A potential role for the gut microbiome in substance use disorders

• Published in: Psychopharmacology Vol. 236; no. 5; pp. 1513 - 1530
• Main Authors: Meckel, Katherine R., Kiraly, Drew D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2019; Springer; Springer Nature B.V
• Subjects: Addiction; Amino acids; Analgesics, Opioid - adverse effects; Animal models; Animals; Biomedical and Life Sciences; Biomedicine; Digestive system; Drug abuse; Drug addiction; Drug use; Dysbacteriosis; Dysbiosis - chemically induced; Dysbiosis - immunology; Dysbiosis - metabolism; Dysbiosis - psychology; Ethanol - adverse effects; Gastric Mucosa - drug effects; Gastric Mucosa - immunology; Gastric Mucosa - metabolism; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - physiology; Gut microbiota; Health aspects; Humans; Illegal drugs; Illicit Drugs - adverse effects; Immune system; Immune System - drug effects; Immune System - immunology; Immune System - metabolism; Immunosuppressive agents; Intestinal microflora; Intracellular signalling; Metabolites; Microbiomes; Microbiota; Neurons; Neurosciences; Pharmacology/Toxicology; Psychiatry; Public health; Public health movements; Review; Substance abuse; Substance use disorder; Substance-Related Disorders - immunology; Substance-Related Disorders - metabolism; Substance-Related Disorders - psychology; Microbiota; Addiction; Metabolites; Gut-brain; Opioid; Alcohol; Cocaine; Dysbiosis; Microbiome

Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few su...