The genetic and clinical characteristics of WFS1 related diabetes in Chinese early onset type 2 diabetes

• Published in: Scientific reports Vol. 13; no. 1; p. 9127
• Main Authors: Li, Yating, Gong, Siqian, Li, Meng, Cai, Xiaoling, Liu, Wei, Zhang, Simin, Ma, Yumin, Luo, Yingying, Zhou, Lingli, Zhang, Xiuying, Huang, Xiuting, Gao, Xueying, Hu, Mengdie, Li, Yufeng, Ren, Qian, Wang, Yanai, Zhou, Xianghai, Han, Xueyao, Ji, Linong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.06.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208/737; 692/163/2743/137; Age; Beta cells; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; East Asian People; Exons; Genetic screening; Genetic Testing; Genetics; Humanities and Social Sciences; Humans; multidisciplinary; Pathogenicity; Pathogens; Patients; Phenotype; Phenotypes; Science; Science (multidisciplinary); Wolfram Syndrome - diagnosis; Wolfram Syndrome - genetics; Wolfram Syndrome - pathology

Diabetes is one of the most common phenotypes of Wolfram syndrome owing to the presence of the variants of the WFS1 gene and is often misdiagnosed as other types of diabetes. We aimed to explore the prevalence of WFS1-related diabetes (WFS1-DM) and its clinical characteristics in a Chinese populatio...