMMBDbhUR2oJJcGLBiTapEzI4SV0vLCKMHyyGpXGI43S6VwOuQ2LxItQ56DxQBGf2QMboaC-t-U6BX1yObu_ujkdLXDg9zrivP2pk4IHZ9zr5dgWYRRERjKt7Ya-qQB_7J0_w7Y_OPU1i-Gw3vkbmvF0o8N7O6TDVc-ILeavJbLh2Q5GA-OE4p3Ji7RlqXwfBrTSUlLwIIPpLl0dA4edDVbUk-pWc5pXdF8hgVfq0lZ06mG-rrMoVkBsG2uWOI3fk9KQM-rRb2kgP8Lz870iJzdiAQek15ZlW6LUMFAWYU21TbU3LEwjZUGh1I4ybjjTPZJ1I11ZlsCdMzD8S3zB_FMZY18MpBP5uWTQZu3qzbThv7j2tq7KMJVTaTu9i-q2XnWaoKMRcZqabVW2nJVOFWAHeE0N8hcqNKoT7Y7AGStPplnV-jvk1erYtAEeLyjS1ctsA4PWQzmMnziSYOXVU8YOK7Ifdgnag1Ja11dLyknF55tPPLJ31XcJ-860F316_9j8fT633hJbsP0zY4PR0fPyJ0YpwQSaIpt0qtnC_ccLL3avGinFCVfbnoW_wLgEmXW
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CXCL5+activates+CXCR2+in+nociceptive+sensory+neurons+to+drive+joint+pain+and+inflammation+in+experimental+gouty+arthritis&rft.jtitle=Nature+communications&rft.au=Yin%2C+Chengyu&rft.au=Liu%2C+Boyu&rft.au=Dong%2C+Zishan&rft.au=Shi%2C+Sai&rft.date=2024-04-16&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=15&rft.issue=1&rft.spage=3263&rft_id=info:doi/10.1038%2Fs41467-024-47640-7&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon