Calcifediol boosts efficacy of ChAdOx1 nCoV-19 vaccine by upregulating genes promoting memory T cell responses

• Published in: npj vaccines Vol. 9; no. 1; pp. 114 - 12
• Main Authors: Saroha, Himanshu Singh, Bhat, Swati, Das, Liza, Dutta, Pinaki, Holick, Michael F., Sachdeva, Naresh, Marwaha, Raman Kumar
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/590/2291; 692/308/409; Antiviral drugs; Biomedical and Life Sciences; Biomedicine; Coronaviruses; COVID-19; Gene expression; Immunogenicity; Infectious Diseases; Lymphocytes; Medical Microbiology; Pandemics; Public Health; Vaccine; Vaccines; Virology; Vitamin D

The ChAdOx1 nCoV-19 (COVISHIELD) vaccine has emerged as a pivotal tool in the global fight against the COVID-19 pandemic. In our previous study eligible subjects were supplemented with calcifediol, a direct precursor to the biologically active form of vitamin D, calcitriol with an objective to enhan...