Lipidome atlas of the adult human brain

• Published in: Nature communications Vol. 15; no. 1; pp. 4455 - 18
• Main Authors: Osetrova, Maria, Tkachev, Anna, Mair, Waltraud, Guijarro Larraz, Patricia, Efimova, Olga, Kurochkin, Ilia, Stekolshchikova, Elena, Anikanov, Nickolay, Foo, Juat Chin, Cazenave-Gassiot, Amaury, Mitina, Aleksandra, Ogurtsova, Polina, Guo, Song, Potashnikova, Daria M., Gulin, Alexander A., Vasin, Alexander A., Sarycheva, Anastasia, Vladimirov, Gleb, Fedorova, Maria, Kostyukevich, Yury, Nikolaev, Evgeny, Wenk, Markus R., Khrameeva, Ekaterina E., Khaitovich, Philipp
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 140/58; 38; 631/378/116; 631/378/2583; 631/378/340; 64/110; Adult; Animals; Brain; Brain - metabolism; Brain mapping; Composition; Data processing; Fatty Acids, Omega-3 - metabolism; Fatty Acids, Omega-6 - metabolism; Female; Functional morphology; Gene expression; Humanities and Social Sciences; Humans; Information processing; Lipid composition; Lipid Metabolism; Lipidomics; Lipids; Lipids - analysis; Lipids - chemistry; Macaca; Male; Mass spectrometry; Mass spectroscopy; Mice; Middle Aged; multidisciplinary; Myelin; Myelin Sheath - metabolism; Neural networks; Neuroimaging; Neurons - metabolism; Polyunsaturated fatty acids; Science; Science (multidisciplinary); Structure-function relationships

Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These di...